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The map label for this gene is idsA [H]

Identifier: 38234187

GI number: 38234187

Start: 1643980

End: 1645104

Strand: Direct

Name: idsA [H]

Synonym: DIP1612

Alternate gene names: 38234187

Gene position: 1643980-1645104 (Clockwise)

Preceding gene: 38234185

Following gene: 38234188

Centisome position: 66.06

GC content: 52.27

Gene sequence:

>1125_bases
TTGTCTACGCACCCCGCCGGTATCTCTGCATGCCATCACTCACTGCCTTCGTTTTCGGAGGTCCCAGCAGCAGTAGAAGA
AGTACTCGCGGAGTTTTTCGAAGGCCGTAAACGCAAGGTAGCCAAGATTGGTGTTCCAGTGAGCAATGCGGTTGAGCTGC
TGGTCGAATATGTCCTTGGCGGTGGAAAACGGATTCGTCCTACGTATGCGTGGGCGGGTTTTGTTGCTAGTGGCGGATTA
ACTAATAAGACGGAAGATCCCGGCGCGGTACTCACAGCAATTGGCTCTCTGGAACTGATCCAAGCGTGTGCGCTTATCCA
CGACGACATTATCGACGCTTCCGATACGAGGCGTGGTAATCCGACTGTGCACCGTGTTGCAGAACGCACCCATGCAGAAT
CCCATCGCTTGGGCGATTCCGCACGTTTTGGCGAGTCGATCGCAATTTTGGTTGGCGATCTTGCGATGGTGTGGGCAGAT
GATATGTTCCATAACTCTGGGCTTAGTGATGCTGCAATTCGTCGTGCTTCGAATGCGTGGCGTGGCATGCGCACTGAAGT
TATTGGCGGACAACTTCTTGATATTTACATTGAATCCACTGGTAGCGAGAGCATCGAACTAGCGGAAACCGTCAATCGTT
TTAAAACTGCCGCCTATACGATTGAGCGCCCTCTTCACATTGGTGCGGCGTTGGCGGGCGCTGATGACCAGACAGTTCAC
TGTCTACGAAATTATGGCCGTGATATCGGCTTGGCGTTCCAGCTTCGCGACGATCTTTTAGGTGTATTTGGTGACCCAAG
TGTTACGGGTAAGCCAGCTGGCGATGACTTGCGTGAAGGAAAGCGCACGGTATTGGTGGCCAAAGCATTAGAAATCTTGG
AGTCTGCGGGCTCGATCCACGAGGCGGAAATGATTCGTCGTGACTTAGGTGCAGTGTCGGGGGCCGAAGATATTGCACAA
TTGGCTTCGATTATTCGCTCCTCTGGTGCCGCCGATGCGGTGGAAGAGCGCATCGCAACCTTGCGAACTTCTGGCCTTGC
GCACATTAGCAATGATGTTATTGATGCAGAGGCCCAAGATTTTCTAAAACACCTAGCTATCAAGGCTACGTCGAGAAGCT
TCTAA

Upstream 100 bases:

>100_bases
TCCCCTAGTTTTCTTAGCTCTTGGCTTAGCTGCGCCCCCACCCTCTAATATGGGTTTAAAGTCTACACCGAATTTACAGT
TTTTAAGGAATGTGAACCAG

Downstream 100 bases:

>100_bases
TTCCCCGGAGATCACACACCTATGGATTTTTTGCAGAAACTTCTGCGTACTAGCTCAACATTATCGCCAGTGGGCGTAGG
AATCTTCGCATCAATTCTGA

Product: putative geranylgeranyl pyrophosphate synthase

Products: NA

Alternate protein names: (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyl pyrophosphate synthase; FPP synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MSTHPAGISACHHSLPSFSEVPAAVEEVLAEFFEGRKRKVAKIGVPVSNAVELLVEYVLGGGKRIRPTYAWAGFVASGGL
TNKTEDPGAVLTAIGSLELIQACALIHDDIIDASDTRRGNPTVHRVAERTHAESHRLGDSARFGESIAILVGDLAMVWAD
DMFHNSGLSDAAIRRASNAWRGMRTEVIGGQLLDIYIESTGSESIELAETVNRFKTAAYTIERPLHIGAALAGADDQTVH
CLRNYGRDIGLAFQLRDDLLGVFGDPSVTGKPAGDDLREGKRTVLVAKALEILESAGSIHEAEMIRRDLGAVSGAEDIAQ
LASIIRSSGAADAVEERIATLRTSGLAHISNDVIDAEAQDFLKHLAIKATSRSF

Sequences:

>Translated_374_residues
MSTHPAGISACHHSLPSFSEVPAAVEEVLAEFFEGRKRKVAKIGVPVSNAVELLVEYVLGGGKRIRPTYAWAGFVASGGL
TNKTEDPGAVLTAIGSLELIQACALIHDDIIDASDTRRGNPTVHRVAERTHAESHRLGDSARFGESIAILVGDLAMVWAD
DMFHNSGLSDAAIRRASNAWRGMRTEVIGGQLLDIYIESTGSESIELAETVNRFKTAAYTIERPLHIGAALAGADDQTVH
CLRNYGRDIGLAFQLRDDLLGVFGDPSVTGKPAGDDLREGKRTVLVAKALEILESAGSIHEAEMIRRDLGAVSGAEDIAQ
LASIIRSSGAADAVEERIATLRTSGLAHISNDVIDAEAQDFLKHLAIKATSRSF
>Mature_373_residues
STHPAGISACHHSLPSFSEVPAAVEEVLAEFFEGRKRKVAKIGVPVSNAVELLVEYVLGGGKRIRPTYAWAGFVASGGLT
NKTEDPGAVLTAIGSLELIQACALIHDDIIDASDTRRGNPTVHRVAERTHAESHRLGDSARFGESIAILVGDLAMVWADD
MFHNSGLSDAAIRRASNAWRGMRTEVIGGQLLDIYIESTGSESIELAETVNRFKTAAYTIERPLHIGAALAGADDQTVHC
LRNYGRDIGLAFQLRDDLLGVFGDPSVTGKPAGDDLREGKRTVLVAKALEILESAGSIHEAEMIRRDLGAVSGAEDIAQL
ASIIRSSGAADAVEERIATLRTSGLAHISNDVIDAEAQDFLKHLAIKATSRSF

Specific function: Supplies Octaprenyl Diphosphate, The Precursor For The Side Chain Of The Isoprenoid Quinones Ubiquinone And Menaquinone. [C]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=241, Percent_Identity=28.2157676348548, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1789578, Length=253, Percent_Identity=32.8063241106719, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1786623, Length=285, Percent_Identity=31.9298245614035, Blast_Score=83, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17508563, Length=250, Percent_Identity=28.8, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17505681, Length=260, Percent_Identity=27.3076923076923, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24651612, Length=263, Percent_Identity=27.7566539923954, Blast_Score=78, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.1; =2.5.1.10 [H]

Molecular weight: Translated: 39908; Mature: 39777

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTHPAGISACHHSLPSFSEVPAAVEEVLAEFFEGRKRKVAKIGVPVSNAVELLVEYVLG
CCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHC
GGKRIRPTYAWAGFVASGGLTNKTEDPGAVLTAIGSLELIQACALIHDDIIDASDTRRGN
CCCEECCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PTVHRVAERTHAESHRLGDSARFGESIAILVGDLAMVWADDMFHNSGLSDAAIRRASNAW
HHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
RGMRTEVIGGQLLDIYIESTGSESIELAETVNRFKTAAYTIERPLHIGAALAGADDQTVH
HCCHHHHHCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHH
CLRNYGRDIGLAFQLRDDLLGVFGDPSVTGKPAGDDLREGKRTVLVAKALEILESAGSIH
HHHHCCCCCEEEEEEHHHHHHHCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHCCCHH
EAEMIRRDLGAVSGAEDIAQLASIIRSSGAADAVEERIATLRTSGLAHISNDVIDAEAQD
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
FLKHLAIKATSRSF
HHHHHHHHHHCCCC
>Mature Secondary Structure 
STHPAGISACHHSLPSFSEVPAAVEEVLAEFFEGRKRKVAKIGVPVSNAVELLVEYVLG
CCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHC
GGKRIRPTYAWAGFVASGGLTNKTEDPGAVLTAIGSLELIQACALIHDDIIDASDTRRGN
CCCEECCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PTVHRVAERTHAESHRLGDSARFGESIAILVGDLAMVWADDMFHNSGLSDAAIRRASNAW
HHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
RGMRTEVIGGQLLDIYIESTGSESIELAETVNRFKTAAYTIERPLHIGAALAGADDQTVH
HCCHHHHHCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHH
CLRNYGRDIGLAFQLRDDLLGVFGDPSVTGKPAGDDLREGKRTVLVAKALEILESAGSIH
HHHHCCCCCEEEEEEHHHHHHHCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHCCCHH
EAEMIRRDLGAVSGAEDIAQLASIIRSSGAADAVEERIATLRTSGLAHISNDVIDAEAQD
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
FLKHLAIKATSRSF
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]