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The map label for this gene is hisB

Identifier: 38234139

GI number: 38234139

Start: 1591132

End: 1591740

Strand: Reverse

Name: hisB

Synonym: DIP1564

Alternate gene names: 38234139

Gene position: 1591740-1591132 (Counterclockwise)

Preceding gene: 38234140

Following gene: 38234138

Centisome position: 63.96

GC content: 48.28

Gene sequence:

>609_bases
ATGGCAACCCAACCTCGAATTGGTTCAATTTCTCGTGTCACAAGCGAATCAGATATTCGCGTCGAAATAAATCTCGATGG
AACAGGCACGGTCGAAATTGACACTGGTGTACCTTTTTTCGATCACATGCTTACTGCCTTTGGCGTCCATGGTGCATTTG
ATTTGAAGGTTAAGGCCACAGGAGACACACACATCGACGCCCACCACACAGTGGAAGACACCGCGATTGTGCTGGGACAG
GCAATAGCACAAGCTGTAGGAGATAAGCGCGGAATTAAACGATTCGGCTCTTTCCAGCTACCAATGGATGAGACGTTGTG
TGAAGCCATCGTCGATTTTTCTGGGCGTCCCTACTTTGTCACCAAAGGCGAACCTGATTACCTTGTGCATTCTGTTATCG
GTAGTCATTATCCGACCGTCTTAAATGAGCATTTTTTTGAATCTTTGGCGCTTAACGCAAAAATTACATTGCACGTATTG
TGCCGCTACGGTCGGGATCCGCACCACATCACCGAAGCTGAATTTAAAGCTGTCGCACGAGCGATCCGTGAAGCAGTCGG
TCCCGATGACCGTCTCACTGGAATCCCCTCAACTAAAGGAGCGCTATAA

Upstream 100 bases:

>100_bases
AGCCCAACAATTCCTGTAATCGCATAAAAGTGGGGCTTACCTTTTATGCAGTACAAACACTTTAGACTCTAAAACGCAGA
AAGCATGGTGACCTTTAATT

Downstream 100 bases:

>100_bases
ACGTGACTGCTATCCACACTTCGGTTGTAGCTCAGTCTACAATCCCACCAGCAAGTTTTTTGTTGGTGTACGTGTTGTTT
TTGGTATCTGGCTTATTAGT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 202; Mature: 201

Protein sequence:

>202_residues
MATQPRIGSISRVTSESDIRVEINLDGTGTVEIDTGVPFFDHMLTAFGVHGAFDLKVKATGDTHIDAHHTVEDTAIVLGQ
AIAQAVGDKRGIKRFGSFQLPMDETLCEAIVDFSGRPYFVTKGEPDYLVHSVIGSHYPTVLNEHFFESLALNAKITLHVL
CRYGRDPHHITEAEFKAVARAIREAVGPDDRLTGIPSTKGAL

Sequences:

>Translated_202_residues
MATQPRIGSISRVTSESDIRVEINLDGTGTVEIDTGVPFFDHMLTAFGVHGAFDLKVKATGDTHIDAHHTVEDTAIVLGQ
AIAQAVGDKRGIKRFGSFQLPMDETLCEAIVDFSGRPYFVTKGEPDYLVHSVIGSHYPTVLNEHFFESLALNAKITLHVL
CRYGRDPHHITEAEFKAVARAIREAVGPDDRLTGIPSTKGAL
>Mature_201_residues
ATQPRIGSISRVTSESDIRVEINLDGTGTVEIDTGVPFFDHMLTAFGVHGAFDLKVKATGDTHIDAHHTVEDTAIVLGQA
IAQAVGDKRGIKRFGSFQLPMDETLCEAIVDFSGRPYFVTKGEPDYLVHSVIGSHYPTVLNEHFFESLALNAKITLHVLC
RYGRDPHHITEAEFKAVARAIREAVGPDDRLTGIPSTKGAL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=204, Percent_Identity=43.1372549019608, Blast_Score=157, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6324776, Length=218, Percent_Identity=39.9082568807339, Blast_Score=149, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_CORDI (P60884)

Other databases:

- EMBL:   BX248358
- RefSeq:   NP_939906.1
- ProteinModelPortal:   P60884
- SMR:   P60884
- GeneID:   2650753
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1564
- NMPDR:   fig|257309.1.peg.1497
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- PhylomeDB:   P60884
- ProtClustDB:   PRK00951
- BioCyc:   CDIP257309:DIP1564-MONOMER
- BRENDA:   4.2.1.19
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 22009; Mature: 21878

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATQPRIGSISRVTSESDIRVEINLDGTGTVEIDTGVPFFDHMLTAFGVHGAFDLKVKAT
CCCCCCCCCHHHCCCCCCEEEEEEECCCEEEEECCCCCHHHHHHHHHCCCCEEEEEEEEC
GDTHIDAHHTVEDTAIVLGQAIAQAVGDKRGIKRFGSFQLPMDETLCEAIVDFSGRPYFV
CCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEE
TKGEPDYLVHSVIGSHYPTVLNEHFFESLALNAKITLHVLCRYGRDPHHITEAEFKAVAR
ECCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHHHH
AIREAVGPDDRLTGIPSTKGAL
HHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ATQPRIGSISRVTSESDIRVEINLDGTGTVEIDTGVPFFDHMLTAFGVHGAFDLKVKAT
CCCCCCCCHHHCCCCCCEEEEEEECCCEEEEECCCCCHHHHHHHHHCCCCEEEEEEEEC
GDTHIDAHHTVEDTAIVLGQAIAQAVGDKRGIKRFGSFQLPMDETLCEAIVDFSGRPYFV
CCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEE
TKGEPDYLVHSVIGSHYPTVLNEHFFESLALNAKITLHVLCRYGRDPHHITEAEFKAVAR
ECCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHHHH
AIREAVGPDDRLTGIPSTKGAL
HHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910