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The map label for this gene is cls1 [H]

Identifier: 15926899

GI number: 15926899

Start: 1315993

End: 1317510

Strand: Direct

Name: cls1 [H]

Synonym: SA1155

Alternate gene names: 15926899

Gene position: 1315993-1317510 (Clockwise)

Preceding gene: 15926898

Following gene: 15926900

Centisome position: 46.75

GC content: 31.49

Gene sequence:

>1518_bases
ATGTTTTTTGTGCCTTTCTTTATAGGAGAAAAGACTATGCGATATACATTTTCAAATGATTTAGGAACACTTTTTACCAT
TATTTTAGCCATTGGATTCATCATTAATTTAGTATTGGCTTTTATTATTATCTTTTTAGAAAGAAATAGACGTACAGCGA
GTTCAACTTGGGCATGGCTATTTGTACTTTTTGTCTTACCATTGATTGGTTTTATTCTTTACTTGTTTTTTGGTAGAACC
GTTTCGGCACGTAAATTGAATAAAAACAATGGTAACGTGTTAACGGATTTCGATGGACTTTTAAAACAACAAATAGAAAG
CTTTGATAAAGGTAATTATGGTACTGATAACAAACAAGTTCAAAAACATCATGATTTAGTAAGTATGCTTTTGATGGATC
AAGATGGTTTTTTAACTGAAAATAATAAAGTTGATCATTTCATTGATGGAAATGATTTATATGATCAAGTTTTAAAAGAT
ATTAAAAATGCAAAAGAATATATCCATTTAGAGTACTATACTTTCGCTTTAGATGGTTTAGGTAAAAGAATTTTACATGC
TTTAGAAGAAAAATTGAAACAAGGTCTAGAAGTAAAAATATTATATGATGATGTTGGATCTAAAAATGTTAAGATGGCAA
ATTTTGATCACTTTAAATCATTAGGTGGCGAAGTTGAAGCATTTTTTGCTTCTAAATTACCCTTATTAAATTTCCGTATG
AATAACAGAAATCATAGAAAAATCATCGTAATCGATGGTCAACTAGGTTATGTCGGAGGATTTAACATTGGTGATGAATA
TCTAGGATTAGGTAAACTAGGGTATTGGAGAGATACGCATTTACGTATACAAGGGGATGCGGTTGATGCACTGCAGTTGC
GATTTATTTTAGACTGGAATTCGCAAGCGCACCGTCCACAGTTTGAATATGATGTTAAGTATTTCCCTAAAAAGAACGGA
CCATTGGGCAATTCACCAATTCAAATAGCTGCAAGTGGCCCAGCTAGTGACTGGCATCAAATTGAATATGGTTATACAAA
AATGATTATGAGCGCTAAGAAGTCGGTATATTTGCAATCGCCTTATTTCATTCCGGATAACTCATATATAAATGCCATTA
AAATTGCAGCTAAATCAGGTGTAGATGTTCATCTAATGATTCCATGTAAGCCAGATCATCCTTTAGTTTATTGGGCGACA
TTTTCAAATGCCTCTGACTTATTATCAAGTGGTGTTAAAATTTATACGTATGAAAATGGATTTATACATTCTAAAATGTG
CTTAATTGATGATGAAATCGTATCAGTGGGCACAGCAAATATGGACTTTAGAAGTTTTGAATTAAATTTTGAAGTAAATG
CCTTTGTATATGATGAAAATCTTGCTAAGGATTTAAGGGTGGCTTATGAACATGATATTACAAAATCAAAACAACTAACC
AAAGAATCATATGCCAATAGACCGCTGTCTGTTAAATTCAAAGAATCGTTAGCAAAATTAGTTTCGCCAATTTTATAA

Upstream 100 bases:

>100_bases
TTAAAGAAATAGAAGAAAGAACATTCCCAAATAATGAAGAAGAATTCAATGCAATTTTAACTTTATCTGTGAATAAATAA
TATGATGTGAAAGGTGCAAA

Downstream 100 bases:

>100_bases
TTTATTTGTAAGGAGTCTCGATTATAGAGGCTCTTTTTATTTTGCCCAAAATTAAAATAACGATAAATATATTATGTAAA
CCTAATAATGACATTTGTCA

Product: hypothetical protein

Products: NA

Alternate protein names: CL synthase 1 [H]

Number of amino acids: Translated: 505; Mature: 505

Protein sequence:

>505_residues
MFFVPFFIGEKTMRYTFSNDLGTLFTIILAIGFIINLVLAFIIIFLERNRRTASSTWAWLFVLFVLPLIGFILYLFFGRT
VSARKLNKNNGNVLTDFDGLLKQQIESFDKGNYGTDNKQVQKHHDLVSMLLMDQDGFLTENNKVDHFIDGNDLYDQVLKD
IKNAKEYIHLEYYTFALDGLGKRILHALEEKLKQGLEVKILYDDVGSKNVKMANFDHFKSLGGEVEAFFASKLPLLNFRM
NNRNHRKIIVIDGQLGYVGGFNIGDEYLGLGKLGYWRDTHLRIQGDAVDALQLRFILDWNSQAHRPQFEYDVKYFPKKNG
PLGNSPIQIAASGPASDWHQIEYGYTKMIMSAKKSVYLQSPYFIPDNSYINAIKIAAKSGVDVHLMIPCKPDHPLVYWAT
FSNASDLLSSGVKIYTYENGFIHSKMCLIDDEIVSVGTANMDFRSFELNFEVNAFVYDENLAKDLRVAYEHDITKSKQLT
KESYANRPLSVKFKESLAKLVSPIL

Sequences:

>Translated_505_residues
MFFVPFFIGEKTMRYTFSNDLGTLFTIILAIGFIINLVLAFIIIFLERNRRTASSTWAWLFVLFVLPLIGFILYLFFGRT
VSARKLNKNNGNVLTDFDGLLKQQIESFDKGNYGTDNKQVQKHHDLVSMLLMDQDGFLTENNKVDHFIDGNDLYDQVLKD
IKNAKEYIHLEYYTFALDGLGKRILHALEEKLKQGLEVKILYDDVGSKNVKMANFDHFKSLGGEVEAFFASKLPLLNFRM
NNRNHRKIIVIDGQLGYVGGFNIGDEYLGLGKLGYWRDTHLRIQGDAVDALQLRFILDWNSQAHRPQFEYDVKYFPKKNG
PLGNSPIQIAASGPASDWHQIEYGYTKMIMSAKKSVYLQSPYFIPDNSYINAIKIAAKSGVDVHLMIPCKPDHPLVYWAT
FSNASDLLSSGVKIYTYENGFIHSKMCLIDDEIVSVGTANMDFRSFELNFEVNAFVYDENLAKDLRVAYEHDITKSKQLT
KESYANRPLSVKFKESLAKLVSPIL
>Mature_505_residues
MFFVPFFIGEKTMRYTFSNDLGTLFTIILAIGFIINLVLAFIIIFLERNRRTASSTWAWLFVLFVLPLIGFILYLFFGRT
VSARKLNKNNGNVLTDFDGLLKQQIESFDKGNYGTDNKQVQKHHDLVSMLLMDQDGFLTENNKVDHFIDGNDLYDQVLKD
IKNAKEYIHLEYYTFALDGLGKRILHALEEKLKQGLEVKILYDDVGSKNVKMANFDHFKSLGGEVEAFFASKLPLLNFRM
NNRNHRKIIVIDGQLGYVGGFNIGDEYLGLGKLGYWRDTHLRIQGDAVDALQLRFILDWNSQAHRPQFEYDVKYFPKKNG
PLGNSPIQIAASGPASDWHQIEYGYTKMIMSAKKSVYLQSPYFIPDNSYINAIKIAAKSGVDVHLMIPCKPDHPLVYWAT
FSNASDLLSSGVKIYTYENGFIHSKMCLIDDEIVSVGTANMDFRSFELNFEVNAFVYDENLAKDLRVAYEHDITKSKQLT
KESYANRPLSVKFKESLAKLVSPIL

Specific function: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787502, Length=499, Percent_Identity=27.4549098196393, Blast_Score=209, Evalue=5e-55,
Organism=Escherichia coli, GI1787007, Length=331, Percent_Identity=29.0030211480363, Blast_Score=139, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022924
- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.-

Molecular weight: Translated: 57758; Mature: 57758

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFFVPFFIGEKTMRYTFSNDLGTLFTIILAIGFIINLVLAFIIIFLERNRRTASSTWAWL
CEEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
FVLFVLPLIGFILYLFFGRTVSARKLNKNNGNVLTDFDGLLKQQIESFDKGNYGTDNKQV
HHHHHHHHHHHHHHHHHCCCCEEHEECCCCCCEEECHHHHHHHHHHHHCCCCCCCCCHHH
QKHHDLVSMLLMDQDGFLTENNKVDHFIDGNDLYDQVLKDIKNAKEYIHLEYYTFALDGL
HHHHHHHHHHHCCCCCCEECCCCCCEEECCCHHHHHHHHHHHCHHHEEEEEEEEEEHHHH
GKRILHALEEKLKQGLEVKILYDDVGSKNVKMANFDHFKSLGGEVEAFFASKLPLLNFRM
HHHHHHHHHHHHHCCCEEEEEEECCCCCCEEECCCHHHHHCCCCEEEHHHCCCCEEEEEE
NNRNHRKIIVIDGQLGYVGGFNIGDEYLGLGKLGYWRDTHLRIQGDAVDALQLRFILDWN
CCCCCCEEEEEECCCCEECCCCCCHHHCCCCCCCCEECCEEEEECCCCCEEEEEEEEECC
SQAHRPQFEYDVKYFPKKNGPLGNSPIQIAASGPASDWHQIEYGYTKMIMSAKKSVYLQS
CCCCCCCEEECEEECCCCCCCCCCCCEEEEECCCCCCCCEEHHHHHHHHHHHHHCEEEEC
PYFIPDNSYINAIKIAAKSGVDVHLMIPCKPDHPLVYWATFSNASDLLSSGVKIYTYENG
CEECCCCCCEEEEEEEECCCCEEEEEEECCCCCCEEEEEECCCHHHHHHCCEEEEEECCC
FIHSKMCLIDDEIVSVGTANMDFRSFELNFEVNAFVYDENLAKDLRVAYEHDITKSKQLT
EEEEEEEEECCHHHEECCCCCCEEEEEEEEEEEEEEECCHHHHHHHHHHHHCCCHHHHHH
KESYANRPLSVKFKESLAKLVSPIL
HHHHCCCCEEEHHHHHHHHHHHCCC
>Mature Secondary Structure
MFFVPFFIGEKTMRYTFSNDLGTLFTIILAIGFIINLVLAFIIIFLERNRRTASSTWAWL
CEEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
FVLFVLPLIGFILYLFFGRTVSARKLNKNNGNVLTDFDGLLKQQIESFDKGNYGTDNKQV
HHHHHHHHHHHHHHHHHCCCCEEHEECCCCCCEEECHHHHHHHHHHHHCCCCCCCCCHHH
QKHHDLVSMLLMDQDGFLTENNKVDHFIDGNDLYDQVLKDIKNAKEYIHLEYYTFALDGL
HHHHHHHHHHHCCCCCCEECCCCCCEEECCCHHHHHHHHHHHCHHHEEEEEEEEEEHHHH
GKRILHALEEKLKQGLEVKILYDDVGSKNVKMANFDHFKSLGGEVEAFFASKLPLLNFRM
HHHHHHHHHHHHHCCCEEEEEEECCCCCCEEECCCHHHHHCCCCEEEHHHCCCCEEEEEE
NNRNHRKIIVIDGQLGYVGGFNIGDEYLGLGKLGYWRDTHLRIQGDAVDALQLRFILDWN
CCCCCCEEEEEECCCCEECCCCCCHHHCCCCCCCCEECCEEEEECCCCCEEEEEEEEECC
SQAHRPQFEYDVKYFPKKNGPLGNSPIQIAASGPASDWHQIEYGYTKMIMSAKKSVYLQS
CCCCCCCEEECEEECCCCCCCCCCCCEEEEECCCCCCCCEEHHHHHHHHHHHHHCEEEEC
PYFIPDNSYINAIKIAAKSGVDVHLMIPCKPDHPLVYWATFSNASDLLSSGVKIYTYENG
CEECCCCCCEEEEEEEECCCCEEEEEEECCCCCCEEEEEECCCHHHHHHCCEEEEEECCC
FIHSKMCLIDDEIVSVGTANMDFRSFELNFEVNAFVYDENLAKDLRVAYEHDITKSKQLT
EEEEEEEEECCHHHEECCCCCCEEEEEEEEEEEEEEECCHHHHHHHHHHHHCCCHHHHHH
KESYANRPLSVKFKESLAKLVSPIL
HHHHCCCCEEEHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA