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The map label for this gene is vicK

Identifier: 15925724

GI number: 15925724

Start: 25648

End: 27474

Strand: Direct

Name: vicK

Synonym: SA0018

Alternate gene names: 15925724

Gene position: 25648-27474 (Clockwise)

Preceding gene: 15925723

Following gene: 15925725

Centisome position: 0.91

GC content: 34.92

Gene sequence:

>1827_bases
ATGAAGTGGCTAAAACAACTACAATCCCTTCATACTAAACTTGTAATTGTTTATGTATTACTGATTATCATTGGTATGCA
AATTATCGGGCTGTATTTTACAAATAATCTTGAAAAAGAGCTGCTTGATAATTTTAAGAAGAATATTACGCAGTACGCTA
AACAATTAGAAATTAGTATTGAAAAAGTATATGACGAAAAGGGCTCCGTAAATGCACAAAAAGATATTCAAAATTTATTA
AGTGAGTATGCCAACCGTCAAGAAATTGGAGAAATTCGTTTTATAGATAAAGACCAAATTATTATTGCGACGACGAAGCA
GTCTAACCGTAGTCTAATCAATCAAAAAGCGAATGATAGTTCTGTCCAAAAAGCACTATCACTAGGACAATCAAACGATC
ATTTAATTTTAAAAGATTATGGCGGTGGTAAGGACCGTGTCTGGGTATATAATATCCCAGTTAAAGTCGATAAAAAGGTA
ATTGGTAATATTTATATCGAATCAAAAATTAATGACGTTTATAACCAATTAAATAATATAAATCAAATATTCATTGTTGG
TACAGCTATTTCATTATTAATCACAGTCATCCTAGGATTCTTTATAGCGCGAACGATTACCAAACCAATCACCGATATGC
GTAACCAGACGGTCGAAATGTCCAGAGGTAACTATACGCAACGTGTGAAGATTTATGGTAATGATGAAATTGGCGAATTA
GCTTTAGCATTTAATAACTTGTCTAAACGTGTACAAGAAGCGCAGGCTAATACTGAAAGTGAGAAACGTAGACTGGACTC
AGTTATCACCCATATGAGTGATGGTATTATTGCAACAGACCGCCGTGGACGTATTCGTATCGTCAATGATATGGCACTCA
AGATGCTTGGTATGGCGAAAGAAGACATCATCGGATATTACATGTTAAGTGTATTAAGTCTTGAAGATGAATTTAAACTT
GAAGAAATTCAAGAGAATAATGATAGTTTTTTATTAGATTTAAATGAAGAAGAAGGTCTAATCGCACGTGTTAACTTTAG
TACGATTGTGCAGGAAACAGGATTTGTAACTGGTTATATCGCTGTGTTACATGACGTTACTGAACAACAACAAGTTGAAC
GTGAGCGTCGTGAATTTGTTGCCAATGTATCACATGAGTTACGTACACCTTTAACTTCTATGAATAGTTACATTGAAGCA
CTTGAAGAAGGTGCATGGAAAGATGAGGAACTTGCGCCACAATTTTTATCTGTTACCCGTGAAGAAACAGAACGAATGAT
TCGACTGGTCAATGACTTGCTACAGTTATCTAAAATGGATAATGAGTCTGATCAAATCAACAAAGAAATTATCGACTTTA
ACATGTTCATTAATAAAATTATTAATCGACATGAAATGTCTGCGAAAGACACAACATTTATTCGAGATATTCCGAAAAAG
ACGATTTTCACAGAATTTGATCCTGATAAAATGACGCAAGTATTCGATAATGTCATTACAAATGCGATGAAATATTCTAG
AGGCGATAAACGTGTCGAGTTCCACGTGAAACAAAATCCACTTTATAATCGAATGACGATTCGTATTAAAGATAATGGCA
TCGGTATTCCTATCAATAAAGTCGATAAGATATTCGACCGATTCTATCGTGTAGATAAGGCACGTACGCGTAAAATGGGT
GGTACTGGATTAGGACTAGCCATTTCGAAAGAGATTGTGGAAGCGCACAATGGTCGTATTTGGGCAAACAGTGTAGAAGG
TCAAGGTACATCTATCTTTATCACACTTCCATGTGAAGTCATTGAAGACGGTGATTGGGATGAATAA

Upstream 100 bases:

>100_bases
ACGTGAAAAGATTGAAGATGATCCGTCACATCCTGAATATATTGTGACGCGTAGAGGCGTTGGATATTTCCTCCAACAAC
ATGAGTAGAGGTCGAAACGA

Downstream 100 bases:

>100_bases
TAAGGAACATATTAAATCTGTCATTTTAGCGCTACTCGTCTTGATGAGTGTCGTATTGACATATATGGTATGGAACTTTT
CTCCTGATATTGCAAATGTC

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MKWLKQLQSLHTKLVIVYVLLIIIGMQIIGLYFTNNLEKELLDNFKKNITQYAKQLEISIEKVYDEKGSVNAQKDIQNLL
SEYANRQEIGEIRFIDKDQIIIATTKQSNRSLINQKANDSSVQKALSLGQSNDHLILKDYGGGKDRVWVYNIPVKVDKKV
IGNIYIESKINDVYNQLNNINQIFIVGTAISLLITVILGFFIARTITKPITDMRNQTVEMSRGNYTQRVKIYGNDEIGEL
ALAFNNLSKRVQEAQANTESEKRRLDSVITHMSDGIIATDRRGRIRIVNDMALKMLGMAKEDIIGYYMLSVLSLEDEFKL
EEIQENNDSFLLDLNEEEGLIARVNFSTIVQETGFVTGYIAVLHDVTEQQQVERERREFVANVSHELRTPLTSMNSYIEA
LEEGAWKDEELAPQFLSVTREETERMIRLVNDLLQLSKMDNESDQINKEIIDFNMFINKIINRHEMSAKDTTFIRDIPKK
TIFTEFDPDKMTQVFDNVITNAMKYSRGDKRVEFHVKQNPLYNRMTIRIKDNGIGIPINKVDKIFDRFYRVDKARTRKMG
GTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLPCEVIEDGDWDE

Sequences:

>Translated_608_residues
MKWLKQLQSLHTKLVIVYVLLIIIGMQIIGLYFTNNLEKELLDNFKKNITQYAKQLEISIEKVYDEKGSVNAQKDIQNLL
SEYANRQEIGEIRFIDKDQIIIATTKQSNRSLINQKANDSSVQKALSLGQSNDHLILKDYGGGKDRVWVYNIPVKVDKKV
IGNIYIESKINDVYNQLNNINQIFIVGTAISLLITVILGFFIARTITKPITDMRNQTVEMSRGNYTQRVKIYGNDEIGEL
ALAFNNLSKRVQEAQANTESEKRRLDSVITHMSDGIIATDRRGRIRIVNDMALKMLGMAKEDIIGYYMLSVLSLEDEFKL
EEIQENNDSFLLDLNEEEGLIARVNFSTIVQETGFVTGYIAVLHDVTEQQQVERERREFVANVSHELRTPLTSMNSYIEA
LEEGAWKDEELAPQFLSVTREETERMIRLVNDLLQLSKMDNESDQINKEIIDFNMFINKIINRHEMSAKDTTFIRDIPKK
TIFTEFDPDKMTQVFDNVITNAMKYSRGDKRVEFHVKQNPLYNRMTIRIKDNGIGIPINKVDKIFDRFYRVDKARTRKMG
GTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLPCEVIEDGDWDE
>Mature_608_residues
MKWLKQLQSLHTKLVIVYVLLIIIGMQIIGLYFTNNLEKELLDNFKKNITQYAKQLEISIEKVYDEKGSVNAQKDIQNLL
SEYANRQEIGEIRFIDKDQIIIATTKQSNRSLINQKANDSSVQKALSLGQSNDHLILKDYGGGKDRVWVYNIPVKVDKKV
IGNIYIESKINDVYNQLNNINQIFIVGTAISLLITVILGFFIARTITKPITDMRNQTVEMSRGNYTQRVKIYGNDEIGEL
ALAFNNLSKRVQEAQANTESEKRRLDSVITHMSDGIIATDRRGRIRIVNDMALKMLGMAKEDIIGYYMLSVLSLEDEFKL
EEIQENNDSFLLDLNEEEGLIARVNFSTIVQETGFVTGYIAVLHDVTEQQQVERERREFVANVSHELRTPLTSMNSYIEA
LEEGAWKDEELAPQFLSVTREETERMIRLVNDLLQLSKMDNESDQINKEIIDFNMFINKIINRHEMSAKDTTFIRDIPKK
TIFTEFDPDKMTQVFDNVITNAMKYSRGDKRVEFHVKQNPLYNRMTIRIKDNGIGIPINKVDKIFDRFYRVDKARTRKMG
GTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLPCEVIEDGDWDE

Specific function: Member of the two-component regulatory system walK/walR that regulates genes involved in autolysis, biofilm formation and cell wall metabolism. WalK functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its

COG id: COG5002

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=345, Percent_Identity=31.0144927536232, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1788393, Length=227, Percent_Identity=33.4801762114537, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1788549, Length=627, Percent_Identity=23.1259968102073, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1786783, Length=236, Percent_Identity=29.6610169491525, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI145693157, Length=238, Percent_Identity=27.7310924369748, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790346, Length=235, Percent_Identity=27.6595744680851, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1789149, Length=238, Percent_Identity=28.5714285714286, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI48994928, Length=254, Percent_Identity=26.3779527559055, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1790436, Length=234, Percent_Identity=31.1965811965812, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1788713, Length=265, Percent_Identity=25.2830188679245, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786912, Length=235, Percent_Identity=28.0851063829787, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1789808, Length=241, Percent_Identity=29.4605809128631, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082128, Length=229, Percent_Identity=24.0174672489083, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1787894, Length=222, Percent_Identity=24.3243243243243, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790861, Length=212, Percent_Identity=22.6415094339623, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87081816, Length=255, Percent_Identity=23.921568627451, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1790300, Length=233, Percent_Identity=28.3261802575107, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1787374, Length=221, Percent_Identity=28.0542986425339, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1790551, Length=226, Percent_Identity=25.2212389380531, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 69925; Mature: 69925

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKWLKQLQSLHTKLVIVYVLLIIIGMQIIGLYFTNNLEKELLDNFKKNITQYAKQLEISI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
EKVYDEKGSVNAQKDIQNLLSEYANRQEIGEIRFIDKDQIIIATTKQSNRSLINQKANDS
HHHHCCCCCCCHHHHHHHHHHHHHCHHHCCCEEEECCCCEEEEECCCCCHHHHHCCCCHH
SVQKALSLGQSNDHLILKDYGGGKDRVWVYNIPVKVDKKVIGNIYIESKINDVYNQLNNI
HHHHHHHCCCCCCEEEEEECCCCCCEEEEEECCCEECCHHHCCEEEEHHHHHHHHHHCCC
NQIFIVGTAISLLITVILGFFIARTITKPITDMRNQTVEMSRGNYTQRVKIYGNDEIGEL
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEEEEEECCCCHHHH
ALAFNNLSKRVQEAQANTESEKRRLDSVITHMSDGIIATDRRGRIRIVNDMALKMLGMAK
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEECCCCCEEEEHHHHHHHHCCHH
EDIIGYYMLSVLSLEDEFKLEEIQENNDSFLLDLNEEEGLIARVNFSTIVQETGFVTGYI
HHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCCCCEEEEECHHHHHHHCCCHHHHH
AVLHDVTEQQQVERERREFVANVSHELRTPLTSMNSYIEALEEGAWKDEELAPQFLSVTR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
EETERMIRLVNDLLQLSKMDNESDQINKEIIDFNMFINKIINRHEMSAKDTTFIRDIPKK
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCH
TIFTEFDPDKMTQVFDNVITNAMKYSRGDKRVEFHVKQNPLYNRMTIRIKDNGIGIPINK
HCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEEEECCCCCCCHHH
VDKIFDRFYRVDKARTRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLPCEV
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECHHH
IEDGDWDE
CCCCCCCC
>Mature Secondary Structure
MKWLKQLQSLHTKLVIVYVLLIIIGMQIIGLYFTNNLEKELLDNFKKNITQYAKQLEISI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
EKVYDEKGSVNAQKDIQNLLSEYANRQEIGEIRFIDKDQIIIATTKQSNRSLINQKANDS
HHHHCCCCCCCHHHHHHHHHHHHHCHHHCCCEEEECCCCEEEEECCCCCHHHHHCCCCHH
SVQKALSLGQSNDHLILKDYGGGKDRVWVYNIPVKVDKKVIGNIYIESKINDVYNQLNNI
HHHHHHHCCCCCCEEEEEECCCCCCEEEEEECCCEECCHHHCCEEEEHHHHHHHHHHCCC
NQIFIVGTAISLLITVILGFFIARTITKPITDMRNQTVEMSRGNYTQRVKIYGNDEIGEL
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEEEEEECCCCHHHH
ALAFNNLSKRVQEAQANTESEKRRLDSVITHMSDGIIATDRRGRIRIVNDMALKMLGMAK
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEECCCCCEEEEHHHHHHHHCCHH
EDIIGYYMLSVLSLEDEFKLEEIQENNDSFLLDLNEEEGLIARVNFSTIVQETGFVTGYI
HHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCCCCEEEEECHHHHHHHCCCHHHHH
AVLHDVTEQQQVERERREFVANVSHELRTPLTSMNSYIEALEEGAWKDEELAPQFLSVTR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
EETERMIRLVNDLLQLSKMDNESDQINKEIIDFNMFINKIINRHEMSAKDTTFIRDIPKK
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCH
TIFTEFDPDKMTQVFDNVITNAMKYSRGDKRVEFHVKQNPLYNRMTIRIKDNGIGIPINK
HCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEEEECCCCCCCHHH
VDKIFDRFYRVDKARTRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLPCEV
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECHHH
IEDGDWDE
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA