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The map label for this gene is ppiB [H]

Identifier: 38233949

GI number: 38233949

Start: 1381185

End: 1382027

Strand: Direct

Name: ppiB [H]

Synonym: DIP1363

Alternate gene names: 38233949

Gene position: 1381185-1382027 (Clockwise)

Preceding gene: 38233945

Following gene: 38233950

Centisome position: 55.5

GC content: 49.7

Gene sequence:

>843_bases
GTGGGCACTAACAAGGAACGCCGTGAGAGCGCTATGCGATCTCTAGAAAAAGAAATCAAGTCAAGAGATCGCGCGGAAAA
AACAAAACCGTTAGGCGTCGTCGCTGCAGCAGCAGTCGCAGTTCTAGCAATCGTCGGCGGTATTTACTGGGCAAACTCCT
CGGATGATTCTGCGCAAACCCAAGCTTCTGACCAAGCTACGCCCACAACTGAAGAATCCAACTTCACCCCCCTAGCAATG
AAACGCGCCAAGGCACTAGGCGATACCGTTACCTGCACCTACAACGATGCAGGTAACGCGTCCAAGGATGTATCGAAACC
TAAAACTGAATCCGTTTCTGCAAAGGGAACAACCACAGTTTCTCTGGATACAAACAAAGGAAAGATTGATCTTGAGCTCG
ACCATGCAGCTTCCCCTTGCACGGTCAATGCCATTGAGCATCTTGCCAAGCAAAAATACTATGACGATACTGTTTGCCAC
CGTTTAACCACTAGTGGAATTTACGTTCTGCAGTGCGGCGATCCAAGCGGTAAGGGTTCAGGTGGACCTGGCTTCCAGTT
TGATAATGAATACCCAACCGATGAAGCTTCCGATAAGCAAACCCCTGTTGTTTACCCTCGCGGAAGCATTGCTATGGCTA
ATGCCGGCGAAGGGACCAACGGATCCCAGTTCTTCCTTAACTACAAGGATTCTCCGCTACCACCTGCATACACGTACTTT
GGAAAAATATCTGACGCTGGCCTTAAGACCCTAGACAAGATTGCCGAAGCAGGGGTAAAAGACGGCGGCACAGATGGCGC
TCCGGCTGAAGAAGTAAAAATCAGGACCGCAGCAGTTTCTTAA

Upstream 100 bases:

>100_bases
TAACTTTGGGGCATCACAACGGCAAGCTAGACTAACCAACGGTAATCAAATAGCGAGCCATTTCATGCTCGGCTCATCTA
AGTAAAGGATTGGAAGGCCT

Downstream 100 bases:

>100_bases
GCAAGCGATTGCGCAAAGGTGCCCACGGAACACATGTGACACTTACATGCCATCAGCCTTTGTTTTCGTGTCTTAAAAAT
TAAAAGTAGCTTTTTATCTA

Product: putative isomerase

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MGTNKERRESAMRSLEKEIKSRDRAEKTKPLGVVAAAAVAVLAIVGGIYWANSSDDSAQTQASDQATPTTEESNFTPLAM
KRAKALGDTVTCTYNDAGNASKDVSKPKTESVSAKGTTTVSLDTNKGKIDLELDHAASPCTVNAIEHLAKQKYYDDTVCH
RLTTSGIYVLQCGDPSGKGSGGPGFQFDNEYPTDEASDKQTPVVYPRGSIAMANAGEGTNGSQFFLNYKDSPLPPAYTYF
GKISDAGLKTLDKIAEAGVKDGGTDGAPAEEVKIRTAAVS

Sequences:

>Translated_280_residues
MGTNKERRESAMRSLEKEIKSRDRAEKTKPLGVVAAAAVAVLAIVGGIYWANSSDDSAQTQASDQATPTTEESNFTPLAM
KRAKALGDTVTCTYNDAGNASKDVSKPKTESVSAKGTTTVSLDTNKGKIDLELDHAASPCTVNAIEHLAKQKYYDDTVCH
RLTTSGIYVLQCGDPSGKGSGGPGFQFDNEYPTDEASDKQTPVVYPRGSIAMANAGEGTNGSQFFLNYKDSPLPPAYTYF
GKISDAGLKTLDKIAEAGVKDGGTDGAPAEEVKIRTAAVS
>Mature_279_residues
GTNKERRESAMRSLEKEIKSRDRAEKTKPLGVVAAAAVAVLAIVGGIYWANSSDDSAQTQASDQATPTTEESNFTPLAMK
RAKALGDTVTCTYNDAGNASKDVSKPKTESVSAKGTTTVSLDTNKGKIDLELDHAASPCTVNAIEHLAKQKYYDDTVCHR
LTTSGIYVLQCGDPSGKGSGGPGFQFDNEYPTDEASDKQTPVVYPRGSIAMANAGEGTNGSQFFLNYKDSPLPPAYTYFG
KISDAGLKTLDKIAEAGVKDGGTDGAPAEEVKIRTAAVS

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI64276486, Length=164, Percent_Identity=32.9268292682927, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI19557636, Length=166, Percent_Identity=33.7349397590361, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI7706339, Length=162, Percent_Identity=33.9506172839506, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI24308049, Length=275, Percent_Identity=28, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17539496, Length=159, Percent_Identity=37.1069182389937, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71997782, Length=147, Percent_Identity=35.3741496598639, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17532641, Length=172, Percent_Identity=35.4651162790698, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71980594, Length=140, Percent_Identity=34.2857142857143, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71980590, Length=140, Percent_Identity=34.2857142857143, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17506311, Length=223, Percent_Identity=30.4932735426009, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI19922376, Length=178, Percent_Identity=36.5168539325843, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17986117, Length=161, Percent_Identity=29.8136645962733, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI21357249, Length=147, Percent_Identity=34.6938775510204, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 29533; Mature: 29402

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTNKERRESAMRSLEKEIKSRDRAEKTKPLGVVAAAAVAVLAIVGGIYWANSSDDSAQT
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEECCCCCCCHHH
QASDQATPTTEESNFTPLAMKRAKALGDTVTCTYNDAGNASKDVSKPKTESVSAKGTTTV
HCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEE
SLDTNKGKIDLELDHAASPCTVNAIEHLAKQKYYDDTVCHRLTTSGIYVLQCGDPSGKGS
EEECCCCEEEEEECCCCCCEEHHHHHHHHHHHCCCHHHHHHHCCCCEEEEECCCCCCCCC
GGPGFQFDNEYPTDEASDKQTPVVYPRGSIAMANAGEGTNGSQFFLNYKDSPLPPAYTYF
CCCCCCCCCCCCCCCCCCCCCCEEECCCCEEEECCCCCCCCCEEEEECCCCCCCCHHHHH
GKISDAGLKTLDKIAEAGVKDGGTDGAPAEEVKIRTAAVS
CCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHEEEEEEECC
>Mature Secondary Structure 
GTNKERRESAMRSLEKEIKSRDRAEKTKPLGVVAAAAVAVLAIVGGIYWANSSDDSAQT
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEECCCCCCCHHH
QASDQATPTTEESNFTPLAMKRAKALGDTVTCTYNDAGNASKDVSKPKTESVSAKGTTTV
HCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEE
SLDTNKGKIDLELDHAASPCTVNAIEHLAKQKYYDDTVCHRLTTSGIYVLQCGDPSGKGS
EEECCCCEEEEEECCCCCCEEHHHHHHHHHHHCCCHHHHHHHCCCCEEEEECCCCCCCCC
GGPGFQFDNEYPTDEASDKQTPVVYPRGSIAMANAGEGTNGSQFFLNYKDSPLPPAYTYF
CCCCCCCCCCCCCCCCCCCCCCEEECCCCEEEECCCCCCCCCEEEEECCCCCCCCHHHHH
GKISDAGLKTLDKIAEAGVKDGGTDGAPAEEVKIRTAAVS
CCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]