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The map label for this gene is lysC

Identifier: 15926973

GI number: 15926973

Start: 1399743

End: 1400948

Strand: Direct

Name: lysC

Synonym: SA1225

Alternate gene names: 15926973

Gene position: 1399743-1400948 (Clockwise)

Preceding gene: 15926972

Following gene: 15926974

Centisome position: 49.73

GC content: 34.74

Gene sequence:

>1206_bases
ATGGTAACAAGAAGTGTGTTGAAATTTGGCGGATCATCCGTCAGTGATTTTACAAAAATAAAAAGGATCGCTGAAATGTT
AAAGGAGCGAGTCAATCAAGATGAACAATTAATTGTCGTTGTAAGTGCTATGGGTAACACAACAGATCAATTAATGACGA
ATGTATCGACCTTGACTAAAGCACCAAAACAACAAGAACTGGCATTATTATTGACAACCGGAGAGCAACAAACTGTATCT
TATTTATCAATGGTATTAAATGATATCGGTGTGAATGCCAAAGCAATGACTGGCTATCAAGCGGGTATTAAAACCATTGG
CCATCATTTAAAAAGTAAAATTGCTCAAATTAATCCTCAAACATTTGAACAAGCCTTTCAAGAAAACGATATTTTAGTAG
TTGCTGGATTTCAAGGCATCAATGAACATCAGGAATTAACAACTTTAGGCAGAGGCGGTTCTGATACGACCGCTGTGGCA
CTTGCTGTTAGTAATCAAATACCTTGTGAAATTTATACCGACGTTGATGGTGTGTATGCCACTGACCCAAGACTTTTACC
AAAGGCTAAACGACTAGACATCGTCTCATATGAAGAAATGATGGAAATGAGCGCTTTAGGTGCTGGTGTACTTGAAACAA
GAAGTGTTGAATTAGCTAAAAACTATAATATCCCTTTATATTTAGGAAAAACTTTATCGAACGTGAAAGGAACATGGATT
ATGTCAAATGAAGAAATATTAGAGAAAAAAGCAGTTACTGGTGTGGCTTTGGATAAACATATGATGCATGTAACAATTAG
TTATCCCCTACCTGACAATCAGCTACTTACCCAACTATTTACGGAACTTGAAGAAGGTGCTGTAAATGTTGATATGATTT
CACAAATCGTCAACTTGGATGGGCTACAACTATCCTTCACGATTAAAGATAGTGATTTTCATCAAATTTCTATGATTCTT
GAAACATTAAAGAATCAATATGAAGCATTAGCTTATAAAATCAATGAGCATTATGTCAAAATTTCATTAATTGGCTCAGG
CATGCGTGATATGTCAGGTGTGGCATCAAAAGCATTTTTGACATTAATTGAAAATAATATACCTTTCTACCAAACAACAA
CATCTGAAATAAGTATTTCATACGTCATTGATGATTTTAATGGGCAACAAGCGGTAGAAAAACTATATGACGCATTTAAC
ATTTAA

Upstream 100 bases:

>100_bases
ATGGAGTGCATCACTTGTATATAGATTAAGAGCAAGTTCGCATTCCGAACTTGTTCTTTTTTTATTATTGTGTGCCCTTC
CTAACAATTAGGAGGATTAT

Downstream 100 bases:

>100_bases
TGGTAAAATGATTGTTAAAATATTCTAAAAATTGGAAATTATTATAAAATGGAGTGACAAGTTATGACAAAGTTAGCAGT
TGTGGGTGCAACAGGATTAG

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase 2; Aspartokinase II [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MVTRSVLKFGGSSVSDFTKIKRIAEMLKERVNQDEQLIVVVSAMGNTTDQLMTNVSTLTKAPKQQELALLLTTGEQQTVS
YLSMVLNDIGVNAKAMTGYQAGIKTIGHHLKSKIAQINPQTFEQAFQENDILVVAGFQGINEHQELTTLGRGGSDTTAVA
LAVSNQIPCEIYTDVDGVYATDPRLLPKAKRLDIVSYEEMMEMSALGAGVLETRSVELAKNYNIPLYLGKTLSNVKGTWI
MSNEEILEKKAVTGVALDKHMMHVTISYPLPDNQLLTQLFTELEEGAVNVDMISQIVNLDGLQLSFTIKDSDFHQISMIL
ETLKNQYEALAYKINEHYVKISLIGSGMRDMSGVASKAFLTLIENNIPFYQTTTSEISISYVIDDFNGQQAVEKLYDAFN
I

Sequences:

>Translated_401_residues
MVTRSVLKFGGSSVSDFTKIKRIAEMLKERVNQDEQLIVVVSAMGNTTDQLMTNVSTLTKAPKQQELALLLTTGEQQTVS
YLSMVLNDIGVNAKAMTGYQAGIKTIGHHLKSKIAQINPQTFEQAFQENDILVVAGFQGINEHQELTTLGRGGSDTTAVA
LAVSNQIPCEIYTDVDGVYATDPRLLPKAKRLDIVSYEEMMEMSALGAGVLETRSVELAKNYNIPLYLGKTLSNVKGTWI
MSNEEILEKKAVTGVALDKHMMHVTISYPLPDNQLLTQLFTELEEGAVNVDMISQIVNLDGLQLSFTIKDSDFHQISMIL
ETLKNQYEALAYKINEHYVKISLIGSGMRDMSGVASKAFLTLIENNIPFYQTTTSEISISYVIDDFNGQQAVEKLYDAFN
I
>Mature_401_residues
MVTRSVLKFGGSSVSDFTKIKRIAEMLKERVNQDEQLIVVVSAMGNTTDQLMTNVSTLTKAPKQQELALLLTTGEQQTVS
YLSMVLNDIGVNAKAMTGYQAGIKTIGHHLKSKIAQINPQTFEQAFQENDILVVAGFQGINEHQELTTLGRGGSDTTAVA
LAVSNQIPCEIYTDVDGVYATDPRLLPKAKRLDIVSYEEMMEMSALGAGVLETRSVELAKNYNIPLYLGKTLSNVKGTWI
MSNEEILEKKAVTGVALDKHMMHVTISYPLPDNQLLTQLFTELEEGAVNVDMISQIVNLDGLQLSFTIKDSDFHQISMIL
ETLKNQYEALAYKINEHYVKISLIGSGMRDMSGVASKAFLTLIENNIPFYQTTTSEISISYVIDDFNGQQAVEKLYDAFN
I

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=450, Percent_Identity=27.3333333333333, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1790455, Length=272, Percent_Identity=27.2058823529412, Blast_Score=90, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320893, Length=372, Percent_Identity=25, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44343; Mature: 44343

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTRSVLKFGGSSVSDFTKIKRIAEMLKERVNQDEQLIVVVSAMGNTTDQLMTNVSTLTK
CCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHC
APKQQELALLLTTGEQQTVSYLSMVLNDIGVNAKAMTGYQAGIKTIGHHLKSKIAQINPQ
CCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHCCHH
TFEQAFQENDILVVAGFQGINEHQELTTLGRGGSDTTAVALAVSNQIPCEIYTDVDGVYA
HHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEECCCCEEE
TDPRLLPKAKRLDIVSYEEMMEMSALGAGVLETRSVELAKNYNIPLYLGKTLSNVKGTWI
CCCCCCCCHHHCCEECHHHHHHHHHHCCCHHHCCCEEHHHCCCCEEEECCHHCCCCCEEE
MSNEEILEKKAVTGVALDKHMMHVTISYPLPDNQLLTQLFTELEEGAVNVDMISQIVNLD
ECCHHHHHHHHHHHEEECCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCC
GLQLSFTIKDSDFHQISMILETLKNQYEALAYKINEHYVKISLIGSGMRDMSGVASKAFL
CEEEEEEEECCCHHHHHHHHHHHHHHHHHHHEEECCEEEEEEEECCCCHHHHHHHHHHHH
TLIENNIPFYQTTTSEISISYVIDDFNGQQAVEKLYDAFNI
HHHHCCCCCEEECCCCEEEEEEEECCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MVTRSVLKFGGSSVSDFTKIKRIAEMLKERVNQDEQLIVVVSAMGNTTDQLMTNVSTLTK
CCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHC
APKQQELALLLTTGEQQTVSYLSMVLNDIGVNAKAMTGYQAGIKTIGHHLKSKIAQINPQ
CCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHCCHH
TFEQAFQENDILVVAGFQGINEHQELTTLGRGGSDTTAVALAVSNQIPCEIYTDVDGVYA
HHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEECCCCEEE
TDPRLLPKAKRLDIVSYEEMMEMSALGAGVLETRSVELAKNYNIPLYLGKTLSNVKGTWI
CCCCCCCCHHHCCEECHHHHHHHHHHCCCHHHCCCEEHHHCCCCEEEECCHHCCCCCEEE
MSNEEILEKKAVTGVALDKHMMHVTISYPLPDNQLLTQLFTELEEGAVNVDMISQIVNLD
ECCHHHHHHHHHHHEEECCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCC
GLQLSFTIKDSDFHQISMILETLKNQYEALAYKINEHYVKISLIGSGMRDMSGVASKAFL
CEEEEEEEECCCHHHHHHHHHHHHHHHHHHHEEECCEEEEEEEECCCCHHHHHHHHHHHH
TLIENNIPFYQTTTSEISISYVIDDFNGQQAVEKLYDAFNI
HHHHCCCCCEEECCCCEEEEEEEECCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1444390 [H]