Click here to switch to the map view.

The map label for this gene is thrB

Identifier: 15926911

GI number: 15926911

Start: 1327841

End: 1328755

Strand: Direct

Name: thrB

Synonym: SA1166

Alternate gene names: 15926911

Gene position: 1327841-1328755 (Clockwise)

Preceding gene: 15926910

Following gene: 15926912

Centisome position: 47.17

GC content: 35.96

Gene sequence:

>915_bases
ATGTCGAATGTTTTGGAGTTAACAATTCCTGCATCAACAGCCAACCTTGGAGTTGGCTTTGATTCTATAGGTATGGCTTT
AGATAAATTTTTGCATCTGTCTGTAAAGGAAACATCAGGGACAAAATGGGAATATATTTTCCATGATGATGCATCTAAGC
AATTGCCTACTGACGAAACAAACTTTATTTATCATGTAGCACAACAAGTTGCTTCTAAATATAGTGTTGACTTGCCTATT
TTATGTATCGAAATGAGAAGTGATATTCCATTGGCAAGAGGGTTAGGTTCGTCAGCTTCTGCTTTAGTAGGAGCTATATA
TATCGCAAATTATTTTGGTGATATCCAACTGTCTAAACATGAGGTATTACAATTAGCGACTGAAATCGAAGGACATCCTG
ATAATGTTGCGCCGACCATTTATGGTGGTTTAATCGCTGGATTTTATAATGATGTCTCGAAAGAAACGTCAGTTGCACAT
ATCGACATACCAGACGTGGATGTGATTGTAACGATACCAACTTATGAACTAAAAACAGAAGCATCAAGACGTGCTTTACC
ACAAAAATTAACACATAGTGAAGCGGTAAAAAGTAGTGCAATTAGTAATACAATGATTTGTGCATTAGCACAGCACAATT
ATGAATTAGCAGGTAAACTCATGCAACAAGATGGCTTTCATGAACCGTATCGTCAGCATTTAATTGCTGAATTTGATGAA
GTGAAAACAATTGCTAGTCAACATAATGCCTATGCAACTGTAATTAGTGGTGCTGGACCAACTATTTTAATATTTAGTCG
TAAAGAAAATAGTGGGGAATTGGTTCGCTCTTTAAATAGTCAGGTAGTATCATGCCATTCTGAATTGGTCGATATTAATA
TCAGTGGTGTTAAAGAACGAATTGTATACCAATAG

Upstream 100 bases:

>100_bases
AAAGATCCTGATACTGCTATTTCACTACTAGATAATCCGATAAAGCCATTGCAAAATGATAAAGATAGCATTATCGATTA
TATTAAAGGAGCTTTATAAC

Downstream 100 bases:

>100_bases
ACGCTTTATATTGTAAAATAGTATTAAATGCAGAATAGAGAGGAGATTTAATGCGATATGACAAATTATAAAGTTGTCGT
TTTAGATATGGATGACACAT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MSNVLELTIPASTANLGVGFDSIGMALDKFLHLSVKETSGTKWEYIFHDDASKQLPTDETNFIYHVAQQVASKYSVDLPI
LCIEMRSDIPLARGLGSSASALVGAIYIANYFGDIQLSKHEVLQLATEIEGHPDNVAPTIYGGLIAGFYNDVSKETSVAH
IDIPDVDVIVTIPTYELKTEASRRALPQKLTHSEAVKSSAISNTMICALAQHNYELAGKLMQQDGFHEPYRQHLIAEFDE
VKTIASQHNAYATVISGAGPTILIFSRKENSGELVRSLNSQVVSCHSELVDINISGVKERIVYQ

Sequences:

>Translated_304_residues
MSNVLELTIPASTANLGVGFDSIGMALDKFLHLSVKETSGTKWEYIFHDDASKQLPTDETNFIYHVAQQVASKYSVDLPI
LCIEMRSDIPLARGLGSSASALVGAIYIANYFGDIQLSKHEVLQLATEIEGHPDNVAPTIYGGLIAGFYNDVSKETSVAH
IDIPDVDVIVTIPTYELKTEASRRALPQKLTHSEAVKSSAISNTMICALAQHNYELAGKLMQQDGFHEPYRQHLIAEFDE
VKTIASQHNAYATVISGAGPTILIFSRKENSGELVRSLNSQVVSCHSELVDINISGVKERIVYQ
>Mature_303_residues
SNVLELTIPASTANLGVGFDSIGMALDKFLHLSVKETSGTKWEYIFHDDASKQLPTDETNFIYHVAQQVASKYSVDLPIL
CIEMRSDIPLARGLGSSASALVGAIYIANYFGDIQLSKHEVLQLATEIEGHPDNVAPTIYGGLIAGFYNDVSKETSVAHI
DIPDVDVIVTIPTYELKTEASRRALPQKLTHSEAVKSSAISNTMICALAQHNYELAGKLMQQDGFHEPYRQHLIAEFDEV
KTIASQHNAYATVISGAGPTILIFSRKENSGELVRSLNSQVVSCHSELVDINISGVKERIVYQ

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily

Homologues:

Organism=Escherichia coli, GI1786184, Length=290, Percent_Identity=26.8965517241379, Blast_Score=100, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6321814, Length=347, Percent_Identity=27.0893371757925, Blast_Score=107, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_STAA1 (A7X1Y2)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001441909.1
- ProteinModelPortal:   A7X1Y2
- SMR:   A7X1Y2
- STRING:   A7X1Y2
- EnsemblBacteria:   EBSTAT00000004182
- GeneID:   5560865
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_1319
- eggNOG:   COG0083
- GeneTree:   EBGT00050000025538
- HOGENOM:   HBG646290
- OMA:   FDCLGAA
- ProtClustDB:   PRK01212
- BioCyc:   SAUR418127:SAHV_1319-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00384
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000676
- PRINTS:   PR00958
- TIGRFAMs:   TIGR00191

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.39

Molecular weight: Translated: 33250; Mature: 33119

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNVLELTIPASTANLGVGFDSIGMALDKFLHLSVKETSGTKWEYIFHDDASKQLPTDET
CCCEEEEEECCCCCCCCCCHHHHHHHHHHHHEEEEECCCCCEEEEEEECCCCCCCCCCCH
NFIYHVAQQVASKYSVDLPILCIEMRSDIPLARGLGSSASALVGAIYIANYFGDIQLSKH
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHCCCCCHHHHHHHHHHHHHHCCEEECHH
EVLQLATEIEGHPDNVAPTIYGGLIAGFYNDVSKETSVAHIDIPDVDVIVTIPTYELKTE
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCHHHCC
ASRRALPQKLTHSEAVKSSAISNTMICALAQHNYELAGKLMQQDGFHEPYRQHLIAEFDE
HHHHHHHHHHHHHHHHHHHHHCHHEEEEEHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
VKTIASQHNAYATVISGAGPTILIFSRKENSGELVRSLNSQVVSCHSELVDINISGVKER
HHHHHHCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHEEEECCCHHHH
IVYQ
HCCC
>Mature Secondary Structure 
SNVLELTIPASTANLGVGFDSIGMALDKFLHLSVKETSGTKWEYIFHDDASKQLPTDET
CCEEEEEECCCCCCCCCCHHHHHHHHHHHHEEEEECCCCCEEEEEEECCCCCCCCCCCH
NFIYHVAQQVASKYSVDLPILCIEMRSDIPLARGLGSSASALVGAIYIANYFGDIQLSKH
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHCCCCCHHHHHHHHHHHHHHCCEEECHH
EVLQLATEIEGHPDNVAPTIYGGLIAGFYNDVSKETSVAHIDIPDVDVIVTIPTYELKTE
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCHHHCC
ASRRALPQKLTHSEAVKSSAISNTMICALAQHNYELAGKLMQQDGFHEPYRQHLIAEFDE
HHHHHHHHHHHHHHHHHHHHHCHHEEEEEHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
VKTIASQHNAYATVISGAGPTILIFSRKENSGELVRSLNSQVVSCHSELVDINISGVKER
HHHHHHCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHEEEECCCHHHH
IVYQ
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA