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The map label for this gene is purD

Identifier: 15926660

GI number: 15926660

Start: 1051699

End: 1052838

Strand: Direct

Name: purD

Synonym: SA0926

Alternate gene names: 15926660

Gene position: 1051699-1052838 (Clockwise)

Preceding gene: 15926659

Following gene: 15926664

Centisome position: 37.36

GC content: 35.44

Gene sequence:

>1140_bases
ATGACACCTATAGCTGAAGTACACACTGAAATTTCAGAATCTAATCATCAAGGGATACTAGATTTTGCTAAACAGCAAAA
TGTTGATTGGGTAGTTATAGGTCCAGAACAGCCGCTAATTGATGGATTAGCAGACATTTTACGAGCGAATGGTTTCAAAG
TGTTTGGTCCAAATAAGCAAGCAGCTCAAATCGAAGGCTCAAAATTATTTGCTAAAAAGATAATGAAAAAATATAATATT
CCAACTGCTGATTATAAAGAAGTTGAGCGAAAAAAGGATGCTTTAACATATATTGAAAACTGTGAATTGCCCGTTGTTGT
CAAGAAAGATGGGTTAGCTGCTGGGAAAGGCGTTATTATTGCAGATACTATTGAAGCAGCCAGAAGTGCTATTGAGATTA
TGTATGGTGATGAAGAAGAAGGTACTGTTGTATTTGAAACGTTTTTAGAAGGTGAAGAGTTCTCGCTAATGACATTTGTT
AATGGTGATTTAGCAGTACCTTTCGACTGTATTGCACAAGATCATAAACGCGCATTTGATCATGATGAAGGACCAAATAC
TGGTGGTATGGGGGCTTATTGTCCAGTACCACATATTAGTGACGATGTTTTAAAACTTACAAATGAAACAATTGCACAAC
CCATTGCAAAGGCAATGCTTAATGAAGGTTATCAATTCTTCGGTGTATTATACATTGGTGCTATTTTAACTAAAGATGGT
CCAAAAGTAATAGAATTTAATGCCCGTTTTGGTGATCCTGAAGCTCAAGTATTATTAAGTCGCATGGAAAGTGATTTAAT
GCAGCATATTATTGATTTAGATGAAGGAAAACGTACTGAATTCAAATGGAAAAATGAATCTATTGTAGGGGTCATGTTGG
CATCAAAAGGATATCCTGATGCATATGAAAAAGGGCATAAAGTAAGTGGCTTTGATTTAAATGAAAACTATTTTGTTAGT
GGATTAAAGAAGCAAGGTGATACCTTTGTTACTTCAGGTGGTAGAGTTATACTTGCCATCGGAAAAGGTGACAATGTACA
AGATGCACAGCGAGACGCATACGAAAAAGTATCTCAAATACAAAGTGACCATTTATTCTATCGTCATGACATTGCGAATA
AAGCACTACAACTTAAATAA

Upstream 100 bases:

>100_bases
ATTAGTAATTGGTGCTGGTGGACGAGAACATGCACTTGCATATAAACTTAATCAATCGAATCTAGTTAAACAAGAGTTTG
TCATTCCAGGTAATGAGGCA

Downstream 100 bases:

>100_bases
GTATATTTAAAAAATACTAAGATTAGCTATGAAGAAATCTATAACGATAGTTTTTTTTCATAGCTTTTTTAGTTGTAGAG
TCTAGGACATTGATTTCTGT

Product: phosphoribosylamine--glycine ligase

Products: NA

Alternate protein names: GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetase [H]

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MTPIAEVHTEISESNHQGILDFAKQQNVDWVVIGPEQPLIDGLADILRANGFKVFGPNKQAAQIEGSKLFAKKIMKKYNI
PTADYKEVERKKDALTYIENCELPVVVKKDGLAAGKGVIIADTIEAARSAIEIMYGDEEEGTVVFETFLEGEEFSLMTFV
NGDLAVPFDCIAQDHKRAFDHDEGPNTGGMGAYCPVPHISDDVLKLTNETIAQPIAKAMLNEGYQFFGVLYIGAILTKDG
PKVIEFNARFGDPEAQVLLSRMESDLMQHIIDLDEGKRTEFKWKNESIVGVMLASKGYPDAYEKGHKVSGFDLNENYFVS
GLKKQGDTFVTSGGRVILAIGKGDNVQDAQRDAYEKVSQIQSDHLFYRHDIANKALQLK

Sequences:

>Translated_379_residues
MTPIAEVHTEISESNHQGILDFAKQQNVDWVVIGPEQPLIDGLADILRANGFKVFGPNKQAAQIEGSKLFAKKIMKKYNI
PTADYKEVERKKDALTYIENCELPVVVKKDGLAAGKGVIIADTIEAARSAIEIMYGDEEEGTVVFETFLEGEEFSLMTFV
NGDLAVPFDCIAQDHKRAFDHDEGPNTGGMGAYCPVPHISDDVLKLTNETIAQPIAKAMLNEGYQFFGVLYIGAILTKDG
PKVIEFNARFGDPEAQVLLSRMESDLMQHIIDLDEGKRTEFKWKNESIVGVMLASKGYPDAYEKGHKVSGFDLNENYFVS
GLKKQGDTFVTSGGRVILAIGKGDNVQDAQRDAYEKVSQIQSDHLFYRHDIANKALQLK
>Mature_378_residues
TPIAEVHTEISESNHQGILDFAKQQNVDWVVIGPEQPLIDGLADILRANGFKVFGPNKQAAQIEGSKLFAKKIMKKYNIP
TADYKEVERKKDALTYIENCELPVVVKKDGLAAGKGVIIADTIEAARSAIEIMYGDEEEGTVVFETFLEGEEFSLMTFVN
GDLAVPFDCIAQDHKRAFDHDEGPNTGGMGAYCPVPHISDDVLKLTNETIAQPIAKAMLNEGYQFFGVLYIGAILTKDGP
KVIEFNARFGDPEAQVLLSRMESDLMQHIIDLDEGKRTEFKWKNESIVGVMLASKGYPDAYEKGHKVSGFDLNENYFVSG
LKKQGDTFVTSGGRVILAIGKGDNVQDAQRDAYEKVSQIQSDHLFYRHDIANKALQLK

Specific function: De novo purine biosynthesis; second step. [C]

COG id: COG0151

COG function: function code F; Phosphoribosylamine-glycine ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI28416899, Length=382, Percent_Identity=41.0994764397906, Blast_Score=286, Evalue=2e-77,
Organism=Homo sapiens, GI4503915, Length=382, Percent_Identity=41.0994764397906, Blast_Score=285, Evalue=3e-77,
Organism=Homo sapiens, GI209869995, Length=382, Percent_Identity=41.0994764397906, Blast_Score=285, Evalue=3e-77,
Organism=Homo sapiens, GI209869993, Length=382, Percent_Identity=41.0994764397906, Blast_Score=285, Evalue=3e-77,
Organism=Escherichia coli, GI1790438, Length=379, Percent_Identity=42.4802110817942, Blast_Score=296, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI17567511, Length=378, Percent_Identity=37.3015873015873, Blast_Score=210, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6321203, Length=404, Percent_Identity=37.3762376237624, Blast_Score=249, Evalue=4e-67,
Organism=Drosophila melanogaster, GI62471619, Length=379, Percent_Identity=40.8970976253298, Blast_Score=247, Evalue=1e-65,
Organism=Drosophila melanogaster, GI24582400, Length=377, Percent_Identity=41.1140583554377, Blast_Score=246, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR020561
- InterPro:   IPR000115
- InterPro:   IPR020560
- InterPro:   IPR020559
- InterPro:   IPR020562
- InterPro:   IPR011054 [H]

Pfam domain/function: PF01071 GARS_A; PF02843 GARS_C; PF02844 GARS_N [H]

EC number: =6.3.4.13 [H]

Molecular weight: Translated: 41973; Mature: 41842

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS50975 ATP_GRASP ; PS00184 GARS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPIAEVHTEISESNHQGILDFAKQQNVDWVVIGPEQPLIDGLADILRANGFKVFGPNKQ
CCCHHHHHHHHHCCCCCCHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCEEEECCCCC
AAQIEGSKLFAKKIMKKYNIPTADYKEVERKKDALTYIENCELPVVVKKDGLAAGKGVII
CCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEE
ADTIEAARSAIEIMYGDEEEGTVVFETFLEGEEFSLMTFVNGDLAVPFDCIAQDHKRAFD
EHHHHHHHHHEEEEECCCCCCEEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHCC
HDEGPNTGGMGAYCPVPHISDDVLKLTNETIAQPIAKAMLNEGYQFFGVLYIGAILTKDG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
PKVIEFNARFGDPEAQVLLSRMESDLMQHIIDLDEGKRTEFKWKNESIVGVMLASKGYPD
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCEEEEEEECCCCCH
AYEKGHKVSGFDLNENYFVSGLKKQGDTFVTSGGRVILAIGKGDNVQDAQRDAYEKVSQI
HHHCCCCCCCEECCCCHHHHHHHHCCCEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHH
QSDHLFYRHDIANKALQLK
HHCCCEEEHHHHCHHEECC
>Mature Secondary Structure 
TPIAEVHTEISESNHQGILDFAKQQNVDWVVIGPEQPLIDGLADILRANGFKVFGPNKQ
CCHHHHHHHHHCCCCCCHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCEEEECCCCC
AAQIEGSKLFAKKIMKKYNIPTADYKEVERKKDALTYIENCELPVVVKKDGLAAGKGVII
CCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEE
ADTIEAARSAIEIMYGDEEEGTVVFETFLEGEEFSLMTFVNGDLAVPFDCIAQDHKRAFD
EHHHHHHHHHEEEEECCCCCCEEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHCC
HDEGPNTGGMGAYCPVPHISDDVLKLTNETIAQPIAKAMLNEGYQFFGVLYIGAILTKDG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
PKVIEFNARFGDPEAQVLLSRMESDLMQHIIDLDEGKRTEFKWKNESIVGVMLASKGYPD
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCEEEEEEECCCCCH
AYEKGHKVSGFDLNENYFVSGLKKQGDTFVTSGGRVILAIGKGDNVQDAQRDAYEKVSQI
HHHCCCCCCCEECCCCHHHHHHHHCCCEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHH
QSDHLFYRHDIANKALQLK
HHCCCEEEHHHHCHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA