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The map label for this gene is dcuA [H]

Identifier: 38233843

GI number: 38233843

Start: 1259869

End: 1261176

Strand: Reverse

Name: dcuA [H]

Synonym: DIP1255

Alternate gene names: 38233843

Gene position: 1261176-1259869 (Counterclockwise)

Preceding gene: 38233844

Following gene: 38233842

Centisome position: 50.68

GC content: 51.61

Gene sequence:

>1308_bases
GTGGTTTTCGTCCACATTCTCATCGTGCTCGCCGCAATTGTCCTCGGTGCACGACTTGGCTCAATTGCTATCGGCTTTGC
CGGTGGCATCGGAGTCCTTCTTCTGGGTGCAACCGGAGTGCCGGTGACGAGAGAAGATATTCCTTTCGACGTTATCGGTA
TCATCATGGCCGTTATTGCAGCGATTTCTGCTATGCAGCGTGCCGGTGGCATGGATTATTTGGTGCATTTGGCGGAGCGT
GCTTTGCGTAAGAGTCCAAAGCATATTACCTATGTCGCACCTGTAGTTACCTATCTGATGACCTTGTTCGCAGGAACAGG
GCATACAGCGTTTTCCACGCTTCCAGTGATCGTGGAAGTTTCTAAAGAATCTGGAGTGCGCCCTTCGCGTCCACTTTCTG
TTGCCGTTCCGGCTTCCCAGATGGCGATTACAGCATCTCCAATTTCCGCAGCAGTCGTCTTTTTGGCTTCCGCGCTGGAA
CCTTTAGGGGTAGGGTATCTGTCTCTTTTGGCAATCGTTATCCCCGCAACATTTCTTGCTATCTTCCCAACTGCTTGGCT
ATGCAATCGTCTCGGGAAAGACCTCTATGATGATCCGGTCTACCAACAGCGTCTTGCCGATGGCCTCGTTGCAGCCCCTG
GCAAGAAAGAGTCCTATGTTCCAACAAGCGCAGCAAAGCTTTCGGTGGGAATTTTCCTTGTAGCAATTGTCGCCGTTATG
GTGTACGCCACATTGATTTCCGATCAAGTAGGACTGATTGCGGATCCTGCGTTGCCTCGCAATGAAGCGATTATGTCGAT
GATGCTTACTGCAGCGACAATCACCGTTATGGCTTGCAAGATTCCGGCAGGCGACATTTTGAATACTCAGGTATTCCGCT
CCGGAATGTCCGCTTGCGTCTGCGTTCTCGGCGTAGCTTGGTTGGGAACAACTTTGATCAACCATTACATCGAGGGAATT
AAGGGGTTCTCAGGCGACATCCTCGAGCGCTCGCCGTGGATGCTCGCGGTCGTTCTATTCGCCGCCGCCGCGCTACTCTA
TTCGCAGGCTGCAACCGCTAAGGCGTTAATTCCTGCAGCATTGGCTATCGGTGTTTCCCCACTGACCGTCATCGCCTCAT
TTGCCGCTGTATCGGCACTATTCGTTCTGCCAACCTATCCAACTCTATTGGCTGCAGTTGAGATGGACGATACAGGTTCG
ACAAGGATCGGCAAAGCAGTGTTTAACCACCCATTCCTCATTCCTGGAACTGTTGGTATTGCGATATCTGTGGCATTGGG
ATTCCTTTTCGGCGGACTTATTCTCTAA

Upstream 100 bases:

>100_bases
TCTGCATTTGCGGAAATTTGTAGTGTCCCTCCAGCGACATTTCGTCGCTACTCATACCTGCATAATGCAGACCTGAAATA
TGTAAAGGTCGGGTGTCACA

Downstream 100 bases:

>100_bases
TTCCCAGTTCATTGCGATCCATCATCCCGTCGAATATTGATTTCTAATCAAATATCGAAATATCACCTCAATCTAGGGTG
ACAAAAACCACCATTTTAAA

Product: anaerobic C4-dicarboxylate transporter

Products: C4-dicarboxylates [Periplasm]; C4-dicarboxylates [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MVFVHILIVLAAIVLGARLGSIAIGFAGGIGVLLLGATGVPVTREDIPFDVIGIIMAVIAAISAMQRAGGMDYLVHLAER
ALRKSPKHITYVAPVVTYLMTLFAGTGHTAFSTLPVIVEVSKESGVRPSRPLSVAVPASQMAITASPISAAVVFLASALE
PLGVGYLSLLAIVIPATFLAIFPTAWLCNRLGKDLYDDPVYQQRLADGLVAAPGKKESYVPTSAAKLSVGIFLVAIVAVM
VYATLISDQVGLIADPALPRNEAIMSMMLTAATITVMACKIPAGDILNTQVFRSGMSACVCVLGVAWLGTTLINHYIEGI
KGFSGDILERSPWMLAVVLFAAAALLYSQAATAKALIPAALAIGVSPLTVIASFAAVSALFVLPTYPTLLAAVEMDDTGS
TRIGKAVFNHPFLIPGTVGIAISVALGFLFGGLIL

Sequences:

>Translated_435_residues
MVFVHILIVLAAIVLGARLGSIAIGFAGGIGVLLLGATGVPVTREDIPFDVIGIIMAVIAAISAMQRAGGMDYLVHLAER
ALRKSPKHITYVAPVVTYLMTLFAGTGHTAFSTLPVIVEVSKESGVRPSRPLSVAVPASQMAITASPISAAVVFLASALE
PLGVGYLSLLAIVIPATFLAIFPTAWLCNRLGKDLYDDPVYQQRLADGLVAAPGKKESYVPTSAAKLSVGIFLVAIVAVM
VYATLISDQVGLIADPALPRNEAIMSMMLTAATITVMACKIPAGDILNTQVFRSGMSACVCVLGVAWLGTTLINHYIEGI
KGFSGDILERSPWMLAVVLFAAAALLYSQAATAKALIPAALAIGVSPLTVIASFAAVSALFVLPTYPTLLAAVEMDDTGS
TRIGKAVFNHPFLIPGTVGIAISVALGFLFGGLIL
>Mature_435_residues
MVFVHILIVLAAIVLGARLGSIAIGFAGGIGVLLLGATGVPVTREDIPFDVIGIIMAVIAAISAMQRAGGMDYLVHLAER
ALRKSPKHITYVAPVVTYLMTLFAGTGHTAFSTLPVIVEVSKESGVRPSRPLSVAVPASQMAITASPISAAVVFLASALE
PLGVGYLSLLAIVIPATFLAIFPTAWLCNRLGKDLYDDPVYQQRLADGLVAAPGKKESYVPTSAAKLSVGIFLVAIVAVM
VYATLISDQVGLIADPALPRNEAIMSMMLTAATITVMACKIPAGDILNTQVFRSGMSACVCVLGVAWLGTTLINHYIEGI
KGFSGDILERSPWMLAVVLFAAAALLYSQAATAKALIPAALAIGVSPLTVIASFAAVSALFVLPTYPTLLAAVEMDDTGS
TRIGKAVFNHPFLIPGTVGIAISVALGFLFGGLIL

Specific function: Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane [H]

COG id: COG2704

COG function: function code R; Anaerobic C4-dicarboxylate transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dcuA/dcuB transporter (TC 2.A.13.1) family [H]

Homologues:

Organism=Escherichia coli, GI1790580, Length=436, Percent_Identity=57.5688073394495, Blast_Score=476, Evalue=1e-135,
Organism=Escherichia coli, GI1790565, Length=406, Percent_Identity=33.9901477832512, Blast_Score=231, Evalue=1e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004668 [H]

Pfam domain/function: PF03605 DcuA_DcuB [H]

EC number: NA

Molecular weight: Translated: 45098; Mature: 45098

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFVHILIVLAAIVLGARLGSIAIGFAGGIGVLLLGATGVPVTREDIPFDVIGIIMAVIA
CHHHHHHHHHHHHHHHHHHHHHHEEHHCCHHHHEECCCCCCCCCCCCCHHHHHHHHHHHH
AISAMQRAGGMDYLVHLAERALRKSPKHITYVAPVVTYLMTLFAGTGHTAFSTLPVIVEV
HHHHHHHHCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCCCHHHHHCCEEEEE
SKESGVRPSRPLSVAVPASQMAITASPISAAVVFLASALEPLGVGYLSLLAIVIPATFLA
CCCCCCCCCCCEEEEECCHHHEEECCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
IFPTAWLCNRLGKDLYDDPVYQQRLADGLVAAPGKKESYVPTSAAKLSVGIFLVAIVAVM
HHHHHHHHHHHCCHHCCCHHHHHHHHCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VYATLISDQVGLIADPALPRNEAIMSMMLTAATITVMACKIPAGDILNTQVFRSGMSACV
HHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHH
CVLGVAWLGTTLINHYIEGIKGFSGDILERSPWMLAVVLFAAAALLYSQAATAKALIPAA
HHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAIGVSPLTVIASFAAVSALFVLPTYPTLLAAVEMDDTGSTRIGKAVFNHPFLIPGTVGI
HHHCCHHHHHHHHHHHHHHHHHHCCHHHHHEEEECCCCCCCHHHHHHHCCCCCCCCHHHH
AISVALGFLFGGLIL
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MVFVHILIVLAAIVLGARLGSIAIGFAGGIGVLLLGATGVPVTREDIPFDVIGIIMAVIA
CHHHHHHHHHHHHHHHHHHHHHHEEHHCCHHHHEECCCCCCCCCCCCCHHHHHHHHHHHH
AISAMQRAGGMDYLVHLAERALRKSPKHITYVAPVVTYLMTLFAGTGHTAFSTLPVIVEV
HHHHHHHHCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCCCHHHHHCCEEEEE
SKESGVRPSRPLSVAVPASQMAITASPISAAVVFLASALEPLGVGYLSLLAIVIPATFLA
CCCCCCCCCCCEEEEECCHHHEEECCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
IFPTAWLCNRLGKDLYDDPVYQQRLADGLVAAPGKKESYVPTSAAKLSVGIFLVAIVAVM
HHHHHHHHHHHCCHHCCCHHHHHHHHCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VYATLISDQVGLIADPALPRNEAIMSMMLTAATITVMACKIPAGDILNTQVFRSGMSACV
HHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHH
CVLGVAWLGTTLINHYIEGIKGFSGDILERSPWMLAVVLFAAAALLYSQAATAKALIPAA
HHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAIGVSPLTVIASFAAVSALFVLPTYPTLLAAVEMDDTGSTRIGKAVFNHPFLIPGTVGI
HHHCCHHHHHHHHHHHHHHHHHHCCHHHHHEEEECCCCCCCHHHHHHHCCCCCCCCHHHH
AISVALGFLFGGLIL
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: C4-dicarboxylates [Periplasm]; C4-dicarboxylates [Periplasm] [C]

Specific reaction: C4-dicarboxylates [Periplasm] + C4-dicarboxylates [Periplasm] = C4-dicarboxylates [Periplasm] + C4-dicarboxylates [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11004174; 14500908; 8898907 [H]