Click here to switch to the map view.

The map label for this gene is serS

Identifier: 15925714

GI number: 15925714

Start: 12793

End: 14079

Strand: Direct

Name: serS

Synonym: SA0009

Alternate gene names: 15925714

Gene position: 12793-14079 (Clockwise)

Preceding gene: 161376701

Following gene: 15925715

Centisome position: 0.45

GC content: 34.42

Gene sequence:

>1287_bases
ATGTTAGACATTAGATTATTCAGAAATGAGCCTGACACAGTTAAGAGCAAAATTGAATTACGTGGAGATGATCCAAAAGT
TGTAGATGAAATTTTAGAATTGGATGAGCAACGACGTAAATTAATTAGTGCAACAGAAGAAATGAAAGCACGTCGTAATA
AAGTAAGCGAAGAAATCGCATTAAAAAAACGTAATAAAGAAAATGCTGATGATGTGATTGCTGAAATGCGCACATTAGGT
GACGATATTAAAGAAAAAGATAGTCAATTAAATGAAATTGATAATAAAATGACAGGTATCCTTTGTCGTATTCCAAATTT
AATAAGTGATGATGTACCTCAAGGTGAATCTGATGAAGATAACGTTGAAGTTAAAAAGTGGGGTACACCACGTGAGTTTT
CATTTGAACCAAAAGCACATTGGGATATTGTAGAAGAATTGAAAATGGCTGATTTTGATCGTGCAGCAAAAGTTTCAGGT
GCGCGTTTTGTATATTTAACAAATGAAGGTGCGCAATTAGAGCGTGCTTTAATGAACTATATGATTACAAAACATACAAC
ACAACATGGTTATACAGAAATGATGGTACCACAGCTTGTGAACGCAGATACAATGTATGGTACAGGTCAATTACCTAAAT
TTGAAGAAGATTTATTTAAAGTAGAAAAAGAAGGATTATATACAATTCCAACTGCTGAAGTACCATTAACGAATTTCTAC
CGTAATGAAATTATTCAACCAGGTGTACTTCCTGAAAAATTCACTGGTCAATCTGCATGTTTCCGTAGTGAAGCAGGATC
AGCAGGTAGAGATACAAGAGGATTAATTCGTTTACATCAATTCGATAAAGTGGAAATGGTACGTTTTGAACAACCTGAAG
ATTCATGGAATGCTTTAGAAGAAATGACAACAAATGCAGAAGCAATTCTAGAAGAGTTAGGTTTACCATACCGTCGTGTT
ATTTTATGTACAGGTGATATTGGATTTAGTGCAAGCAAAACATATGATATAGAAGTTTGGTTACCAAGCTACAATGATTA
TAAAGAAATTAGTTCATGCTCAAACTGTACGGATTTCCAAGCGCGTCGTGCTAACATCCGCTTCAAGCGTGACAAAGCAG
CTAAACCAGAATTAGCACATACATTAAATGGTAGTGGTTTAGCAGTTGGACGTACATTTGCTGCTATTGTTGAAAATTAC
CAAAATGAAGATGGAACAGTAACAATTCCAGAAGCATTAGTACCATTTATGGGTGGTAAAACACAAATTTCAAAACCAGT
TAAATAA

Upstream 100 bases:

>100_bases
ACGTCCCTTGTAGGGATGTGGTCTTTTTTTATTTTCTAAAAAATAAAGACGTACGTCATTCCATAATAAATGATAATTAT
TTGGGAAAGGATGAAGGTTA

Downstream 100 bases:

>100_bases
AGGCTTTAGCTACAAGCTTTAAAAAGTATATATTCTACGTATACTTAAAGCAAGGGCAAGATACTTTAAATAATATTTTA
AAAAGTGGTGACGAAGCTGT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MLDIRLFRNEPDTVKSKIELRGDDPKVVDEILELDEQRRKLISATEEMKARRNKVSEEIALKKRNKENADDVIAEMRTLG
DDIKEKDSQLNEIDNKMTGILCRIPNLISDDVPQGESDEDNVEVKKWGTPREFSFEPKAHWDIVEELKMADFDRAAKVSG
ARFVYLTNEGAQLERALMNYMITKHTTQHGYTEMMVPQLVNADTMYGTGQLPKFEEDLFKVEKEGLYTIPTAEVPLTNFY
RNEIIQPGVLPEKFTGQSACFRSEAGSAGRDTRGLIRLHQFDKVEMVRFEQPEDSWNALEEMTTNAEAILEELGLPYRRV
ILCTGDIGFSASKTYDIEVWLPSYNDYKEISSCSNCTDFQARRANIRFKRDKAAKPELAHTLNGSGLAVGRTFAAIVENY
QNEDGTVTIPEALVPFMGGKTQISKPVK

Sequences:

>Translated_428_residues
MLDIRLFRNEPDTVKSKIELRGDDPKVVDEILELDEQRRKLISATEEMKARRNKVSEEIALKKRNKENADDVIAEMRTLG
DDIKEKDSQLNEIDNKMTGILCRIPNLISDDVPQGESDEDNVEVKKWGTPREFSFEPKAHWDIVEELKMADFDRAAKVSG
ARFVYLTNEGAQLERALMNYMITKHTTQHGYTEMMVPQLVNADTMYGTGQLPKFEEDLFKVEKEGLYTIPTAEVPLTNFY
RNEIIQPGVLPEKFTGQSACFRSEAGSAGRDTRGLIRLHQFDKVEMVRFEQPEDSWNALEEMTTNAEAILEELGLPYRRV
ILCTGDIGFSASKTYDIEVWLPSYNDYKEISSCSNCTDFQARRANIRFKRDKAAKPELAHTLNGSGLAVGRTFAAIVENY
QNEDGTVTIPEALVPFMGGKTQISKPVK
>Mature_428_residues
MLDIRLFRNEPDTVKSKIELRGDDPKVVDEILELDEQRRKLISATEEMKARRNKVSEEIALKKRNKENADDVIAEMRTLG
DDIKEKDSQLNEIDNKMTGILCRIPNLISDDVPQGESDEDNVEVKKWGTPREFSFEPKAHWDIVEELKMADFDRAAKVSG
ARFVYLTNEGAQLERALMNYMITKHTTQHGYTEMMVPQLVNADTMYGTGQLPKFEEDLFKVEKEGLYTIPTAEVPLTNFY
RNEIIQPGVLPEKFTGQSACFRSEAGSAGRDTRGLIRLHQFDKVEMVRFEQPEDSWNALEEMTTNAEAILEELGLPYRRV
ILCTGDIGFSASKTYDIEVWLPSYNDYKEISSCSNCTDFQARRANIRFKRDKAAKPELAHTLNGSGLAVGRTFAAIVENY
QNEDGTVTIPEALVPFMGGKTQISKPVK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=465, Percent_Identity=33.7634408602151, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI8923421, Length=433, Percent_Identity=31.4087759815243, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI225579074, Length=444, Percent_Identity=31.5315315315315, Blast_Score=198, Evalue=8e-51,
Organism=Escherichia coli, GI1787120, Length=426, Percent_Identity=52.112676056338, Blast_Score=436, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17539260, Length=466, Percent_Identity=32.4034334763949, Blast_Score=241, Evalue=7e-64,
Organism=Caenorhabditis elegans, GI17542084, Length=314, Percent_Identity=30.5732484076433, Blast_Score=148, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6320226, Length=448, Percent_Identity=32.5892857142857, Blast_Score=238, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6321799, Length=422, Percent_Identity=31.9905213270142, Blast_Score=234, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24581334, Length=473, Percent_Identity=30.4439746300211, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI17737985, Length=285, Percent_Identity=34.3859649122807, Blast_Score=164, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_STAA1 (A7WWP0)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001440599.1
- ProteinModelPortal:   A7WWP0
- SMR:   A7WWP0
- STRING:   A7WWP0
- EnsemblBacteria:   EBSTAT00000005182
- GeneID:   5558977
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_0009
- eggNOG:   COG0172
- GeneTree:   EBGT00050000024520
- HOGENOM:   HBG629391
- OMA:   AHWDLGP
- ProtClustDB:   PRK05431
- BioCyc:   SAUR418127:SAHV_0009-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48641; Mature: 48641

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 285-285 BINDING 385-385

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIRLFRNEPDTVKSKIELRGDDPKVVDEILELDEQRRKLISATEEMKARRNKVSEEIA
CCEEEEECCCCHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKKRNKENADDVIAEMRTLGDDIKEKDSQLNEIDNKMTGILCRIPNLISDDVPQGESDED
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCC
NVEVKKWGTPREFSFEPKAHWDIVEELKMADFDRAAKVSGARFVYLTNEGAQLERALMNY
CEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCEEEEEECCCHHHHHHHHHH
MITKHTTQHGYTEMMVPQLVNADTMYGTGQLPKFEEDLFKVEKEGLYTIPTAEVPLTNFY
HHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCEEECCCCCCCHHHHH
RNEIIQPGVLPEKFTGQSACFRSEAGSAGRDTRGLIRLHQFDKVEMVRFEQPEDSWNALE
HHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCHHHHHHH
EMTTNAEAILEELGLPYRRVILCTGDIGFSASKTYDIEVWLPSYNDYKEISSCSNCTDFQ
HHHCCHHHHHHHHCCCEEEEEEEECCCCCCCCCEEEEEEEECCCCCHHHHHHCCCCCHHH
ARRANIRFKRDKAAKPELAHTLNGSGLAVGRTFAAIVENYQNEDGTVTIPEALVPFMGGK
HHHCCCEEECCCCCCCHHHHHCCCCCEEHHHHHHHHHHHHCCCCCCEECHHHHHHHCCCC
TQISKPVK
CCCCCCCC
>Mature Secondary Structure
MLDIRLFRNEPDTVKSKIELRGDDPKVVDEILELDEQRRKLISATEEMKARRNKVSEEIA
CCEEEEECCCCHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKKRNKENADDVIAEMRTLGDDIKEKDSQLNEIDNKMTGILCRIPNLISDDVPQGESDED
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCC
NVEVKKWGTPREFSFEPKAHWDIVEELKMADFDRAAKVSGARFVYLTNEGAQLERALMNY
CEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCEEEEEECCCHHHHHHHHHH
MITKHTTQHGYTEMMVPQLVNADTMYGTGQLPKFEEDLFKVEKEGLYTIPTAEVPLTNFY
HHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCEEECCCCCCCHHHHH
RNEIIQPGVLPEKFTGQSACFRSEAGSAGRDTRGLIRLHQFDKVEMVRFEQPEDSWNALE
HHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCHHHHHHH
EMTTNAEAILEELGLPYRRVILCTGDIGFSASKTYDIEVWLPSYNDYKEISSCSNCTDFQ
HHHCCHHHHHHHHCCCEEEEEEEECCCCCCCCCEEEEEEEECCCCCHHHHHHCCCCCHHH
ARRANIRFKRDKAAKPELAHTLNGSGLAVGRTFAAIVENYQNEDGTVTIPEALVPFMGGK
HHHCCCEEECCCCCCCHHHHHCCCCCEEHHHHHHHHHHHHCCCCCCEECHHHHHHHCCCC
TQISKPVK
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA