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The map label for this gene is yhcA [H]

Identifier: 15898706

GI number: 15898706

Start: 1728731

End: 1730149

Strand: Reverse

Name: yhcA [H]

Synonym: SSO1909

Alternate gene names: 15898706

Gene position: 1730149-1728731 (Counterclockwise)

Preceding gene: 15898708

Following gene: 15898705

Centisome position: 57.82

GC content: 37.35

Gene sequence:

>1419_bases
ATGGATCCAAAAGGAACCATGCGTACTTTAATTACCCTCACTCTCATGCTAACTTTAGTAAATTACGTAGAGACAATGGT
TATACCTGCGTTACCGAAAATTGAAGATCAGTTCTCTACCACAGCAACAACTGTTGCGTGGGTTACATCAGCTTATCTTA
TAGTTGGTGCAATTGCATCGCCGCTTTTTGGAAAGCTAGGTGATAGGTATGGAAAGAAGAAAGTTTATCTCTTATCTATT
GGCTTTTATTCGCTAGCCGTATTATTAGCTGGGTTCTCAACAAACATCTACTTTTTAATTTTCGCTAGGGCGATTCAAGG
ATTAGGTTATGCAACGTTTCCTCTTGCGATAGCGATTATAACTGACCTATTTCCCAAAGAGAGAGTAGCCTGGGCTCAAG
GTATTTTAAGTGCTACACTTGCAGCCGGCCCAGCCTTAGGACTATTAGTTGGTTCCTATATAGTTCAAGATCTGGGATGG
CCTTATGCATTTCATACTGCGTTTATATTATCGATAATTTTGGTAATAGTTTCCGCAAAGTACATAGTCGAAATACCCCA
GAAGACTAAGGAGAAGATAGATTATTTAGGAGCTACGTTCCTTATGTTAACAGTGGTTCCGTTATTAGTATACTTATCTA
ACGGTCCTAACGTCGGTTGGACTTCAACTAGTCAATTCTTATTAATTGTAATTTCAATAATAGCATTTCCCATATTTTTA
TGGGTAGAGGGAAGAACCAACGAACCCTTGATGAGACTTGATCTATTTAGAATAAGGAATATAATGGTCGCAAATATAGC
TGGGTTAATATCTGGAGCTGGAATGTTTTTAATGTTTACGGGACTAGTTTACTATCTTCAATTGCCTAAGCCTTATGGAC
TAGGCTTATCAATAATAGAGTCTGGGCTCTTAATGGCACCGGTAGCATTAGTGATGATGATTGTTGGACCAATAGTAGGT
AGGTTAATTAACAATATTGGTCCTAAGCCATTACTTATGATAGGTTCTATAATTAGCATTGTTGGCTATTTACTTCTAGA
TACTTTTAGGTATAGCATATATGAGGTGGTAGTTGATGTCATGATAACTGCTGTAGGATTAGTCAATATTATGATTCCAT
TAGTTAACATGGTTGCCGTATCTTTACCAGAGGAGCAAAGGGGAATAGGAATAGGTATGAACACTTTAATAAGAACCATC
GGAAGTTCAATTGGTCCAGTAATCTCAACTGTGTTTATGGACACTTATACTACTTGGATAATATATGACTTTAATAACCA
AATTGTACCAGTAGCTCAAGTGCCGTCTTATTCAGCTTTTCATTACATGTATACTGCTGCAGTTGGTATAATGTTCCTAA
ATCTTATAGTGGCTCTATTCACCAGAAATTACGTAATTAAGGCAGGGCAGCATGCGTAA

Upstream 100 bases:

>100_bases
CCTAAAAGCTATCTTTTCACATTTTTGTAAGCTATTTCTCAACGTCTATTGAAAAAGATATATCGAAAAATTTATTTGCC
TTTACAATGTTCTTTACTCT

Downstream 100 bases:

>100_bases
ACTTTCTACTTATTTTTTCTATTTAAGGATTGCACTACAAATTGTATAAATTATACATATTCCTAATCATGGATTATACA
TAAATGCTTATTACTGTAGA

Product: multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MDPKGTMRTLITLTLMLTLVNYVETMVIPALPKIEDQFSTTATTVAWVTSAYLIVGAIASPLFGKLGDRYGKKKVYLLSI
GFYSLAVLLAGFSTNIYFLIFARAIQGLGYATFPLAIAIITDLFPKERVAWAQGILSATLAAGPALGLLVGSYIVQDLGW
PYAFHTAFILSIILVIVSAKYIVEIPQKTKEKIDYLGATFLMLTVVPLLVYLSNGPNVGWTSTSQFLLIVISIIAFPIFL
WVEGRTNEPLMRLDLFRIRNIMVANIAGLISGAGMFLMFTGLVYYLQLPKPYGLGLSIIESGLLMAPVALVMMIVGPIVG
RLINNIGPKPLLMIGSIISIVGYLLLDTFRYSIYEVVVDVMITAVGLVNIMIPLVNMVAVSLPEEQRGIGIGMNTLIRTI
GSSIGPVISTVFMDTYTTWIIYDFNNQIVPVAQVPSYSAFHYMYTAAVGIMFLNLIVALFTRNYVIKAGQHA

Sequences:

>Translated_472_residues
MDPKGTMRTLITLTLMLTLVNYVETMVIPALPKIEDQFSTTATTVAWVTSAYLIVGAIASPLFGKLGDRYGKKKVYLLSI
GFYSLAVLLAGFSTNIYFLIFARAIQGLGYATFPLAIAIITDLFPKERVAWAQGILSATLAAGPALGLLVGSYIVQDLGW
PYAFHTAFILSIILVIVSAKYIVEIPQKTKEKIDYLGATFLMLTVVPLLVYLSNGPNVGWTSTSQFLLIVISIIAFPIFL
WVEGRTNEPLMRLDLFRIRNIMVANIAGLISGAGMFLMFTGLVYYLQLPKPYGLGLSIIESGLLMAPVALVMMIVGPIVG
RLINNIGPKPLLMIGSIISIVGYLLLDTFRYSIYEVVVDVMITAVGLVNIMIPLVNMVAVSLPEEQRGIGIGMNTLIRTI
GSSIGPVISTVFMDTYTTWIIYDFNNQIVPVAQVPSYSAFHYMYTAAVGIMFLNLIVALFTRNYVIKAGQHA
>Mature_472_residues
MDPKGTMRTLITLTLMLTLVNYVETMVIPALPKIEDQFSTTATTVAWVTSAYLIVGAIASPLFGKLGDRYGKKKVYLLSI
GFYSLAVLLAGFSTNIYFLIFARAIQGLGYATFPLAIAIITDLFPKERVAWAQGILSATLAAGPALGLLVGSYIVQDLGW
PYAFHTAFILSIILVIVSAKYIVEIPQKTKEKIDYLGATFLMLTVVPLLVYLSNGPNVGWTSTSQFLLIVISIIAFPIFL
WVEGRTNEPLMRLDLFRIRNIMVANIAGLISGAGMFLMFTGLVYYLQLPKPYGLGLSIIESGLLMAPVALVMMIVGPIVG
RLINNIGPKPLLMIGSIISIVGYLLLDTFRYSIYEVVVDVMITAVGLVNIMIPLVNMVAVSLPEEQRGIGIGMNTLIRTI
GSSIGPVISTVFMDTYTTWIIYDFNNQIVPVAQVPSYSAFHYMYTAAVGIMFLNLIVALFTRNYVIKAGQHA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=407, Percent_Identity=25.7985257985258, Blast_Score=125, Evalue=9e-30,
Organism=Escherichia coli, GI1789042, Length=415, Percent_Identity=24.8192771084337, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI87081983, Length=394, Percent_Identity=25.1269035532995, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1790195, Length=405, Percent_Identity=21.9753086419753, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1788392, Length=430, Percent_Identity=25.1162790697674, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI48994889, Length=162, Percent_Identity=29.0123456790123, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324954, Length=403, Percent_Identity=25.0620347394541, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319770, Length=218, Percent_Identity=29.3577981651376, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323735, Length=319, Percent_Identity=22.884012539185, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24654044, Length=172, Percent_Identity=26.7441860465116, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI17864456, Length=170, Percent_Identity=27.0588235294118, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24654039, Length=170, Percent_Identity=27.0588235294118, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24654037, Length=170, Percent_Identity=27.0588235294118, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24654041, Length=170, Percent_Identity=27.0588235294118, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 51621; Mature: 51621

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPKGTMRTLITLTLMLTLVNYVETMVIPALPKIEDQFSTTATTVAWVTSAYLIVGAIAS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLFGKLGDRYGKKKVYLLSIGFYSLAVLLAGFSTNIYFLIFARAIQGLGYATFPLAIAII
HHHHHHHHHCCCCEEEEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHH
TDLFPKERVAWAQGILSATLAAGPALGLLVGSYIVQDLGWPYAFHTAFILSIILVIVSAK
HHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
YIVEIPQKTKEKIDYLGATFLMLTVVPLLVYLSNGPNVGWTSTSQFLLIVISIIAFPIFL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHE
WVEGRTNEPLMRLDLFRIRNIMVANIAGLISGAGMFLMFTGLVYYLQLPKPYGLGLSIIE
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHH
SGLLMAPVALVMMIVGPIVGRLINNIGPKPLLMIGSIISIVGYLLLDTFRYSIYEVVVDV
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MITAVGLVNIMIPLVNMVAVSLPEEQRGIGIGMNTLIRTIGSSIGPVISTVFMDTYTTWI
HHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEE
IYDFNNQIVPVAQVPSYSAFHYMYTAAVGIMFLNLIVALFTRNYVIKAGQHA
EEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHEECCCCC
>Mature Secondary Structure
MDPKGTMRTLITLTLMLTLVNYVETMVIPALPKIEDQFSTTATTVAWVTSAYLIVGAIAS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLFGKLGDRYGKKKVYLLSIGFYSLAVLLAGFSTNIYFLIFARAIQGLGYATFPLAIAII
HHHHHHHHHCCCCEEEEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHH
TDLFPKERVAWAQGILSATLAAGPALGLLVGSYIVQDLGWPYAFHTAFILSIILVIVSAK
HHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
YIVEIPQKTKEKIDYLGATFLMLTVVPLLVYLSNGPNVGWTSTSQFLLIVISIIAFPIFL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHE
WVEGRTNEPLMRLDLFRIRNIMVANIAGLISGAGMFLMFTGLVYYLQLPKPYGLGLSIIE
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHH
SGLLMAPVALVMMIVGPIVGRLINNIGPKPLLMIGSIISIVGYLLLDTFRYSIYEVVVDV
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MITAVGLVNIMIPLVNMVAVSLPEEQRGIGIGMNTLIRTIGSSIGPVISTVFMDTYTTWI
HHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEE
IYDFNNQIVPVAQVPSYSAFHYMYTAAVGIMFLNLIVALFTRNYVIKAGQHA
EEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969498 [H]