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The map label for this gene is trpC2 [H]

Identifier: 38234130

GI number: 38234130

Start: 1584186

End: 1584998

Strand: Reverse

Name: trpC2 [H]

Synonym: DIP1555

Alternate gene names: 38234130

Gene position: 1584998-1584186 (Counterclockwise)

Preceding gene: 38234131

Following gene: 38234129

Centisome position: 63.69

GC content: 56.33

Gene sequence:

>813_bases
ATGGCTATGGTTACAGTCTTCGATGAGATCATCGCTGGTGTTGTGGAAGACGTTGCCGCGCGCGAAGCGCAGGTTTCATT
CCAGGACATCAAAGCGCAGTCTCGTCTGTGCGCGCCACCTAGGGATGCTTGTGGGGCATTGTTAGCAAGTGGCTGTGGAA
TCATCGCGGAGATCAAAAGGGCAGCACCTGGCCAAGGTTTGCTTGCGGAGATTCCTTCGCCGGTAGATCTGGCTCTTGAG
CTCGAGTCCGGCGGTGCGGCGTTGATTGCTTGTCACACAGAGCGCCGGCGGTTTCATGGTTCTTTGACGGAGATGGCAAA
GATTCGGCGTCACGTGTCCGTTCCAGTTATGTGTCGCGATTTTATTGTTGATCCCTATCAGATTCATGAAGCTCGCTGCT
ATGGAGCTGATATGGTGCCGCTTCGGGTAGCTGCGCTTGCGCAGTCACGACTTGTTGCATTGATTGATCGGGTGGAGTCC
CTGGGGATGGCTGCGCTTGTCGAGGTACGCGATACTGCGGAGGCATCTCGTGCCTTAGATGCTGGTGCCCGAATTATCGG
CGTTAATGCGAGAGATTTTTCTACGATGACCCTTAACCGAGCGGCTTTTTGCGAGATCGCTCCAGGACTTCCTAGCGACG
TGGTCCGAGTGGCGCTTTCAGGGGTTCGTAATGCTAAAGAGCTTTTAGACTACGCCTCGGCTGGGGCAGACGCCGTGGTG
ATTGGCCAAAGCATCGTGACGGCGCAATCGCCTCGAGGGGCGACGCGTGCCTTGGTTGCTGCAGGCCAGCATCCCTCGTG
TCCCTCACGTTAG

Upstream 100 bases:

>100_bases
CGGTAATGTTTCATTGTGACCGTGTACCCGAATGATTTTTTAACTTGGTAGGCAAACAAGTAGCCTAAGAAGTGGCAAAC
GTCGCTTGAGACCCTGTGGG

Downstream 100 bases:

>100_bases
CGAAAGCAACGGTTAAGATGGTCCACAGTGTGACTTTGTCCTGAGACTAAAAATACTGTGGAGAAAAATTAGTGGGAAAC
ATCCAATATCTTGCGGCTAT

Product: indole-3-glycerol phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MAMVTVFDEIIAGVVEDVAAREAQVSFQDIKAQSRLCAPPRDACGALLASGCGIIAEIKRAAPGQGLLAEIPSPVDLALE
LESGGAALIACHTERRRFHGSLTEMAKIRRHVSVPVMCRDFIVDPYQIHEARCYGADMVPLRVAALAQSRLVALIDRVES
LGMAALVEVRDTAEASRALDAGARIIGVNARDFSTMTLNRAAFCEIAPGLPSDVVRVALSGVRNAKELLDYASAGADAVV
IGQSIVTAQSPRGATRALVAAGQHPSCPSR

Sequences:

>Translated_270_residues
MAMVTVFDEIIAGVVEDVAAREAQVSFQDIKAQSRLCAPPRDACGALLASGCGIIAEIKRAAPGQGLLAEIPSPVDLALE
LESGGAALIACHTERRRFHGSLTEMAKIRRHVSVPVMCRDFIVDPYQIHEARCYGADMVPLRVAALAQSRLVALIDRVES
LGMAALVEVRDTAEASRALDAGARIIGVNARDFSTMTLNRAAFCEIAPGLPSDVVRVALSGVRNAKELLDYASAGADAVV
IGQSIVTAQSPRGATRALVAAGQHPSCPSR
>Mature_269_residues
AMVTVFDEIIAGVVEDVAAREAQVSFQDIKAQSRLCAPPRDACGALLASGCGIIAEIKRAAPGQGLLAEIPSPVDLALEL
ESGGAALIACHTERRRFHGSLTEMAKIRRHVSVPVMCRDFIVDPYQIHEARCYGADMVPLRVAALAQSRLVALIDRVESL
GMAALVEVRDTAEASRALDAGARIIGVNARDFSTMTLNRAAFCEIAPGLPSDVVRVALSGVRNAKELLDYASAGADAVVI
GQSIVTAQSPRGATRALVAAGQHPSCPSR

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=265, Percent_Identity=28.6792452830189, Blast_Score=108, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6322638, Length=235, Percent_Identity=31.9148936170213, Blast_Score=125, Evalue=8e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 28407; Mature: 28276

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMVTVFDEIIAGVVEDVAAREAQVSFQDIKAQSRLCAPPRDACGALLASGCGIIAEIKR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHH
AAPGQGLLAEIPSPVDLALELESGGAALIACHTERRRFHGSLTEMAKIRRHVSVPVMCRD
CCCCCCHHHHCCCCCEEEEEECCCCEEEEEEEHHHHHHCCCHHHHHHHHHHCCCCHHHHH
FIVDPYQIHEARCYGADMVPLRVAALAQSRLVALIDRVESLGMAALVEVRDTAEASRALD
HCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
AGARIIGVNARDFSTMTLNRAAFCEIAPGLPSDVVRVALSGVRNAKELLDYASAGADAVV
CCCEEEECCCCCCCEEEECCHHHEEECCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCEEE
IGQSIVTAQSPRGATRALVAAGQHPSCPSR
ECCHHHCCCCCCCHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
AMVTVFDEIIAGVVEDVAAREAQVSFQDIKAQSRLCAPPRDACGALLASGCGIIAEIKR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHH
AAPGQGLLAEIPSPVDLALELESGGAALIACHTERRRFHGSLTEMAKIRRHVSVPVMCRD
CCCCCCHHHHCCCCCEEEEEECCCCEEEEEEEHHHHHHCCCHHHHHHHHHHCCCCHHHHH
FIVDPYQIHEARCYGADMVPLRVAALAQSRLVALIDRVESLGMAALVEVRDTAEASRALD
HCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
AGARIIGVNARDFSTMTLNRAAFCEIAPGLPSDVVRVALSGVRNAKELLDYASAGADAVV
CCCEEEECCCCCCCEEEECCHHHEEECCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCEEE
IGQSIVTAQSPRGATRALVAAGQHPSCPSR
ECCHHHCCCCCCCHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA