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The map label for this gene is strD [H]

Identifier: 15898579

GI number: 15898579

Start: 1614979

End: 1616013

Strand: Reverse

Name: strD [H]

Synonym: SSO1782

Alternate gene names: 15898579

Gene position: 1616013-1614979 (Counterclockwise)

Preceding gene: 15898580

Following gene: 15898578

Centisome position: 54.01

GC content: 35.85

Gene sequence:

>1035_bases
ATGGAGGCAGTAATCTTACACGGAGGACAAGGAACTCGTTTAAGACCATTAACTCATACTGGTCCTAAGCAATTAATAAA
AGTTGCAGGAAAGCCAATATCCCAGTGGGTTTTAGAACAAATTAGGGATTCTGGAATTAAAGATATATTACTAATTTTAG
GAGATAATACTCCTACACGTGTTGTAGATTACTACGGTGATGGGAGCAAATTTGGAGTAAACATTACTTACGTTTATCAA
GGGAAAGCAAGGGGTTTGGCTGACGCAGTATATAGGGTTAAGGATTTGGTATCTGAGAAATTCCTAGTGTACTTAGGTGA
TAACTTAGTCTTTTATGATCTGAGGAAGTTTCTATCCTTTAAAGGATCGGCATCAATTCTTTTAGCTAAGGTTGATAATC
CTAATCGTTTCGGAGTTGCAGTAATAAATGAGAATAAAGTGATAAGATTAGTTGAAAAGCCTAAGGAAAAAATTTCCGAT
TTAGCTTTGGTAGGGGTTTACGGTTTTACAGATGAAATTTTCGAAGTAATTGAAAAACTAAAACCTAGCTGGAGAGGAGA
ATTAGAAATTACTGACGCAATTCAAGGTTTGATAAATGAAGGTAAGGAAGTAAACTACGAAATTATACAAGGTTGGTGGA
AGGATACTGGAACTCCTAAGGATATCTTAGAAGCAAACTCCTTCTTACTGGATAGGTATGCTGAAAGGAAGATTGAAGGT
GAAGTAGAAAATTCGACAATAGACGGTAGAGTTATATTGGAGAAAGGAGCTGTAGTAAAAAACTCCGTAATTAGAGGCCC
AGCTTACATAGGTAAGGATACTAAGATAATTAATTCTTACATAGGACCTTTCACTTCAATAGGGGATTTAAGTGAAATAT
CCGGCAGCGAGATTGAGTACAGTGTAATCCTCGATAACGTTAGGATTAAAGGTGTTTCACTAATGGATTCTCTAATTGGA
AATAATTCAACTGTAGAAAAGGGTACTAAATGGCAAAAGTTGATAATAGGTGAGAACTCATCGGTGATAATATGA

Upstream 100 bases:

>100_bases
TAGCTAAGAGACCCTACGATTCCTCATTAGACATTTCTAAGGCTAGGAAATTACTTACAATAGATTTTTACACACTGGAT
TTAGAAGGGATGATTTAAAA

Downstream 100 bases:

>100_bases
TAATTATAGGCGGTGCTGGTTTCATAGGTTCAGCGTTTGTAAGGGAGGTTAATAAAAGAGGAATTAAACCAATAGTAGTG
GACTTATTAACTTATGCTGG

Product: sugar phosphate nucleotydyl transferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MEAVILHGGQGTRLRPLTHTGPKQLIKVAGKPISQWVLEQIRDSGIKDILLILGDNTPTRVVDYYGDGSKFGVNITYVYQ
GKARGLADAVYRVKDLVSEKFLVYLGDNLVFYDLRKFLSFKGSASILLAKVDNPNRFGVAVINENKVIRLVEKPKEKISD
LALVGVYGFTDEIFEVIEKLKPSWRGELEITDAIQGLINEGKEVNYEIIQGWWKDTGTPKDILEANSFLLDRYAERKIEG
EVENSTIDGRVILEKGAVVKNSVIRGPAYIGKDTKIINSYIGPFTSIGDLSEISGSEIEYSVILDNVRIKGVSLMDSLIG
NNSTVEKGTKWQKLIIGENSSVII

Sequences:

>Translated_344_residues
MEAVILHGGQGTRLRPLTHTGPKQLIKVAGKPISQWVLEQIRDSGIKDILLILGDNTPTRVVDYYGDGSKFGVNITYVYQ
GKARGLADAVYRVKDLVSEKFLVYLGDNLVFYDLRKFLSFKGSASILLAKVDNPNRFGVAVINENKVIRLVEKPKEKISD
LALVGVYGFTDEIFEVIEKLKPSWRGELEITDAIQGLINEGKEVNYEIIQGWWKDTGTPKDILEANSFLLDRYAERKIEG
EVENSTIDGRVILEKGAVVKNSVIRGPAYIGKDTKIINSYIGPFTSIGDLSEISGSEIEYSVILDNVRIKGVSLMDSLIG
NNSTVEKGTKWQKLIIGENSSVII
>Mature_344_residues
MEAVILHGGQGTRLRPLTHTGPKQLIKVAGKPISQWVLEQIRDSGIKDILLILGDNTPTRVVDYYGDGSKFGVNITYVYQ
GKARGLADAVYRVKDLVSEKFLVYLGDNLVFYDLRKFLSFKGSASILLAKVDNPNRFGVAVINENKVIRLVEKPKEKISD
LALVGVYGFTDEIFEVIEKLKPSWRGELEITDAIQGLINEGKEVNYEIIQGWWKDTGTPKDILEANSFLLDRYAERKIEG
EVENSTIDGRVILEKGAVVKNSVIRGPAYIGKDTKIINSYIGPFTSIGDLSEISGSEIEYSVILDNVRIKGVSLMDSLIG
NNSTVEKGTKWQKLIIGENSSVII

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=328, Percent_Identity=26.8292682926829, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI11761619, Length=328, Percent_Identity=26.8292682926829, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI31881779, Length=372, Percent_Identity=25.2688172043011, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI45447090, Length=372, Percent_Identity=25.2688172043011, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1788351, Length=241, Percent_Identity=34.4398340248963, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1790224, Length=242, Percent_Identity=34.7107438016529, Blast_Score=126, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI133931050, Length=319, Percent_Identity=28.2131661442006, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17509979, Length=346, Percent_Identity=29.4797687861272, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17509981, Length=332, Percent_Identity=27.710843373494, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320148, Length=345, Percent_Identity=30.1449275362319, Blast_Score=134, Evalue=3e-32,
Organism=Drosophila melanogaster, GI21355443, Length=347, Percent_Identity=27.3775216138329, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24644084, Length=347, Percent_Identity=27.3775216138329, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24653912, Length=381, Percent_Identity=27.2965879265092, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 38168; Mature: 38168

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAVILHGGQGTRLRPLTHTGPKQLIKVAGKPISQWVLEQIRDSGIKDILLILGDNTPTR
CCEEEEECCCCCEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCE
VVDYYGDGSKFGVNITYVYQGKARGLADAVYRVKDLVSEKFLVYLGDNLVFYDLRKFLSF
EEEECCCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCC
KGSASILLAKVDNPNRFGVAVINENKVIRLVEKPKEKISDLALVGVYGFTDEIFEVIEKL
CCCCEEEEEEECCCCCEEEEEECCCCEEEEHHCHHHHHHCEEEEEEECCHHHHHHHHHHH
KPSWRGELEITDAIQGLINEGKEVNYEIIQGWWKDTGTPKDILEANSFLLDRYAERKIEG
CCCCCCCEEHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCC
EVENSTIDGRVILEKGAVVKNSVIRGPAYIGKDTKIINSYIGPFTSIGDLSEISGSEIEY
CCCCCCCCCEEEEECCCEECCCEECCCCCCCCCHHHHHHHCCCCCCCCCHHHCCCCCEEE
SVILDNVRIKGVSLMDSLIGNNSTVEKGTKWQKLIIGENSSVII
EEEEECEEEEHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCEEC
>Mature Secondary Structure
MEAVILHGGQGTRLRPLTHTGPKQLIKVAGKPISQWVLEQIRDSGIKDILLILGDNTPTR
CCEEEEECCCCCEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCE
VVDYYGDGSKFGVNITYVYQGKARGLADAVYRVKDLVSEKFLVYLGDNLVFYDLRKFLSF
EEEECCCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCC
KGSASILLAKVDNPNRFGVAVINENKVIRLVEKPKEKISDLALVGVYGFTDEIFEVIEKL
CCCCEEEEEEECCCCCEEEEEECCCCEEEEHHCHHHHHHCEEEEEEECCHHHHHHHHHHH
KPSWRGELEITDAIQGLINEGKEVNYEIIQGWWKDTGTPKDILEANSFLLDRYAERKIEG
CCCCCCCEEHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCC
EVENSTIDGRVILEKGAVVKNSVIRGPAYIGKDTKIINSYIGPFTSIGDLSEISGSEIEY
CCCCCCCCCEEEEECCCEECCCEECCCCCCCCCHHHHHHHCCCCCCCCCHHHCCCCCEEE
SVILDNVRIKGVSLMDSLIGNNSTVEKGTKWQKLIIGENSSVII
EEEEECEEEEHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]