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The map label for this gene is prs [H]

Identifier: 15897912

GI number: 15897912

Start: 903948

End: 904832

Strand: Reverse

Name: prs [H]

Synonym: SSO1045

Alternate gene names: 15897912

Gene position: 904832-903948 (Counterclockwise)

Preceding gene: 15897921

Following gene: 15897911

Centisome position: 30.24

GC content: 34.8

Gene sequence:

>885_bases
ATGATAATAATGATAATAATAGGTGGATCAGCCACTAATGGAATAGACGAAAGCTTATCAAAAATATTATCCATACCTTT
AGTAAAAGTGGAAAACAAAATATTTCCCGATGGGGAATCTTACATAAGAGTACCCTCTTCAATAAGAGATGAAGAAGTAT
TATTAGTACAGACAACAGATTACCCACAAGATAAACATCTAATAGAACTATTTCTAATTGCAGAAACAATAAGGGATCTA
GGAGCTAAAAAACTGACTGCTATAGTACCATACTTAGCATATAGTAGACAAGACAGAAGATTCAAAGATGGAGAAGCAAT
TAGCATAAAAACAATCTTACATATACTGAGCGAAGTAGGAGTTAACACTTTAGTAGTAGTAGAACCACATAAGCCAGAAG
AGTTATCGTACTTTAAAGGGGAACTTAAGATAGTCCATCCTTATCATCAAATTGCGAGAAAAATAAAAGAAATTATCGAA
GACCCATTCATATTGGCACCGGATAGAGGAGCATTAGATAGAGCTAGAAAAATCGCTGAGGAAATTAATGCTCCGTACTC
TTATATCGAAAAGGAAAGGGATAGAACAACGGGTGAAGTCAGAATAAAAGAGGCGCCAAATATTAACCTAAAAGGTAAAG
ATGTAGTTATAATAGACGATATAATTAGCACAGGGGGCACCATAGTACAAGCTACACGCTTAGCCTATTCATTAGGTGCT
AAAAGCGTTACAGCAGCAGCAATTCACCTATTGCTAGTAGGAGGTGCAAAAGAGAGATTAAGAGAGGTGGGAGTAAAAAC
GTTAATAGGAACAAATACCATCAATGTAAATGATAAAGATATAATAACTATAGACGTTTCACAATCAATAGCACTAAGCT
TATGA

Upstream 100 bases:

>100_bases
TTGTCAAGGTTGTCTTTCCTGATCCCGCAGTTCCAAGTATAAAAACATAGTACATATCTCTTTTCACTCAGCTTTTAATC
TTAAAAACTTCCCCTTAAAG

Downstream 100 bases:

>100_bases
AAACTACATCCTATGCCGTATTAAAAGGGAACAACTATTTTTTGTCATTGGCCGAATTGAGAGCTCTGCTTAACGATGAT
AACGCTGAGATTAACTATTT

Product: ribose phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MIIMIIIGGSATNGIDESLSKILSIPLVKVENKIFPDGESYIRVPSSIRDEEVLLVQTTDYPQDKHLIELFLIAETIRDL
GAKKLTAIVPYLAYSRQDRRFKDGEAISIKTILHILSEVGVNTLVVVEPHKPEELSYFKGELKIVHPYHQIARKIKEIIE
DPFILAPDRGALDRARKIAEEINAPYSYIEKERDRTTGEVRIKEAPNINLKGKDVVIIDDIISTGGTIVQATRLAYSLGA
KSVTAAAIHLLLVGGAKERLREVGVKTLIGTNTINVNDKDIITIDVSQSIALSL

Sequences:

>Translated_294_residues
MIIMIIIGGSATNGIDESLSKILSIPLVKVENKIFPDGESYIRVPSSIRDEEVLLVQTTDYPQDKHLIELFLIAETIRDL
GAKKLTAIVPYLAYSRQDRRFKDGEAISIKTILHILSEVGVNTLVVVEPHKPEELSYFKGELKIVHPYHQIARKIKEIIE
DPFILAPDRGALDRARKIAEEINAPYSYIEKERDRTTGEVRIKEAPNINLKGKDVVIIDDIISTGGTIVQATRLAYSLGA
KSVTAAAIHLLLVGGAKERLREVGVKTLIGTNTINVNDKDIITIDVSQSIALSL
>Mature_294_residues
MIIMIIIGGSATNGIDESLSKILSIPLVKVENKIFPDGESYIRVPSSIRDEEVLLVQTTDYPQDKHLIELFLIAETIRDL
GAKKLTAIVPYLAYSRQDRRFKDGEAISIKTILHILSEVGVNTLVVVEPHKPEELSYFKGELKIVHPYHQIARKIKEIIE
DPFILAPDRGALDRARKIAEEINAPYSYIEKERDRTTGEVRIKEAPNINLKGKDVVIIDDIISTGGTIVQATRLAYSLGA
KSVTAAAIHLLLVGGAKERLREVGVKTLIGTNTINVNDKDIITIDVSQSIALSL

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=294, Percent_Identity=27.2108843537415, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI4506129, Length=296, Percent_Identity=26.0135135135135, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI84875539, Length=299, Percent_Identity=26.4214046822742, Blast_Score=114, Evalue=7e-26,
Organism=Homo sapiens, GI28557709, Length=277, Percent_Identity=26.3537906137184, Blast_Score=109, Evalue=3e-24,
Organism=Escherichia coli, GI1787458, Length=281, Percent_Identity=28.4697508896797, Blast_Score=131, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI25149168, Length=272, Percent_Identity=25.3676470588235, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17554704, Length=272, Percent_Identity=25.3676470588235, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17554702, Length=292, Percent_Identity=25, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71989924, Length=292, Percent_Identity=25, Blast_Score=104, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17570245, Length=323, Percent_Identity=22.6006191950464, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320946, Length=292, Percent_Identity=27.0547945205479, Blast_Score=123, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6319403, Length=277, Percent_Identity=25.6317689530686, Blast_Score=115, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6321776, Length=289, Percent_Identity=26.643598615917, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6322667, Length=167, Percent_Identity=23.3532934131737, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21355239, Length=272, Percent_Identity=26.8382352941176, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI45551540, Length=295, Percent_Identity=24.7457627118644, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281362873, Length=302, Percent_Identity=22.8476821192053, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24651454, Length=302, Percent_Identity=22.8476821192053, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24651458, Length=302, Percent_Identity=22.8476821192053, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24651456, Length=302, Percent_Identity=22.8476821192053, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 32537; Mature: 32537

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIMIIIGGSATNGIDESLSKILSIPLVKVENKIFPDGESYIRVPSSIRDEEVLLVQTTD
CEEEEEECCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCEEECCCCCCCCEEEEEEECC
YPQDKHLIELFLIAETIRDLGAKKLTAIVPYLAYSRQDRRFKDGEAISIKTILHILSEVG
CCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHCC
VNTLVVVEPHKPEELSYFKGELKIVHPYHQIARKIKEIIEDPFILAPDRGALDRARKIAE
CCEEEEECCCCCCHHHEECCCEEEECHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHH
EINAPYSYIEKERDRTTGEVRIKEAPNINLKGKDVVIIDDIISTGGTIVQATRLAYSLGA
HHCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEEHHHHCCCHHHHHHHHHHHHCC
KSVTAAAIHLLLVGGAKERLREVGVKTLIGTNTINVNDKDIITIDVSQSIALSL
CHHHHHHHHHHEECCHHHHHHHCCHHHEECCCEECCCCCEEEEEECCCCEEECC
>Mature Secondary Structure
MIIMIIIGGSATNGIDESLSKILSIPLVKVENKIFPDGESYIRVPSSIRDEEVLLVQTTD
CEEEEEECCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCEEECCCCCCCCEEEEEEECC
YPQDKHLIELFLIAETIRDLGAKKLTAIVPYLAYSRQDRRFKDGEAISIKTILHILSEVG
CCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHCC
VNTLVVVEPHKPEELSYFKGELKIVHPYHQIARKIKEIIEDPFILAPDRGALDRARKIAE
CCEEEEECCCCCCHHHEECCCEEEECHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHH
EINAPYSYIEKERDRTTGEVRIKEAPNINLKGKDVVIIDDIISTGGTIVQATRLAYSLGA
HHCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEEHHHHCCCHHHHHHHHHHHHCC
KSVTAAAIHLLLVGGAKERLREVGVKTLIGTNTINVNDKDIITIDVSQSIALSL
CHHHHHHHHHHEECCHHHHHHHCCHHHEECCCEECCCCCEEEEEECCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11427726 [H]