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The map label for this gene is mtr [H]

Identifier: 38234073

GI number: 38234073

Start: 1516191

End: 1517582

Strand: Direct

Name: mtr [H]

Synonym: DIP1494

Alternate gene names: 38234073

Gene position: 1516191-1517582 (Clockwise)

Preceding gene: 38234072

Following gene: 38234080

Centisome position: 60.92

GC content: 49.28

Gene sequence:

>1392_bases
ATGAATAATCAACAACCACGCCATTACGACCTGATCATTGTTGGCTCCGGCTCAGGTAATTCCATCCCAGGTCCCGAATT
TGACGATAAATCCATTGCCATCGTGGAAAAAGGGAAATTTGGTGGTACCTGCCTCAACGTAGGGTGCATTCCGACCAAGA
TGTTCGTATACGCTTCTGAAATCGCCCAGGTCATCGTCGATTCCGAGCGCTTTGGCATTTCGGCTTCTATTGACTCCGTG
CAGTGGCCTGACATCGTAGAGCGCGTATTTGCGCATCGCATTGATCCTATTGCAGCAAGCGGCGAAGAATATCGACGCGG
GGACAAAACCCCCAATATCGACGTATACGACCAACATGCGCGTTTTATTGCACCTAAAACATTGCAGATTGGCGATGGCG
AAAACGCCCCGATTATTTCCGGTGACACTATCGTCATTGCCACCGGTTCGCGTCCATTTATTCCTTCCTATATTGAAGAA
TCAAAGGTCACCTACTACACCAATGAGACGATTATGCGGATGCCCGATTTGCCGCGTTCCATGGTTGTCTTGGGTGGTGG
TTACATCGCTATGGAGTTTGCCCATGTGTTCTCCGCACTAGGAGTAAACGTAACGGTGGTCAATCGTTCGCCTCAGCTTC
TTCGTGTACTCGATGAGGATATTTCTCATCGTTTCACTGAAATCACCAAGACCAAGATGGATTGTCGTCTGGGGCGCACA
GTGTCCAGCGTTGATCAGGACTCCAATGGTGTCACTTTGACGCTTGACGACGGCTCCACTGCCACCGGCGAAGTGCTTTT
GGTGGCAACTGGTCGTATTCCTAATGGTGATCAGATGAATCTGGATTCAGCAGGAATCGACATGGATGGCAAACGCATTA
AGGTTGATGATTTTGGTCGCACTACTGCCGACGGTGTGTGGGCGCTAGGTGATGTGTCTTCACCTTATCAGCTCAAGCAT
GTTGCTAATGCTGAGATGCGTGCAGTAAAGCATAATTTGCTACATCCTGAAGATCTCAAATCAATGCCGCATCAACATGT
TCCTGCAGGTGTATTCACACACCCTCAGATTGCAACAGTAGGCCTTACTGAGCAAGAAGCTCGTGACGCTGGATATTCCA
TCACAGTGAAGATTCAAAACTATGGTGACGTAGCCTATGGCTGGGCTATGGAAGATACCCAGCATTTTGCGAAGCTCATT
GCGGATAAGAAGACTGGACGGTTGCTCGGCGCGCACTTTATCGGCCCTCAAGCCTCCACTCTTATTCAGCAGCTTATTAC
CGTCATGGCCTTCGATTTGGATGTGCGAGAGGTAGCAACAAAACAGTACTGGATCCATCCGGCACTGCCTGAGCTAACAG
AAAACGCACTGCTCGGACTCGATTTCTCCTAA

Upstream 100 bases:

>100_bases
TGATCTTTGCTTCAGCTTCGAAATATATTTTGATACTGATAGTTTGTATGTCATCGTGGCTCACTGCTTCCGGATTCCCT
GAAAGGACTCCTCTTTCCTT

Downstream 100 bases:

>100_bases
TCGCATAAAGCGAAGGGCTGTACAACTATTTTGTTGTACAGCCCTTCGCTTTATTCTTTAGGTAAGCGCTGCAATGAGTT
GGTCAAGATCCCAATGTTGT

Product: mycothione reductase

Products: NA

Alternate protein names: Mycothiol-disulfide reductase; NADPH-dependent mycothione reductase [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MNNQQPRHYDLIIVGSGSGNSIPGPEFDDKSIAIVEKGKFGGTCLNVGCIPTKMFVYASEIAQVIVDSERFGISASIDSV
QWPDIVERVFAHRIDPIAASGEEYRRGDKTPNIDVYDQHARFIAPKTLQIGDGENAPIISGDTIVIATGSRPFIPSYIEE
SKVTYYTNETIMRMPDLPRSMVVLGGGYIAMEFAHVFSALGVNVTVVNRSPQLLRVLDEDISHRFTEITKTKMDCRLGRT
VSSVDQDSNGVTLTLDDGSTATGEVLLVATGRIPNGDQMNLDSAGIDMDGKRIKVDDFGRTTADGVWALGDVSSPYQLKH
VANAEMRAVKHNLLHPEDLKSMPHQHVPAGVFTHPQIATVGLTEQEARDAGYSITVKIQNYGDVAYGWAMEDTQHFAKLI
ADKKTGRLLGAHFIGPQASTLIQQLITVMAFDLDVREVATKQYWIHPALPELTENALLGLDFS

Sequences:

>Translated_463_residues
MNNQQPRHYDLIIVGSGSGNSIPGPEFDDKSIAIVEKGKFGGTCLNVGCIPTKMFVYASEIAQVIVDSERFGISASIDSV
QWPDIVERVFAHRIDPIAASGEEYRRGDKTPNIDVYDQHARFIAPKTLQIGDGENAPIISGDTIVIATGSRPFIPSYIEE
SKVTYYTNETIMRMPDLPRSMVVLGGGYIAMEFAHVFSALGVNVTVVNRSPQLLRVLDEDISHRFTEITKTKMDCRLGRT
VSSVDQDSNGVTLTLDDGSTATGEVLLVATGRIPNGDQMNLDSAGIDMDGKRIKVDDFGRTTADGVWALGDVSSPYQLKH
VANAEMRAVKHNLLHPEDLKSMPHQHVPAGVFTHPQIATVGLTEQEARDAGYSITVKIQNYGDVAYGWAMEDTQHFAKLI
ADKKTGRLLGAHFIGPQASTLIQQLITVMAFDLDVREVATKQYWIHPALPELTENALLGLDFS
>Mature_463_residues
MNNQQPRHYDLIIVGSGSGNSIPGPEFDDKSIAIVEKGKFGGTCLNVGCIPTKMFVYASEIAQVIVDSERFGISASIDSV
QWPDIVERVFAHRIDPIAASGEEYRRGDKTPNIDVYDQHARFIAPKTLQIGDGENAPIISGDTIVIATGSRPFIPSYIEE
SKVTYYTNETIMRMPDLPRSMVVLGGGYIAMEFAHVFSALGVNVTVVNRSPQLLRVLDEDISHRFTEITKTKMDCRLGRT
VSSVDQDSNGVTLTLDDGSTATGEVLLVATGRIPNGDQMNLDSAGIDMDGKRIKVDDFGRTTADGVWALGDVSSPYQLKH
VANAEMRAVKHNLLHPEDLKSMPHQHVPAGVFTHPQIATVGLTEQEARDAGYSITVKIQNYGDVAYGWAMEDTQHFAKLI
ADKKTGRLLGAHFIGPQASTLIQQLITVMAFDLDVREVATKQYWIHPALPELTENALLGLDFS

Specific function: Catalyzes the NAD(P)H-dependent reduction of mycothione (the oxidized disulfide form of mycothiol) to mycothiol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=446, Percent_Identity=28.47533632287, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI91199540, Length=481, Percent_Identity=27.4428274428274, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI22035672, Length=432, Percent_Identity=28.0092592592593, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI148277065, Length=442, Percent_Identity=24.6606334841629, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI33519430, Length=442, Percent_Identity=24.6606334841629, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI33519428, Length=442, Percent_Identity=24.6606334841629, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI33519426, Length=442, Percent_Identity=24.6606334841629, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI148277071, Length=442, Percent_Identity=24.6606334841629, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI291045266, Length=432, Percent_Identity=24.7685185185185, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI291045268, Length=428, Percent_Identity=22.6635514018692, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1789915, Length=434, Percent_Identity=30.6451612903226, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1786307, Length=438, Percent_Identity=27.8538812785388, Blast_Score=162, Evalue=6e-41,
Organism=Escherichia coli, GI87081717, Length=454, Percent_Identity=28.8546255506608, Blast_Score=155, Evalue=7e-39,
Organism=Escherichia coli, GI87082354, Length=425, Percent_Identity=25.1764705882353, Blast_Score=134, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI32565766, Length=478, Percent_Identity=28.2426778242678, Blast_Score=161, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI71983429, Length=342, Percent_Identity=29.2397660818713, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI71983419, Length=342, Percent_Identity=29.2397660818713, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI17557007, Length=467, Percent_Identity=26.7665952890792, Blast_Score=134, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI71982272, Length=447, Percent_Identity=24.3847874720358, Blast_Score=96, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6325166, Length=470, Percent_Identity=24.6808510638298, Blast_Score=150, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6321091, Length=475, Percent_Identity=27.7894736842105, Blast_Score=146, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6325240, Length=491, Percent_Identity=23.2179226069246, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21358499, Length=475, Percent_Identity=26.5263157894737, Blast_Score=158, Evalue=7e-39,
Organism=Drosophila melanogaster, GI24640553, Length=480, Percent_Identity=26.875, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24640549, Length=483, Percent_Identity=26.9151138716356, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24640551, Length=480, Percent_Identity=26.875, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17737741, Length=481, Percent_Identity=25.7796257796258, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017817
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.15 [H]

Molecular weight: Translated: 50671; Mature: 50671

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNQQPRHYDLIIVGSGSGNSIPGPEFDDKSIAIVEKGKFGGTCLNVGCIPTKMFVYASE
CCCCCCCEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCEEEECCCCCHHHHHHHHH
IAQVIVDSERFGISASIDSVQWPDIVERVFAHRIDPIAASGEEYRRGDKTPNIDVYDQHA
HHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCEEECCC
RFIAPKTLQIGDGENAPIISGDTIVIATGSRPFIPSYIEESKVTYYTNETIMRMPDLPRS
EEECCCEEEECCCCCCCEEECCEEEEECCCCCCCCHHHCCCCEEEEECCEEEECCCCCCE
MVVLGGGYIAMEFAHVFSALGVNVTVVNRSPQLLRVLDEDISHRFTEITKTKMDCRLGRT
EEEECCCHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
VSSVDQDSNGVTLTLDDGSTATGEVLLVATGRIPNGDQMNLDSAGIDMDGKRIKVDDFGR
HHHCCCCCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCC
TTADGVWALGDVSSPYQLKHVANAEMRAVKHNLLHPEDLKSMPHQHVPAGVFTHPQIATV
CCCCCEEEECCCCCCCHHHHHCCHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCEEEE
GLTEQEARDAGYSITVKIQNYGDVAYGWAMEDTQHFAKLIADKKTGRLLGAHFIGPQAST
CCCHHHHHCCCCEEEEEEECCCCEEEEEEHHHHHHHHHHHHCCCCCCEEEEEECCCCHHH
LIQQLITVMAFDLDVREVATKQYWIHPALPELTENALLGLDFS
HHHHHHHHHHCCCCHHHHHHHHEEECCCCHHHCCCCEEEECCC
>Mature Secondary Structure
MNNQQPRHYDLIIVGSGSGNSIPGPEFDDKSIAIVEKGKFGGTCLNVGCIPTKMFVYASE
CCCCCCCEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCEEEECCCCCHHHHHHHHH
IAQVIVDSERFGISASIDSVQWPDIVERVFAHRIDPIAASGEEYRRGDKTPNIDVYDQHA
HHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCEEECCC
RFIAPKTLQIGDGENAPIISGDTIVIATGSRPFIPSYIEESKVTYYTNETIMRMPDLPRS
EEECCCEEEECCCCCCCEEECCEEEEECCCCCCCCHHHCCCCEEEEECCEEEECCCCCCE
MVVLGGGYIAMEFAHVFSALGVNVTVVNRSPQLLRVLDEDISHRFTEITKTKMDCRLGRT
EEEECCCHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
VSSVDQDSNGVTLTLDDGSTATGEVLLVATGRIPNGDQMNLDSAGIDMDGKRIKVDDFGR
HHHCCCCCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCC
TTADGVWALGDVSSPYQLKHVANAEMRAVKHNLLHPEDLKSMPHQHVPAGVFTHPQIATV
CCCCCEEEECCCCCCCHHHHHCCHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCEEEE
GLTEQEARDAGYSITVKIQNYGDVAYGWAMEDTQHFAKLIADKKTGRLLGAHFIGPQAST
CCCHHHHHCCCCEEEEEEECCCCEEEEEEHHHHHHHHHHHHCCCCCCEEEEEECCCCHHH
LIQQLITVMAFDLDVREVATKQYWIHPALPELTENALLGLDFS
HHHHHHHHHHCCCCHHHHHHHHEEECCCCHHHCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]