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The map label for this gene is glmS

Identifier: 39995380

GI number: 39995380

Start: 276632

End: 278461

Strand: Reverse

Name: glmS

Synonym: GSU0270

Alternate gene names: 39995380

Gene position: 278461-276632 (Counterclockwise)

Preceding gene: 39995381

Following gene: 39995375

Centisome position: 7.3

GC content: 64.81

Gene sequence:

>1830_bases
ATGTGCGGAATAGTCGGCTATATCGGCGCTCAGGAAGCAACCCCCATCATCCTCGACGGGCTCAAGCGGCTCGAATACCG
GGGCTACGACTCGGCGGGAATCTGCACCCTTCTGGAAGGGAAGGCGGACAAGCGCCGCAGCGAAGGAAAACTCATCAACC
TTGAGAGGCTCATCCAGAGCACTCCCCTGGCGGGCCGCATCGGCATCGGCCACACCCGGTGGGCGACCCACGGCCCCCCT
TCGGAGCGCAACGCCCACCCCCACCAGGCCGGCTCCATCATCGTGGTGCACAACGGCATCATCGAAAACTACCTGGAACT
GAAGCAACGGCTCGTGACAAGCGGCCGGGTTTTCAACAGCGACACGGACACTGAAGTCATCGCCCATCTGATCGACGACA
AGTTCGCGGGCACGGGCGACTTCGAGCGGGCGGTTCGGGAGGCCCTGGCCGAGGTCCGCGGCGCCTATGCCCTCTGCATC
CTCTGCGAGCGGGAGCCCGGCGTGCTCATCGCCGCCAAGCAGGGCTCCCCCATGGTGGTCGGCCTGGGCGAGGGGGAATT
TTTCGTCGCCTCGGACATTCCCGCCATCCTCTCCCACACCCGGGAGATGGTCTTCATGGAGGACGGCGAGATAGTTGTCT
TCCGGGACGGCCACCCCACCTTTTCCACCGTGGCCGGCGCGCCCCTGGATAAAAAATCGCGCCACATCGACTGGTCCCCC
CTCATGGCTGAAAAGGGTGGGTACAAGCACTTCATGCTCAAGGAAATCTTCGAGCAGCCCCGGGCGGTCCAGGACACCAT
CACCGGCCGGTTGCTGGAGGAGCAGGGGGACGTGCGGCTTGAGGAGATGAAGCTCGCCGACGAGCAGTTGCGGGGAATCG
GCCGGATCTGCATCGTTGCCTGCGGCACCTCCTGGCATTCGGCACTCGTGGGCAAGTTCCTCATGGAGGAGCACTGCCGC
ATCCCGGTAGAGGTGGACATCGCCTCCGAGTTCCGCTACCGCAACCCGGTCATCGACTCGAAGACGCTGCTGCTGGTCAT
CTCCCAATCCGGCGAGACCGCCGACACCCTGGCCGCCCTCCGGGAAGCCAAGGCCCGGGGCGCCATGACCGCCGCCATCT
GCAACGTGGTGGATTCCTCCATCGCCCGGGAAGCCCACGGCGTGCTCTATACCCATGCCGGACCCGAGATCGGGGTGGCT
TCCACCAAGGCCTTCGTCACCCAACTGGTGGCCCTCTACCTCTTCACCATCCGCCTTGGCCGGGCCGTCGGCACCATCGA
CTGCGAGCAGGGACGCACCATGATCGGCGGCCTGCTCAAGGTGCCGGCACTCCTGGAGCAGGCCCTGGAGACCAACGAGC
AGGTGGAGCGGATCGCCCGGCGCTACATGAATGCCCGCGACTTCCTCTACCTGGGGCGGGGCATGAACTATCCCATCGCC
CTGGAAGGCGCCCTGAAGCTCAAGGAGATTTCCTACATCCACGCCGAAGGCTACCCGGCCGGCGAGATGAAGCACGGCCC
CATCGCCCTCATCGATGAGAACATGCCGGTGGTGGTTCTCGTGCCGAAAAACAGCACCTACGAAAAGGTCCTCTCCAACA
TGGAGGAGGTCATCGCCCGGGGCGGACGGGTGATCGCCATCTGCTCCGCCGGTGACGAGGCGATTGCGAAAAAGGCCGAG
GTAACCCTGGAGGTGCCCACCGACGGCGAGGAACTGGCCCCGATCATCCTCTCGGTGCCGCTTCAGCTCCTGGCCTACCA
CGTGGCGGTCCTCAAGGGGACCGACGTGGACCAGCCGCGGAACCTGGCGAAATCAGTCACGGTGGAGTAG

Upstream 100 bases:

>100_bases
AGGAAGGCTGGAAACTCAGGAAACGGGATCAGTAATCATGACGCGGGGATCGCTGACACGCGCCCCCACTGAGCCCCCCA
TACAAACGGAGACCTGATCT

Downstream 100 bases:

>100_bases
ACATGCGACGGCTGTGATGTCGTTTGCAGCCAAGCGGCGCGAGTAGTAATGCAAAAGGGGCCTTCGGGCCCCTTTTTGAT
GGTATTGAAACCGGTGCCCT

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase

Number of amino acids: Translated: 609; Mature: 609

Protein sequence:

>609_residues
MCGIVGYIGAQEATPIILDGLKRLEYRGYDSAGICTLLEGKADKRRSEGKLINLERLIQSTPLAGRIGIGHTRWATHGPP
SERNAHPHQAGSIIVVHNGIIENYLELKQRLVTSGRVFNSDTDTEVIAHLIDDKFAGTGDFERAVREALAEVRGAYALCI
LCEREPGVLIAAKQGSPMVVGLGEGEFFVASDIPAILSHTREMVFMEDGEIVVFRDGHPTFSTVAGAPLDKKSRHIDWSP
LMAEKGGYKHFMLKEIFEQPRAVQDTITGRLLEEQGDVRLEEMKLADEQLRGIGRICIVACGTSWHSALVGKFLMEEHCR
IPVEVDIASEFRYRNPVIDSKTLLLVISQSGETADTLAALREAKARGAMTAAICNVVDSSIAREAHGVLYTHAGPEIGVA
STKAFVTQLVALYLFTIRLGRAVGTIDCEQGRTMIGGLLKVPALLEQALETNEQVERIARRYMNARDFLYLGRGMNYPIA
LEGALKLKEISYIHAEGYPAGEMKHGPIALIDENMPVVVLVPKNSTYEKVLSNMEEVIARGGRVIAICSAGDEAIAKKAE
VTLEVPTDGEELAPIILSVPLQLLAYHVAVLKGTDVDQPRNLAKSVTVE

Sequences:

>Translated_609_residues
MCGIVGYIGAQEATPIILDGLKRLEYRGYDSAGICTLLEGKADKRRSEGKLINLERLIQSTPLAGRIGIGHTRWATHGPP
SERNAHPHQAGSIIVVHNGIIENYLELKQRLVTSGRVFNSDTDTEVIAHLIDDKFAGTGDFERAVREALAEVRGAYALCI
LCEREPGVLIAAKQGSPMVVGLGEGEFFVASDIPAILSHTREMVFMEDGEIVVFRDGHPTFSTVAGAPLDKKSRHIDWSP
LMAEKGGYKHFMLKEIFEQPRAVQDTITGRLLEEQGDVRLEEMKLADEQLRGIGRICIVACGTSWHSALVGKFLMEEHCR
IPVEVDIASEFRYRNPVIDSKTLLLVISQSGETADTLAALREAKARGAMTAAICNVVDSSIAREAHGVLYTHAGPEIGVA
STKAFVTQLVALYLFTIRLGRAVGTIDCEQGRTMIGGLLKVPALLEQALETNEQVERIARRYMNARDFLYLGRGMNYPIA
LEGALKLKEISYIHAEGYPAGEMKHGPIALIDENMPVVVLVPKNSTYEKVLSNMEEVIARGGRVIAICSAGDEAIAKKAE
VTLEVPTDGEELAPIILSVPLQLLAYHVAVLKGTDVDQPRNLAKSVTVE
>Mature_609_residues
MCGIVGYIGAQEATPIILDGLKRLEYRGYDSAGICTLLEGKADKRRSEGKLINLERLIQSTPLAGRIGIGHTRWATHGPP
SERNAHPHQAGSIIVVHNGIIENYLELKQRLVTSGRVFNSDTDTEVIAHLIDDKFAGTGDFERAVREALAEVRGAYALCI
LCEREPGVLIAAKQGSPMVVGLGEGEFFVASDIPAILSHTREMVFMEDGEIVVFRDGHPTFSTVAGAPLDKKSRHIDWSP
LMAEKGGYKHFMLKEIFEQPRAVQDTITGRLLEEQGDVRLEEMKLADEQLRGIGRICIVACGTSWHSALVGKFLMEEHCR
IPVEVDIASEFRYRNPVIDSKTLLLVISQSGETADTLAALREAKARGAMTAAICNVVDSSIAREAHGVLYTHAGPEIGVA
STKAFVTQLVALYLFTIRLGRAVGTIDCEQGRTMIGGLLKVPALLEQALETNEQVERIARRYMNARDFLYLGRGMNYPIA
LEGALKLKEISYIHAEGYPAGEMKHGPIALIDENMPVVVLVPKNSTYEKVLSNMEEVIARGGRVIAICSAGDEAIAKKAE
VTLEVPTDGEELAPIILSVPLQLLAYHVAVLKGTDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains

Homologues:

Organism=Homo sapiens, GI4826742, Length=685, Percent_Identity=37.6642335766423, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI205277386, Length=684, Percent_Identity=35.8187134502924, Blast_Score=431, Evalue=1e-120,
Organism=Escherichia coli, GI1790167, Length=612, Percent_Identity=48.8562091503268, Blast_Score=560, Evalue=1e-160,
Organism=Escherichia coli, GI87082251, Length=313, Percent_Identity=23.0031948881789, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1788651, Length=220, Percent_Identity=28.6363636363636, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17539970, Length=433, Percent_Identity=42.4942263279446, Blast_Score=323, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI17532897, Length=440, Percent_Identity=41.1363636363636, Blast_Score=320, Evalue=1e-87,
Organism=Caenorhabditis elegans, GI17532899, Length=440, Percent_Identity=41.1363636363636, Blast_Score=320, Evalue=1e-87,
Organism=Saccharomyces cerevisiae, GI6322745, Length=448, Percent_Identity=41.9642857142857, Blast_Score=322, Evalue=1e-88,
Organism=Saccharomyces cerevisiae, GI6323731, Length=428, Percent_Identity=31.7757009345794, Blast_Score=225, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6323730, Length=207, Percent_Identity=35.7487922705314, Blast_Score=117, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6323958, Length=167, Percent_Identity=28.7425149700599, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21357745, Length=685, Percent_Identity=38.6861313868613, Blast_Score=456, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMS_GEOSL (Q74GH6)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_951331.1
- ProteinModelPortal:   Q74GH6
- SMR:   Q74GH6
- GeneID:   2687531
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU0270
- NMPDR:   fig|243231.1.peg.269
- TIGR:   GSU0270
- HOGENOM:   HBG645312
- OMA:   RICIIAC
- ProtClustDB:   PRK00331
- BioCyc:   GSUL243231:GSU_0270-MONOMER
- BRENDA:   2.6.1.16
- GO:   GO:0005737
- HAMAP:   MF_00164
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347
- TIGRFAMs:   TIGR01135

Pfam domain/function: PF00310 GATase_2; PF01380 SIS

EC number: =2.6.1.16

Molecular weight: Translated: 66460; Mature: 66460

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS51278 GATASE_TYPE_2; PS51464 SIS; PS00443 GATASE_TYPE_II

Important sites: ACT_SITE 2-2 ACT_SITE 604-604

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYIGAQEATPIILDGLKRLEYRGYDSAGICTLLEGKADKRRSEGKLINLERLIQS
CCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHCCCCEEEHHHHHHC
TPLAGRIGIGHTRWATHGPPSERNAHPHQAGSIIVVHNGIIENYLELKQRLVTSGRVFNS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCEECC
DTDTEVIAHLIDDKFAGTGDFERAVREALAEVRGAYALCILCEREPGVLIAAKQGSPMVV
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEECCCCCEEE
GLGEGEFFVASDIPAILSHTREMVFMEDGEIVVFRDGHPTFSTVAGAPLDKKSRHIDWSP
EECCCCEEEECCCHHHHHCCCEEEEEECCCEEEEECCCCCHHHHCCCCCCCCCCCCCCCC
LMAEKGGYKHFMLKEIFEQPRAVQDTITGRLLEEQGDVRLEEMKLADEQLRGIGRICIVA
HHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEEE
CGTSWHSALVGKFLMEEHCRIPVEVDIASEFRYRNPVIDSKTLLLVISQSGETADTLAAL
ECCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHH
REAKARGAMTAAICNVVDSSIAREAHGVLYTHAGPEIGVASTKAFVTQLVALYLFTIRLG
HHHHHCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHC
RAVGTIDCEQGRTMIGGLLKVPALLEQALETNEQVERIARRYMNARDFLYLGRGMNYPIA
CHHCCEECCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCEEEECCCCCCCEE
LEGALKLKEISYIHAEGYPAGEMKHGPIALIDENMPVVVLVPKNSTYEKVLSNMEEVIAR
ECCCEEEEHEEEEEECCCCCCCCCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHC
GGRVIAICSAGDEAIAKKAEVTLEVPTDGEELAPIILSVPLQLLAYHVAVLKGTDVDQPR
CCCEEEEECCCCHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
NLAKSVTVE
HHHHHCCCC
>Mature Secondary Structure
MCGIVGYIGAQEATPIILDGLKRLEYRGYDSAGICTLLEGKADKRRSEGKLINLERLIQS
CCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHCCCCEEEHHHHHHC
TPLAGRIGIGHTRWATHGPPSERNAHPHQAGSIIVVHNGIIENYLELKQRLVTSGRVFNS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCEECC
DTDTEVIAHLIDDKFAGTGDFERAVREALAEVRGAYALCILCEREPGVLIAAKQGSPMVV
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEECCCCCEEE
GLGEGEFFVASDIPAILSHTREMVFMEDGEIVVFRDGHPTFSTVAGAPLDKKSRHIDWSP
EECCCCEEEECCCHHHHHCCCEEEEEECCCEEEEECCCCCHHHHCCCCCCCCCCCCCCCC
LMAEKGGYKHFMLKEIFEQPRAVQDTITGRLLEEQGDVRLEEMKLADEQLRGIGRICIVA
HHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEEE
CGTSWHSALVGKFLMEEHCRIPVEVDIASEFRYRNPVIDSKTLLLVISQSGETADTLAAL
ECCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHH
REAKARGAMTAAICNVVDSSIAREAHGVLYTHAGPEIGVASTKAFVTQLVALYLFTIRLG
HHHHHCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHC
RAVGTIDCEQGRTMIGGLLKVPALLEQALETNEQVERIARRYMNARDFLYLGRGMNYPIA
CHHCCEECCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCEEEECCCCCCCEE
LEGALKLKEISYIHAEGYPAGEMKHGPIALIDENMPVVVLVPKNSTYEKVLSNMEEVIAR
ECCCEEEEHEEEEEECCCCCCCCCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHC
GGRVIAICSAGDEAIAKKAEVTLEVPTDGEELAPIILSVPLQLLAYHVAVLKGTDVDQPR
CCCEEEEECCCCHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
NLAKSVTVE
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA