Click here to switch to the map view.

The map label for this gene is norB [H]

Identifier: 15925434

GI number: 15925434

Start: 2578981

End: 2580381

Strand: Reverse

Name: norB [H]

Synonym: SAV2444

Alternate gene names: 15925434

Gene position: 2580381-2578981 (Counterclockwise)

Preceding gene: 15925435

Following gene: 15925433

Centisome position: 89.64

GC content: 34.4

Gene sequence:

>1401_bases
ATGGACACATCAAAACAATTTAGAGGTGACAACCGATTGCTTTTGGGTATCGTTTTAGGGGTTATTACCTTTTGGCTATT
CGCGCAGTCACTTGTTAATCTTGTTGTCCCATTACAATCAACATATAGTAGTGACGTTGGAACGATAAATATCGCTGTTA
GCTTATCTGCCTTATTTGCTGGTTTGTTTATCGTAGGTGCTGGTGATGTTGCTGATAAATTTGGTCGCGTCAAAATTACT
TATGTAGGATTGATATTAAATGTTGTAGGTTCATTACTCATCATCATTACACCTTTGCCAGCATTTTTAATTATAGGTAG
AATAATTCAAGGTTTGTCTGCAGCATGTATTATGCCATCCACACTTGCTATTATTAACGAATATTATATTGGTACAAGAA
GACAACGTGCCTTAAGCTATTGGTCTATTGGTTCTTGGGGTGGTAGTGGTATTTGTACGTTGTTTGGTGGCTTAATGGCT
ACATATATAGGTTGGCGTTCAATATTTGTTGTTTCAATTCTATTAACATTATTAGCAATGTACTTAATCAAACATGCACC
TGAGACTAAAGCAGAACCAATCAAAGGTATGAAAGCAGAAGCTAAAAAGTTTGACGTTATTGGTTTAGTCATTTTAGTAG
TGACGATGTTAAGTTTAAATGTAATCATCACACAGACGTCTCATTTTGGTTTAGTTTCACCGTTAATTCTAGGTTTAATT
GTTGTGTTTATCTGTTCATTAGTTGGTTTTGTATATTACGAAAATAAAATAAAGCATCCACTTGTTGATTTTTCAATTTT
TAAAAATAGAGGATACAGTGGTGCAACTATTTCAAACTTCTTATTAAATGGTGTAGCAGGTGGTGCACTTATCGTTATTA
ACACGTATTATCAACAACAATTAGGATTTAATTCTTCGCAAACGGGTTATATTTCATTAACGTATTTAATAGCAGTGTTG
TCAATGATTCGTGTAGGTGAAAAGATTTTATCTCAACATGGTCCGAAGCGCCCACTATTACTAGGAAGTGGCTTTACAGT
GATTGGGTTAATCTTATTGTCGTTAACATTTTTACCAGAAGTGTGGTATATCATATCTAGTATAGTTGGATATTTATTGT
TTGGTACTGGTTTAGGATTATATGCTACACCATCAACTGATACAGCAGTTGCTAGTGCGCCAGATGATAAGTCGGGTGTT
GCTTCAGGCGTATATAAAATGGCGTCATCATTAGGAAATGCATTTGGAGTAGCAGTATCTGGTACAGTTTATACTGTGTT
AGCAGCTAATTTAAATTTGAACTTAGGTGGTTTCACAGGTATGATGTTTAATGCCTTGCTAGCAATTGTTGCATTTTTAG
TCATTTTACTATTAGTTCCTAAAAATCAAACGAATTTGTAA

Upstream 100 bases:

>100_bases
AGATGTTTTATTTATAATTTTCTGCAAATTTATGATATTGTTTCTTAATATATCATATTAAAAATTTGTTTTTCTTAAAC
ATAGGAGGCTTATCTAATTC

Downstream 100 bases:

>100_bases
AACCGAAATGAAAGCAAGTTATTATGTAGGGATTTTAAAGGAAATTTTGTGAAAGTAAGTTTATCATACACACTTAATGT
TACGTATTGACGTTTAATGT

Product: integral membrane efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MDTSKQFRGDNRLLLGIVLGVITFWLFAQSLVNLVVPLQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKIT
YVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMA
TYIGWRSIFVVSILLTLLAMYLIKHAPETKAEPIKGMKAEAKKFDVIGLVILVVTMLSLNVIITQTSHFGLVSPLILGLI
VVFICSLVGFVYYENKIKHPLVDFSIFKNRGYSGATISNFLLNGVAGGALIVINTYYQQQLGFNSSQTGYISLTYLIAVL
SMIRVGEKILSQHGPKRPLLLGSGFTVIGLILLSLTFLPEVWYIISSIVGYLLFGTGLGLYATPSTDTAVASAPDDKSGV
ASGVYKMASSLGNAFGVAVSGTVYTVLAANLNLNLGGFTGMMFNALLAIVAFLVILLLVPKNQTNL

Sequences:

>Translated_466_residues
MDTSKQFRGDNRLLLGIVLGVITFWLFAQSLVNLVVPLQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKIT
YVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMA
TYIGWRSIFVVSILLTLLAMYLIKHAPETKAEPIKGMKAEAKKFDVIGLVILVVTMLSLNVIITQTSHFGLVSPLILGLI
VVFICSLVGFVYYENKIKHPLVDFSIFKNRGYSGATISNFLLNGVAGGALIVINTYYQQQLGFNSSQTGYISLTYLIAVL
SMIRVGEKILSQHGPKRPLLLGSGFTVIGLILLSLTFLPEVWYIISSIVGYLLFGTGLGLYATPSTDTAVASAPDDKSGV
ASGVYKMASSLGNAFGVAVSGTVYTVLAANLNLNLGGFTGMMFNALLAIVAFLVILLLVPKNQTNL
>Mature_466_residues
MDTSKQFRGDNRLLLGIVLGVITFWLFAQSLVNLVVPLQSTYSSDVGTINIAVSLSALFAGLFIVGAGDVADKFGRVKIT
YVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPSTLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMA
TYIGWRSIFVVSILLTLLAMYLIKHAPETKAEPIKGMKAEAKKFDVIGLVILVVTMLSLNVIITQTSHFGLVSPLILGLI
VVFICSLVGFVYYENKIKHPLVDFSIFKNRGYSGATISNFLLNGVAGGALIVINTYYQQQLGFNSSQTGYISLTYLIAVL
SMIRVGEKILSQHGPKRPLLLGSGFTVIGLILLSLTFLPEVWYIISSIVGYLLFGTGLGLYATPSTDTAVASAPDDKSGV
ASGVYKMASSLGNAFGVAVSGTVYTVLAANLNLNLGGFTGMMFNALLAIVAFLVILLLVPKNQTNL

Specific function: Multidrug efflux pump that acts independently of norA and is one of the factors that confers resistance against diverse quinolones and chemical compounds [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI87081983, Length=352, Percent_Identity=25, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1788710, Length=333, Percent_Identity=23.7237237237237, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790195, Length=374, Percent_Identity=22.192513368984, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6324954, Length=411, Percent_Identity=22.8710462287105, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49812; Mature: 49812

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTSKQFRGDNRLLLGIVLGVITFWLFAQSLVNLVVPLQSTYSSDVGTINIAVSLSALFA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHH
GLFIVGAGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPS
HHHHCCCCHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCHH
TLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVVSILLTLLAM
HHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLIKHAPETKAEPIKGMKAEAKKFDVIGLVILVVTMLSLNVIITQTSHFGLVSPLILGLI
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHH
VVFICSLVGFVYYENKIKHPLVDFSIFKNRGYSGATISNFLLNGVAGGALIVINTYYQQQ
HHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEEHHHHHH
LGFNSSQTGYISLTYLIAVLSMIRVGEKILSQHGPKRPLLLGSGFTVIGLILLSLTFLPE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHH
VWYIISSIVGYLLFGTGLGLYATPSTDTAVASAPDDKSGVASGVYKMASSLGNAFGVAVS
HHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHCEEEC
GTVYTVLAANLNLNLGGFTGMMFNALLAIVAFLVILLLVPKNQTNL
CCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDTSKQFRGDNRLLLGIVLGVITFWLFAQSLVNLVVPLQSTYSSDVGTINIAVSLSALFA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHH
GLFIVGAGDVADKFGRVKITYVGLILNVVGSLLIIITPLPAFLIIGRIIQGLSAACIMPS
HHHHCCCCHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCHH
TLAIINEYYIGTRRQRALSYWSIGSWGGSGICTLFGGLMATYIGWRSIFVVSILLTLLAM
HHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLIKHAPETKAEPIKGMKAEAKKFDVIGLVILVVTMLSLNVIITQTSHFGLVSPLILGLI
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHH
VVFICSLVGFVYYENKIKHPLVDFSIFKNRGYSGATISNFLLNGVAGGALIVINTYYQQQ
HHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEEHHHHHH
LGFNSSQTGYISLTYLIAVLSMIRVGEKILSQHGPKRPLLLGSGFTVIGLILLSLTFLPE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHH
VWYIISSIVGYLLFGTGLGLYATPSTDTAVASAPDDKSGVASGVYKMASSLGNAFGVAVS
HHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHCEEEC
GTVYTVLAANLNLNLGGFTGMMFNALLAIVAFLVILLLVPKNQTNL
CCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA