Click here to switch to the map view.

The map label for this gene is tkt [H]

Identifier: 38233888

GI number: 38233888

Start: 1311649

End: 1313751

Strand: Direct

Name: tkt [H]

Synonym: DIP1302

Alternate gene names: 38233888

Gene position: 1311649-1313751 (Clockwise)

Preceding gene: 38233886

Following gene: 38233889

Centisome position: 52.71

GC content: 52.31

Gene sequence:

>2103_bases
GTGACTTTATCTCCGGAGCTTCAGGCTCTTACCTCCCGTCACTACCCTAGCGACTGGGACGACCTCGATACTCAGGCAGT
TGACACAGCACGTGTACTCGCTGCCGATGCAGTCCAGAATTGCGGTTCGGGCCACCCAGGCACTGCAATGAGCTTGGCAC
CTCTGGCTTACACTCTTTTCCAACGTGTCATGAATGTCGATCCTGCGGATCCGCATTGGGCTGGTCGCGATCGTTTTGTG
TTGTCATGTGGGCACACTTCACTTACGCAATACATCCAGCTTTACTTCGGCGGTTACGGCCTCGAACTTGAAGACCTTAA
AGCCCTGCGTACTTGGGGCGCATTAACTCCTGGCCACCCAGAATACCGCCATACTAAAGGCGTTGAAATCACAACTGGCC
CATTGGGTCAAGGCTTGGCATCGGCTGTTGGCATGGCGATGGCCTCACGACGTGAGCGCGCGTTGTTCGATCCCACTGCG
GCAGATGGTGCATCTCCATTCGACCACTATATTTATGTGATTGCTTCTGATGGCGACCTTCAGGAAGGTGTCACTGCGGA
GGCATGTTCGCTTGCCGGAACTCAAAAGCTTGGAAATCTCATCGTTTTCTGGGATGATAACCGGATCTCGATCGAAGAAG
ATACTGAGATTGCATTCAACGAAAAGGTTGTCGATCGTTACCGTGCTTATAACTGGCAAGTAATCGAAATTGACGGCGGC
GAAAACGTTGAAGCGATTGAAAAGGCAGTCGCAGAGGCTAAAGCCGATACTTCTCGTCCTACTTTTATCCGCGTACGTAC
CGTTATTGGCTATCCTGCGCCAACAAAGATGAATACCGGTGCTGTGCATGGTGCTGCTCTTGGTGCTGAAGAAGTCGCCG
GAACTAAGAAAGCACTCGGTTTTAATCCTGAGGAATCCTTCGCGGTAGCTCCGGAGGTCATTTCTCATACACGGAAACTT
CTAGAGCGAGGTGCTCAACGACATGCTGAGTGGCGTGAGCATTTCGAATCTTGGGCGGAAACAAACCCCGAAAATAAAGC
CCTCTTTGACCGGATGGCTTCCCGCGAACTTCCAGATGGTTTCGATGCTGATCTACCTTCGTGGGAGCCTGATGCCAAAG
GCGTCGCAACCCGCAAGGCTTCTGAAGCTACGTTACAGGCACTCGGTGCAACGCTTCCGGAGCTGTGGGGCGGTTCTGCC
GACCTAGCAGGCTCGAACAACACTGTTATTAAGGGTTCTCCATCGTTTGGTCCATCTACGATTTCTACGTCCACATGGAC
TGCTGAGCCAGGTGGACGTAATCTCCATTTCGGTATCCGCGAACATGCCATGGGCGCAATTATCAATGGCATTTCTCTCC
ACGGTGGAACCCGTCCTTATGGTGGAACCTTCCTGATTTTCTCGGATTACATGCGCCCTGCTGTTCGTCTGGCTGCCTTG
ATGGGAACCGACGCATACTATGTTTGGACACACGATTCCATCGGATTAGGCGAAGACGGCCCTACTCATCAACCTGTCGA
GCAGCTTGCATCGCTGCGTGCTATTCCTGGTGTTTCGATGCTTCGTCCCGCTGATGCTAACGAAACTGCTGCGGCTTGGC
GTGCGGCACTCCTGTATAAGGAAGGTCCTAAAGGTCTAGCCCTTACACGTCAAAACGTCCTTGTTCTCGAAGGAACAAAA
GAAAAAGCGCGGGATGGTGTCTCACGAGGGGCATATGTTCTCGTTGAAGGATCTAAGAAAACTCCTGACGTTATTTTGAT
GGCTTCAGGCTCCGAAGTACAGCTTGCAGTCGAAGCGGCTAAAACTTTGGAAGCAGAAAAGATTGCAGCTCGAGTCGTGT
CTGTGCCTTGCTTAGATTGGTTCGAGGAACAAGACGCCGCTTATCAAGAAGAGATACTTCCGCAGGCGGTTAGCGCTCGC
GTATCGGTGGAAGCGGGTGTCGCTTTGTCTTGGTATCGCCATCTGGGCACCCATGGTCGGGCCGTGTCCCTTGAGCACTT
CGGCGCATCTGCTCCGTATGAGAAGCTCTTCAGTGAATTTGGCATAACCACTGAAGCAGTTATTGCTGCAGCTCGCGAAT
CACTTGCTGCTGCTCAGCAATAA

Upstream 100 bases:

>100_bases
CATAACTGCCACGAATCCTACTAAGGTGGCAACTGTAACTTTTTTGATCCGTCATTTGGATTGAAATTTCACAATATTCG
CAACACAAGGATGGCAAACA

Downstream 100 bases:

>100_bases
AACGCGATTTTCTCCATACTGCAAACGCAGGTTGTTGGTCCGCTTATGTTGCTGCACCACTAACCTGCGTTTGTTGTTCT
TTAGGAAATCACAACCATCA

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 700; Mature: 699

Protein sequence:

>700_residues
MTLSPELQALTSRHYPSDWDDLDTQAVDTARVLAADAVQNCGSGHPGTAMSLAPLAYTLFQRVMNVDPADPHWAGRDRFV
LSCGHTSLTQYIQLYFGGYGLELEDLKALRTWGALTPGHPEYRHTKGVEITTGPLGQGLASAVGMAMASRRERALFDPTA
ADGASPFDHYIYVIASDGDLQEGVTAEACSLAGTQKLGNLIVFWDDNRISIEEDTEIAFNEKVVDRYRAYNWQVIEIDGG
ENVEAIEKAVAEAKADTSRPTFIRVRTVIGYPAPTKMNTGAVHGAALGAEEVAGTKKALGFNPEESFAVAPEVISHTRKL
LERGAQRHAEWREHFESWAETNPENKALFDRMASRELPDGFDADLPSWEPDAKGVATRKASEATLQALGATLPELWGGSA
DLAGSNNTVIKGSPSFGPSTISTSTWTAEPGGRNLHFGIREHAMGAIINGISLHGGTRPYGGTFLIFSDYMRPAVRLAAL
MGTDAYYVWTHDSIGLGEDGPTHQPVEQLASLRAIPGVSMLRPADANETAAAWRAALLYKEGPKGLALTRQNVLVLEGTK
EKARDGVSRGAYVLVEGSKKTPDVILMASGSEVQLAVEAAKTLEAEKIAARVVSVPCLDWFEEQDAAYQEEILPQAVSAR
VSVEAGVALSWYRHLGTHGRAVSLEHFGASAPYEKLFSEFGITTEAVIAAARESLAAAQQ

Sequences:

>Translated_700_residues
MTLSPELQALTSRHYPSDWDDLDTQAVDTARVLAADAVQNCGSGHPGTAMSLAPLAYTLFQRVMNVDPADPHWAGRDRFV
LSCGHTSLTQYIQLYFGGYGLELEDLKALRTWGALTPGHPEYRHTKGVEITTGPLGQGLASAVGMAMASRRERALFDPTA
ADGASPFDHYIYVIASDGDLQEGVTAEACSLAGTQKLGNLIVFWDDNRISIEEDTEIAFNEKVVDRYRAYNWQVIEIDGG
ENVEAIEKAVAEAKADTSRPTFIRVRTVIGYPAPTKMNTGAVHGAALGAEEVAGTKKALGFNPEESFAVAPEVISHTRKL
LERGAQRHAEWREHFESWAETNPENKALFDRMASRELPDGFDADLPSWEPDAKGVATRKASEATLQALGATLPELWGGSA
DLAGSNNTVIKGSPSFGPSTISTSTWTAEPGGRNLHFGIREHAMGAIINGISLHGGTRPYGGTFLIFSDYMRPAVRLAAL
MGTDAYYVWTHDSIGLGEDGPTHQPVEQLASLRAIPGVSMLRPADANETAAAWRAALLYKEGPKGLALTRQNVLVLEGTK
EKARDGVSRGAYVLVEGSKKTPDVILMASGSEVQLAVEAAKTLEAEKIAARVVSVPCLDWFEEQDAAYQEEILPQAVSAR
VSVEAGVALSWYRHLGTHGRAVSLEHFGASAPYEKLFSEFGITTEAVIAAARESLAAAQQ
>Mature_699_residues
TLSPELQALTSRHYPSDWDDLDTQAVDTARVLAADAVQNCGSGHPGTAMSLAPLAYTLFQRVMNVDPADPHWAGRDRFVL
SCGHTSLTQYIQLYFGGYGLELEDLKALRTWGALTPGHPEYRHTKGVEITTGPLGQGLASAVGMAMASRRERALFDPTAA
DGASPFDHYIYVIASDGDLQEGVTAEACSLAGTQKLGNLIVFWDDNRISIEEDTEIAFNEKVVDRYRAYNWQVIEIDGGE
NVEAIEKAVAEAKADTSRPTFIRVRTVIGYPAPTKMNTGAVHGAALGAEEVAGTKKALGFNPEESFAVAPEVISHTRKLL
ERGAQRHAEWREHFESWAETNPENKALFDRMASRELPDGFDADLPSWEPDAKGVATRKASEATLQALGATLPELWGGSAD
LAGSNNTVIKGSPSFGPSTISTSTWTAEPGGRNLHFGIREHAMGAIINGISLHGGTRPYGGTFLIFSDYMRPAVRLAALM
GTDAYYVWTHDSIGLGEDGPTHQPVEQLASLRAIPGVSMLRPADANETAAAWRAALLYKEGPKGLALTRQNVLVLEGTKE
KARDGVSRGAYVLVEGSKKTPDVILMASGSEVQLAVEAAKTLEAEKIAARVVSVPCLDWFEEQDAAYQEEILPQAVSARV
SVEAGVALSWYRHLGTHGRAVSLEHFGASAPYEKLFSEFGITTEAVIAAARESLAAAQQ

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=708, Percent_Identity=26.271186440678, Blast_Score=150, Evalue=4e-36,
Organism=Homo sapiens, GI4507521, Length=708, Percent_Identity=26.271186440678, Blast_Score=150, Evalue=4e-36,
Organism=Homo sapiens, GI133778974, Length=696, Percent_Identity=25.2873563218391, Blast_Score=109, Evalue=7e-24,
Organism=Escherichia coli, GI48994911, Length=669, Percent_Identity=45.7399103139013, Blast_Score=564, Evalue=1e-162,
Organism=Escherichia coli, GI1788808, Length=672, Percent_Identity=44.4940476190476, Blast_Score=542, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI17539652, Length=707, Percent_Identity=25.035360678925, Blast_Score=135, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6325331, Length=685, Percent_Identity=44.5255474452555, Blast_Score=542, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6319593, Length=684, Percent_Identity=43.2748538011696, Blast_Score=523, Evalue=1e-149,
Organism=Drosophila melanogaster, GI45551847, Length=584, Percent_Identity=26.541095890411, Blast_Score=152, Evalue=7e-37,
Organism=Drosophila melanogaster, GI45550715, Length=584, Percent_Identity=26.541095890411, Blast_Score=152, Evalue=7e-37,
Organism=Drosophila melanogaster, GI24645119, Length=557, Percent_Identity=26.2118491921005, Blast_Score=136, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24666278, Length=587, Percent_Identity=25.2129471890971, Blast_Score=126, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 75389; Mature: 75258

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSPELQALTSRHYPSDWDDLDTQAVDTARVLAADAVQNCGSGHPGTAMSLAPLAYTLF
CCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
QRVMNVDPADPHWAGRDRFVLSCGHTSLTQYIQLYFGGYGLELEDLKALRTWGALTPGHP
HHHHCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCC
EYRHTKGVEITTGPLGQGLASAVGMAMASRRERALFDPTAADGASPFDHYIYVIASDGDL
CCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCC
QEGVTAEACSLAGTQKLGNLIVFWDDNRISIEEDTEIAFNEKVVDRYRAYNWQVIEIDGG
CCCCCHHHHHHHCHHHHCCEEEEECCCEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCC
ENVEAIEKAVAEAKADTSRPTFIRVRTVIGYPAPTKMNTGAVHGAALGAEEVAGTKKALG
CCHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCCCCHHHCCHHHHCCCHHHCC
FNPEESFAVAPEVISHTRKLLERGAQRHAEWREHFESWAETNPENKALFDRMASRELPDG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
FDADLPSWEPDAKGVATRKASEATLQALGATLPELWGGSADLAGSNNTVIKGSPSFGPST
CCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCC
ISTSTWTAEPGGRNLHFGIREHAMGAIINGISLHGGTRPYGGTFLIFSDYMRPAVRLAAL
CCCCEEECCCCCCEEECCHHHHHHHHHHCCEEECCCCCCCCCEEEEEHHHHHHHHHHHHH
MGTDAYYVWTHDSIGLGEDGPTHQPVEQLASLRAIPGVSMLRPADANETAAAWRAALLYK
HCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCHHCCCCCCCHHHHHHHHHHHHC
EGPKGLALTRQNVLVLEGTKEKARDGVSRGAYVLVEGSKKTPDVILMASGSEVQLAVEAA
CCCCCEEEECCCEEEEECCHHHHHCCCCCCCEEEEECCCCCCCEEEEECCCCEEEEHHHH
KTLEAEKIAARVVSVPCLDWFEEQDAAYQEEILPQAVSARVSVEAGVALSWYRHLGTHGR
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHCCCCC
AVSLEHFGASAPYEKLFSEFGITTEAVIAAARESLAAAQQ
EEEHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TLSPELQALTSRHYPSDWDDLDTQAVDTARVLAADAVQNCGSGHPGTAMSLAPLAYTLF
CCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
QRVMNVDPADPHWAGRDRFVLSCGHTSLTQYIQLYFGGYGLELEDLKALRTWGALTPGHP
HHHHCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCC
EYRHTKGVEITTGPLGQGLASAVGMAMASRRERALFDPTAADGASPFDHYIYVIASDGDL
CCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCC
QEGVTAEACSLAGTQKLGNLIVFWDDNRISIEEDTEIAFNEKVVDRYRAYNWQVIEIDGG
CCCCCHHHHHHHCHHHHCCEEEEECCCEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCC
ENVEAIEKAVAEAKADTSRPTFIRVRTVIGYPAPTKMNTGAVHGAALGAEEVAGTKKALG
CCHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCCCCHHHCCHHHHCCCHHHCC
FNPEESFAVAPEVISHTRKLLERGAQRHAEWREHFESWAETNPENKALFDRMASRELPDG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
FDADLPSWEPDAKGVATRKASEATLQALGATLPELWGGSADLAGSNNTVIKGSPSFGPST
CCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCC
ISTSTWTAEPGGRNLHFGIREHAMGAIINGISLHGGTRPYGGTFLIFSDYMRPAVRLAAL
CCCCEEECCCCCCEEECCHHHHHHHHHHCCEEECCCCCCCCCEEEEEHHHHHHHHHHHHH
MGTDAYYVWTHDSIGLGEDGPTHQPVEQLASLRAIPGVSMLRPADANETAAAWRAALLYK
HCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCHHCCCCCCCHHHHHHHHHHHHC
EGPKGLALTRQNVLVLEGTKEKARDGVSRGAYVLVEGSKKTPDVILMASGSEVQLAVEAA
CCCCCEEEECCCEEEEECCHHHHHCCCCCCCEEEEECCCCCCCEEEEECCCCEEEEHHHH
KTLEAEKIAARVVSVPCLDWFEEQDAAYQEEILPQAVSARVSVEAGVALSWYRHLGTHGR
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHCCCCC
AVSLEHFGASAPYEKLFSEFGITTEAVIAAARESLAAAQQ
EEEHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]