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The map label for this gene is fadH [C]

Identifier: 15898696

GI number: 15898696

Start: 1715787

End: 1717454

Strand: Reverse

Name: fadH [C]

Synonym: SSO1900

Alternate gene names: 15898696

Gene position: 1717454-1715787 (Counterclockwise)

Preceding gene: 15898697

Following gene: 15898694

Centisome position: 57.4

GC content: 41.07

Gene sequence:

>1668_bases
ATGGATCTATCGAAGCTACTGGTTCCAATAAGAGTTGGTGATGTGGTCTTAAAGAACAGAATAGCCATGTCACCAATGAT
TAGCAATCTAGGTACACCTGAGGGTTACCCGAGCGATGCTCATATAGCTTACTTAGCTGAGAGAGCTAAGGGAGGAGTTG
GGTTAATAATAACGGAGTACACTTACGTTAACCACGTAGATGCTAGGGGGTCTGTTAACGAATTGGGGATGTATTCAGAT
GAGCTAACACCAAAGTTTACGAGGTTGACTGAGTTAATTCACGCTTTGGGAAGTAAGATTTTCGTGCAGTTAGTTCACGT
TGGCAGGAAGACTAGGAAGGATATAATTTGGGGTAACAAACCCATAGCTCCTTCACCAATTCCAATAATGGACGAAGTAA
GGGAAATGACTAAAGAGGATATAGAGAGGGTTAAAAACGATTTCATAAACGCAGCAATAAGGGCTAAGAGGGCTGGATTT
GACGGAATAGAACTTCACGGAGCTCACGGATACTTAATCGCACAATTCCTTTCCCCTGCAACTAACAAAAGGGGTGATGA
ATACAAAGACGGTGTAAAGTTCGTTGAGGAAATCCTCAAGGGTATAAGGGAAAAAGTTAGAATCACTGTAGGTATAAGGA
TCAGTGTAACCGAATTCGACAATGGGGGCTTAACTCCAGAAATTGTGGCTGAAATAGGTAAAAGGTTAGAAAAGGCTGGA
ATAGATTACATTCACTTATCAGCTGGAAGAGATGGTCCTTTAGGTTCTAGCATGCCATATTATTATAAGAGAACATCATT
CCTTGAGGAGGCGAAGGTAGTGAGGGATACGGTCAAGATTCCAATATTTCTCGTTGGGTCTATAATAACTCCACAAGATG
CGATTAAGGCCAGAGAAATTGCCGATGTCGTTGTGTTAGGGAGACAATTATTAGCTGATCCCTATTGGCTTGAGAAAGCT
AAAAGGGATTTGCCAATAAGGCCATGTATTAGGTGTAATCAGTCGTGTAGAGGAGTTGTCTATAAGGAAGTAAGATGTGA
TGTTAATCCAGAGTTAGGTTGGGAGCTACTGCCCCCGCTAGAGAAGGGTAGAGGAGAAGTTACTGTGGTGGGTGGGGGAG
TAATGGGTTTAGAAGCTGCTAGGGTTTTGGCCTTAAGGGGCTTTGCAGTAACCTTATATGAACAAAACAATAAGTTGGGA
GGGCAGTTTCTACTTTACAGAGATCCTTGGAAGGTTAATGAGTTTCAAGCGTTAATTGATTACTACGAGAGAGAGTTAAG
GAGACTTAATGTAGAGATTAAGCTTAACGTTAAGATGGAGTGTTCTGACTGTATAATGGCTATACCGGACTATGAAATAC
CTAAAATGCCAGATGTTAAGGGGGAGAAAGTACTAATAGATTCTAACCTTTACGTTTATCACGACTATGCCTTCGAATTG
GCCAAATATAACGAAGTTTACATGACTGAGAGGTCCTTTAAGGGGCTGGATAGAACTAGGGAGTACTTGTTAAGAAAGGA
GTTAAGTGAGGTAGGTGTGAAGTTTATAGAGGAAAGCAACAGTATCAAATTTGATGTGGAGATACACGATATTGTCGATG
ATCAGCCAAGTATTGGTAAAGCTATACAAAGAGGTTACTGGTTAGGTAGGAGCTTTAAGTCATATTAA

Upstream 100 bases:

>100_bases
GAGCTCTCTTTATATATTATATTAATTTGAAATTTAGTAATTCTAGGAAAATACGGAACCTTATAGTTAACTTTTTAACT
ATCACATTCTAATAAGTTTC

Downstream 100 bases:

>100_bases
AAACATGTCATCACATTTTTCAGTCCTGGCCACTCTAATCATTCAAAGTAATATGTTTCACTAACTCTGTATATAAAGTT
TATTAAGAACAATGCTTTGG

Product: NADH oxidase

Products: trans-transtetradehydroacyl-CoA; NADPH [C]

Alternate protein names: NA

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
MDLSKLLVPIRVGDVVLKNRIAMSPMISNLGTPEGYPSDAHIAYLAERAKGGVGLIITEYTYVNHVDARGSVNELGMYSD
ELTPKFTRLTELIHALGSKIFVQLVHVGRKTRKDIIWGNKPIAPSPIPIMDEVREMTKEDIERVKNDFINAAIRAKRAGF
DGIELHGAHGYLIAQFLSPATNKRGDEYKDGVKFVEEILKGIREKVRITVGIRISVTEFDNGGLTPEIVAEIGKRLEKAG
IDYIHLSAGRDGPLGSSMPYYYKRTSFLEEAKVVRDTVKIPIFLVGSIITPQDAIKAREIADVVVLGRQLLADPYWLEKA
KRDLPIRPCIRCNQSCRGVVYKEVRCDVNPELGWELLPPLEKGRGEVTVVGGGVMGLEAARVLALRGFAVTLYEQNNKLG
GQFLLYRDPWKVNEFQALIDYYERELRRLNVEIKLNVKMECSDCIMAIPDYEIPKMPDVKGEKVLIDSNLYVYHDYAFEL
AKYNEVYMTERSFKGLDRTREYLLRKELSEVGVKFIEESNSIKFDVEIHDIVDDQPSIGKAIQRGYWLGRSFKSY

Sequences:

>Translated_555_residues
MDLSKLLVPIRVGDVVLKNRIAMSPMISNLGTPEGYPSDAHIAYLAERAKGGVGLIITEYTYVNHVDARGSVNELGMYSD
ELTPKFTRLTELIHALGSKIFVQLVHVGRKTRKDIIWGNKPIAPSPIPIMDEVREMTKEDIERVKNDFINAAIRAKRAGF
DGIELHGAHGYLIAQFLSPATNKRGDEYKDGVKFVEEILKGIREKVRITVGIRISVTEFDNGGLTPEIVAEIGKRLEKAG
IDYIHLSAGRDGPLGSSMPYYYKRTSFLEEAKVVRDTVKIPIFLVGSIITPQDAIKAREIADVVVLGRQLLADPYWLEKA
KRDLPIRPCIRCNQSCRGVVYKEVRCDVNPELGWELLPPLEKGRGEVTVVGGGVMGLEAARVLALRGFAVTLYEQNNKLG
GQFLLYRDPWKVNEFQALIDYYERELRRLNVEIKLNVKMECSDCIMAIPDYEIPKMPDVKGEKVLIDSNLYVYHDYAFEL
AKYNEVYMTERSFKGLDRTREYLLRKELSEVGVKFIEESNSIKFDVEIHDIVDDQPSIGKAIQRGYWLGRSFKSY
>Mature_555_residues
MDLSKLLVPIRVGDVVLKNRIAMSPMISNLGTPEGYPSDAHIAYLAERAKGGVGLIITEYTYVNHVDARGSVNELGMYSD
ELTPKFTRLTELIHALGSKIFVQLVHVGRKTRKDIIWGNKPIAPSPIPIMDEVREMTKEDIERVKNDFINAAIRAKRAGF
DGIELHGAHGYLIAQFLSPATNKRGDEYKDGVKFVEEILKGIREKVRITVGIRISVTEFDNGGLTPEIVAEIGKRLEKAG
IDYIHLSAGRDGPLGSSMPYYYKRTSFLEEAKVVRDTVKIPIFLVGSIITPQDAIKAREIADVVVLGRQLLADPYWLEKA
KRDLPIRPCIRCNQSCRGVVYKEVRCDVNPELGWELLPPLEKGRGEVTVVGGGVMGLEAARVLALRGFAVTLYEQNNKLG
GQFLLYRDPWKVNEFQALIDYYERELRRLNVEIKLNVKMECSDCIMAIPDYEIPKMPDVKGEKVLIDSNLYVYHDYAFEL
AKYNEVYMTERSFKGLDRTREYLLRKELSEVGVKFIEESNSIKFDVEIHDIVDDQPSIGKAIQRGYWLGRSFKSY

Specific function: Reduces a range of alternative electron acceptors [H]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1789463, Length=460, Percent_Identity=32.1739130434783, Blast_Score=186, Evalue=5e-48,
Organism=Escherichia coli, GI1787939, Length=362, Percent_Identity=30.6629834254144, Blast_Score=134, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI72001454, Length=312, Percent_Identity=30.4487179487179, Blast_Score=108, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17564188, Length=347, Percent_Identity=27.9538904899135, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17565138, Length=333, Percent_Identity=30.03003003003, Blast_Score=105, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17540738, Length=341, Percent_Identity=26.6862170087977, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17559804, Length=307, Percent_Identity=28.6644951140065, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17559802, Length=334, Percent_Identity=28.4431137724551, Blast_Score=100, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17566914, Length=230, Percent_Identity=27.8260869565217, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6325086, Length=275, Percent_Identity=29.8181818181818, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6321973, Length=375, Percent_Identity=26.1333333333333, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013027
- InterPro:   IPR016040
- InterPro:   IPR001155
- InterPro:   IPR001327
- InterPro:   IPR000103 [H]

Pfam domain/function: PF00724 Oxidored_FMN; PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: 1.3.1.34 [C]

Molecular weight: Translated: 62812; Mature: 62812

Theoretical pI: Translated: 7.54; Mature: 7.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLSKLLVPIRVGDVVLKNRIAMSPMISNLGTPEGYPSDAHIAYLAERAKGGVGLIITEY
CCHHHEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCEEEEEEEE
TYVNHVDARGSVNELGMYSDELTPKFTRLTELIHALGSKIFVQLVHVGRKTRKDIIWGNK
EEEECCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PIAPSPIPIMDEVREMTKEDIERVKNDFINAAIRAKRAGFDGIELHGAHGYLIAQFLSPA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHCCC
TNKRGDEYKDGVKFVEEILKGIREKVRITVGIRISVTEFDNGGLTPEIVAEIGKRLEKAG
CCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEEEECCCCCCHHHHHHHHHHHHHCC
IDYIHLSAGRDGPLGSSMPYYYKRTSFLEEAKVVRDTVKIPIFLVGSIITPQDAIKAREI
CCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHH
ADVVVLGRQLLADPYWLEKAKRDLPIRPCIRCNQSCRGVVYKEVRCDVNPELGWELLPPL
HHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHCCCCCCCEEEEEEECCCCCCCCCEECCCH
EKGRGEVTVVGGGVMGLEAARVLALRGFAVTLYEQNNKLGGQFLLYRDPWKVNEFQALID
HCCCCCEEEEECCCHHHHHHHHHHHCCEEEEEEECCCCCCCEEEEEECCCCCHHHHHHHH
YYERELRRLNVEIKLNVKMECSDCIMAIPDYEIPKMPDVKGEKVLIDSNLYVYHDYAFEL
HHHHHHHHEEEEEEEEEEEECCCCEEECCCCCCCCCCCCCCCEEEEECCEEEEEHHHHHH
AKYNEVYMTERSFKGLDRTREYLLRKELSEVGVKFIEESNSIKFDVEIHDIVDDQPSIGK
HHCCCEEEECHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHH
AIQRGYWLGRSFKSY
HHHHHHHHCCCCCCC
>Mature Secondary Structure
MDLSKLLVPIRVGDVVLKNRIAMSPMISNLGTPEGYPSDAHIAYLAERAKGGVGLIITEY
CCHHHEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCEEEEEEEE
TYVNHVDARGSVNELGMYSDELTPKFTRLTELIHALGSKIFVQLVHVGRKTRKDIIWGNK
EEEECCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PIAPSPIPIMDEVREMTKEDIERVKNDFINAAIRAKRAGFDGIELHGAHGYLIAQFLSPA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHCCC
TNKRGDEYKDGVKFVEEILKGIREKVRITVGIRISVTEFDNGGLTPEIVAEIGKRLEKAG
CCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEEEECCCCCCHHHHHHHHHHHHHCC
IDYIHLSAGRDGPLGSSMPYYYKRTSFLEEAKVVRDTVKIPIFLVGSIITPQDAIKAREI
CCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHH
ADVVVLGRQLLADPYWLEKAKRDLPIRPCIRCNQSCRGVVYKEVRCDVNPELGWELLPPL
HHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHCCCCCCCEEEEEEECCCCCCCCCEECCCH
EKGRGEVTVVGGGVMGLEAARVLALRGFAVTLYEQNNKLGGQFLLYRDPWKVNEFQALID
HCCCCCEEEEECCCHHHHHHHHHHHCCEEEEEEECCCCCCCEEEEEECCCCCHHHHHHHH
YYERELRRLNVEIKLNVKMECSDCIMAIPDYEIPKMPDVKGEKVLIDSNLYVYHDYAFEL
HHHHHHHHEEEEEEEEEEEECCCCEEECCCCCCCCCCCCCCCEEEEECCEEEEEHHHHHH
AKYNEVYMTERSFKGLDRTREYLLRKELSEVGVKFIEESNSIKFDVEIHDIVDDQPSIGK
HHCCCEEEECHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHH
AIQRGYWLGRSFKSY
HHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: transDidehydroacyl-CoA; NADP+ [C]

Specific reaction: transDidehydroacyl-CoA + NADP+ =trans-transtetradehydroacyl-CoA + NADPH [C]

General reaction: Redox reaction [C]

Inhibitor: Iodoacetic acid; N-Ethyl maleimide [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8357835 [H]