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The map label for this gene is rad32/mre11

Identifier: 15899023

GI number: 15899023

Start: 2065994

End: 2067139

Strand: Reverse

Name: rad32/mre11

Synonym: SSO2250

Alternate gene names: 15899023

Gene position: 2067139-2065994 (Counterclockwise)

Preceding gene: 15899024

Following gene: 15899022

Centisome position: 69.08

GC content: 33.42

Gene sequence:

>1146_bases
ATGGTACAAATTTTACATATTTCTGATACTCATTTAGGAAAAAGGCAGTACTCTCTAGTTGAAAGAGAGAAGGATATCTA
CGATATTTTCTCACAACTAGTTGATATTGCTATAAAGGAACACGTTGACGTTATAATACATTCTGGAGATCTTTTTGACG
TTTCGAGTCCTACTACAAATGCATTAGTTATGGCTATTAAAATACTAAAAAGGCTGAAAGACGTCAATATACCATTCTTA
TCTATACCGGGGGACCACGACACTCCAAAGAGGAAAGGTTATCTCATTCCTCATAATATTTTAAGTGAATTGGATTTAAT
TAAGATATTGAATTATGAGAAGCCATACATAATAAAAGGCATTGAAGTGTATGGAATCCCTCATATTCCAACAGTTTCAA
AAAGTATCTTAGTTAGCGCGTTATCCGCTTTAAGGCCAAAGTCTAGTAGGAGTATACTACTACTACATCAAGGAGTAAAA
CAGATATTGCCATATGATGGTTCATGGCAAATGGAATTAGGAAGTTTACCTAAAGGTTTTGGATATTACGCTTTAGGCCA
TATACATACTAGGTGGAGACTTACTCAGGATGACGGTTCAGTAATTGCAATAGCTGGCTCACCGGATATAATGAGAGAAG
AGGAGATAGAAGGATATGAAAAATTTGGAAAGGGAGCATACCTAATAGACTTTTCAAAAGACTTACCTATACTTAGCACG
ATAAATATTACAGTAAGGCCACAAAAGGTTGTAACTATAAATACAAAGAACATAAAGAAGGATATATTAACGATAAGAGA
TGATCTAATTGAACATAATAAAAGTGAAAACAACAAACCAATATTGCATATTATCGTAGAGGGTGAAAGGATGAGAAAGG
ACCTACTTTACAAGGAGTTACTTCCTTTGAACGATGTTGCGCTTTATTATAGAATATATAAGGATGAAACTACTCAAACA
GTAGATAACTTATCCTACACCTTGCCACGAGATAAGGGATTAGATAAGATAATAATTGAATATCTTACTAAATATGAGAA
GTTTAGCGAGGATGAAGCAAATTTGATCTTACAAATGATAAAGAACGTTGAGTCTGACGAGATAGTAAATGAGATATTAA
AAAAGTTAACAGGTGTTAACTTATGA

Upstream 100 bases:

>100_bases
GATCAGACCCTGACATGATAGGGGAATGGAAGAAAGTCGAGGAAAGTGAAAAAATAGCTAAAGGTTTTGCTGACTTTGGA
ACAGAAATTGGTGATTAAAA

Downstream 100 bases:

>100_bases
GAATTGATAAAATTACTTTAACTAATTTCTTAAGTCATGAACACAGCGAAATCCAGTTCATGGGTGAAATAAATGTAATA
GTAGGCCAAAATGGAGCAGG

Product: DNA repair protein (rad32/mre11)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MVQILHISDTHLGKRQYSLVEREKDIYDIFSQLVDIAIKEHVDVIIHSGDLFDVSSPTTNALVMAIKILKRLKDVNIPFL
SIPGDHDTPKRKGYLIPHNILSELDLIKILNYEKPYIIKGIEVYGIPHIPTVSKSILVSALSALRPKSSRSILLLHQGVK
QILPYDGSWQMELGSLPKGFGYYALGHIHTRWRLTQDDGSVIAIAGSPDIMREEEIEGYEKFGKGAYLIDFSKDLPILST
INITVRPQKVVTINTKNIKKDILTIRDDLIEHNKSENNKPILHIIVEGERMRKDLLYKELLPLNDVALYYRIYKDETTQT
VDNLSYTLPRDKGLDKIIIEYLTKYEKFSEDEANLILQMIKNVESDEIVNEILKKLTGVNL

Sequences:

>Translated_381_residues
MVQILHISDTHLGKRQYSLVEREKDIYDIFSQLVDIAIKEHVDVIIHSGDLFDVSSPTTNALVMAIKILKRLKDVNIPFL
SIPGDHDTPKRKGYLIPHNILSELDLIKILNYEKPYIIKGIEVYGIPHIPTVSKSILVSALSALRPKSSRSILLLHQGVK
QILPYDGSWQMELGSLPKGFGYYALGHIHTRWRLTQDDGSVIAIAGSPDIMREEEIEGYEKFGKGAYLIDFSKDLPILST
INITVRPQKVVTINTKNIKKDILTIRDDLIEHNKSENNKPILHIIVEGERMRKDLLYKELLPLNDVALYYRIYKDETTQT
VDNLSYTLPRDKGLDKIIIEYLTKYEKFSEDEANLILQMIKNVESDEIVNEILKKLTGVNL
>Mature_381_residues
MVQILHISDTHLGKRQYSLVEREKDIYDIFSQLVDIAIKEHVDVIIHSGDLFDVSSPTTNALVMAIKILKRLKDVNIPFL
SIPGDHDTPKRKGYLIPHNILSELDLIKILNYEKPYIIKGIEVYGIPHIPTVSKSILVSALSALRPKSSRSILLLHQGVK
QILPYDGSWQMELGSLPKGFGYYALGHIHTRWRLTQDDGSVIAIAGSPDIMREEEIEGYEKFGKGAYLIDFSKDLPILST
INITVRPQKVVTINTKNIKKDILTIRDDLIEHNKSENNKPILHIIVEGERMRKDLLYKELLPLNDVALYYRIYKDETTQT
VDNLSYTLPRDKGLDKIIIEYLTKYEKFSEDEANLILQMIKNVESDEIVNEILKKLTGVNL

Specific function: Involved in DNA double-strand break repair (DSBR). The rad50/mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity

COG id: COG0420

COG function: function code L; DNA repair exonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MRE11/RAD32 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRE11_SULSO (Q97WG9)

Other databases:

- EMBL:   AE006641
- PIR:   C90395
- RefSeq:   NP_343628.1
- ProteinModelPortal:   Q97WG9
- GeneID:   1453745
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO2250
- NMPDR:   fig|273057.1.peg.2051
- HOGENOM:   HBG553822
- OMA:   ERENDFY
- ProtClustDB:   CLSK803276
- BioCyc:   SSOL273057:SSO2250-MONOMER
- InterPro:   IPR003701
- InterPro:   IPR004843
- PANTHER:   PTHR10139

Pfam domain/function: PF00149 Metallophos

EC number: NA

Molecular weight: Translated: 43551; Mature: 43551

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: ACT_SITE 86-86

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQILHISDTHLGKRQYSLVEREKDIYDIFSQLVDIAIKEHVDVIIHSGDLFDVSSPTTN
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCEEECCCCCHH
ALVMAIKILKRLKDVNIPFLSIPGDHDTPKRKGYLIPHNILSELDLIKILNYEKPYIIKG
HHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCEECCHHHHHHHHHHHHHCCCCCEEEEE
IEVYGIPHIPTVSKSILVSALSALRPKSSRSILLLHQGVKQILPYDGSWQMELGSLPKGF
EEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHCCCCCCCEEECCCCCCCC
GYYALGHIHTRWRLTQDDGSVIAIAGSPDIMREEEIEGYEKFGKGAYLIDFSKDLPILST
CCEEEEEEEEEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHCCCEEEEEECCCCCEEEE
INITVRPQKVVTINTKNIKKDILTIRDDLIEHNKSENNKPILHIIVEGERMRKDLLYKEL
EEEEECCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHH
LPLNDVALYYRIYKDETTQTVDNLSYTLPRDKGLDKIIIEYLTKYEKFSEDEANLILQMI
CCCCCEEEEEEEECCCHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
KNVESDEIVNEILKKLTGVNL
HCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVQILHISDTHLGKRQYSLVEREKDIYDIFSQLVDIAIKEHVDVIIHSGDLFDVSSPTTN
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCEEECCCCCHH
ALVMAIKILKRLKDVNIPFLSIPGDHDTPKRKGYLIPHNILSELDLIKILNYEKPYIIKG
HHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCEECCHHHHHHHHHHHHHCCCCCEEEEE
IEVYGIPHIPTVSKSILVSALSALRPKSSRSILLLHQGVKQILPYDGSWQMELGSLPKGF
EEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHCCCCCCCEEECCCCCCCC
GYYALGHIHTRWRLTQDDGSVIAIAGSPDIMREEEIEGYEKFGKGAYLIDFSKDLPILST
CCEEEEEEEEEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHCCCEEEEEECCCCCEEEE
INITVRPQKVVTINTKNIKKDILTIRDDLIEHNKSENNKPILHIIVEGERMRKDLLYKEL
EEEEECCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHH
LPLNDVALYYRIYKDETTQTVDNLSYTLPRDKGLDKIIIEYLTKYEKFSEDEANLILQMI
CCCCCEEEEEEEECCCHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
KNVESDEIVNEILKKLTGVNL
HCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11427726