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The map label for this gene is mvaK1

Identifier: 15926268

GI number: 15926268

Start: 640833

End: 641672

Strand: Direct

Name: mvaK1

Synonym: SA0547

Alternate gene names: 15926268

Gene position: 640833-641672 (Clockwise)

Preceding gene: 15926267

Following gene: 15926269

Centisome position: 22.77

GC content: 38.1

Gene sequence:

>840_bases
ATTGCAGTACCGTTTAACGCAGGTAAAATCAAAGTTTTAATAGAAGCCTTAGAGAGCGGGAACTATTCGTCTATTAAAAG
CGATGTTTACGATGGTATGTTATATGATGCGCCTGACCATCTTAAGTCTTTGGTGAACCGTTTTGTAGAATTAAATAATA
TTACAGAGCCGCTAGCAGTAACGATCCAAACGAATTTACCACCATCACGTGGATTAGGATCGAGTGCAGCTGTCGCGGTT
GCTTTTGTTCGTGCAAGTTATGATTTTTTAGGGAAATCATTAACGAAAGAAGAACTCATTGAAAAGGCTAATTGGGCAGA
GCAAATTGCACATGGTAAACCAAGTGGTATTGATACGCAAACGATTGTATCAGGCAAACCAGTTTGGTTCCAAAAAGGTC
ATGCTGAAACATTGAAAACGTTAAGTTTAGACGGCTATATGGTTGTTATTGATACTGGTGTGAAAGGTTCAACAAGACAA
GCGGTAGAAGATGTTCATAAACTTTGTGAGGATCCTCAGTACATGTCACATGTAAAACATATCGGTAAGTTAGTTTTACG
TGCGAGTGATGTGATTGAACATCATAACTTTGAAGCCCTAGCGGATATTTTTAATGAATGTCATGCGGATTTAAAGGCGT
TGACAGTTAGTCATGATAAAATAGAACAATTAATGAAAATTGGTAAAGAAAATGGTGCGATTGCTGGAAAACTTACTGGT
GCTGGTCGTGGTGGAAGTATGTTATTGCTTGCCAAAGATTTACCAACAGCGAAAAATATTGTGAAAGCTGTAGAAAAAGC
TGGTGCAGCACATACATGGATTGAGAATTTAGGAGGTTAA

Upstream 100 bases:

>100_bases
TATAAAAGGTGATATTGACATGACAAGAAAAGGATATGGGGAATCGACAGGTAAGATTATTTTAATAGGAGAACATGCTG
TTACATTTGGAGAGCCTGCT

Downstream 100 bases:

>100_bases
TGCGTTGATTAAAAGTGGCAAAGCACGTGCACATACGAATATTGCACTTATAAAATATTGGGGTAAAAAAGATGAAGCAC
TAATCATTCCAATGAATAAT

Product: mevalonate kinase

Products: NA

Alternate protein names: MK [H]

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MAVPFNAGKIKVLIEALESGNYSSIKSDVYDGMLYDAPDHLKSLVNRFVELNNITEPLAVTIQTNLPPSRGLGSSAAVAV
AFVRASYDFLGKSLTKEELIEKANWAEQIAHGKPSGIDTQTIVSGKPVWFQKGHAETLKTLSLDGYMVVIDTGVKGSTRQ
AVEDVHKLCEDPQYMSHVKHIGKLVLRASDVIEHHNFEALADIFNECHADLKALTVSHDKIEQLMKIGKENGAIAGKLTG
AGRGGSMLLLAKDLPTAKNIVKAVEKAGAAHTWIENLGG

Sequences:

>Translated_279_residues
MAVPFNAGKIKVLIEALESGNYSSIKSDVYDGMLYDAPDHLKSLVNRFVELNNITEPLAVTIQTNLPPSRGLGSSAAVAV
AFVRASYDFLGKSLTKEELIEKANWAEQIAHGKPSGIDTQTIVSGKPVWFQKGHAETLKTLSLDGYMVVIDTGVKGSTRQ
AVEDVHKLCEDPQYMSHVKHIGKLVLRASDVIEHHNFEALADIFNECHADLKALTVSHDKIEQLMKIGKENGAIAGKLTG
AGRGGSMLLLAKDLPTAKNIVKAVEKAGAAHTWIENLGG
>Mature_278_residues
AVPFNAGKIKVLIEALESGNYSSIKSDVYDGMLYDAPDHLKSLVNRFVELNNITEPLAVTIQTNLPPSRGLGSSAAVAVA
FVRASYDFLGKSLTKEELIEKANWAEQIAHGKPSGIDTQTIVSGKPVWFQKGHAETLKTLSLDGYMVVIDTGVKGSTRQA
VEDVHKLCEDPQYMSHVKHIGKLVLRASDVIEHHNFEALADIFNECHADLKALTVSHDKIEQLMKIGKENGAIAGKLTGA
GRGGSMLLLAKDLPTAKNIVKAVEKAGAAHTWIENLGG

Specific function: Unknown

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Mevalonate kinase subfamily [H]

Homologues:

Organism=Drosophila melanogaster, GI78707210, Length=212, Percent_Identity=28.7735849056604, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006205
- InterPro:   IPR006206
- InterPro:   IPR022937
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.36 [H]

Molecular weight: Translated: 30092; Mature: 29961

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVPFNAGKIKVLIEALESGNYSSIKSDVYDGMLYDAPDHLKSLVNRFVELNNITEPLAV
CCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCEEE
TIQTNLPPSRGLGSSAAVAVAFVRASYDFLGKSLTKEELIEKANWAEQIAHGKPSGIDTQ
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCC
TIVSGKPVWFQKGHAETLKTLSLDGYMVVIDTGVKGSTRQAVEDVHKLCEDPQYMSHVKH
EEECCCCCEEECCCHHHHHHEECCCEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHH
IGKLVLRASDVIEHHNFEALADIFNECHADLKALTVSHDKIEQLMKIGKENGAIAGKLTG
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEECC
AGRGGSMLLLAKDLPTAKNIVKAVEKAGAAHTWIENLGG
CCCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure 
AVPFNAGKIKVLIEALESGNYSSIKSDVYDGMLYDAPDHLKSLVNRFVELNNITEPLAV
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCEEE
TIQTNLPPSRGLGSSAAVAVAFVRASYDFLGKSLTKEELIEKANWAEQIAHGKPSGIDTQ
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCC
TIVSGKPVWFQKGHAETLKTLSLDGYMVVIDTGVKGSTRQAVEDVHKLCEDPQYMSHVKH
EEECCCCCEEECCCHHHHHHEECCCEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHH
IGKLVLRASDVIEHHNFEALADIFNECHADLKALTVSHDKIEQLMKIGKENGAIAGKLTG
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEECC
AGRGGSMLLLAKDLPTAKNIVKAVEKAGAAHTWIENLGG
CCCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA