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The map label for this gene is hisE

Identifier: 38233845

GI number: 38233845

Start: 1262464

End: 1262727

Strand: Reverse

Name: hisE

Synonym: DIP1257

Alternate gene names: 38233845

Gene position: 1262727-1262464 (Counterclockwise)

Preceding gene: 38233846

Following gene: 38233844

Centisome position: 50.74

GC content: 46.21

Gene sequence:

>264_bases
GTGAAAAATTTCGATTCCCTTTACCATGAACTAGCCGAACGAGCAGAAAAGCGACCTGAAGGCTCCGGCACGGTTGCTGC
TTTAAATTCGAGCCTCCACACTTTAGGCAAAAAAGTGATTGAAGAGGCCGGTGAAGTTTGGCTCGCTGCTGAGTACCAGA
GCGATGCAGAACTCGCTGAAGAGATCTCGCAACTTATGTACTGGGCGCAAGTCATCATGATTAAACGTGGCCTTACTCCG
GAAGATATCTATAAATATCTTTAA

Upstream 100 bases:

>100_bases
GCACGGATCTGCAGATTTCAGAGGTGTATCAGCCGAAGAAATTATGCAATGGTACGCAACATTGTCACCGAATGCTCAAT
AGGTATGTCATACTAAAGGG

Downstream 100 bases:

>100_bases
TTACCGCAGGTGAGCAGAGTTTTTAGGTAGGTTTTTGCCGCATGCTTACCCCTAGTTATTTTGATAAGGCTACACAAATA
TATGCTAAAAATTGCTATCC

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 87; Mature: 87

Protein sequence:

>87_residues
MKNFDSLYHELAERAEKRPEGSGTVAALNSSLHTLGKKVIEEAGEVWLAAEYQSDAELAEEISQLMYWAQVIMIKRGLTP
EDIYKYL

Sequences:

>Translated_87_residues
MKNFDSLYHELAERAEKRPEGSGTVAALNSSLHTLGKKVIEEAGEVWLAAEYQSDAELAEEISQLMYWAQVIMIKRGLTP
EDIYKYL
>Mature_87_residues
MKNFDSLYHELAERAEKRPEGSGTVAALNSSLHTLGKKVIEEAGEVWLAAEYQSDAELAEEISQLMYWAQVIMIKRGLTP
EDIYKYL

Specific function: Unknown

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_CORDI (P60535)

Other databases:

- EMBL:   BX248357
- RefSeq:   NP_939612.1
- ProteinModelPortal:   P60535
- SMR:   P60535
- GeneID:   2650087
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1257
- NMPDR:   fig|257309.1.peg.1203
- HOGENOM:   HBG646527
- OMA:   VWMAAEY
- ProtClustDB:   PRK00400
- BioCyc:   CDIP257309:DIP1257-MONOMER
- BRENDA:   3.6.1.31
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 9876; Mature: 9876

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNFDSLYHELAERAEKRPEGSGTVAALNSSLHTLGKKVIEEAGEVWLAAEYQSDAELAE
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEHHCCCCHHHHHH
EISQLMYWAQVIMIKRGLTPEDIYKYL
HHHHHHHHHHHHHHHCCCCHHHHHHCC
>Mature Secondary Structure
MKNFDSLYHELAERAEKRPEGSGTVAALNSSLHTLGKKVIEEAGEVWLAAEYQSDAELAE
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEHHCCCCHHHHHH
EISQLMYWAQVIMIKRGLTPEDIYKYL
HHHHHHHHHHHHHHHCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910