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The map label for this gene is mutS2

Identifier: 15926728

GI number: 15926728

Start: 1122096

End: 1124444

Strand: Direct

Name: mutS2

Synonym: SA0991

Alternate gene names: 15926728

Gene position: 1122096-1124444 (Clockwise)

Preceding gene: 15926727

Following gene: 15926729

Centisome position: 39.86

GC content: 32.95

Gene sequence:

>2349_bases
ATGAGACAAAAAACATTAGACGTCTTAGAATTTGAAAAAATAAAATCACTCGTTGCCAATGAAACTATTAGTGACTTAGG
CTTGGAAAAGGTCAATCAAATGATGCCAGCTACTAATTTTGAAACGGTTGTTTTTCAAATGGAAGAAACGGATGAGATTG
CTCAAATCTATAATAAGCATCGTTTACCAAGCTTGAGTGGCTTATCTAAAGTATCAGCATTCATTCATCGCGCTGATATT
GGCGGCGTTTTAAATGTATCAGAGCTTAACTTGATAAAAAGATTAATTCAAGTACAAAATCAATTTAAGACATTTTATAA
TCAATTGGTTGAAGAAGATGAAGGTGTTAAATACCCAATATTAGATGACAAGATGAATCAATTACCTGTGTTAACTGATC
TTTTTCATCAAATAAATGAAACATGCGATACGTATGATTTATATGATAATGCGAGTTATGAATTGCAAGGGATTAGAAGT
AAAATTTCTAGCACGAATCAACGTATTAGACAAAATTTGGACCGTATTGTTAAAAGCCAAGCAAATCAGAAAAAATTATC
AGATGCTATTGTAACAGTTAGGAATGAAAGAAACGTTATACCTGTCAAAGCTGAATATCGACAAGATTTTAATGGGATTG
TACATGATCAATCTGCTTCAGGACAAACATTGTATATTGAGCCATCATCAGTTGTTGAAATGAATAATCAAATTAGTCGA
TTACGTCATGACGAAGCAATTGAAAAAGAACGCGTTTTAACGCAACTAACTGGTTATGTGGCTGCGGACAAAGATGCACT
ACTTGTGGCAGAACAAGTCATGGGGCAGTTAGATTTTTTAATCGCAAAAGCGAGATATAGTAGAAGTATTAAAGGAACAA
AGCCGATATTTAAAGAGGAACGTACTGTATATTTACCTAAAGCATACCATCCATTATTAAATCGTGAGACTGTTGTAGCT
AATACCATCGAATTTATGGAAGATATTGAAACGGTAATTATTACAGGACCGAATACAGGTGGTAAAACTGTAACATTAAA
AACATTAGGTTTAATTATTGTTATGGCTCAATCAGGATTGTTGATTCCCACACTTGATGGTAGTCAGTTAAGTGTATTTA
AAAATGTATATTGCGATATCGGAGATGAACAATCAATAGAACAATCATTATCAACTTTTTCATCTCATATGACGAATATA
GTTGAAATTTTAAAGCATGCAGACAAACATAGTTTAGTTTTATTTGATGAATTAGGTGCAGGTACAGATCCAAGTGAAGG
TGCTGCATTAGCAATGAGCATTTTAGATCATGTTAGAAAAATTGGTTCTCTAGTAATGGCAACGACGCACTATCCTGAAC
TTAAAGCATATAGTTATAATCGAGAAGGCGTTATGAATGCGAGTGTAGAATTTGATGTAGATACTTTGAGTCCAACGTAT
AAGTTATTAATGGGTGTGCCGGGTCGTTCAAATGCTTTTGACATTTCTAAAAAGTTAGGTCTTAGTTTGAATATTATTAA
TAAGGCTAAGACGATGATTGGTACTGATGAAAAAGAAATAAATGAAATGATTGAATCATTAGAGCGTAATTATAAACGTG
TAGAGACACAGAGGTTAGAACTGGACCGTCTTGTAAAAGAAGCGGAGCAAGTGCATGATGATTTATCTAAGCAGTATCAA
CAATTCCAAAATTATGAAAAGTCTCTAATAGAGGAAGCGAAAGAAAAAGCAAATCAGAAGATTAAAGCTGCAACAAAAGA
AGCTGACGATATTATTAAAGACTTAAGACAATTGCGTGAACAAAAAGGTGCAGATGTTAAAGAACATGAATTGATTGATA
AGAAGAAACGATTAGATGATCATTATGAAGCGAAATCTATAAAGCAAAATGTACAAAAGCAAAAATACGATAAAATTGTT
GCTGGTGATGAAGTAAAAGTATTATCTTACGGTCAAAAGGGTGAAGTTTTAGAAATTGTCAATGATGAAGAAGCAATTGT
TCAAATGGGAATTATTAAAATGAAGTTACCTATTGAAGATTTAGAGAAAAAACAAAAAGAAAAAGTTAAGCCAACGAAAA
TGGTTACACGTCAAAATCGTCAAACAATTAAAACTGAACTTGACTTACGAGGCTATCGTTATGAGGATGCTTTAATTGAA
CTAGATCAATATTTAGATCAAGCCGTTTTAAGTAATTACGAACAAGTTTATATCATTCATGGTAAAGGTACAGGTGCACT
TCAAAAAGGTGTACAACAACATTTGAAGAAGCATAAAAGTGTTAGTGACTTTAGAGGTGGTATGCCAAGCGAAGGTGGAT
TTGGCGTTACCGTTGCAACACTAAAATAA

Upstream 100 bases:

>100_bases
AGGATTTGTAACAAAAGATAGAGTGATTAACGCATTATCGCGTGAAGCTTTTAAAGACTTTATTGAAAATAATATAAAAC
TTAAGAAATAGAGGGATTTT

Downstream 100 bases:

>100_bases
ATTATAATTTGATAAATTAAATAGCTGCAGTTAAAATAATGTAAAGCAACAAGAATACATTTCAAACATGTTATTTGAAA
TAAGCATAAAAATTGAGCAA

Product: recombination and DNA strand exchange inhibitor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 782; Mature: 782

Protein sequence:

>782_residues
MRQKTLDVLEFEKIKSLVANETISDLGLEKVNQMMPATNFETVVFQMEETDEIAQIYNKHRLPSLSGLSKVSAFIHRADI
GGVLNVSELNLIKRLIQVQNQFKTFYNQLVEEDEGVKYPILDDKMNQLPVLTDLFHQINETCDTYDLYDNASYELQGIRS
KISSTNQRIRQNLDRIVKSQANQKKLSDAIVTVRNERNVIPVKAEYRQDFNGIVHDQSASGQTLYIEPSSVVEMNNQISR
LRHDEAIEKERVLTQLTGYVAADKDALLVAEQVMGQLDFLIAKARYSRSIKGTKPIFKEERTVYLPKAYHPLLNRETVVA
NTIEFMEDIETVIITGPNTGGKTVTLKTLGLIIVMAQSGLLIPTLDGSQLSVFKNVYCDIGDEQSIEQSLSTFSSHMTNI
VEILKHADKHSLVLFDELGAGTDPSEGAALAMSILDHVRKIGSLVMATTHYPELKAYSYNREGVMNASVEFDVDTLSPTY
KLLMGVPGRSNAFDISKKLGLSLNIINKAKTMIGTDEKEINEMIESLERNYKRVETQRLELDRLVKEAEQVHDDLSKQYQ
QFQNYEKSLIEEAKEKANQKIKAATKEADDIIKDLRQLREQKGADVKEHELIDKKKRLDDHYEAKSIKQNVQKQKYDKIV
AGDEVKVLSYGQKGEVLEIVNDEEAIVQMGIIKMKLPIEDLEKKQKEKVKPTKMVTRQNRQTIKTELDLRGYRYEDALIE
LDQYLDQAVLSNYEQVYIIHGKGTGALQKGVQQHLKKHKSVSDFRGGMPSEGGFGVTVATLK

Sequences:

>Translated_782_residues
MRQKTLDVLEFEKIKSLVANETISDLGLEKVNQMMPATNFETVVFQMEETDEIAQIYNKHRLPSLSGLSKVSAFIHRADI
GGVLNVSELNLIKRLIQVQNQFKTFYNQLVEEDEGVKYPILDDKMNQLPVLTDLFHQINETCDTYDLYDNASYELQGIRS
KISSTNQRIRQNLDRIVKSQANQKKLSDAIVTVRNERNVIPVKAEYRQDFNGIVHDQSASGQTLYIEPSSVVEMNNQISR
LRHDEAIEKERVLTQLTGYVAADKDALLVAEQVMGQLDFLIAKARYSRSIKGTKPIFKEERTVYLPKAYHPLLNRETVVA
NTIEFMEDIETVIITGPNTGGKTVTLKTLGLIIVMAQSGLLIPTLDGSQLSVFKNVYCDIGDEQSIEQSLSTFSSHMTNI
VEILKHADKHSLVLFDELGAGTDPSEGAALAMSILDHVRKIGSLVMATTHYPELKAYSYNREGVMNASVEFDVDTLSPTY
KLLMGVPGRSNAFDISKKLGLSLNIINKAKTMIGTDEKEINEMIESLERNYKRVETQRLELDRLVKEAEQVHDDLSKQYQ
QFQNYEKSLIEEAKEKANQKIKAATKEADDIIKDLRQLREQKGADVKEHELIDKKKRLDDHYEAKSIKQNVQKQKYDKIV
AGDEVKVLSYGQKGEVLEIVNDEEAIVQMGIIKMKLPIEDLEKKQKEKVKPTKMVTRQNRQTIKTELDLRGYRYEDALIE
LDQYLDQAVLSNYEQVYIIHGKGTGALQKGVQQHLKKHKSVSDFRGGMPSEGGFGVTVATLK
>Mature_782_residues
MRQKTLDVLEFEKIKSLVANETISDLGLEKVNQMMPATNFETVVFQMEETDEIAQIYNKHRLPSLSGLSKVSAFIHRADI
GGVLNVSELNLIKRLIQVQNQFKTFYNQLVEEDEGVKYPILDDKMNQLPVLTDLFHQINETCDTYDLYDNASYELQGIRS
KISSTNQRIRQNLDRIVKSQANQKKLSDAIVTVRNERNVIPVKAEYRQDFNGIVHDQSASGQTLYIEPSSVVEMNNQISR
LRHDEAIEKERVLTQLTGYVAADKDALLVAEQVMGQLDFLIAKARYSRSIKGTKPIFKEERTVYLPKAYHPLLNRETVVA
NTIEFMEDIETVIITGPNTGGKTVTLKTLGLIIVMAQSGLLIPTLDGSQLSVFKNVYCDIGDEQSIEQSLSTFSSHMTNI
VEILKHADKHSLVLFDELGAGTDPSEGAALAMSILDHVRKIGSLVMATTHYPELKAYSYNREGVMNASVEFDVDTLSPTY
KLLMGVPGRSNAFDISKKLGLSLNIINKAKTMIGTDEKEINEMIESLERNYKRVETQRLELDRLVKEAEQVHDDLSKQYQ
QFQNYEKSLIEEAKEKANQKIKAATKEADDIIKDLRQLREQKGADVKEHELIDKKKRLDDHYEAKSIKQNVQKQKYDKIV
AGDEVKVLSYGQKGEVLEIVNDEEAIVQMGIIKMKLPIEDLEKKQKEKVKPTKMVTRQNRQTIKTELDLRGYRYEDALIE
LDQYLDQAVLSNYEQVYIIHGKGTGALQKGVQQHLKKHKSVSDFRGGMPSEGGFGVTVATLK

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain

Homologues:

Organism=Homo sapiens, GI284813531, Length=345, Percent_Identity=27.2463768115942, Blast_Score=117, Evalue=5e-26,
Organism=Homo sapiens, GI4504191, Length=320, Percent_Identity=29.375, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI4557761, Length=223, Percent_Identity=30.9417040358744, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI36949366, Length=184, Percent_Identity=31.5217391304348, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI26638666, Length=296, Percent_Identity=27.7027027027027, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI4505253, Length=296, Percent_Identity=27.7027027027027, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI26638664, Length=297, Percent_Identity=27.6094276094276, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI262231786, Length=201, Percent_Identity=32.3383084577114, Blast_Score=82, Evalue=3e-15,
Organism=Escherichia coli, GI1789089, Length=254, Percent_Identity=27.9527559055118, Blast_Score=106, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17534743, Length=270, Percent_Identity=28.5185185185185, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17508445, Length=258, Percent_Identity=26.7441860465116, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17508447, Length=264, Percent_Identity=25.7575757575758, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17539736, Length=214, Percent_Identity=23.3644859813084, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319935, Length=274, Percent_Identity=31.021897810219, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324482, Length=310, Percent_Identity=27.4193548387097, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6321109, Length=235, Percent_Identity=26.8085106382979, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321912, Length=210, Percent_Identity=27.1428571428571, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320302, Length=212, Percent_Identity=31.1320754716981, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320047, Length=204, Percent_Identity=25, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24664545, Length=220, Percent_Identity=33.1818181818182, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24584320, Length=341, Percent_Identity=25.8064516129032, Blast_Score=106, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTS2_STAA1 (A7X169)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001441725.1
- ProteinModelPortal:   A7X169
- SMR:   A7X169
- STRING:   A7X169
- EnsemblBacteria:   EBSTAT00000003568
- GeneID:   5560668
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_1135
- eggNOG:   COG1193
- GeneTree:   EBGT00050000023774
- HOGENOM:   HBG486560
- OMA:   PGLVHDQ
- ProtClustDB:   PRK00409
- BioCyc:   SAUR418127:SAHV_1135-MONOMER
- HAMAP:   MF_00092
- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625
- PANTHER:   PTHR11361
- PIRSF:   PIRSF005814
- SMART:   SM00534
- SMART:   SM00533
- SMART:   SM00463
- TIGRFAMs:   TIGR01069

Pfam domain/function: PF00488 MutS_V; PF01713 Smr; SSF48334 DNA_repair_MutS_domIII

EC number: NA

Molecular weight: Translated: 88672; Mature: 88672

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00486 DNA_MISMATCH_REPAIR_2; PS50828 SMR; PS00591 GLYCOSYL_HYDROL_F10

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQKTLDVLEFEKIKSLVANETISDLGLEKVNQMMPATNFETVVFQMEETDEIAQIYNKH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHH
RLPSLSGLSKVSAFIHRADIGGVLNVSELNLIKRLIQVQNQFKTFYNQLVEEDEGVKYPI
CCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
LDDKMNQLPVLTDLFHQINETCDTYDLYDNASYELQGIRSKISSTNQRIRQNLDRIVKSQ
CCCCHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ANQKKLSDAIVTVRNERNVIPVKAEYRQDFNGIVHDQSASGQTLYIEPSSVVEMNNQISR
CHHHHHHHHHEEEECCCCEEEEEHHHHHCCCCCEECCCCCCCEEEECCHHHHHHHHHHHH
LRHDEAIEKERVLTQLTGYVAADKDALLVAEQVMGQLDFLIAKARYSRSIKGTKPIFKEE
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCC
RTVYLPKAYHPLLNRETVVANTIEFMEDIETVIITGPNTGGKTVTLKTLGLIIVMAQSGL
CEEECCHHHHHHCCCCHHHHHHHHHHHCCCEEEEECCCCCCCEEEHHHHHHHHHEECCCE
LIPTLDGSQLSVFKNVYCDIGDEQSIEQSLSTFSSHMTNIVEILKHADKHSLVLFDELGA
EEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCC
GTDPSEGAALAMSILDHVRKIGSLVMATTHYPELKAYSYNREGVMNASVEFDVDTLSPTY
CCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCEECCCCCCCEECCEEEECCCCCHHH
KLLMGVPGRSNAFDISKKLGLSLNIINKAKTMIGTDEKEINEMIESLERNYKRVETQRLE
HHHCCCCCCCCCHHHHHHCCCEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LDRLVKEAEQVHDDLSKQYQQFQNYEKSLIEEAKEKANQKIKAATKEADDIIKDLRQLRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKGADVKEHELIDKKKRLDDHYEAKSIKQNVQKQKYDKIVAGDEVKVLSYGQKGEVLEIV
HHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEE
NDEEAIVQMGIIKMKLPIEDLEKKQKEKVKPTKMVTRQNRQTIKTELDLRGYRYEDALIE
CCHHHHHHHHHHEEECCHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHCCCCCCHHHHHHH
LDQYLDQAVLSNYEQVYIIHGKGTGALQKGVQQHLKKHKSVSDFRGGMPSEGGFGVTVAT
HHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCEEEEEE
LK
EC
>Mature Secondary Structure
MRQKTLDVLEFEKIKSLVANETISDLGLEKVNQMMPATNFETVVFQMEETDEIAQIYNKH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHH
RLPSLSGLSKVSAFIHRADIGGVLNVSELNLIKRLIQVQNQFKTFYNQLVEEDEGVKYPI
CCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
LDDKMNQLPVLTDLFHQINETCDTYDLYDNASYELQGIRSKISSTNQRIRQNLDRIVKSQ
CCCCHHCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ANQKKLSDAIVTVRNERNVIPVKAEYRQDFNGIVHDQSASGQTLYIEPSSVVEMNNQISR
CHHHHHHHHHEEEECCCCEEEEEHHHHHCCCCCEECCCCCCCEEEECCHHHHHHHHHHHH
LRHDEAIEKERVLTQLTGYVAADKDALLVAEQVMGQLDFLIAKARYSRSIKGTKPIFKEE
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCC
RTVYLPKAYHPLLNRETVVANTIEFMEDIETVIITGPNTGGKTVTLKTLGLIIVMAQSGL
CEEECCHHHHHHCCCCHHHHHHHHHHHCCCEEEEECCCCCCCEEEHHHHHHHHHEECCCE
LIPTLDGSQLSVFKNVYCDIGDEQSIEQSLSTFSSHMTNIVEILKHADKHSLVLFDELGA
EEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCC
GTDPSEGAALAMSILDHVRKIGSLVMATTHYPELKAYSYNREGVMNASVEFDVDTLSPTY
CCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCEECCCCCCCEECCEEEECCCCCHHH
KLLMGVPGRSNAFDISKKLGLSLNIINKAKTMIGTDEKEINEMIESLERNYKRVETQRLE
HHHCCCCCCCCCHHHHHHCCCEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LDRLVKEAEQVHDDLSKQYQQFQNYEKSLIEEAKEKANQKIKAATKEADDIIKDLRQLRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKGADVKEHELIDKKKRLDDHYEAKSIKQNVQKQKYDKIVAGDEVKVLSYGQKGEVLEIV
HHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEE
NDEEAIVQMGIIKMKLPIEDLEKKQKEKVKPTKMVTRQNRQTIKTELDLRGYRYEDALIE
CCHHHHHHHHHHEEECCHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHCCCCCCHHHHHHH
LDQYLDQAVLSNYEQVYIIHGKGTGALQKGVQQHLKKHKSVSDFRGGMPSEGGFGVTVAT
HHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCEEEEEE
LK
EC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA