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The map label for this gene is hpt

Identifier: 15926187

GI number: 15926187

Start: 540088

End: 540627

Strand: Direct

Name: hpt

Synonym: SA0468

Alternate gene names: 15926187

Gene position: 540088-540627 (Clockwise)

Preceding gene: 15926186

Following gene: 15926188

Centisome position: 19.19

GC content: 30.37

Gene sequence:

>540_bases
ATGCATAATGATTTGAAAGAAGTATTGTTAACTGAAGAAGATATTCAAAATATCTGTAAGGAATTGGGAGCACAATTAAC
AAAGGATTATCAAGGTAAACCATTAGTATGCGTGGGTATCTTAAAAGGCTCAGCAATGTTTATGTCAGATTTAATTAAAC
GAATTGATACCCATTTATCAATTGATTTCATGGATGTTTCTAGTTATCACGGAGGCACTGAGTCAACTGGTGAAGTTCAA
ATCATTAAAGATTTAGGTTCTTCTATTGAAAATAAAGACGTATTAATTATTGAAGATATCTTAGAGACTGGTACTACACT
TAAGTCAATTACTGAATTATTACAATCTAGAAAAGTTAATTCATTAGAAATAGTTACTTTATTAGATAAACCAAACCGTC
GTAAAGCGGACATTGAAGCTAAGTATGTAGGTAAAAAAATACCAGATGAATTTGTTGTTGGTTACGGTTTAGATTATCGT
GAATTATACCGAAACTTACCATATATCGGTACGTTAAAACCTGAAGTGTATTCAAATTAA

Upstream 100 bases:

>100_bases
TTGGATAAACAACAGCGCATTATTGCGGTAGGAGATTTATATCAACAACAAACAATAAAAAAATGGATTATAATTAGTAA
AAATGGAGATGAATAGCGTT

Downstream 100 bases:

>100_bases
TTTTTTAATCAATTTCAGTTATTATTACTATGCGTTTGAGAAATAATAGTGTAGACTCAAAAATATGAAAAATGTATTTC
ATATATATTTAATTTTAGAC

Product: hypothetical protein

Products: NA

Alternate protein names: HGPRT; HGPRTase

Number of amino acids: Translated: 179; Mature: 179

Protein sequence:

>179_residues
MHNDLKEVLLTEEDIQNICKELGAQLTKDYQGKPLVCVGILKGSAMFMSDLIKRIDTHLSIDFMDVSSYHGGTESTGEVQ
IIKDLGSSIENKDVLIIEDILETGTTLKSITELLQSRKVNSLEIVTLLDKPNRRKADIEAKYVGKKIPDEFVVGYGLDYR
ELYRNLPYIGTLKPEVYSN

Sequences:

>Translated_179_residues
MHNDLKEVLLTEEDIQNICKELGAQLTKDYQGKPLVCVGILKGSAMFMSDLIKRIDTHLSIDFMDVSSYHGGTESTGEVQ
IIKDLGSSIENKDVLIIEDILETGTTLKSITELLQSRKVNSLEIVTLLDKPNRRKADIEAKYVGKKIPDEFVVGYGLDYR
ELYRNLPYIGTLKPEVYSN
>Mature_179_residues
MHNDLKEVLLTEEDIQNICKELGAQLTKDYQGKPLVCVGILKGSAMFMSDLIKRIDTHLSIDFMDVSSYHGGTESTGEVQ
IIKDLGSSIENKDVLIIEDILETGTTLKSITELLQSRKVNSLEIVTLLDKPNRRKADIEAKYVGKKIPDEFVVGYGLDYR
ELYRNLPYIGTLKPEVYSN

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4504483, Length=176, Percent_Identity=31.8181818181818, Blast_Score=95, Evalue=3e-20,
Organism=Homo sapiens, GI9910262, Length=178, Percent_Identity=32.5842696629214, Blast_Score=92, Evalue=2e-19,
Organism=Escherichia coli, GI87081689, Length=166, Percent_Identity=48.7951807228916, Blast_Score=167, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17510817, Length=183, Percent_Identity=31.1475409836066, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HPRT_STAAC (Q5HIG5)

Other databases:

- EMBL:   CP000046
- RefSeq:   YP_185442.1
- ProteinModelPortal:   Q5HIG5
- SMR:   Q5HIG5
- STRING:   Q5HIG5
- EnsemblBacteria:   EBSTAT00000010119
- GeneID:   3237122
- GenomeReviews:   CP000046_GR
- KEGG:   sac:SACOL0554
- TIGR:   SACOL0554
- eggNOG:   COG0634
- GeneTree:   EBGT00050000024017
- HOGENOM:   HBG536385
- OMA:   KHIDTYL
- ProtClustDB:   CLSK884701
- BioCyc:   SAUR93062:SACOL0554-MONOMER
- GO:   GO:0005737
- InterPro:   IPR005904
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01203

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.8

Molecular weight: Translated: 20154; Mature: 20154

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNDLKEVLLTEEDIQNICKELGAQLTKDYQGKPLVCVGILKGSAMFMSDLIKRIDTHLS
CCCHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCE
IDFMDVSSYHGGTESTGEVQIIKDLGSSIENKDVLIIEDILETGTTLKSITELLQSRKVN
EEEEECCCCCCCCCCCCCEEHHHHHCCCCCCCCEEEEHHHHHCCCHHHHHHHHHHHCCCC
SLEIVTLLDKPNRRKADIEAKYVGKKIPDEFVVGYGLDYRELYRNLPYIGTLKPEVYSN
CEEEEEEECCCCCCCCCCHHHHHCCCCCHHHEEECCCCHHHHHHCCCCCCCCCCHHCCC
>Mature Secondary Structure
MHNDLKEVLLTEEDIQNICKELGAQLTKDYQGKPLVCVGILKGSAMFMSDLIKRIDTHLS
CCCHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCE
IDFMDVSSYHGGTESTGEVQIIKDLGSSIENKDVLIIEDILETGTTLKSITELLQSRKVN
EEEEECCCCCCCCCCCCCEEHHHHHCCCCCCCCEEEEHHHHHCCCHHHHHHHHHHHCCCC
SLEIVTLLDKPNRRKADIEAKYVGKKIPDEFVVGYGLDYRELYRNLPYIGTLKPEVYSN
CEEEEEEECCCCCCCCCCHHHHHCCCCCHHHEEECCCCHHHHHHCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA