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The map label for this gene is htrA

Identifier: 15926610

GI number: 15926610

Start: 997117

End: 999426

Strand: Direct

Name: htrA

Synonym: SA0879

Alternate gene names: 15926610

Gene position: 997117-999426 (Clockwise)

Preceding gene: 15926609

Following gene: 15926611

Centisome position: 35.42

GC content: 31.3

Gene sequence:

>2310_bases
GTGGATATTGGTAAAAAACATGTAATTCCTAAAAGTCAGTACCGACGTAAGCGTCGTGAATTCTTCCACAACGAAGACAG
AGAAGAAAATTTAAATCAACATCAAGATAAACAAAATATAGATAATACAACATCAAAAAAAGCAGATAAGCAAATACATA
AAGATTCAATTGATAAGCACGAACGTTTTAAAAATAGTTTATCATCGCATTTAGAACAGAGAAACCGTGATGTTAATGAG
AATAAAGCTGAAGAAAGTAAAAGTAATCAGGATAGTAAGTCAGCATATAACAGAGATCATTATTTAACAGACGATGTATC
TAAAAAACAAAATTCATTAGATTCAGTGGACCAAGATACAGAGAAATCAAAATATTATGAGCAAAATTCTGAAGCGACTT
TATCAACTAAATCAACCGATAAAGTAGAATCAACTGAAATGAGAAAGCTAAGTTCAGATAAAAACAAAGTTGGTCATGAA
GAGCAACATGTACTTTCTAAACCTTCAGAACATGATAAAGAGACTAGAATTGATTCTGAGTCTTCAAGAACTGATTCAGA
CAGCTCGATGCAGACAGAGAAAATAAAAAAAGACAGTTCAGATGGAAATAAAAGTAGTAATCTGAAATCTGAAGTAATAT
CAGACAAATCAAATACAGTACCAAAATTGTCGGAATCTGATGATGAAGTAAATAATCAGAAGCCATTAACTTTACCGGAA
GAACAGAAATTGAAAAGACAGCAAAGTCAAAATGAGCAAACAAAAACCTATACATATGGTGATAGCGAACAAAATGACAA
GTCTAATCATGAAAATGATTTAAGTCATCATACACCATCGATAAGTGATGATAAAGATAACGTTATGAGAGAAAATCATA
TTGTTGACGATAATCCTGATAATGATATCAATACACTATCATTATCAAAAATAGATGACGATCGAAAACTTGATGAAAAA
ATTCATGTTGAAGATAAACATAAACAAAATGCAGACTCGTCTGAAACGGTGGGATATCAAAGTCAGTCAACTGCATCTCA
TCGTAGCACTGAAAAAAGAAATATTTCTATTAATGACCATGATAAATTAAACGGTCAAAAAACAAATACAAAGACATCGG
CAAATAATAATCAAAAAAAGGCTACATCAAAATTGAACAAAGGGCGCGCTACGAATAATAATTATAGTGACATTTTGAAA
AAGTTTTGGATGATGTATTGGCCTAAATTAGTTATTCTAATGGGTATTATTATTCTAATTGTTATTTTGAATGCCATTTT
TAATAATGTGAACAAAAATGATCGCATGAATGATAATAATGATGCAGATGCTCAAAAATATACGACAACGATGAAAAATG
CCAATAACACAGTTAAATCGGTCGTTACAGTTGAAAATGAAACATCAAAAGATTCATCATTACCTAAAGATAAAGCATCT
CAAGACGAAGTGGGATCAGGTGTTGTATATAAAAAATCTGGAGATACGTTATATATTGTTACGAATGCACACGTTGTCGG
TGATAAAGAAAATCAAAAAATAACTTTCTCGAATAATAAAAGTGTTGTTGGGAAAGTGCTTGGTAAAGATAAATGGTCAG
ATTTAGCTGTTGTTAAAGCAACTTCTTCAGACAGTTCAGTGAAAGAGATAGCTATTGGAGATTCAAATAATTTAGTGTTA
GGAGAGCCAATATTAGTCGTAGGTAATCCACTTGGTGTAGACTTTAAAGGCACTGTGACAGAAGGTATTATTTCAGGTCT
GAACAGAAATGTTCCTATTGATTTCGATAAAGATAATAAATATGATATGTTGATGAAAGCTTTCCAAATTGATGCATCAG
TAAATCCAGGTAACTCGGGTGGTGCTGTCGTCAATAGAGAAGGAAAATTAATAGGTGTAGTTGCAGCTAAAATTAGTATG
CCAAACGTTGAAAATATGTCATTTGCAATACCTGTTAATGAAGTACAAAAGATTGTAAAAGATTTAGAAACAAAAGGTAA
AATTGACTATCCCGATGTAGGTGTTAAAATGAAGAATATTGCCAGTCTAAATAGTTTTGAAAGACAAGCAGTTAAATTGC
CAGGAAAAGTTAAGAACGGTGTTGTTGTAGATCAAGTTGACAACAATGGTTTAGCAGATCAATCTGGTCTGAAAAAAGGT
GATGTAATTACTGAATTAGATGGCAAACTTTTAGAAGATGATTTACGCTTTAGGCAGATTATATTTAGTCATAAAGATGA
CTTGAAATCAATTACAGCGAAGATTTATAGAGATGGTAAAGAGAAAGAAATTAATATTAAACTAAAATAA

Upstream 100 bases:

>100_bases
TATTTAGCATTTTTTCAATAGAAATTATATAGATTTTAAAGCAAATTAGGTGTTAATGTGTCATAATGATAAGTGATTTT
ATTGAATGGAGTGGACATTA

Downstream 100 bases:

>100_bases
TGTTGAGGTGAACAACGTGTCAATTTTTAGCCAGTTTTTAAAAAGATCAAGCCCTCAACAAGGTATTGTATTGTACTATA
TCGTCGCAATTGTCATTGCA

Product: serine protease HtrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 769; Mature: 769

Protein sequence:

>769_residues
MDIGKKHVIPKSQYRRKRREFFHNEDREENLNQHQDKQNIDNTTSKKADKQIHKDSIDKHERFKNSLSSHLEQRNRDVNE
NKAEESKSNQDSKSAYNRDHYLTDDVSKKQNSLDSVDQDTEKSKYYEQNSEATLSTKSTDKVESTEMRKLSSDKNKVGHE
EQHVLSKPSEHDKETRIDSESSRTDSDSSMQTEKIKKDSSDGNKSSNLKSEVISDKSNTVPKLSESDDEVNNQKPLTLPE
EQKLKRQQSQNEQTKTYTYGDSEQNDKSNHENDLSHHTPSISDDKDNVMRENHIVDDNPDNDINTLSLSKIDDDRKLDEK
IHVEDKHKQNADSSETVGYQSQSTASHRSTEKRNISINDHDKLNGQKTNTKTSANNNQKKATSKLNKGRATNNNYSDILK
KFWMMYWPKLVILMGIIILIVILNAIFNNVNKNDRMNDNNDADAQKYTTTMKNANNTVKSVVTVENETSKDSSLPKDKAS
QDEVGSGVVYKKSGDTLYIVTNAHVVGDKENQKITFSNNKSVVGKVLGKDKWSDLAVVKATSSDSSVKEIAIGDSNNLVL
GEPILVVGNPLGVDFKGTVTEGIISGLNRNVPIDFDKDNKYDMLMKAFQIDASVNPGNSGGAVVNREGKLIGVVAAKISM
PNVENMSFAIPVNEVQKIVKDLETKGKIDYPDVGVKMKNIASLNSFERQAVKLPGKVKNGVVVDQVDNNGLADQSGLKKG
DVITELDGKLLEDDLRFRQIIFSHKDDLKSITAKIYRDGKEKEINIKLK

Sequences:

>Translated_769_residues
MDIGKKHVIPKSQYRRKRREFFHNEDREENLNQHQDKQNIDNTTSKKADKQIHKDSIDKHERFKNSLSSHLEQRNRDVNE
NKAEESKSNQDSKSAYNRDHYLTDDVSKKQNSLDSVDQDTEKSKYYEQNSEATLSTKSTDKVESTEMRKLSSDKNKVGHE
EQHVLSKPSEHDKETRIDSESSRTDSDSSMQTEKIKKDSSDGNKSSNLKSEVISDKSNTVPKLSESDDEVNNQKPLTLPE
EQKLKRQQSQNEQTKTYTYGDSEQNDKSNHENDLSHHTPSISDDKDNVMRENHIVDDNPDNDINTLSLSKIDDDRKLDEK
IHVEDKHKQNADSSETVGYQSQSTASHRSTEKRNISINDHDKLNGQKTNTKTSANNNQKKATSKLNKGRATNNNYSDILK
KFWMMYWPKLVILMGIIILIVILNAIFNNVNKNDRMNDNNDADAQKYTTTMKNANNTVKSVVTVENETSKDSSLPKDKAS
QDEVGSGVVYKKSGDTLYIVTNAHVVGDKENQKITFSNNKSVVGKVLGKDKWSDLAVVKATSSDSSVKEIAIGDSNNLVL
GEPILVVGNPLGVDFKGTVTEGIISGLNRNVPIDFDKDNKYDMLMKAFQIDASVNPGNSGGAVVNREGKLIGVVAAKISM
PNVENMSFAIPVNEVQKIVKDLETKGKIDYPDVGVKMKNIASLNSFERQAVKLPGKVKNGVVVDQVDNNGLADQSGLKKG
DVITELDGKLLEDDLRFRQIIFSHKDDLKSITAKIYRDGKEKEINIKLK
>Mature_769_residues
MDIGKKHVIPKSQYRRKRREFFHNEDREENLNQHQDKQNIDNTTSKKADKQIHKDSIDKHERFKNSLSSHLEQRNRDVNE
NKAEESKSNQDSKSAYNRDHYLTDDVSKKQNSLDSVDQDTEKSKYYEQNSEATLSTKSTDKVESTEMRKLSSDKNKVGHE
EQHVLSKPSEHDKETRIDSESSRTDSDSSMQTEKIKKDSSDGNKSSNLKSEVISDKSNTVPKLSESDDEVNNQKPLTLPE
EQKLKRQQSQNEQTKTYTYGDSEQNDKSNHENDLSHHTPSISDDKDNVMRENHIVDDNPDNDINTLSLSKIDDDRKLDEK
IHVEDKHKQNADSSETVGYQSQSTASHRSTEKRNISINDHDKLNGQKTNTKTSANNNQKKATSKLNKGRATNNNYSDILK
KFWMMYWPKLVILMGIIILIVILNAIFNNVNKNDRMNDNNDADAQKYTTTMKNANNTVKSVVTVENETSKDSSLPKDKAS
QDEVGSGVVYKKSGDTLYIVTNAHVVGDKENQKITFSNNKSVVGKVLGKDKWSDLAVVKATSSDSSVKEIAIGDSNNLVL
GEPILVVGNPLGVDFKGTVTEGIISGLNRNVPIDFDKDNKYDMLMKAFQIDASVNPGNSGGAVVNREGKLIGVVAAKISM
PNVENMSFAIPVNEVQKIVKDLETKGKIDYPDVGVKMKNIASLNSFERQAVKLPGKVKNGVVVDQVDNNGLADQSGLKKG
DVITELDGKLLEDDLRFRQIIFSHKDDLKSITAKIYRDGKEKEINIKLK

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=274, Percent_Identity=27.3722627737226, Blast_Score=91, Evalue=6e-18,
Organism=Homo sapiens, GI4506141, Length=257, Percent_Identity=30.7392996108949, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI24308541, Length=254, Percent_Identity=31.8897637795276, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI7019477, Length=260, Percent_Identity=26.9230769230769, Blast_Score=70, Evalue=9e-12,
Organism=Escherichia coli, GI1786356, Length=288, Percent_Identity=33.6805555555556, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1789629, Length=300, Percent_Identity=31.3333333333333, Blast_Score=106, Evalue=7e-24,
Organism=Escherichia coli, GI1789630, Length=250, Percent_Identity=30.8, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24646839, Length=260, Percent_Identity=29.6153846153846, Blast_Score=88, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 86449; Mature: 86449

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIGKKHVIPKSQYRRKRREFFHNEDREENLNQHQDKQNIDNTTSKKADKQIHKDSIDKH
CCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
ERFKNSLSSHLEQRNRDVNENKAEESKSNQDSKSAYNRDHYLTDDVSKKQNSLDSVDQDT
HHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCHH
EKSKYYEQNSEATLSTKSTDKVESTEMRKLSSDKNKVGHEEQHVLSKPSEHDKETRIDSE
HHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHCCCCC
SSRTDSDSSMQTEKIKKDSSDGNKSSNLKSEVISDKSNTVPKLSESDDEVNNQKPLTLPE
CCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCH
EQKLKRQQSQNEQTKTYTYGDSEQNDKSNHENDLSHHTPSISDDKDNVMRENHIVDDNPD
HHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHCCCCCCCCC
NDINTLSLSKIDDDRKLDEKIHVEDKHKQNADSSETVGYQSQSTASHRSTEKRNISINDH
CCCCEEEECCCCCCHHHCCCCCCCHHHHCCCCCCHHCCCCCCCCHHHHCCCCCCCCCCCC
DKLNGQKTNTKTSANNNQKKATSKLNKGRATNNNYSDILKKFWMMYWPKLVILMGIIILI
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VILNAIFNNVNKNDRMNDNNDADAQKYTTTMKNANNTVKSVVTVENETSKDSSLPKDKAS
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCC
QDEVGSGVVYKKSGDTLYIVTNAHVVGDKENQKITFSNNKSVVGKVLGKDKWSDLAVVKA
CHHCCCCEEEEECCCEEEEEECCEEECCCCCCEEEECCCCHHHHHHHCCCCCCCEEEEEE
TSSDSSVKEIAIGDSNNLVLGEPILVVGNPLGVDFKGTVTEGIISGLNRNVPIDFDKDNK
CCCCCCCEEEEECCCCCEEECCCEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCH
YDMLMKAFQIDASVNPGNSGGAVVNREGKLIGVVAAKISMPNVENMSFAIPVNEVQKIVK
HHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEEEEEECCCCCCCCEEEECHHHHHHHHH
DLETKGKIDYPDVGVKMKNIASLNSFERQAVKLPGKVKNGVVVDQVDNNGLADQSGLKKG
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCC
DVITELDGKLLEDDLRFRQIIFSHKDDLKSITAKIYRDGKEKEINIKLK
CEEECCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCEEEEEEC
>Mature Secondary Structure
MDIGKKHVIPKSQYRRKRREFFHNEDREENLNQHQDKQNIDNTTSKKADKQIHKDSIDKH
CCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
ERFKNSLSSHLEQRNRDVNENKAEESKSNQDSKSAYNRDHYLTDDVSKKQNSLDSVDQDT
HHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCHH
EKSKYYEQNSEATLSTKSTDKVESTEMRKLSSDKNKVGHEEQHVLSKPSEHDKETRIDSE
HHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHCCCCC
SSRTDSDSSMQTEKIKKDSSDGNKSSNLKSEVISDKSNTVPKLSESDDEVNNQKPLTLPE
CCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCH
EQKLKRQQSQNEQTKTYTYGDSEQNDKSNHENDLSHHTPSISDDKDNVMRENHIVDDNPD
HHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHCCCCCCCCC
NDINTLSLSKIDDDRKLDEKIHVEDKHKQNADSSETVGYQSQSTASHRSTEKRNISINDH
CCCCEEEECCCCCCHHHCCCCCCCHHHHCCCCCCHHCCCCCCCCHHHHCCCCCCCCCCCC
DKLNGQKTNTKTSANNNQKKATSKLNKGRATNNNYSDILKKFWMMYWPKLVILMGIIILI
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VILNAIFNNVNKNDRMNDNNDADAQKYTTTMKNANNTVKSVVTVENETSKDSSLPKDKAS
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCC
QDEVGSGVVYKKSGDTLYIVTNAHVVGDKENQKITFSNNKSVVGKVLGKDKWSDLAVVKA
CHHCCCCEEEEECCCEEEEEECCEEECCCCCCEEEECCCCHHHHHHHCCCCCCCEEEEEE
TSSDSSVKEIAIGDSNNLVLGEPILVVGNPLGVDFKGTVTEGIISGLNRNVPIDFDKDNK
CCCCCCCEEEEECCCCCEEECCCEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCH
YDMLMKAFQIDASVNPGNSGGAVVNREGKLIGVVAAKISMPNVENMSFAIPVNEVQKIVK
HHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEEEEEECCCCCCCCEEEECHHHHHHHHH
DLETKGKIDYPDVGVKMKNIASLNSFERQAVKLPGKVKNGVVVDQVDNNGLADQSGLKKG
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCC
DVITELDGKLLEDDLRFRQIIFSHKDDLKSITAKIYRDGKEKEINIKLK
CEEECCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA