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The map label for this gene is hisG

Identifier: 38233844

GI number: 38233844

Start: 1261537

End: 1262382

Strand: Reverse

Name: hisG

Synonym: DIP1256

Alternate gene names: 38233844

Gene position: 1262382-1261537 (Counterclockwise)

Preceding gene: 38233845

Following gene: 38233843

Centisome position: 50.73

GC content: 47.4

Gene sequence:

>846_bases
ATGCTAAAAATTGCTATCCCAAATAAAGGTTCTTTGTCTGAGGCTGCAGTAGAGATTCTCGCTGAGGCGGGTTATGCCGG
CCGAGGCGAATCTAAGACTCTCAATGTTTATGACAAAACAAATGACGTAGAATTCTTTTTCCTTCGTCCTAAAGACATCG
CCATTTATGTCGCTGGAGGACAACTAGACCTCGGCATCACTGGTCGAGATCTTGCTACGGATTCCCATGCAAACGTTGAA
GAAGTGATGAGTCTCGGATTTGGCAATTCATCCTTTAGATATGCGGCTCCTGCAGATCAAAAATGGACTGTTGAAATGCT
CGAAGGCAAGCGCATTGCAACCTCATACCCCAATTTAGTTCGAGATGATTTGCAAGCGCGTGGTATTAACGCAACTGTCA
TTCGGCTTGATGGTGCTGTAGAAATCTCGATTAAACTTGGCGTAGCTGACGCCATCGCTGACGTAGTTTCAACGGGCCGG
ACATTACGCAAACAAGGTCTCGCAACTTTCGGTGAAGTGATTTGCCAATCCGAAGCTGTCATTGTCGGCCAACAAGGTAA
TGTGGTTGACAACGAGCAAAAGGTTTTCCTTCGTCGCATCGAAGGAATCCTACACGCCCAGAATTACCTCATGCTTGATT
ACAACATCGATCGAGTAAACCTCGCCGCTTCTGAAAAAATCACACCAGGTATTTCGGGTCCAACCGTCTCACCTCTGGCC
CGCGAAAACTGGGTAGCAGTGCGTGCAATGGTGCCGCGTAAAGAAGCCAACCACATCATGGACCAGCTTTCTGAGCTAGG
TGCTCAAGCAATTTTGGCTTCTGAGATTCGTATTGCACGCTTGTAG

Upstream 100 bases:

>100_bases
TATCTATAAATATCTTTAATTACCGCAGGTGAGCAGAGTTTTTAGGTAGGTTTTTGCCGCATGCTTACCCCTAGTTATTT
TGATAAGGCTACACAAATAT

Downstream 100 bases:

>100_bases
CTAGCCATACCATTTTTTAAAAATAAATTAACTGCACATTAATGGTGATATCACCTAATGTGCAGTTTTATTTCTATACC
TCTATAGTGTGATCAATTAG

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MLKIAIPNKGSLSEAAVEILAEAGYAGRGESKTLNVYDKTNDVEFFFLRPKDIAIYVAGGQLDLGITGRDLATDSHANVE
EVMSLGFGNSSFRYAAPADQKWTVEMLEGKRIATSYPNLVRDDLQARGINATVIRLDGAVEISIKLGVADAIADVVSTGR
TLRKQGLATFGEVICQSEAVIVGQQGNVVDNEQKVFLRRIEGILHAQNYLMLDYNIDRVNLAASEKITPGISGPTVSPLA
RENWVAVRAMVPRKEANHIMDQLSELGAQAILASEIRIARL

Sequences:

>Translated_281_residues
MLKIAIPNKGSLSEAAVEILAEAGYAGRGESKTLNVYDKTNDVEFFFLRPKDIAIYVAGGQLDLGITGRDLATDSHANVE
EVMSLGFGNSSFRYAAPADQKWTVEMLEGKRIATSYPNLVRDDLQARGINATVIRLDGAVEISIKLGVADAIADVVSTGR
TLRKQGLATFGEVICQSEAVIVGQQGNVVDNEQKVFLRRIEGILHAQNYLMLDYNIDRVNLAASEKITPGISGPTVSPLA
RENWVAVRAMVPRKEANHIMDQLSELGAQAILASEIRIARL
>Mature_281_residues
MLKIAIPNKGSLSEAAVEILAEAGYAGRGESKTLNVYDKTNDVEFFFLRPKDIAIYVAGGQLDLGITGRDLATDSHANVE
EVMSLGFGNSSFRYAAPADQKWTVEMLEGKRIATSYPNLVRDDLQARGINATVIRLDGAVEISIKLGVADAIADVVSTGR
TLRKQGLATFGEVICQSEAVIVGQQGNVVDNEQKVFLRRIEGILHAQNYLMLDYNIDRVNLAASEKITPGISGPTVSPLA
RENWVAVRAMVPRKEANHIMDQLSELGAQAILASEIRIARL

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=291, Percent_Identity=31.9587628865979, Blast_Score=129, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6320896, Length=288, Percent_Identity=34.0277777777778, Blast_Score=143, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_CORDI (P60803)

Other databases:

- EMBL:   BX248357
- RefSeq:   NP_939611.1
- ProteinModelPortal:   P60803
- SMR:   P60803
- GeneID:   2649811
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1256
- NMPDR:   fig|257309.1.peg.1202
- HOGENOM:   HBG391868
- OMA:   YLRPRDI
- PhylomeDB:   P60803
- ProtClustDB:   PRK00489
- BioCyc:   CDIP257309:DIP1256-MONOMER
- BRENDA:   2.4.2.17
- GO:   GO:0005737
- HAMAP:   MF_00079
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867
- Gene3D:   G3DSA:3.30.70.120
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070
- TIGRFAMs:   TIGR03455

Pfam domain/function: PF01634 HisG; PF08029 HisG_C; SSF54913 N-reg_PII-like_a/b

EC number: =2.4.2.17

Molecular weight: Translated: 30481; Mature: 30481

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKIAIPNKGSLSEAAVEILAEAGYAGRGESKTLNVYDKTNDVEFFFLRPKDIAIYVAGG
CEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEEECCCEEEEEEECC
QLDLGITGRDLATDSHANVEEVMSLGFGNSSFRYAAPADQKWTVEMLEGKRIATSYPNLV
EEEEEECCCCCCCCCCCCHHHHHHHCCCCCCCEEECCCCCCEEEEEECCCEEECCCCHHH
RDDLQARGINATVIRLDGAVEISIKLGVADAIADVVSTGRTLRKQGLATFGEVICQSEAV
HHHHHHCCCCEEEEEECCEEEEEEEECHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEE
IVGQQGNVVDNEQKVFLRRIEGILHAQNYLMLDYNIDRVNLAASEKITPGISGPTVSPLA
EEECCCCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCC
RENWVAVRAMVPRKEANHIMDQLSELGAQAILASEIRIARL
CCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCEEEECC
>Mature Secondary Structure
MLKIAIPNKGSLSEAAVEILAEAGYAGRGESKTLNVYDKTNDVEFFFLRPKDIAIYVAGG
CEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEEECCCEEEEEEECC
QLDLGITGRDLATDSHANVEEVMSLGFGNSSFRYAAPADQKWTVEMLEGKRIATSYPNLV
EEEEEECCCCCCCCCCCCHHHHHHHCCCCCCCEEECCCCCCEEEEEECCCEEECCCCHHH
RDDLQARGINATVIRLDGAVEISIKLGVADAIADVVSTGRTLRKQGLATFGEVICQSEAV
HHHHHHCCCCEEEEEECCEEEEEEEECHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEE
IVGQQGNVVDNEQKVFLRRIEGILHAQNYLMLDYNIDRVNLAASEKITPGISGPTVSPLA
EEECCCCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCC
RENWVAVRAMVPRKEANHIMDQLSELGAQAILASEIRIARL
CCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910