Click here to switch to the map view.

The map label for this gene is purC [H]

Identifier: 39997189

GI number: 39997189

Start: 2297786

End: 2298676

Strand: Direct

Name: purC [H]

Synonym: GSU2091

Alternate gene names: 39997189

Gene position: 2297786-2298676 (Clockwise)

Preceding gene: 39997188

Following gene: 39997198

Centisome position: 60.24

GC content: 61.5

Gene sequence:

>891_bases
ATGGCAGAACTGGTGCTCAAGACCGATTTCCCCGACCTGAAACTTGCCGGCCGCGGCAAGGTACGCGACATTTACGATCT
GGGCGACGCGCTGCTCATCGTCACCACCGACCGGATCTCGGCCTTCGACGTCATCATGAACGAGGCGATTCCCGACAAGG
GGTACGTCCTCACCCAGATATCCTCTTTCTGGTTCCGCCAGATGGAGGACATCATCCCCAACCACATCATCTCCACCGAC
GTGAAGGACTTCCCGGCCGAGTGCCAGAAGTATGCGGCCCAGCTCGAAGGCCGTTCCATGCTGGTCAAGAAGGCCAAGCC
CCTGCCGGTGGAATGCATCGTGCGCGGCTACATCTCCGGCTCCGGCTGGAAGGACTACAAGGCCACCGGCGCCATCTGCG
GCATCACGCTCCCGGCCGGCCTCGTGGAATCCGACAAGCTGGAGGAGCCCATCTTCACCCCCTCCACCAAGGCGGAACTG
GGTGAGCATGACGAGAACATCTCCTTCGACAAGTGCGTGGAGCTGATCGGGCGTGAACTGGCCGAAAAGATCCGCGACGT
CACCATCGCCATCTACAAGCGGGCCCGGGACATCGCCGACACCAAAGGAATCATCATCGCCGACACCAAGTTCGAGTACG
GCATCTACAACGGCGAACTGATCATCATCGACGAGTGCATGACCCCGGACTCCTCGCGCTTCTGGCCCAAGGACAGCTAC
AAGCCGGGCGGCGCCCAGCCCTCCTTTGACAAGCAGTTCCTGCGGGACTACCTGGAGACCCTCGACTGGGGCAAAACCGC
GCCGGCGCCGCCCCTGCCCGAGGAAATCGTCCGCAAGACCGGCGAGAAGTACATGGAAGCCCTGGTCCGTCTCACCGGAA
AAGGCAAGTAA

Upstream 100 bases:

>100_bases
GAATATCGCAAATGGATCGAAGAGCTTCGGAGCAAGGCGAAGATCGAGATCAACCCCGCCCTCAAGGACATTTGACCATT
AACAAGAGGAGATTCAAGCC

Downstream 100 bases:

>100_bases
CCCGTCCTCTTCCACCAGATCAAAAGCACGAAACCCCGGCCGCTACGGTCGGGGTTTCGTGCTTTCCGGCTCGGGATGTA
AGGGGACGAAGAGTCAGCCG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MAELVLKTDFPDLKLAGRGKVRDIYDLGDALLIVTTDRISAFDVIMNEAIPDKGYVLTQISSFWFRQMEDIIPNHIISTD
VKDFPAECQKYAAQLEGRSMLVKKAKPLPVECIVRGYISGSGWKDYKATGAICGITLPAGLVESDKLEEPIFTPSTKAEL
GEHDENISFDKCVELIGRELAEKIRDVTIAIYKRARDIADTKGIIIADTKFEYGIYNGELIIIDECMTPDSSRFWPKDSY
KPGGAQPSFDKQFLRDYLETLDWGKTAPAPPLPEEIVRKTGEKYMEALVRLTGKGK

Sequences:

>Translated_296_residues
MAELVLKTDFPDLKLAGRGKVRDIYDLGDALLIVTTDRISAFDVIMNEAIPDKGYVLTQISSFWFRQMEDIIPNHIISTD
VKDFPAECQKYAAQLEGRSMLVKKAKPLPVECIVRGYISGSGWKDYKATGAICGITLPAGLVESDKLEEPIFTPSTKAEL
GEHDENISFDKCVELIGRELAEKIRDVTIAIYKRARDIADTKGIIIADTKFEYGIYNGELIIIDECMTPDSSRFWPKDSY
KPGGAQPSFDKQFLRDYLETLDWGKTAPAPPLPEEIVRKTGEKYMEALVRLTGKGK
>Mature_295_residues
AELVLKTDFPDLKLAGRGKVRDIYDLGDALLIVTTDRISAFDVIMNEAIPDKGYVLTQISSFWFRQMEDIIPNHIISTDV
KDFPAECQKYAAQLEGRSMLVKKAKPLPVECIVRGYISGSGWKDYKATGAICGITLPAGLVESDKLEEPIFTPSTKAELG
EHDENISFDKCVELIGRELAEKIRDVTIAIYKRARDIADTKGIIIADTKFEYGIYNGELIIIDECMTPDSSRFWPKDSYK
PGGAQPSFDKQFLRDYLETLDWGKTAPAPPLPEEIVRKTGEKYMEALVRLTGKGK

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Escherichia coli, GI1788820, Length=226, Percent_Identity=25.6637168141593, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319326, Length=291, Percent_Identity=50.5154639175258, Blast_Score=281, Evalue=1e-76,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 33138; Mature: 33007

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS01057 SAICAR_SYNTHETASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELVLKTDFPDLKLAGRGKVRDIYDLGDALLIVTTDRISAFDVIMNEAIPDKGYVLTQI
CCCEEEECCCCCCEECCCCCCHHHHHCCCEEEEEEECCHHHHHHHHHHCCCCCCCHHHHH
SSFWFRQMEDIIPNHIISTDVKDFPAECQKYAAQLEGRSMLVKKAKPLPVECIVRGYISG
HHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHCC
SGWKDYKATGAICGITLPAGLVESDKLEEPIFTPSTKAELGEHDENISFDKCVELIGREL
CCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHH
AEKIRDVTIAIYKRARDIADTKGIIIADTKFEYGIYNGELIIIDECMTPDSSRFWPKDSY
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEEECCEEEEEECCCCCCCCCCCCCCCC
KPGGAQPSFDKQFLRDYLETLDWGKTAPAPPLPEEIVRKTGEKYMEALVRLTGKGK
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AELVLKTDFPDLKLAGRGKVRDIYDLGDALLIVTTDRISAFDVIMNEAIPDKGYVLTQI
CCEEEECCCCCCEECCCCCCHHHHHCCCEEEEEEECCHHHHHHHHHHCCCCCCCHHHHH
SSFWFRQMEDIIPNHIISTDVKDFPAECQKYAAQLEGRSMLVKKAKPLPVECIVRGYISG
HHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHCC
SGWKDYKATGAICGITLPAGLVESDKLEEPIFTPSTKAELGEHDENISFDKCVELIGREL
CCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHH
AEKIRDVTIAIYKRARDIADTKGIIIADTKFEYGIYNGELIIIDECMTPDSSRFWPKDSY
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEEECCEEEEEECCCCCCCCCCCCCCCC
KPGGAQPSFDKQFLRDYLETLDWGKTAPAPPLPEEIVRKTGEKYMEALVRLTGKGK
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA