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The map label for this gene is dinB

Identifier: 38234163

GI number: 38234163

Start: 1615746

End: 1617101

Strand: Reverse

Name: dinB

Synonym: DIP1588

Alternate gene names: 38234163

Gene position: 1617101-1615746 (Counterclockwise)

Preceding gene: 38234164

Following gene: 38234161

Centisome position: 64.98

GC content: 53.24

Gene sequence:

>1356_bases
ATGCAACGGTGGGTGATTCATGTTGATATGGATGCATTTTTTGCGTCTTGTGAGCAACTGACCCGTCCGACGCTTCGGGG
GCGGCCGGTGCTTGTGGGCGGTGCGAGTGGTCGCGGAGTGGTTGCGGGGGCATCGTACGAGGCGCGCACTTTTGGAGCCC
GATCTGCTATGCCAATGTATCAGGCCAAAGCGCTCATTGGTATGCGAGGAGTTGTGGTGAGTCCGCGGTTCGCGGTGTAT
CGAGCGGCGTCGCAACGAGTCTTTTCCATTTTGGAGCGTATGGGCGGCACCGTTGAAAAGATTTCTATTGACGAGGGGTT
TGTCGAGCCGCCTGAGCTTTACGGTGCAAGCGCAAGTGAAGTTGATACATGGGCGCAGCGATTACGAGCAGTAATTCGCG
ATGAGACAGGTTTGCCCGCTTCTGTAGGAGGGGGTGCGGGAAAACAGGTTGCCAAGATTTGTTCCGATCTGGCTAAACCT
GACGGTATTTACTTGTGTGCTGCATCGGAGCATGAAGAAAAAATGTATCCGCTACCCGTAGGCCGTTTGTGGGGTGTAGG
TCCGGTCACGCGGACGAAGTTGCAGCAGCTTGGGGTGGAAACAATTGGCGATCTAGCTCGTATGAGCGAACGCGAAATCG
ATATTAGCCTCGGCACAACGGTGGGTAGAAGTTTATGGCGTCTAGCCCAAGGTCACGACGATCGTGAAGTGGCACCACGT
GCTATCGCAAAACAGATCTCTGTAGAACACACATACCCAAAAGACCTTGTTACTTCGCGGGCGGTGGATACCGCCATCAT
TCGGGCGTCACGGGAAAGTCATCGACGATTGCTTGACGACGGTCGTGGGGCGCGAACTGTGAGCGTAAAGCTCCGAATGG
CGGATTTTAGGATCGAATCGCGTTCAGCAACATTGCCCTATGCGACCGATAATCTAGACACAGTTACAGCTACCGCATTA
AAGCTGGCACGATATCCCGATGAGGTTGGTCCGATACGCCTCGTCGGTGTTGGTCTTTCTGGGCTTGAAGATGCCCGCCA
AGACATACTTTTCCCTGAATTAGATCGAGTAGTTCCTGTAAAAGATACCGATTTTGAGGTAGGAGTAAGTGACCCACACG
ATTCTGACTTGGAGATCTCTACGACTGATGAGTCACCCACAGCAATCGGATGGCGAGCAACTCAAGATATTTGGCATCCC
GACTATGGGCACGGCTGGGTACAAGGGCTAGGGCACGGAAAGATCACCGTTCGTTTTGAAACCCGCACCACAGGACCTGG
CAAAGTGCGTACGTTTGACACTAACGACGCCCTTTTGAGCAGCGCAGATCCTATCAACAGCCTAGATTGGTCTTAA

Upstream 100 bases:

>100_bases
TGAGGGCAGTGCTGCGGTAAGTGGCACTGCCCTCATCTGTTATTTCGTTGAAAAGTAGAGGATTAGACAGTAGCCAGTAA
GTCGAACTAATGTTTGGTGC

Downstream 100 bases:

>100_bases
CTACAACAACGTAGCGGGATGCACACCACTGGCAATGGCGATTGCCAACAAAACACGAGCTTGGCCGGATCGGAAATATG
TTGAGTTGACAGCCCCTTTG

Product: DNA polymerase IV

Products: NA

Alternate protein names: Pol IV

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MQRWVIHVDMDAFFASCEQLTRPTLRGRPVLVGGASGRGVVAGASYEARTFGARSAMPMYQAKALIGMRGVVVSPRFAVY
RAASQRVFSILERMGGTVEKISIDEGFVEPPELYGASASEVDTWAQRLRAVIRDETGLPASVGGGAGKQVAKICSDLAKP
DGIYLCAASEHEEKMYPLPVGRLWGVGPVTRTKLQQLGVETIGDLARMSEREIDISLGTTVGRSLWRLAQGHDDREVAPR
AIAKQISVEHTYPKDLVTSRAVDTAIIRASRESHRRLLDDGRGARTVSVKLRMADFRIESRSATLPYATDNLDTVTATAL
KLARYPDEVGPIRLVGVGLSGLEDARQDILFPELDRVVPVKDTDFEVGVSDPHDSDLEISTTDESPTAIGWRATQDIWHP
DYGHGWVQGLGHGKITVRFETRTTGPGKVRTFDTNDALLSSADPINSLDWS

Sequences:

>Translated_451_residues
MQRWVIHVDMDAFFASCEQLTRPTLRGRPVLVGGASGRGVVAGASYEARTFGARSAMPMYQAKALIGMRGVVVSPRFAVY
RAASQRVFSILERMGGTVEKISIDEGFVEPPELYGASASEVDTWAQRLRAVIRDETGLPASVGGGAGKQVAKICSDLAKP
DGIYLCAASEHEEKMYPLPVGRLWGVGPVTRTKLQQLGVETIGDLARMSEREIDISLGTTVGRSLWRLAQGHDDREVAPR
AIAKQISVEHTYPKDLVTSRAVDTAIIRASRESHRRLLDDGRGARTVSVKLRMADFRIESRSATLPYATDNLDTVTATAL
KLARYPDEVGPIRLVGVGLSGLEDARQDILFPELDRVVPVKDTDFEVGVSDPHDSDLEISTTDESPTAIGWRATQDIWHP
DYGHGWVQGLGHGKITVRFETRTTGPGKVRTFDTNDALLSSADPINSLDWS
>Mature_451_residues
MQRWVIHVDMDAFFASCEQLTRPTLRGRPVLVGGASGRGVVAGASYEARTFGARSAMPMYQAKALIGMRGVVVSPRFAVY
RAASQRVFSILERMGGTVEKISIDEGFVEPPELYGASASEVDTWAQRLRAVIRDETGLPASVGGGAGKQVAKICSDLAKP
DGIYLCAASEHEEKMYPLPVGRLWGVGPVTRTKLQQLGVETIGDLARMSEREIDISLGTTVGRSLWRLAQGHDDREVAPR
AIAKQISVEHTYPKDLVTSRAVDTAIIRASRESHRRLLDDGRGARTVSVKLRMADFRIESRSATLPYATDNLDTVTATAL
KLARYPDEVGPIRLVGVGLSGLEDARQDILFPELDRVVPVKDTDFEVGVSDPHDSDLEISTTDESPTAIGWRATQDIWHP
DYGHGWVQGLGHGKITVRFETRTTGPGKVRTFDTNDALLSSADPINSLDWS

Specific function: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain

Homologues:

Organism=Homo sapiens, GI84043967, Length=410, Percent_Identity=26.5853658536585, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI7706681, Length=411, Percent_Identity=26.5206812652068, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI7705344, Length=176, Percent_Identity=31.25, Blast_Score=80, Evalue=6e-15,
Organism=Escherichia coli, GI1786425, Length=345, Percent_Identity=33.6231884057971, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1787432, Length=301, Percent_Identity=28.2392026578073, Blast_Score=102, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI193205700, Length=408, Percent_Identity=26.4705882352941, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17537959, Length=447, Percent_Identity=24.8322147651007, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI193205702, Length=228, Percent_Identity=30.2631578947368, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324921, Length=379, Percent_Identity=23.4828496042216, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI19923006, Length=415, Percent_Identity=27.2289156626506, Blast_Score=144, Evalue=8e-35,
Organism=Drosophila melanogaster, GI21355641, Length=338, Percent_Identity=25.7396449704142, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24644984, Length=338, Percent_Identity=25.7396449704142, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DPO4_CORDI (Q6NGD8)

Other databases:

- EMBL:   BX248358
- RefSeq:   NP_939930.1
- HSSP:   Q9UHC5
- ProteinModelPortal:   Q6NGD8
- SMR:   Q6NGD8
- GeneID:   2650777
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1588
- NMPDR:   fig|257309.1.peg.1521
- HOGENOM:   HBG734504
- OMA:   PYATTEA
- PhylomeDB:   Q6NGD8
- ProtClustDB:   PRK03348
- BioCyc:   CDIP257309:DIP1588-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01113
- InterPro:   IPR017962
- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963
- InterPro:   IPR022880
- Gene3D:   G3DSA:3.30.1490.100
- PANTHER:   PTHR11076

Pfam domain/function: PF00817 IMS; SSF100879 DNA_pol_Y-fam_little_finger

EC number: =2.7.7.7

Molecular weight: Translated: 49208; Mature: 49208

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS50173 UMUC

Important sites: ACT_SITE 105-105

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRWVIHVDMDAFFASCEQLTRPTLRGRPVLVGGASGRGVVAGASYEARTFGARSAMPMY
CCEEEEEEEHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEECCCCHHHCCCCCCCHHH
QAKALIGMRGVVVSPRFAVYRAASQRVFSILERMGGTVEKISIDEGFVEPPELYGASASE
HHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHCCCCHHH
VDTWAQRLRAVIRDETGLPASVGGGAGKQVAKICSDLAKPDGIYLCAASEHEEKMYPLPV
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCC
GRLWGVGPVTRTKLQQLGVETIGDLARMSEREIDISLGTTVGRSLWRLAQGHDDREVAPR
HHHCCCCCHHHHHHHHCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCCHHHHHH
AIAKQISVEHTYPKDLVTSRAVDTAIIRASRESHRRLLDDGRGARTVSVKLRMADFRIES
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCEEEEEEEEEEEEEEEC
RSATLPYATDNLDTVTATALKLARYPDEVGPIRLVGVGLSGLEDARQDILFPELDRVVPV
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCEECC
KDTDFEVGVSDPHDSDLEISTTDESPTAIGWRATQDIWHPDYGHGWVQGLGHGKITVRFE
CCCCEEECCCCCCCCCCEEEECCCCCCEECEECCCCCCCCCCCCHHHHCCCCCEEEEEEE
TRTTGPGKVRTFDTNDALLSSADPINSLDWS
EECCCCCEEEEECCCCHHHCCCCCCCCCCCC
>Mature Secondary Structure
MQRWVIHVDMDAFFASCEQLTRPTLRGRPVLVGGASGRGVVAGASYEARTFGARSAMPMY
CCEEEEEEEHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEECCCCHHHCCCCCCCHHH
QAKALIGMRGVVVSPRFAVYRAASQRVFSILERMGGTVEKISIDEGFVEPPELYGASASE
HHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHCCCCHHH
VDTWAQRLRAVIRDETGLPASVGGGAGKQVAKICSDLAKPDGIYLCAASEHEEKMYPLPV
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCC
GRLWGVGPVTRTKLQQLGVETIGDLARMSEREIDISLGTTVGRSLWRLAQGHDDREVAPR
HHHCCCCCHHHHHHHHCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCCHHHHHH
AIAKQISVEHTYPKDLVTSRAVDTAIIRASRESHRRLLDDGRGARTVSVKLRMADFRIES
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCEEEEEEEEEEEEEEEC
RSATLPYATDNLDTVTATALKLARYPDEVGPIRLVGVGLSGLEDARQDILFPELDRVVPV
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCEECC
KDTDFEVGVSDPHDSDLEISTTDESPTAIGWRATQDIWHPDYGHGWVQGLGHGKITVRFE
CCCCEEECCCCCCCCCCEEEECCCCCCEECEECCCCCCCCCCCCHHHHCCCCCEEEEEEE
TRTTGPGKVRTFDTNDALLSSADPINSLDWS
EECCCCCEEEEECCCCHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910