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The map label for this gene is ilvE

Identifier: 15926232

GI number: 15926232

Start: 599248

End: 600324

Strand: Direct

Name: ilvE

Synonym: SA0512

Alternate gene names: 15926232

Gene position: 599248-600324 (Clockwise)

Preceding gene: 15926231

Following gene: 15926233

Centisome position: 21.29

GC content: 34.91

Gene sequence:

>1077_bases
ATGTCACAAGCAGTTAAAGTTGAACGACGAGAAACATTAAAACAAAAACCAAATACATCTCAACTAGGTTTTGGTAAATA
TTTTACTGATTATATGTTGAGTTATGATTATGATGCAGATAAAGGATGGCATGATTTGAAGATAGTACCTTATGGTCCTA
TTGAAATTTCACCTGCTGCACAAGGTGTTCATTATGGTCAATCGGTATTCGAAGGATTAAAAGCATATAAAAGAGATGGG
GAAGTTGCACTTTTCCGTCCTGAAGAAAATTTTAAGCGTCTTAATAACTCGTTAGCACGATTAGAAATGCCTCAAGTAGA
CGAAGCAGAATTGTTAGAGGGGCTAAAACAATTAGTTGATATAGAAAGAGATTGGATTCCTGAAGGGGAAGGTCAATCAT
TATATATTCGTCCATTTGTTTTTGCAACAGAAGGGGCACTTGGCGTTGGTGCATCACATCAGTATAAATTATTAATTATT
TTATCTCCTTCAGGTGCATATTATGGTGGTGAGACTTTAAAACCAACTAAAATCTATGTAGAAGATGAATATGTGCGTGC
TGTTCGTGGCGGTGTAGGCTTTGCAAAAGTTGCAGGTAACTATGCGGCAAGTTTATTAGCACAAACAAATGCAAATAAAT
TAGGTTATGACCAAGTATTATGGCTTGATGGTGTTGAACAGAAATATATCGAAGAAGTTGGTAGCATGAATATTTTCTTC
GTTGAAAATGGAAAAGTAATTACACCAGAGTTGAATGGCAGTATTTTACCTGGTATTACACGTAAATCTATTATCGAATT
AGCTAAAAACTTAGGATATGAAGTCGAAGAGCGCCGCGTTTCAATCGATGAATTATTCGAATCATATGATAAAGGTGAGT
TAACAGAAGTATTTGGTAGTGGTACTGCAGCAGTTATTTCACCTGTGGGTACATTGAGATACGAAGATCGTGAAATCGTT
ATTAATAATAATGAGACTGGTGAAATTACTCAAAAATTATACGACGTCTATACTGGTATTCAAAATGGTACTTTAGAAGA
TAAAAATGGTTGGAGAGTCGTTGTACCAAAATATTAA

Upstream 100 bases:

>100_bases
TAATTTTGAATTTTTAGAAAATTTATTGAACAGCAAAATATGGATTGTTATAATTTAAGTTAAACAAATTCTTATACAAT
ATTATTAGGAGGCAATCACC

Downstream 100 bases:

>100_bases
TAAAAATTGAATATAATCATGAAAACAATATGTAAAAGTTAATCATGACTAAAATCCCTTTCAATGAAGCGAAGCATGGT
AATAAATTAAGTTTACAATG

Product: branched-chain amino acid aminotransferase

Products: NA

Alternate protein names: BCAT

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MSQAVKVERRETLKQKPNTSQLGFGKYFTDYMLSYDYDADKGWHDLKIVPYGPIEISPAAQGVHYGQSVFEGLKAYKRDG
EVALFRPEENFKRLNNSLARLEMPQVDEAELLEGLKQLVDIERDWIPEGEGQSLYIRPFVFATEGALGVGASHQYKLLII
LSPSGAYYGGETLKPTKIYVEDEYVRAVRGGVGFAKVAGNYAASLLAQTNANKLGYDQVLWLDGVEQKYIEEVGSMNIFF
VENGKVITPELNGSILPGITRKSIIELAKNLGYEVEERRVSIDELFESYDKGELTEVFGSGTAAVISPVGTLRYEDREIV
INNNETGEITQKLYDVYTGIQNGTLEDKNGWRVVVPKY

Sequences:

>Translated_358_residues
MSQAVKVERRETLKQKPNTSQLGFGKYFTDYMLSYDYDADKGWHDLKIVPYGPIEISPAAQGVHYGQSVFEGLKAYKRDG
EVALFRPEENFKRLNNSLARLEMPQVDEAELLEGLKQLVDIERDWIPEGEGQSLYIRPFVFATEGALGVGASHQYKLLII
LSPSGAYYGGETLKPTKIYVEDEYVRAVRGGVGFAKVAGNYAASLLAQTNANKLGYDQVLWLDGVEQKYIEEVGSMNIFF
VENGKVITPELNGSILPGITRKSIIELAKNLGYEVEERRVSIDELFESYDKGELTEVFGSGTAAVISPVGTLRYEDREIV
INNNETGEITQKLYDVYTGIQNGTLEDKNGWRVVVPKY
>Mature_357_residues
SQAVKVERRETLKQKPNTSQLGFGKYFTDYMLSYDYDADKGWHDLKIVPYGPIEISPAAQGVHYGQSVFEGLKAYKRDGE
VALFRPEENFKRLNNSLARLEMPQVDEAELLEGLKQLVDIERDWIPEGEGQSLYIRPFVFATEGALGVGASHQYKLLIIL
SPSGAYYGGETLKPTKIYVEDEYVRAVRGGVGFAKVAGNYAASLLAQTNANKLGYDQVLWLDGVEQKYIEEVGSMNIFFV
ENGKVITPELNGSILPGITRKSIIELAKNLGYEVEERRVSIDELFESYDKGELTEVFGSGTAAVISPVGTLRYEDREIVI
NNNETGEITQKLYDVYTGIQNGTLEDKNGWRVVVPKY

Specific function: Acts on leucine, isoleucine and valine

COG id: COG0115

COG function: function code EH; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Homo sapiens, GI50658084, Length=331, Percent_Identity=39.8791540785499, Blast_Score=260, Evalue=1e-69,
Organism=Homo sapiens, GI296010904, Length=351, Percent_Identity=38.7464387464387, Blast_Score=255, Evalue=4e-68,
Organism=Homo sapiens, GI38176287, Length=351, Percent_Identity=38.7464387464387, Blast_Score=255, Evalue=5e-68,
Organism=Homo sapiens, GI296010906, Length=351, Percent_Identity=38.7464387464387, Blast_Score=255, Evalue=5e-68,
Organism=Homo sapiens, GI258614015, Length=266, Percent_Identity=41.3533834586466, Blast_Score=219, Evalue=2e-57,
Organism=Homo sapiens, GI296010902, Length=350, Percent_Identity=35.1428571428571, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI296010900, Length=350, Percent_Identity=35.1428571428571, Blast_Score=213, Evalue=2e-55,
Organism=Escherichia coli, GI48994963, Length=316, Percent_Identity=33.2278481012658, Blast_Score=155, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17568601, Length=356, Percent_Identity=38.7640449438202, Blast_Score=248, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI17565728, Length=358, Percent_Identity=36.5921787709497, Blast_Score=216, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6322608, Length=356, Percent_Identity=39.6067415730337, Blast_Score=239, Evalue=7e-64,
Organism=Saccharomyces cerevisiae, GI6322002, Length=356, Percent_Identity=38.2022471910112, Blast_Score=233, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24641779, Length=362, Percent_Identity=37.292817679558, Blast_Score=232, Evalue=2e-61,

Paralogues:

None

Copy number: 2342 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 11,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ILVE_STAAC (Q5HIC1)

Other databases:

- EMBL:   CP000046
- RefSeq:   YP_185486.1
- ProteinModelPortal:   Q5HIC1
- SMR:   Q5HIC1
- STRING:   Q5HIC1
- EnsemblBacteria:   EBSTAT00000009315
- GeneID:   3236201
- GenomeReviews:   CP000046_GR
- KEGG:   sac:SACOL0600
- TIGR:   SACOL0600
- eggNOG:   COG0115
- GeneTree:   EBGT00050000024343
- HOGENOM:   HBG617123
- OMA:   YLRPFMF
- ProtClustDB:   PRK13357
- BioCyc:   SAUR93062:SACOL0600-MONOMER
- InterPro:   IPR001544
- InterPro:   IPR018300
- InterPro:   IPR005786
- PANTHER:   PTHR11825
- PANTHER:   PTHR11825:SF2
- PIRSF:   PIRSF006468
- TIGRFAMs:   TIGR01123

Pfam domain/function: PF01063 Aminotran_4; SSF56752 Aminotrans_IV

EC number: =2.6.1.42

Molecular weight: Translated: 40087; Mature: 39956

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00770 AA_TRANSFER_CLASS_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQAVKVERRETLKQKPNTSQLGFGKYFTDYMLSYDYDADKGWHDLKIVPYGPIEISPAA
CCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHEEECCCCCCCCCEEEEEECCCEEECCCC
QGVHYGQSVFEGLKAYKRDGEVALFRPEENFKRLNNSLARLEMPQVDEAELLEGLKQLVD
CCHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
IERDWIPEGEGQSLYIRPFVFATEGALGVGASHQYKLLIILSPSGAYYGGETLKPTKIYV
HHHHCCCCCCCCEEEEEEEEEEECCCEECCCCCCEEEEEEECCCCCCCCCCCCCCCEEEE
EDEYVRAVRGGVGFAKVAGNYAASLLAQTNANKLGYDQVLWLDGVEQKYIEEVGSMNIFF
EHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHCCEEEEE
VENGKVITPELNGSILPGITRKSIIELAKNLGYEVEERRVSIDELFESYDKGELTEVFGS
EECCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCHHHHHHHCCCCCHHHHHCC
GTAAVISPVGTLRYEDREIVINNNETGEITQKLYDVYTGIQNGTLEDKNGWRVVVPKY
CCEEEECCCHHEEECCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCC
>Mature Secondary Structure 
SQAVKVERRETLKQKPNTSQLGFGKYFTDYMLSYDYDADKGWHDLKIVPYGPIEISPAA
CCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHEEECCCCCCCCCEEEEEECCCEEECCCC
QGVHYGQSVFEGLKAYKRDGEVALFRPEENFKRLNNSLARLEMPQVDEAELLEGLKQLVD
CCHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
IERDWIPEGEGQSLYIRPFVFATEGALGVGASHQYKLLIILSPSGAYYGGETLKPTKIYV
HHHHCCCCCCCCEEEEEEEEEEECCCEECCCCCCEEEEEEECCCCCCCCCCCCCCCEEEE
EDEYVRAVRGGVGFAKVAGNYAASLLAQTNANKLGYDQVLWLDGVEQKYIEEVGSMNIFF
EHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHCCEEEEE
VENGKVITPELNGSILPGITRKSIIELAKNLGYEVEERRVSIDELFESYDKGELTEVFGS
EECCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCHHHHHHHCCCCCHHHHHCC
GTAAVISPVGTLRYEDREIVINNNETGEITQKLYDVYTGIQNGTLEDKNGWRVVVPKY
CCEEEECCCHHEEECCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA