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The map label for this gene is gdh [H]

Identifier: 38234122

GI number: 38234122

Start: 1572978

End: 1574324

Strand: Reverse

Name: gdh [H]

Synonym: DIP1547

Alternate gene names: 38234122

Gene position: 1574324-1572978 (Counterclockwise)

Preceding gene: 38234124

Following gene: 38234121

Centisome position: 63.26

GC content: 52.34

Gene sequence:

>1347_bases
ATGTCGCCTATCGATGAGAAGGTACAGGGCTACTACGAGCTGCTTTTGAAGCGAAACCCTGCGGAGCCGGAATTCCACCA
GGCAGTTAACGAAGTCCTTGACTCTCTGAAAATTGTTTTGGAAAAGGATCCTCACTACGCGGACTACGGCTTGATTCAGC
GCTTGTGTGAGCCTGAGCGCCAGCTTATGTTCCGCGTTCCATGGGTAGATGACAACGGAGTTGTCCAGGTTAACCGTGGT
TTCCGCGTTCAATTTAACTCGGCCATCGGTCCTTATAAGGGCGGCCTGCGTTTCCACCCATCCGTTAACTTGGGCATCAT
CAAGTTCTTAGGCTTTGAGCAGATCTTTAAGAACTCTTTGACCGGTCTTCCTATCGGCGGTGGCAAGGGTGGTTCCGACT
TCGACCCTAAGGGTAAGTCTGATGTAGAAATTATGCGCTTCTGCCAGTCCTTCATGACAGAGCTTTACCGCCACATCGGC
GAGTACCGTGACGTTCCTGCTGGCGACATCGGAGTTGGCGGCCGTGAGATTGGTTATTTATTCGGTCAGTATCGTCGACT
AGCAAACCAGCATGAGTCCGGTGTTTTGACCGGTAAGGGTCTTACCTGGGGCGGATCCTTGGTCCGTACCGAGGCTACCG
GTTATGGATTGGTGTACTTCACTGCTGAGATGCTTGCTCATCACGGCCAGTCCTTCGAAGGTAAGAAGGTTATTGTTTCC
GGTTCCGGCAACGTGGCAATTTACGCCATCGAGAAAGCTCAGGAACTGGGCGCAACCGTGATTGGTTTCTCTGATTCTTC
TGCTTGGGTTGAAACTCCTAACGGTGTGGATGTTGCCAAACTCAAGGAGATCAAGGAAGTCCGTCGTGAGCGTGTATCGA
GCTATGTCGACGAAGTTGAAGGCGCAATCCTGCACACTGAGGGCTCGATTTGGGATCTCACCTGTGATGTTGCTCTTCCA
TGTGCCACCCAAAACGAGCTTGATGGCGAGCATGCCAAGAAACTAGCTGACAATGGCTGTGCCTTCGTTGCAGAGGGTGC
CAACATGCCATCGACTGCTGATGCTATCGAGGTCTACCGCGAGCGTGGAATCCACTTTGGTCCAGGTAAGGCTGCTAACG
CTGGCGGCGTGGCAACCTCAGCACTGGAGATGCAGCAGAACGCATCTCGTGATTCGTGGAGCTTCGAGTATGCAGATCAG
CGCCTTCGCGAGATCATGAAGGGTATCTTCAAGAACTGTGAGTCTACTGCTCGCGAATATGGTCATGAGGGCGACTACGT
AGTAGGTGCCAACATTGCAGGCTTCAAGAAGGTCGCAGATGCGATGCTTGCACAAGGTGTCATCTAA

Upstream 100 bases:

>100_bases
GATAACACATCGGCCGAAAACGGACATAGCTTAAGCGGCTAGATGGCTGCAGGGGCATAGTCCTTAAGTCCGGAGACCAC
GTTCCTGAGGAGGTACGAAA

Downstream 100 bases:

>100_bases
GTTCTGTTAACGGGTGCAGTGGCCCCCTCTAGTAATAGTCGTGTGATGTCTAGTGACTTCTTGGACTCGGAGTCCAGTTA
GTTTTTTGACGCGGAGTCCA

Product: glutamate dehydrogenase

Products: NA

Alternate protein names: NADP-GDH [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MSPIDEKVQGYYELLLKRNPAEPEFHQAVNEVLDSLKIVLEKDPHYADYGLIQRLCEPERQLMFRVPWVDDNGVVQVNRG
FRVQFNSAIGPYKGGLRFHPSVNLGIIKFLGFEQIFKNSLTGLPIGGGKGGSDFDPKGKSDVEIMRFCQSFMTELYRHIG
EYRDVPAGDIGVGGREIGYLFGQYRRLANQHESGVLTGKGLTWGGSLVRTEATGYGLVYFTAEMLAHHGQSFEGKKVIVS
GSGNVAIYAIEKAQELGATVIGFSDSSAWVETPNGVDVAKLKEIKEVRRERVSSYVDEVEGAILHTEGSIWDLTCDVALP
CATQNELDGEHAKKLADNGCAFVAEGANMPSTADAIEVYRERGIHFGPGKAANAGGVATSALEMQQNASRDSWSFEYADQ
RLREIMKGIFKNCESTAREYGHEGDYVVGANIAGFKKVADAMLAQGVI

Sequences:

>Translated_448_residues
MSPIDEKVQGYYELLLKRNPAEPEFHQAVNEVLDSLKIVLEKDPHYADYGLIQRLCEPERQLMFRVPWVDDNGVVQVNRG
FRVQFNSAIGPYKGGLRFHPSVNLGIIKFLGFEQIFKNSLTGLPIGGGKGGSDFDPKGKSDVEIMRFCQSFMTELYRHIG
EYRDVPAGDIGVGGREIGYLFGQYRRLANQHESGVLTGKGLTWGGSLVRTEATGYGLVYFTAEMLAHHGQSFEGKKVIVS
GSGNVAIYAIEKAQELGATVIGFSDSSAWVETPNGVDVAKLKEIKEVRRERVSSYVDEVEGAILHTEGSIWDLTCDVALP
CATQNELDGEHAKKLADNGCAFVAEGANMPSTADAIEVYRERGIHFGPGKAANAGGVATSALEMQQNASRDSWSFEYADQ
RLREIMKGIFKNCESTAREYGHEGDYVVGANIAGFKKVADAMLAQGVI
>Mature_447_residues
SPIDEKVQGYYELLLKRNPAEPEFHQAVNEVLDSLKIVLEKDPHYADYGLIQRLCEPERQLMFRVPWVDDNGVVQVNRGF
RVQFNSAIGPYKGGLRFHPSVNLGIIKFLGFEQIFKNSLTGLPIGGGKGGSDFDPKGKSDVEIMRFCQSFMTELYRHIGE
YRDVPAGDIGVGGREIGYLFGQYRRLANQHESGVLTGKGLTWGGSLVRTEATGYGLVYFTAEMLAHHGQSFEGKKVIVSG
SGNVAIYAIEKAQELGATVIGFSDSSAWVETPNGVDVAKLKEIKEVRRERVSSYVDEVEGAILHTEGSIWDLTCDVALPC
ATQNELDGEHAKKLADNGCAFVAEGANMPSTADAIEVYRERGIHFGPGKAANAGGVATSALEMQQNASRDSWSFEYADQR
LREIMKGIFKNCESTAREYGHEGDYVVGANIAGFKKVADAMLAQGVI

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=408, Percent_Identity=27.6960784313726, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI4885281, Length=408, Percent_Identity=27.9411764705882, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI1788059, Length=445, Percent_Identity=59.5505617977528, Blast_Score=511, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17544676, Length=387, Percent_Identity=27.1317829457364, Blast_Score=124, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6319256, Length=455, Percent_Identity=52.7472527472528, Blast_Score=412, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6324951, Length=453, Percent_Identity=51.8763796909492, Blast_Score=406, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24649283, Length=390, Percent_Identity=28.2051282051282, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI45553475, Length=437, Percent_Identity=28.3752860411899, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI45549226, Length=414, Percent_Identity=28.5024154589372, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24649460, Length=316, Percent_Identity=28.7974683544304, Blast_Score=106, Evalue=4e-23,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.4 [H]

Molecular weight: Translated: 49080; Mature: 48949

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00074 GLFV_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPIDEKVQGYYELLLKRNPAEPEFHQAVNEVLDSLKIVLEKDPHYADYGLIQRLCEPER
CCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCH
QLMFRVPWVDDNGVVQVNRGFRVQFNSAIGPYKGGLRFHPSVNLGIIKFLGFEQIFKNSL
HEEEECCCCCCCCEEEECCCEEEEECCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCC
TGLPIGGGKGGSDFDPKGKSDVEIMRFCQSFMTELYRHIGEYRDVPAGDIGVGGREIGYL
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
FGQYRRLANQHESGVLTGKGLTWGGSLVRTEATGYGLVYFTAEMLAHHGQSFEGKKVIVS
HHHHHHHHHHCCCCEEECCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEEE
GSGNVAIYAIEKAQELGATVIGFSDSSAWVETPNGVDVAKLKEIKEVRRERVSSYVDEVE
CCCCEEEEEECCHHHCCCEEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHC
GAILHTEGSIWDLTCDVALPCATQNELDGEHAKKLADNGCAFVAEGANMPSTADAIEVYR
CEEEECCCCEEEEEECEEECCCCCCCCCHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHH
ERGIHFGPGKAANAGGVATSALEMQQNASRDSWSFEYADQRLREIMKGIFKNCESTAREY
HCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GHEGDYVVGANIAGFKKVADAMLAQGVI
CCCCCEEEECCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SPIDEKVQGYYELLLKRNPAEPEFHQAVNEVLDSLKIVLEKDPHYADYGLIQRLCEPER
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCH
QLMFRVPWVDDNGVVQVNRGFRVQFNSAIGPYKGGLRFHPSVNLGIIKFLGFEQIFKNSL
HEEEECCCCCCCCEEEECCCEEEEECCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCC
TGLPIGGGKGGSDFDPKGKSDVEIMRFCQSFMTELYRHIGEYRDVPAGDIGVGGREIGYL
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
FGQYRRLANQHESGVLTGKGLTWGGSLVRTEATGYGLVYFTAEMLAHHGQSFEGKKVIVS
HHHHHHHHHHCCCCEEECCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEEE
GSGNVAIYAIEKAQELGATVIGFSDSSAWVETPNGVDVAKLKEIKEVRRERVSSYVDEVE
CCCCEEEEEECCHHHCCCEEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHC
GAILHTEGSIWDLTCDVALPCATQNELDGEHAKKLADNGCAFVAEGANMPSTADAIEVYR
CEEEECCCCEEEEEECEEECCCCCCCCCHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHH
ERGIHFGPGKAANAGGVATSALEMQQNASRDSWSFEYADQRLREIMKGIFKNCESTAREY
HCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GHEGDYVVGANIAGFKKVADAMLAQGVI
CCCCCEEEECCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]