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The map label for this gene is lysE

Identifier: 38233685

GI number: 38233685

Start: 1074172

End: 1074858

Strand: Reverse

Name: lysE

Synonym: DIP1091

Alternate gene names: 38233685

Gene position: 1074858-1074172 (Counterclockwise)

Preceding gene: 38233687

Following gene: 38233677

Centisome position: 43.19

GC content: 51.97

Gene sequence:

>687_bases
ATGAGTATTGCTATCGCTGGATTCCTCATGGGTCTGTCCTTGATCGTGGCCATCGGGCCACAAAATGCCTTGATTATTCG
TCAAGGCATTAAACGCGAAGGTCTAATCCCCATTCTGGTTGTATGCATACTCTCTGACGTGATCCTCATTTTTGGAGGCA
CTGCCGGTGTCGGCGCATTAGTCGATCGAGCCCCCATCGCACTAGTAGTACTGAAATGGCTCGGTGTAGCGTACTTGCTC
TATTTCGGATTCACTTGTTTTAAAGAAGCATTTAAACGTCACGGCCAAGCGCTCGCAGTCGAGCAAAGCGAACCGGTGGC
CTACGAACCAGTGGCTGACGCATCATCCGGAGTGATCACTAAAACACGCACAAAAGCTCAGCCCAAGTCAGCGCAGCGCA
CGTGGGTTAAACCAGTGCTTGCAGCGTTGGCTTTCACGTGGCTTAATCCAGCTGCTTATATAGACGTTCTTGTCATGTTG
GGAGGAATCGCCAACCAACACGGTCCCGACGGGCGCTGGGTCTTCGCCCTCGGCGCACTGTGCGCGAGTCTCACGTGGTT
TCCGTTTATTGGATATACCTCCACACGCTTTTCTACCGTGCTATCGCGGCCAGCCGTGTGGCGATATATCAACATAGCAA
TCGGAATCATCATGATGATCATGTGCGCACGTCTCATCATGCACTAG

Upstream 100 bases:

>100_bases
GAGCAAGGTTTCTAAATGAAGCGGATTCATGAAGCAATTCTAACCCAACCTGAAAGTCTGTTATTTTACTTCAGCATTTC
AGAGGAGCATATTGCTTAGT

Downstream 100 bases:

>100_bases
GCTCATTGCTCTTTAAGGTACCCCGCCTTTAATCGTGAACCTTCGAGGCAGTAGCACCCGCCCAAATATTAATTCCAGCG
TCCTTGGCAACAGTGTCAAT

Product: lysine exporter protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MSIAIAGFLMGLSLIVAIGPQNALIIRQGIKREGLIPILVVCILSDVILIFGGTAGVGALVDRAPIALVVLKWLGVAYLL
YFGFTCFKEAFKRHGQALAVEQSEPVAYEPVADASSGVITKTRTKAQPKSAQRTWVKPVLAALAFTWLNPAAYIDVLVML
GGIANQHGPDGRWVFALGALCASLTWFPFIGYTSTRFSTVLSRPAVWRYINIAIGIIMMIMCARLIMH

Sequences:

>Translated_228_residues
MSIAIAGFLMGLSLIVAIGPQNALIIRQGIKREGLIPILVVCILSDVILIFGGTAGVGALVDRAPIALVVLKWLGVAYLL
YFGFTCFKEAFKRHGQALAVEQSEPVAYEPVADASSGVITKTRTKAQPKSAQRTWVKPVLAALAFTWLNPAAYIDVLVML
GGIANQHGPDGRWVFALGALCASLTWFPFIGYTSTRFSTVLSRPAVWRYINIAIGIIMMIMCARLIMH
>Mature_227_residues
SIAIAGFLMGLSLIVAIGPQNALIIRQGIKREGLIPILVVCILSDVILIFGGTAGVGALVDRAPIALVVLKWLGVAYLLY
FGFTCFKEAFKRHGQALAVEQSEPVAYEPVADASSGVITKTRTKAQPKSAQRTWVKPVLAALAFTWLNPAAYIDVLVMLG
GIANQHGPDGRWVFALGALCASLTWFPFIGYTSTRFSTVLSRPAVWRYINIAIGIIMMIMCARLIMH

Specific function: Involved in the efflux of excess of L-lysine. This is necessary to control the intracellular L-lysine level

COG id: COG1279

COG function: function code R; Lysine efflux permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LysE/ArgO transporter (TC 2.A.75) family

Homologues:

Organism=Escherichia coli, GI1789290, Length=224, Percent_Identity=31.25, Blast_Score=105, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LYSE_CORDI (Q6NHP1)

Other databases:

- EMBL:   BX248357
- RefSeq:   NP_939452.1
- GeneID:   2650833
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1091
- NMPDR:   fig|257309.1.peg.1043
- HOGENOM:   HBG683136
- OMA:   AMRWGGA
- PhylomeDB:   Q6NHP1
- ProtClustDB:   CLSK633306
- BioCyc:   CDIP257309:DIP1091-MONOMER
- InterPro:   IPR001123

Pfam domain/function: PF01810 LysE

EC number: NA

Molecular weight: Translated: 24662; Mature: 24531

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x118951dc)-; HASH(0x12147890)-; HASH(0x1148ba0c)-; HASH(0x11789a20)-; HASH(0x11c9aadc)-; HASH(0x119456a8)-;

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIAIAGFLMGLSLIVAIGPQNALIIRQGIKREGLIPILVVCILSDVILIFGGTAGVGAL
CCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHH
VDRAPIALVVLKWLGVAYLLYFGFTCFKEAFKRHGQALAVEQSEPVAYEPVADASSGVIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCEE
KTRTKAQPKSAQRTWVKPVLAALAFTWLNPAAYIDVLVMLGGIANQHGPDGRWVFALGAL
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
CASLTWFPFIGYTSTRFSTVLSRPAVWRYINIAIGIIMMIMCARLIMH
HHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure 
SIAIAGFLMGLSLIVAIGPQNALIIRQGIKREGLIPILVVCILSDVILIFGGTAGVGAL
CHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHH
VDRAPIALVVLKWLGVAYLLYFGFTCFKEAFKRHGQALAVEQSEPVAYEPVADASSGVIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCEE
KTRTKAQPKSAQRTWVKPVLAALAFTWLNPAAYIDVLVMLGGIANQHGPDGRWVFALGAL
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
CASLTWFPFIGYTSTRFSTVLSRPAVWRYINIAIGIIMMIMCARLIMH
HHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14602910