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The map label for this gene is dapA

Identifier: 15926975

GI number: 15926975

Start: 1402003

End: 1402890

Strand: Direct

Name: dapA

Synonym: SA1227

Alternate gene names: 15926975

Gene position: 1402003-1402890 (Clockwise)

Preceding gene: 15926974

Following gene: 15926976

Centisome position: 49.81

GC content: 35.7

Gene sequence:

>888_bases
ATGACACATTTATTTGAGGGTGTTGGCGTTGCACTTACAACCCCTTTTACAAATAACAAAGTTAATCTTGAAGCTTTGAA
AGCACACGTTAATTTTTTACTAGAAAATAATGCCCAAGCAATCATCGTTAATGGAACTACTGCTGAGAGCCCTACTTTAA
CAACAGATGAAAAAGAACGCATTCTAAAAACAGTTATTGATCTTGTAGATAAACGTGTTCCTGTCATAGCTGGAACTGGA
ACTAATGATACTGAAAAGTCAATCCAAGCTTCATTCCAAGCTAAAGCCTTAGGGGCTGATGCAATTATGTTAATTACGCC
CTACTACAACAAAACGAACCAACGTGGTTTAGTCAAACACTTTGAAGCGATTACAGATGCTGTGAAATTACCAGTCGTGC
TGTACAATGTTCCTTCAAGAACGAACATGACAATTGAACCAGAAACTGTAGAAATATTAAGTCAACATCCTTATATAGTT
GCTTTAAAAGATGCTACGAATGATTTTGAGTATTTAGAAGAAGTGAAAAAGCGAATTGATACAAATTCATTTGCATTATA
TAGTGGCAATGATGACAACGTCGTCGAATACTATCAACGTGGCGGTCAAGGGGTTATCTCTGTTATTGCCAATGTCATTC
CTAAAGAATTTCAAGCGTTATACGATGCTCAACAAAGTGGATTAGATATTCAAGATCAATTTAAACCAATCGGCACACTG
TTATCAGCCCTATCAGTTGATATTAACCCAATTCCTATTAAAGCTTTAACAAGTTATTTAGAATTTGGAAACTATGAATT
ACGTTTACCATTGGTTAGCCTAGAAGATACAGATACTAAAGTGCTTCGTGAAGCATATGACACATTTAAAGCGGGTGAAA
ATGAGTGA

Upstream 100 bases:

>100_bases
TTCCATGTATGGTGTACATCAGACAATTTATTAAAAGGTGCTGCATTAAATGCTGTACAAGTATTGGAACAAGTTATGCG
TTTAAAAGGAGCGAATTAAA

Downstream 100 bases:

>100_bases
AAATATTACTAATTGGCTATGGTGCAATGAATCAACGCGTTGCTAGATTAGCAGAAGAAAAAGGACATGAAATCGTTGGG
GTCATTGAAAATACACCGAA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MTHLFEGVGVALTTPFTNNKVNLEALKAHVNFLLENNAQAIIVNGTTAESPTLTTDEKERILKTVIDLVDKRVPVIAGTG
TNDTEKSIQASFQAKALGADAIMLITPYYNKTNQRGLVKHFEAITDAVKLPVVLYNVPSRTNMTIEPETVEILSQHPYIV
ALKDATNDFEYLEEVKKRIDTNSFALYSGNDDNVVEYYQRGGQGVISVIANVIPKEFQALYDAQQSGLDIQDQFKPIGTL
LSALSVDINPIPIKALTSYLEFGNYELRLPLVSLEDTDTKVLREAYDTFKAGENE

Sequences:

>Translated_295_residues
MTHLFEGVGVALTTPFTNNKVNLEALKAHVNFLLENNAQAIIVNGTTAESPTLTTDEKERILKTVIDLVDKRVPVIAGTG
TNDTEKSIQASFQAKALGADAIMLITPYYNKTNQRGLVKHFEAITDAVKLPVVLYNVPSRTNMTIEPETVEILSQHPYIV
ALKDATNDFEYLEEVKKRIDTNSFALYSGNDDNVVEYYQRGGQGVISVIANVIPKEFQALYDAQQSGLDIQDQFKPIGTL
LSALSVDINPIPIKALTSYLEFGNYELRLPLVSLEDTDTKVLREAYDTFKAGENE
>Mature_294_residues
THLFEGVGVALTTPFTNNKVNLEALKAHVNFLLENNAQAIIVNGTTAESPTLTTDEKERILKTVIDLVDKRVPVIAGTGT
NDTEKSIQASFQAKALGADAIMLITPYYNKTNQRGLVKHFEAITDAVKLPVVLYNVPSRTNMTIEPETVEILSQHPYIVA
LKDATNDFEYLEEVKKRIDTNSFALYSGNDDNVVEYYQRGGQGVISVIANVIPKEFQALYDAQQSGLDIQDQFKPIGTLL
SALSVDINPIPIKALTSYLEFGNYELRLPLVSLEDTDTKVLREAYDTFKAGENE

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=278, Percent_Identity=26.978417266187, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI13540533, Length=228, Percent_Identity=27.1929824561404, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1788823, Length=291, Percent_Identity=35.3951890034364, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI1786463, Length=228, Percent_Identity=30.7017543859649, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI87082415, Length=227, Percent_Identity=29.9559471365639, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1789620, Length=229, Percent_Identity=27.5109170305677, Blast_Score=99, Evalue=4e-22,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_STAA1 (A7X271)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001441973.1
- ProteinModelPortal:   A7X271
- SMR:   A7X271
- STRING:   A7X271
- EnsemblBacteria:   EBSTAT00000004871
- GeneID:   5561606
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_1383
- eggNOG:   COG0329
- GeneTree:   EBGT00050000024245
- HOGENOM:   HBG358848
- OMA:   LAYKQDI
- ProtClustDB:   PRK03170
- BioCyc:   SAUR418127:SAHV_1383-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 32660; Mature: 32529

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 163-163 BINDING 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHLFEGVGVALTTPFTNNKVNLEALKAHVNFLLENNAQAIIVNGTTAESPTLTTDEKER
CCCCCCCCCEEEECCCCCCEEHHHHHHHHHHHEEECCCCEEEEECCCCCCCCCCCCHHHH
ILKTVIDLVDKRVPVIAGTGTNDTEKSIQASFQAKALGADAIMLITPYYNKTNQRGLVKH
HHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHH
FEAITDAVKLPVVLYNVPSRTNMTIEPETVEILSQHPYIVALKDATNDFEYLEEVKKRID
HHHHHHHHHCCEEEEECCCCCCEEECCHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCC
TNSFALYSGNDDNVVEYYQRGGQGVISVIANVIPKEFQALYDAQQSGLDIQDQFKPIGTL
CCCEEEEECCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LSALSVDINPIPIKALTSYLEFGNYELRLPLVSLEDTDTKVLREAYDTFKAGENE
HHHHHCCCCCCCHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
THLFEGVGVALTTPFTNNKVNLEALKAHVNFLLENNAQAIIVNGTTAESPTLTTDEKER
CCCCCCCCEEEECCCCCCEEHHHHHHHHHHHEEECCCCEEEEECCCCCCCCCCCCHHHH
ILKTVIDLVDKRVPVIAGTGTNDTEKSIQASFQAKALGADAIMLITPYYNKTNQRGLVKH
HHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHH
FEAITDAVKLPVVLYNVPSRTNMTIEPETVEILSQHPYIVALKDATNDFEYLEEVKKRID
HHHHHHHHHCCEEEEECCCCCCEEECCHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCC
TNSFALYSGNDDNVVEYYQRGGQGVISVIANVIPKEFQALYDAQQSGLDIQDQFKPIGTL
CCCEEEEECCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LSALSVDINPIPIKALTSYLEFGNYELRLPLVSLEDTDTKVLREAYDTFKAGENE
HHHHHCCCCCCCHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA