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The map label for this gene is gmk

Identifier: 38233914

GI number: 38233914

Start: 1340681

End: 1341256

Strand: Reverse

Name: gmk

Synonym: DIP1328

Alternate gene names: 38233914

Gene position: 1341256-1340681 (Counterclockwise)

Preceding gene: 38233915

Following gene: 38233913

Centisome position: 53.9

GC content: 51.91

Gene sequence:

>576_bases
ATGAGTGGCGATAACCCAGTAGGCCGTCTGGTGGTACTCGCAGGGCCTTCTGCCGTGGGTAAATCCACGGTGGTTCATCG
CCTCCGCGAAGAAATTGAAGACCTCTACTTCAGCGTATCTATGACCACGCGTGCTCCTCGACCAGGAGAGCGCGATGGCG
TGGACTATTTTTTTGTGTCACCTGAAGAGTTTCAATCCAAGATTGATGCGGGGGAGATGCTGGAATGGGCTGATATTCAC
GGTGGTCTTCAACGTTCGGGAACTCCTGCGGGACCTGTTGAAGCTGCACTTCTGGCCGGTCGACCTGTTCTCGTTGAGGT
GGATTTGGTCGGTGCGCGAAACGTGGCATCGCTAAAACCTGAATCTGAGACTGTATTTTTAGCCCCGCCATCGTGGGAAG
TTTTAGTGGAACGTCTGACAGGACGTGGTACTGAACCCGAAGACGTAATTACTCGTCGACTGGAAACAGCGAAGAATGAA
CTTACTGCTCAGCATGAGTTCAAACACGTTGTTGTCAATGAGGACGTGGAAAAAGCTGTGTCGGACATCAAGGAAATCCT
TGTCGGCCGTCGTTAA

Upstream 100 bases:

>100_bases
GGAGGAACTTGAAATTGCTCAGACCCGTCGTCTGCGCGGTTTGGGTGATCGTCAGCGTCGTGCTCTGCTCGAGCGTTTCG
GATACTCGGAGGACTAATTC

Downstream 100 bases:

>100_bases
AGCTAGCGCCTGCTACATTTTTGTGTAGCTGTTGAATCCGAGAACTATCAAGCTGTGAAGAAGAGGTGCCTCCGTGAGCA
ACGTGGCAGAGAACAATGAC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 191; Mature: 190

Protein sequence:

>191_residues
MSGDNPVGRLVVLAGPSAVGKSTVVHRLREEIEDLYFSVSMTTRAPRPGERDGVDYFFVSPEEFQSKIDAGEMLEWADIH
GGLQRSGTPAGPVEAALLAGRPVLVEVDLVGARNVASLKPESETVFLAPPSWEVLVERLTGRGTEPEDVITRRLETAKNE
LTAQHEFKHVVVNEDVEKAVSDIKEILVGRR

Sequences:

>Translated_191_residues
MSGDNPVGRLVVLAGPSAVGKSTVVHRLREEIEDLYFSVSMTTRAPRPGERDGVDYFFVSPEEFQSKIDAGEMLEWADIH
GGLQRSGTPAGPVEAALLAGRPVLVEVDLVGARNVASLKPESETVFLAPPSWEVLVERLTGRGTEPEDVITRRLETAKNE
LTAQHEFKHVVVNEDVEKAVSDIKEILVGRR
>Mature_190_residues
SGDNPVGRLVVLAGPSAVGKSTVVHRLREEIEDLYFSVSMTTRAPRPGERDGVDYFFVSPEEFQSKIDAGEMLEWADIHG
GLQRSGTPAGPVEAALLAGRPVLVEVDLVGARNVASLKPESETVFLAPPSWEVLVERLTGRGTEPEDVITRRLETAKNEL
TAQHEFKHVVVNEDVEKAVSDIKEILVGRR

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874831, Length=191, Percent_Identity=39.7905759162304, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI226874833, Length=191, Percent_Identity=39.7905759162304, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI4504221, Length=191, Percent_Identity=39.7905759162304, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI38570142, Length=184, Percent_Identity=28.804347826087, Blast_Score=71, Evalue=7e-13,
Organism=Escherichia coli, GI1790080, Length=186, Percent_Identity=36.0215053763441, Blast_Score=125, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI193203132, Length=184, Percent_Identity=35.3260869565217, Blast_Score=112, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17508835, Length=184, Percent_Identity=35.3260869565217, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320662, Length=190, Percent_Identity=39.4736842105263, Blast_Score=135, Evalue=4e-33,
Organism=Drosophila melanogaster, GI21356141, Length=187, Percent_Identity=33.6898395721925, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_CORDI (P60550)

Other databases:

- EMBL:   BX248357
- RefSeq:   NP_939681.1
- ProteinModelPortal:   P60550
- SMR:   P60550
- GeneID:   2649882
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1328
- NMPDR:   fig|257309.1.peg.1272
- HOGENOM:   HBG671982
- OMA:   EWAEFAG
- ProtClustDB:   PRK00300
- BioCyc:   CDIP257309:DIP1328-MONOMER
- BRENDA:   2.7.4.8
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 20896; Mature: 20765

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGDNPVGRLVVLAGPSAVGKSTVVHRLREEIEDLYFSVSMTTRAPRPGERDGVDYFFVS
CCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCEEEEC
PEEFQSKIDAGEMLEWADIHGGLQRSGTPAGPVEAALLAGRPVLVEVDLVGARNVASLKP
HHHHHHHCCHHHHHHHHHHCCCHHCCCCCCCCHHHHHHCCCCEEEEEEECCCCCCCCCCC
ESETVFLAPPSWEVLVERLTGRGTEPEDVITRRLETAKNELTAQHEFKHVVVNEDVEKAV
CCCEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHHHH
SDIKEILVGRR
HHHHHHHCCCC
>Mature Secondary Structure 
SGDNPVGRLVVLAGPSAVGKSTVVHRLREEIEDLYFSVSMTTRAPRPGERDGVDYFFVS
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCEEEEC
PEEFQSKIDAGEMLEWADIHGGLQRSGTPAGPVEAALLAGRPVLVEVDLVGARNVASLKP
HHHHHHHCCHHHHHHHHHHCCCHHCCCCCCCCHHHHHHCCCCEEEEEEECCCCCCCCCCC
ESETVFLAPPSWEVLVERLTGRGTEPEDVITRRLETAKNELTAQHEFKHVVVNEDVEKAV
CCCEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHHHH
SDIKEILVGRR
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910