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The map label for this gene is femB

Identifier: 15926955

GI number: 15926955

Start: 1380485

End: 1381744

Strand: Direct

Name: femB

Synonym: SA1207

Alternate gene names: 15926955

Gene position: 1380485-1381744 (Clockwise)

Preceding gene: 15926954

Following gene: 15926956

Centisome position: 49.04

GC content: 31.59

Gene sequence:

>1260_bases
ATGAAATTTACAGAGTTAACTGTTACCGAATTTGACAACTTTGTACAAAATCCATCATTGGAAAGTCATTATTTCCAAGT
AAAAGAAAATATAGTTACCCGTGAGAATGATGGCTTTGAAGTAGTTTTATTAGGTATTAAAGACGACAATAACAAAGTAA
TTGCAGCAAGCCTTTTCTCTAAAATTCCTACTATGGGAAGTTATGTTTACTATTCGAATCGTGGTCCAGTAATGGATTTT
TCAGATTTAGGATTAGTTGATTATTATTTAAAAGAGTTAGATAAATATTTACAGCAACATCAATGTTTATATGTTAAATT
AGATCCGTATTGGTTATATCATCTATATGATAAAGATATCGTGCCATTTGAAGGTCGCGAGAAAAATGATGCCTTAGTAA
ACTTGTTTAAATCACATGGTTACGAGCATCATGGCTTTACAACTGAGTATGATACATCGAGCCAAGTACGATGGATGGGC
GTATTAAACCTTGAAGGTAAAACACCCGAAACATTGAAAAAGACATTTGATAGTCAACGTAAACGTAATATTAATAAAGC
GATAAACTATGGTGTTAAAGTCAGATTCCTTGAACGTGATGAGTTCAATCTTTTCTTAGATTTATATCGTGAAACTGAAG
AGCGTGCTGGATTTGTGTCAAAAACAGATGATTATTTTTATAACTTTATTGACACATATGGAGATAAAGTATTAGTACCA
TTAGCATATATTGACCTTGATGAATATGTGTTAAAGTTGCAACAGGAATTGAATGACAAAGAAAATCGTCGTGATCAAAT
GATGGCGAAAGAAAACAAATCAGATAAACAAATGAAGAAAATTGCAGAATTAGATAAGCAAATTGATCATGATCAGCATG
AATTATTGAATGCAAGTGAATTGAGCAAAACGGACGGCCCAATTCTAAACCTTGCTTCTGGCGTTTATTTTGCAAATGCA
TATGAAGTGAATTATTTCTCTGGTGGTTCATCAGAAAAATATAATCAATTTATGGGACCATACATGATGCATTGGTTTAT
GATTAACTATTGCTTCGATAATGGCTATGATCGTTATAATTTCTATGGTTTATCAGGTGATTTTACGGAAAACAGTGAAG
ATTATGGCGTATACCGCTTTAAACGTGGATTTAATGTACAAATCGAAGAATTAATAGGGGATTTCTATAAACCAATTCAT
AAAGTGAAATATTGGTTGTTCACAACATTGGATAAATTACGTAAAAAATTAAAGAAATAG

Upstream 100 bases:

>100_bases
TGGTGACTTTATTAAACCAATTAATAAACCTGTTTACGCAGCATATACCGCACTTAAAAAAGTTAAAGACAGAATTTTTT
AGGAAGGGAATTATCAAAAC

Downstream 100 bases:

>100_bases
ATGTAAATGATGTTAGGGCTTATAGTTATTGATACTATAGGCTCTTTTTTATGCTTTTTTTAGCGAAATTTTAATTATTT
CACACTAAGAAAAACTAGTA

Product: FemB protein

Products: NA

Alternate protein names: Factor essential for expression of methicillin resistance B

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MKFTELTVTEFDNFVQNPSLESHYFQVKENIVTRENDGFEVVLLGIKDDNNKVIAASLFSKIPTMGSYVYYSNRGPVMDF
SDLGLVDYYLKELDKYLQQHQCLYVKLDPYWLYHLYDKDIVPFEGREKNDALVNLFKSHGYEHHGFTTEYDTSSQVRWMG
VLNLEGKTPETLKKTFDSQRKRNINKAINYGVKVRFLERDEFNLFLDLYRETEERAGFVSKTDDYFYNFIDTYGDKVLVP
LAYIDLDEYVLKLQQELNDKENRRDQMMAKENKSDKQMKKIAELDKQIDHDQHELLNASELSKTDGPILNLASGVYFANA
YEVNYFSGGSSEKYNQFMGPYMMHWFMINYCFDNGYDRYNFYGLSGDFTENSEDYGVYRFKRGFNVQIEELIGDFYKPIH
KVKYWLFTTLDKLRKKLKK

Sequences:

>Translated_419_residues
MKFTELTVTEFDNFVQNPSLESHYFQVKENIVTRENDGFEVVLLGIKDDNNKVIAASLFSKIPTMGSYVYYSNRGPVMDF
SDLGLVDYYLKELDKYLQQHQCLYVKLDPYWLYHLYDKDIVPFEGREKNDALVNLFKSHGYEHHGFTTEYDTSSQVRWMG
VLNLEGKTPETLKKTFDSQRKRNINKAINYGVKVRFLERDEFNLFLDLYRETEERAGFVSKTDDYFYNFIDTYGDKVLVP
LAYIDLDEYVLKLQQELNDKENRRDQMMAKENKSDKQMKKIAELDKQIDHDQHELLNASELSKTDGPILNLASGVYFANA
YEVNYFSGGSSEKYNQFMGPYMMHWFMINYCFDNGYDRYNFYGLSGDFTENSEDYGVYRFKRGFNVQIEELIGDFYKPIH
KVKYWLFTTLDKLRKKLKK
>Mature_419_residues
MKFTELTVTEFDNFVQNPSLESHYFQVKENIVTRENDGFEVVLLGIKDDNNKVIAASLFSKIPTMGSYVYYSNRGPVMDF
SDLGLVDYYLKELDKYLQQHQCLYVKLDPYWLYHLYDKDIVPFEGREKNDALVNLFKSHGYEHHGFTTEYDTSSQVRWMG
VLNLEGKTPETLKKTFDSQRKRNINKAINYGVKVRFLERDEFNLFLDLYRETEERAGFVSKTDDYFYNFIDTYGDKVLVP
LAYIDLDEYVLKLQQELNDKENRRDQMMAKENKSDKQMKKIAELDKQIDHDQHELLNASELSKTDGPILNLASGVYFANA
YEVNYFSGGSSEKYNQFMGPYMMHWFMINYCFDNGYDRYNFYGLSGDFTENSEDYGVYRFKRGFNVQIEELIGDFYKPIH
KVKYWLFTTLDKLRKKLKK

Specific function: Catalyzes the formation of the pentaglycine interpeptide bridge, which is characteristic of the S.aureus peptidoglycan. Adds glycines 4 and 5 of the pentaglycine bridge, using glycyl- tRNA(Gly) as donor. Involved in resistance to methicillin

COG id: COG2348

COG function: function code V; Uncharacterized protein involved in methicillin resistance

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the femABX family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FEMB_STAA8 (Q2FYR1)

Other databases:

- EMBL:   CP000253
- RefSeq:   YP_499901.1
- ProteinModelPortal:   Q2FYR1
- SMR:   Q2FYR1
- STRING:   Q2FYR1
- EnsemblBacteria:   EBSTAT00000028311
- GeneID:   3920783
- GenomeReviews:   CP000253_GR
- KEGG:   sao:SAOUHSC_01374
- eggNOG:   COG2348
- GeneTree:   EBGT00050000023974
- HOGENOM:   HBG535278
- OMA:   SEKYNQY
- ProtClustDB:   CLSK885230
- BioCyc:   SAUR93061:SAOUHSC_01374-MONOMER
- GO:   GO:0005737
- InterPro:   IPR016181
- InterPro:   IPR003447
- Gene3D:   G3DSA:3.40.630.30

Pfam domain/function: PF02388 FemAB; SSF55729 Acyl_CoA_acyltransferase

EC number: NA

Molecular weight: Translated: 49677; Mature: 49677

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS51191 FEMABX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFTELTVTEFDNFVQNPSLESHYFQVKENIVTRENDGFEVVLLGIKDDNNKVIAASLFS
CCCEEEEHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCEEHHHHHH
KIPTMGSYVYYSNRGPVMDFSDLGLVDYYLKELDKYLQQHQCLYVKLDPYWLYHLYDKDI
HCCCCCCEEEECCCCCCCCCHHCCHHHHHHHHHHHHHHHCCEEEEEECCEEEEEEECCCC
VPFEGREKNDALVNLFKSHGYEHHGFTTEYDTSSQVRWMGVLNLEGKTPETLKKTFDSQR
CCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHH
KRNINKAINYGVKVRFLERDEFNLFLDLYRETEERAGFVSKTDDYFYNFIDTYGDKVLVP
HHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEE
LAYIDLDEYVLKLQQELNDKENRRDQMMAKENKSDKQMKKIAELDKQIDHDQHELLNASE
EEEECHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHCCHHH
LSKTDGPILNLASGVYFANAYEVNYFSGGSSEKYNQFMGPYMMHWFMINYCFDNGYDRYN
CCCCCCCEEEHHCCEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
FYGLSGDFTENSEDYGVYRFKRGFNVQIEELIGDFYKPIHKVKYWLFTTLDKLRKKLKK
EEECCCCCCCCCCCCCEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKFTELTVTEFDNFVQNPSLESHYFQVKENIVTRENDGFEVVLLGIKDDNNKVIAASLFS
CCCEEEEHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCEEHHHHHH
KIPTMGSYVYYSNRGPVMDFSDLGLVDYYLKELDKYLQQHQCLYVKLDPYWLYHLYDKDI
HCCCCCCEEEECCCCCCCCCHHCCHHHHHHHHHHHHHHHCCEEEEEECCEEEEEEECCCC
VPFEGREKNDALVNLFKSHGYEHHGFTTEYDTSSQVRWMGVLNLEGKTPETLKKTFDSQR
CCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHH
KRNINKAINYGVKVRFLERDEFNLFLDLYRETEERAGFVSKTDDYFYNFIDTYGDKVLVP
HHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEE
LAYIDLDEYVLKLQQELNDKENRRDQMMAKENKSDKQMKKIAELDKQIDHDQHELLNASE
EEEECHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHCCHHH
LSKTDGPILNLASGVYFANAYEVNYFSGGSSEKYNQFMGPYMMHWFMINYCFDNGYDRYN
CCCCCCCEEEHHCCEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
FYGLSGDFTENSEDYGVYRFKRGFNVQIEELIGDFYKPIHKVKYWLFTTLDKLRKKLKK
EEECCCCCCCCCCCCCEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA