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The map label for this gene is ffh [H]

Identifier: 38234110

GI number: 38234110

Start: 1553918

End: 1555534

Strand: Reverse

Name: ffh [H]

Synonym: DIP1533

Alternate gene names: 38234110

Gene position: 1555534-1553918 (Counterclockwise)

Preceding gene: 38234111

Following gene: 38234109

Centisome position: 62.51

GC content: 50.77

Gene sequence:

>1617_bases
GTGTTTGAATCCCTATCTGACCGGCTCGGCAATGCCCTTTCTGGGTTGCGTTCTAAGGGCAAGGTTACTGAGGCTGACAT
CAATACCGTTGCCCGAGAGATCCGCCTTGCGTTGCTCGAAGCCGATGTTTCATTACCAGTCGTTCGTGGATTTATCTCGA
GGATAAAAGATCGTGCGTTAGGCGTTGAAGTCTCCAAAGCGCTTAATCCAGCAGAGCAAGTTATCAAGATTGTTGATGAA
GAGCTAACGGGAATTCTTGGTGGCGAAACACGACGATTGAACCTAGCGAAGAACCCGCCAACGGTGATCATGTTGGCTGG
TTTGCAGGGTGCTGGTAAGACCACTCTCGCAGGTAAATTGGCTAAGCACCTGGTGGAGCAGGGGCATACTCCGATGCTGG
TTGCTTGCGACTTGCAACGCCCCGGCGCTGTTCAGCAGCTGACGATCGTTGGTGAGCGAGCAGGTGTTCCTACCTTTGCA
CCGGATCCAGGTACCTCTATCGATTCCAGTGATCATGAAATGGGTACGTCCCATGGTGACCCAGTAGCAGTGGCACAACA
GGGTATCGCAGAAGCCAAGCGTACCCAACATGATATTGTCATCGTCGATACAGCTGGTCGCTTGGGCATCGACGAAGCCT
TGATGACGCAGGCTCGCAACATTCGTGATGCTATTAATCCGGATGAAGTTCTGTTTGTCATCGACGCGATGATTGGTCAA
GATGCAGTTAATACTGCAGAAGCTTTCCGCGATGGCGTGGATTTCACTGGTGTTGTTTTGACCAAGCTTGATGGTGATGC
CCGCGGTGGTGCAGCGCTATCTATTCGAGAAGTCACCGGCAAACCGATCATGTTTGCCTCTACCGGTGAAAAGCTTGAAG
ACTTCGACATTTTCCACCCAGAGCGTATGTCTAGCCGAATTCTCGGCATGGGCGATATGTTGACGCTGATCGAACAAGCA
GAAAAGAAACTCGATCAGCAACAAGCACTGGAAACTGCACAAAAGCTCGGTACTGGCGAACTTACTCTCGACGATTTCTT
GAACCAGATGCTCATGGTGCGTCGAATGGGGCCACTAGGCAACATTTTGAAGATGCTGCCTGGTGGAAAAGCTATGTCGG
ACATGGCGGATATGGTTGATGAGAAGCAGCTCGACCGTATTCAGGCGATCATTCGCGGCATGACTCCAGCTGAGCGCAAC
GATCCAAAGATCTTGAACGCTTCTCGACGCAAGCGTATTGCTCTTGGTTCAGGAGTTTCGGTAGCCGAAGTTAATCAGCT
TGTAGAGCGCTTCTTTGAAGCGAAGAAGATGATGAACAAAATGGCTGGCCAGTTCGGCATGGGTGGTGGATCGCGTAGTG
CTACCAAGAAGAAGCCCAAAGGTCGAAAAGGTAAAAACGGTAAACGTAAGCCTGCTAAGAATCGCAGTGGCGGAATGCCG
AATATGGGCGGTATGCCGGGTATGCCGAACATGGCGGAATTGCAAAAACTTCAGCAGCAGATGGAGCAGGGTGGCGGTAT
GCCAGGGATGGGAGGATTCCCTGGAATGCCTAAACTTCCAAAAGGCATGGAAAATATTGATCTCAACAACCTTGATTTCG
GTCAAGGCAAGAAGTAA

Upstream 100 bases:

>100_bases
GTTAAAAGATAATGGGTCTGGGTGTTGCTGCGCTGCATCGCCGATCTCCACGTGTCATATGGTTGCTGGAGAAATAAAGT
TTTAGAGGAGAGTACGTCTC

Downstream 100 bases:

>100_bases
TAGATTTGCTTTATAGTCGGTGCCGCTGACACATTCTGATTTGAAAGTGTCGGTGGCACCGACTATATTTACTGAAGTTG
TCTGTAGTAGGGCAGCTTGT

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 538; Mature: 538

Protein sequence:

>538_residues
MFESLSDRLGNALSGLRSKGKVTEADINTVAREIRLALLEADVSLPVVRGFISRIKDRALGVEVSKALNPAEQVIKIVDE
ELTGILGGETRRLNLAKNPPTVIMLAGLQGAGKTTLAGKLAKHLVEQGHTPMLVACDLQRPGAVQQLTIVGERAGVPTFA
PDPGTSIDSSDHEMGTSHGDPVAVAQQGIAEAKRTQHDIVIVDTAGRLGIDEALMTQARNIRDAINPDEVLFVIDAMIGQ
DAVNTAEAFRDGVDFTGVVLTKLDGDARGGAALSIREVTGKPIMFASTGEKLEDFDIFHPERMSSRILGMGDMLTLIEQA
EKKLDQQQALETAQKLGTGELTLDDFLNQMLMVRRMGPLGNILKMLPGGKAMSDMADMVDEKQLDRIQAIIRGMTPAERN
DPKILNASRRKRIALGSGVSVAEVNQLVERFFEAKKMMNKMAGQFGMGGGSRSATKKKPKGRKGKNGKRKPAKNRSGGMP
NMGGMPGMPNMAELQKLQQQMEQGGGMPGMGGFPGMPKLPKGMENIDLNNLDFGQGKK

Sequences:

>Translated_538_residues
MFESLSDRLGNALSGLRSKGKVTEADINTVAREIRLALLEADVSLPVVRGFISRIKDRALGVEVSKALNPAEQVIKIVDE
ELTGILGGETRRLNLAKNPPTVIMLAGLQGAGKTTLAGKLAKHLVEQGHTPMLVACDLQRPGAVQQLTIVGERAGVPTFA
PDPGTSIDSSDHEMGTSHGDPVAVAQQGIAEAKRTQHDIVIVDTAGRLGIDEALMTQARNIRDAINPDEVLFVIDAMIGQ
DAVNTAEAFRDGVDFTGVVLTKLDGDARGGAALSIREVTGKPIMFASTGEKLEDFDIFHPERMSSRILGMGDMLTLIEQA
EKKLDQQQALETAQKLGTGELTLDDFLNQMLMVRRMGPLGNILKMLPGGKAMSDMADMVDEKQLDRIQAIIRGMTPAERN
DPKILNASRRKRIALGSGVSVAEVNQLVERFFEAKKMMNKMAGQFGMGGGSRSATKKKPKGRKGKNGKRKPAKNRSGGMP
NMGGMPGMPNMAELQKLQQQMEQGGGMPGMGGFPGMPKLPKGMENIDLNNLDFGQGKK
>Mature_538_residues
MFESLSDRLGNALSGLRSKGKVTEADINTVAREIRLALLEADVSLPVVRGFISRIKDRALGVEVSKALNPAEQVIKIVDE
ELTGILGGETRRLNLAKNPPTVIMLAGLQGAGKTTLAGKLAKHLVEQGHTPMLVACDLQRPGAVQQLTIVGERAGVPTFA
PDPGTSIDSSDHEMGTSHGDPVAVAQQGIAEAKRTQHDIVIVDTAGRLGIDEALMTQARNIRDAINPDEVLFVIDAMIGQ
DAVNTAEAFRDGVDFTGVVLTKLDGDARGGAALSIREVTGKPIMFASTGEKLEDFDIFHPERMSSRILGMGDMLTLIEQA
EKKLDQQQALETAQKLGTGELTLDDFLNQMLMVRRMGPLGNILKMLPGGKAMSDMADMVDEKQLDRIQAIIRGMTPAERN
DPKILNASRRKRIALGSGVSVAEVNQLVERFFEAKKMMNKMAGQFGMGGGSRSATKKKPKGRKGKNGKRKPAKNRSGGMP
NMGGMPGMPNMAELQKLQQQMEQGGGMPGMGGFPGMPKLPKGMENIDLNNLDFGQGKK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=523, Percent_Identity=33.6520076481836, Blast_Score=248, Evalue=7e-66,
Organism=Homo sapiens, GI226371618, Length=465, Percent_Identity=34.4086021505376, Blast_Score=225, Evalue=7e-59,
Organism=Homo sapiens, GI89061728, Length=152, Percent_Identity=43.421052631579, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI23308697, Length=306, Percent_Identity=29.4117647058824, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI295424842, Length=306, Percent_Identity=29.4117647058824, Blast_Score=108, Evalue=1e-23,
Organism=Escherichia coli, GI1788963, Length=434, Percent_Identity=47.6958525345622, Blast_Score=396, Evalue=1e-111,
Organism=Escherichia coli, GI1789874, Length=278, Percent_Identity=34.5323741007194, Blast_Score=142, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI17539958, Length=513, Percent_Identity=29.2397660818713, Blast_Score=210, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI193206261, Length=303, Percent_Identity=28.7128712871287, Blast_Score=98, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6325345, Length=522, Percent_Identity=32.9501915708812, Blast_Score=250, Evalue=3e-67,
Organism=Saccharomyces cerevisiae, GI6320498, Length=218, Percent_Identity=30.2752293577982, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17647949, Length=452, Percent_Identity=31.1946902654867, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24641198, Length=294, Percent_Identity=29.5918367346939, Blast_Score=111, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 57747; Mature: 57747

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFESLSDRLGNALSGLRSKGKVTEADINTVAREIRLALLEADVSLPVVRGFISRIKDRAL
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
GVEVSKALNPAEQVIKIVDEELTGILGGETRRLNLAKNPPTVIMLAGLQGAGKTTLAGKL
CHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCCCCCCHHHHHHH
AKHLVEQGHTPMLVACDLQRPGAVQQLTIVGERAGVPTFAPDPGTSIDSSDHEMGTSHGD
HHHHHHCCCCCEEEEECCCCCCCCEEEEEEEHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
PVAVAQQGIAEAKRTQHDIVIVDTAGRLGIDEALMTQARNIRDAINPDEVLFVIDAMIGQ
CHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
DAVNTAEAFRDGVDFTGVVLTKLDGDARGGAALSIREVTGKPIMFASTGEKLEDFDIFHP
HHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCEEEECCCCCHHHCCCCCH
ERMSSRILGMGDMLTLIEQAEKKLDQQQALETAQKLGTGELTLDDFLNQMLMVRRMGPLG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCHH
NILKMLPGGKAMSDMADMVDEKQLDRIQAIIRGMTPAERNDPKILNASRRKRIALGSGVS
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCEEECCCCCC
VAEVNQLVERFFEAKKMMNKMAGQFGMGGGSRSATKKKPKGRKGKNGKRKPAKNRSGGMP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
NMGGMPGMPNMAELQKLQQQMEQGGGMPGMGGFPGMPKLPKGMENIDLNNLDFGQGKK
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFESLSDRLGNALSGLRSKGKVTEADINTVAREIRLALLEADVSLPVVRGFISRIKDRAL
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
GVEVSKALNPAEQVIKIVDEELTGILGGETRRLNLAKNPPTVIMLAGLQGAGKTTLAGKL
CHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCCCCCCHHHHHHH
AKHLVEQGHTPMLVACDLQRPGAVQQLTIVGERAGVPTFAPDPGTSIDSSDHEMGTSHGD
HHHHHHCCCCCEEEEECCCCCCCCEEEEEEEHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
PVAVAQQGIAEAKRTQHDIVIVDTAGRLGIDEALMTQARNIRDAINPDEVLFVIDAMIGQ
CHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
DAVNTAEAFRDGVDFTGVVLTKLDGDARGGAALSIREVTGKPIMFASTGEKLEDFDIFHP
HHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCEEEECCCCCHHHCCCCCH
ERMSSRILGMGDMLTLIEQAEKKLDQQQALETAQKLGTGELTLDDFLNQMLMVRRMGPLG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCHH
NILKMLPGGKAMSDMADMVDEKQLDRIQAIIRGMTPAERNDPKILNASRRKRIALGSGVS
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCEEECCCCCC
VAEVNQLVERFFEAKKMMNKMAGQFGMGGGSRSATKKKPKGRKGKNGKRKPAKNRSGGMP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
NMGGMPGMPNMAELQKLQQQMEQGGGMPGMGGFPGMPKLPKGMENIDLNNLDFGQGKK
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]