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The map label for this gene is trxA-2 [H]

Identifier: 15899007

GI number: 15899007

Start: 2050756

End: 2051163

Strand: Reverse

Name: trxA-2 [H]

Synonym: SSO2232

Alternate gene names: 15899007

Gene position: 2051163-2050756 (Counterclockwise)

Preceding gene: 15899010

Following gene: 15899006

Centisome position: 68.55

GC content: 34.07

Gene sequence:

>408_bases
ATGAATGACGAACTAAATGACCCAGAATTACAAAAAATCCTCTCTAAAAAAACAACTCAAATACTCAATAATTTAAAAGA
GAAAGTTAAAGAGCCAGTAAAACATCTCAATTCAAAAAACTTTGATGAATTCATAACTAAAAACAAAATAGTGGTTGTCG
ACTTTTGGGCAGAATGGTGTGCGCCATGCTTAATACTGGCTCCGGTAATAGAAGAACTTGCAAATGACTACCCTCAAGTA
GCATTTGGAAAATTAAACACTGAAGAGAGCCAAGATATTGCGATGAGATATGGAATAATGAGTCTTCCGACAATTATGTT
CTTTAAAAATGGAGAGCTTGTAGACCAAATATTAGGAGCAGTACCTAGAGAAGAAATAGAGGTAAGACTAAAGTCCCTAT
TAGAGTAA

Upstream 100 bases:

>100_bases
ATTAAACCTGTTATTCCACTGCCTACAATTACAAGTTTTGTCATGTCTAATCTCTTTATATGATAAAAACTTTTTAAATG
AATACTATATATAATCTCTT

Downstream 100 bases:

>100_bases
CAAGTGAGAGAAATGAATCCTTTGTTACTAGGAATAGATGGGTTAAGCTATACTAGTTTCATGAAATGTAACCCGAGGAC
ATTATTTACACTATTTAGTA

Product: thioredoxin (trxA-2)

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 135; Mature: 135

Protein sequence:

>135_residues
MNDELNDPELQKILSKKTTQILNNLKEKVKEPVKHLNSKNFDEFITKNKIVVVDFWAEWCAPCLILAPVIEELANDYPQV
AFGKLNTEESQDIAMRYGIMSLPTIMFFKNGELVDQILGAVPREEIEVRLKSLLE

Sequences:

>Translated_135_residues
MNDELNDPELQKILSKKTTQILNNLKEKVKEPVKHLNSKNFDEFITKNKIVVVDFWAEWCAPCLILAPVIEELANDYPQV
AFGKLNTEESQDIAMRYGIMSLPTIMFFKNGELVDQILGAVPREEIEVRLKSLLE
>Mature_135_residues
MNDELNDPELQKILSKKTTQILNNLKEKVKEPVKHLNSKNFDEFITKNKIVVVDFWAEWCAPCLILAPVIEELANDYPQV
AFGKLNTEESQDIAMRYGIMSLPTIMFFKNGELVDQILGAVPREEIEVRLKSLLE

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=94, Percent_Identity=35.1063829787234, Blast_Score=75, Evalue=1e-14,
Organism=Homo sapiens, GI50592994, Length=105, Percent_Identity=35.2380952380952, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI95113651, Length=86, Percent_Identity=37.2093023255814, Blast_Score=68, Evalue=2e-12,
Organism=Homo sapiens, GI4758304, Length=102, Percent_Identity=31.3725490196078, Blast_Score=64, Evalue=5e-11,
Organism=Escherichia coli, GI1788936, Length=103, Percent_Identity=40.7766990291262, Blast_Score=89, Evalue=8e-20,
Organism=Escherichia coli, GI87082331, Length=101, Percent_Identity=35.6435643564356, Blast_Score=87, Evalue=4e-19,
Organism=Escherichia coli, GI87081747, Length=107, Percent_Identity=32.7102803738318, Blast_Score=65, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=108, Percent_Identity=35.1851851851852, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71980562, Length=106, Percent_Identity=35.8490566037736, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17507705, Length=93, Percent_Identity=35.4838709677419, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI212646193, Length=98, Percent_Identity=35.7142857142857, Blast_Score=73, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71998175, Length=92, Percent_Identity=40.2173913043478, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25144092, Length=89, Percent_Identity=35.9550561797753, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=72, Percent_Identity=41.6666666666667, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323072, Length=86, Percent_Identity=43.0232558139535, Blast_Score=91, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6321648, Length=77, Percent_Identity=44.1558441558442, Blast_Score=84, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6319925, Length=90, Percent_Identity=37.7777777777778, Blast_Score=76, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24639826, Length=90, Percent_Identity=36.6666666666667, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24658597, Length=72, Percent_Identity=38.8888888888889, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17648013, Length=76, Percent_Identity=42.1052631578947, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583090, Length=76, Percent_Identity=42.1052631578947, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24664269, Length=94, Percent_Identity=37.2340425531915, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 15520; Mature: 15520

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDELNDPELQKILSKKTTQILNNLKEKVKEPVKHLNSKNFDEFITKNKIVVVDFWAEWC
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCEEEEECHHHHH
APCLILAPVIEELANDYPQVAFGKLNTEESQDIAMRYGIMSLPTIMFFKNGELVDQILGA
HHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
VPREEIEVRLKSLLE
CCHHHHHHHHHHHCC
>Mature Secondary Structure
MNDELNDPELQKILSKKTTQILNNLKEKVKEPVKHLNSKNFDEFITKNKIVVVDFWAEWC
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCEEEEECHHHHH
APCLILAPVIEELANDYPQVAFGKLNTEESQDIAMRYGIMSLPTIMFFKNGELVDQILGA
HHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
VPREEIEVRLKSLLE
CCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3294835 [H]