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The map label for this gene is cdr

Identifier: 15926559

GI number: 15926559

Start: 941465

End: 942781

Strand: Reverse

Name: cdr

Synonym: SA0831

Alternate gene names: 15926559

Gene position: 942781-941465 (Counterclockwise)

Preceding gene: 15926560

Following gene: 15926550

Centisome position: 33.49

GC content: 35.46

Gene sequence:

>1317_bases
ATGCCCAAAATAGTCGTAGTCGGAGCAGTCGCTGGCGGTGCAACATGTGCCAGCCAAATTCGACGTTTAGATAAAGAAAG
TGACATTATTATTTTTGAAAAAGATCGTGATATGAGCTTTGCTAATTGTGCATTGCCTTATGTCATTGGCGAAGTTGTTG
AAGATAGAAAATATGCTTTAGCGTATACACCTGAAAAATTTTATGATAGAAAGCAAATTACAGTAAAAACTTATCATGAA
GTTATTGCAATCAATGATGAAAGACAAACTGTAACTGTATTAAATAGAAAGACCAACGAACAATTTGAAGAATCTTACGA
TAAACTCATTTTAAGCCCTGGTGCAAGTGCAAATAGCCTTGGCTTTGAAAGTGATATTACATTTACACTTAGAAATTTAG
AAGACACTGATGCTATCGATCAATTCATCAAAGCAAATCAAGTTGATAAAGTATTGGTTATAGGTGCAGGGTATGTTTCA
TTAGAAGTTCTTGAAAATCTTTACGAACGTGGTTTACACCCTACTTTAATTCATCGATCTGATAAGATAAATAAATTAAT
GGATGCTGACATGAATCAACCTATACTTGATGAATTAGATAAGCGGGAGATTCCATACCGTTTAAATGAGGAAATTGATG
CTATCAATGGAAATGAAATTACATTTAAATCAGGAAAAGTTGAACATTACGATATGATTATTGAAGGTGTCGGTACTCAC
CCCAATTCAAAATTTATCGAAAGTTCAAATATCAAACTTGATCGAAAAGGTTTCATACCGGTAAACGATAAATTTGAAAC
AAATGTTCCAAACATTTATGCAATAGGCGATATTGCAACATCACATTATCGACATGTCGATCTACCGGCTAGTGTTCCTT
TAGCTTGGGGCGCTCACCGTGCAGCAAGTATTGTTGCCGAACAAATTGCTGGAAATGACACTATTGAATTCAAAGGCTTC
TTAGGCAACAATATTGTGAAGTTCTTTGATTATACATTTGCGAGTGTCGGCGTTAAACCAAATGAACTAAAGCAATTTGA
CTATAAAATGGTGGAAGTCACTCAAGGTGCACACGCGAATTATTACCCAGGAAATTCCCCTTTACACTTAAGGGTATATT
ATGACACTTCAAACCGTCAGATTTTAAGAGCAGCTGCAGTAGGAAAAGAAGGTGCAGATAAACGTATTGATGTACTATCG
ATGGCAATGATGAACCAGCTAACTGTAGATGAGTTAACTGAGTTTGAAGTGGCTTATGCACCACCATATAGCCACCCTAA
AGATTTAATCAATATGATTGGTTACAAAGCTAAATAA

Upstream 100 bases:

>100_bases
TCGATATTTGAATGATTTCTTTAATTTAAATATTAGATATTACTGTTAATTTATAACTAATCATTTTATAATATTTTAAA
ACAATAGGAGGTAAGTTACG

Downstream 100 bases:

>100_bases
ATGAATCATGCGATTCAATCTAATCTTAATTGTCTAGGTTAGAATTATTTTGGACTGGTACTACTATCCAGTCCTTTTTT
TATGTTTAAACATTTTTAGA

Product: coenzyme A disulfide reductase

Products: NA

Alternate protein names: CoA-disulfide reductase; CoADR

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MPKIVVVGAVAGGATCASQIRRLDKESDIIIFEKDRDMSFANCALPYVIGEVVEDRKYALAYTPEKFYDRKQITVKTYHE
VIAINDERQTVTVLNRKTNEQFEESYDKLILSPGASANSLGFESDITFTLRNLEDTDAIDQFIKANQVDKVLVIGAGYVS
LEVLENLYERGLHPTLIHRSDKINKLMDADMNQPILDELDKREIPYRLNEEIDAINGNEITFKSGKVEHYDMIIEGVGTH
PNSKFIESSNIKLDRKGFIPVNDKFETNVPNIYAIGDIATSHYRHVDLPASVPLAWGAHRAASIVAEQIAGNDTIEFKGF
LGNNIVKFFDYTFASVGVKPNELKQFDYKMVEVTQGAHANYYPGNSPLHLRVYYDTSNRQILRAAAVGKEGADKRIDVLS
MAMMNQLTVDELTEFEVAYAPPYSHPKDLINMIGYKAK

Sequences:

>Translated_438_residues
MPKIVVVGAVAGGATCASQIRRLDKESDIIIFEKDRDMSFANCALPYVIGEVVEDRKYALAYTPEKFYDRKQITVKTYHE
VIAINDERQTVTVLNRKTNEQFEESYDKLILSPGASANSLGFESDITFTLRNLEDTDAIDQFIKANQVDKVLVIGAGYVS
LEVLENLYERGLHPTLIHRSDKINKLMDADMNQPILDELDKREIPYRLNEEIDAINGNEITFKSGKVEHYDMIIEGVGTH
PNSKFIESSNIKLDRKGFIPVNDKFETNVPNIYAIGDIATSHYRHVDLPASVPLAWGAHRAASIVAEQIAGNDTIEFKGF
LGNNIVKFFDYTFASVGVKPNELKQFDYKMVEVTQGAHANYYPGNSPLHLRVYYDTSNRQILRAAAVGKEGADKRIDVLS
MAMMNQLTVDELTEFEVAYAPPYSHPKDLINMIGYKAK
>Mature_437_residues
PKIVVVGAVAGGATCASQIRRLDKESDIIIFEKDRDMSFANCALPYVIGEVVEDRKYALAYTPEKFYDRKQITVKTYHEV
IAINDERQTVTVLNRKTNEQFEESYDKLILSPGASANSLGFESDITFTLRNLEDTDAIDQFIKANQVDKVLVIGAGYVSL
EVLENLYERGLHPTLIHRSDKINKLMDADMNQPILDELDKREIPYRLNEEIDAINGNEITFKSGKVEHYDMIIEGVGTHP
NSKFIESSNIKLDRKGFIPVNDKFETNVPNIYAIGDIATSHYRHVDLPASVPLAWGAHRAASIVAEQIAGNDTIEFKGFL
GNNIVKFFDYTFASVGVKPNELKQFDYKMVEVTQGAHANYYPGNSPLHLRVYYDTSNRQILRAAAVGKEGADKRIDVLSM
AMMNQLTVDELTEFEVAYAPPYSHPKDLINMIGYKAK

Specific function: Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family

Homologues:

Organism=Homo sapiens, GI21389617, Length=319, Percent_Identity=26.9592476489028, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI226437568, Length=319, Percent_Identity=26.9592476489028, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI65787454, Length=319, Percent_Identity=26.9592476489028, Blast_Score=130, Evalue=3e-30,
Organism=Escherichia coli, GI1788892, Length=289, Percent_Identity=21.4532871972318, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17559934, Length=403, Percent_Identity=23.3250620347395, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24639257, Length=292, Percent_Identity=25.3424657534247, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281359715, Length=292, Percent_Identity=25.3424657534247, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI281359713, Length=292, Percent_Identity=25.3424657534247, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24639250, Length=292, Percent_Identity=25.3424657534247, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI18543267, Length=292, Percent_Identity=25.3424657534247, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24639252, Length=292, Percent_Identity=25.3424657534247, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24585130, Length=288, Percent_Identity=23.6111111111111, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CDR_STAA1 (A7X0I7)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001441555.1
- ProteinModelPortal:   A7X0I7
- SMR:   A7X0I7
- STRING:   A7X0I7
- EnsemblBacteria:   EBSTAT00000002875
- GeneID:   5561676
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_0965
- eggNOG:   COG0446
- GeneTree:   EBGT00050000023767
- HOGENOM:   HBG535576
- OMA:   RIDARVY
- ProtClustDB:   PRK13512
- BioCyc:   SAUR418127:SAHV_0965-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01608
- InterPro:   IPR017758
- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327
- Gene3D:   G3DSA:3.30.390.30
- PRINTS:   PR00368
- TIGRFAMs:   TIGR03385

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim; SSF55424 FAD/NAD-linked_reductase_dimer

EC number: =1.8.1.14

Molecular weight: Translated: 49291; Mature: 49160

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: ACT_SITE 43-43 ACT_SITE 43-43 BINDING 15-15 BINDING 19-19 BINDING 22-22 BINDING 39-39 BINDING 42-42 BINDING 71-71 BINDING 299-299 BINDING 419-419 BINDING 427-427

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKIVVVGAVAGGATCASQIRRLDKESDIIIFEKDRDMSFANCALPYVIGEVVEDRKYAL
CCCEEEEEECCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEE
AYTPEKFYDRKQITVKTYHEVIAINDERQTVTVLNRKTNEQFEESYDKLILSPGASANSL
EECCHHHCCCCEEEEEEEEEEEEECCCCCEEEEEECCCHHHHHHHHCEEEECCCCCCCCC
GFESDITFTLRNLEDTDAIDQFIKANQVDKVLVIGAGYVSLEVLENLYERGLHPTLIHRS
CCCCCEEEEEECCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEECC
DKINKLMDADMNQPILDELDKREIPYRLNEEIDAINGNEITFKSGKVEHYDMIIEGVGTH
HHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEEEECCCC
PNSKFIESSNIKLDRKGFIPVNDKFETNVPNIYAIGDIATSHYRHVDLPASVPLAWGAHR
CCCCCEECCCCEECCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEECCCCCCCCCCCHHH
AASIVAEQIAGNDTIEFKGFLGNNIVKFFDYTFASVGVKPNELKQFDYKMVEVTQGAHAN
HHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHCEEEEEEECCCCCC
YYPGNSPLHLRVYYDTSNRQILRAAAVGKEGADKRIDVLSMAMMNQLTVDELTEFEVAYA
CCCCCCCEEEEEEEECCCCEEEEEHHCCCCCCCCHHHHHHHHHHHHCCHHHHHCEEEEEC
PPYSHPKDLINMIGYKAK
CCCCCHHHHHHHCCCCCC
>Mature Secondary Structure 
PKIVVVGAVAGGATCASQIRRLDKESDIIIFEKDRDMSFANCALPYVIGEVVEDRKYAL
CCEEEEEECCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEE
AYTPEKFYDRKQITVKTYHEVIAINDERQTVTVLNRKTNEQFEESYDKLILSPGASANSL
EECCHHHCCCCEEEEEEEEEEEEECCCCCEEEEEECCCHHHHHHHHCEEEECCCCCCCCC
GFESDITFTLRNLEDTDAIDQFIKANQVDKVLVIGAGYVSLEVLENLYERGLHPTLIHRS
CCCCCEEEEEECCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEECC
DKINKLMDADMNQPILDELDKREIPYRLNEEIDAINGNEITFKSGKVEHYDMIIEGVGTH
HHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEEEECCCC
PNSKFIESSNIKLDRKGFIPVNDKFETNVPNIYAIGDIATSHYRHVDLPASVPLAWGAHR
CCCCCEECCCCEECCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEECCCCCCCCCCCHHH
AASIVAEQIAGNDTIEFKGFLGNNIVKFFDYTFASVGVKPNELKQFDYKMVEVTQGAHAN
HHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHCEEEEEEECCCCCC
YYPGNSPLHLRVYYDTSNRQILRAAAVGKEGADKRIDVLSMAMMNQLTVDELTEFEVAYA
CCCCCCCEEEEEEEECCCCEEEEEHHCCCCCCCCHHHHHHHHHHHHCCHHHHHCEEEEEC
PPYSHPKDLINMIGYKAK
CCCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA