Definition | Streptococcus pyogenes M1 GAS chromosome, complete genome. |
---|---|
Accession | NC_002737 |
Length | 1,852,441 |
Click here to switch to the map view.
The map label for this gene is hasA
Identifier: 15675933
GI number: 15675933
Start: 1832625
End: 1833884
Strand: Direct
Name: hasA
Synonym: SPy_2200
Alternate gene names: 15675933
Gene position: 1832625-1833884 (Clockwise)
Preceding gene: 15675924
Following gene: 15675934
Centisome position: 98.93
GC content: 32.54
Gene sequence:
>1260_bases GTGCCTATTTTTAAAAAAACTTTAATTGTTTTATCCTTTATTTTTTTGATATCTATCTTGATTTATCTAAATATGTATCT ATTTGGAACATCAACTGTAGGAATTTATGGAGTAATATTAATAACCTATCTAGTTATTAAACTTGGATTATCTTTCCTTT ATGAGCCATTTAAAGGAAAGCCACATGACTATAAAGTTGCTGCTGTAATTCCTTCTTATAATGAAGATGCCGAGTCATTA TTAGAAACTCTTAAAAGTGTGTTAGCACAGACCTATCCGTTATCAGAAATTTATATTGTTGATGATGGGAGTTCAAACAC AGATGCAATACAATTAATTGAAGAGTATGTAAATAGAGAAGTGGATATTTGTCGAAACGTTATCGTTCACCGTTCCCTTG TCAATAAAGGAAAACGCCATGCTCAAGCGTGGGCATTTGAAAGATCTGACGCTGACGTTTTTTTAACCGTAGATTCAGAT ACTTATATCTATCCAAATGCCTTAGAAGAACTCCTAAAAAGCTTCAATGATGAGACAGTTTATGCTGCAACAGGACATTT GAATGCTAGAAACAGACAAACTAATCTATTAACGCGACTTACAGATATCCGTTACGATAATGCCTTTGGGGTGGAGCGTG CTGCTCAATCATTAACAGGTAATATTTTAGTTTGCTCAGGACCATTGAGTATTTATCGACGTGAAGTGATTATTCCTAAC TTAGAGCGCTATAAAAATCAAACATTCCTAGGTTTACCTGTTAGCATTGGGGATGATCGATGTTTAACAAATTATGCTAT TGATTTAGGACGCACTGTCTACCAATCAACAGCTAGATGTGATACTGATGTACCTTTCCAATTAAAAAGTTATTTAAAGC AACAAAATCGATGGAATAAATCTTTTTTTAAAGAATCTATTATTTCTGTTAAAAAAATTCTTTCTAATCCCATCGTTGCC TTATGGACTATTTTCGAAGTCGTTATGTTTATGATGTTGATTGTCGCAATTGGGAATCTTTTGTTTAATCAAGCTATTCA ATTAGACCTTATTAAACTTTTTGCCTTTTTATCCATCATCTTTATCGTTGCTTTATGTCGTAATGTTCATTATATGATCA AACATCCTGCTAGTTTTTTGTTATCTCCTCTGTATGGAATATTACACTTGTTTGTCTTACAGCCCCTAAAACTTTATTCT TTATGCACCATTAAAAATACGGAATGGGGAACACGTAAAAAGGTCACTATTTTTAAATAA
Upstream 100 bases:
>100_bases TTAAAAATATTTCTATGACTAGTTGACATTACCCCTTATTTATATTAGAATATCGAGGTCCCTGTCTTTCAAGGAAATTA AAAAAGAAAGAGGTGTAATT
Downstream 100 bases:
>100_bases TATGTGCATCGAGTAGTTAGAGAAGGAGTAATTTTATGAAAATAGCAGTTGCTGGATCAGGATATGTTGGATTATCACTA GGAGTTCTTTTATCACTTCA
Product: hyaluronate synthase
Products: NA
Alternate protein names: Hyaluronate synthase; Hyaluronic acid synthase; HA synthase
Number of amino acids: Translated: 419; Mature: 418
Protein sequence:
>419_residues MPIFKKTLIVLSFIFLISILIYLNMYLFGTSTVGIYGVILITYLVIKLGLSFLYEPFKGKPHDYKVAAVIPSYNEDAESL LETLKSVLAQTYPLSEIYIVDDGSSNTDAIQLIEEYVNREVDICRNVIVHRSLVNKGKRHAQAWAFERSDADVFLTVDSD TYIYPNALEELLKSFNDETVYAATGHLNARNRQTNLLTRLTDIRYDNAFGVERAAQSLTGNILVCSGPLSIYRREVIIPN LERYKNQTFLGLPVSIGDDRCLTNYAIDLGRTVYQSTARCDTDVPFQLKSYLKQQNRWNKSFFKESIISVKKILSNPIVA LWTIFEVVMFMMLIVAIGNLLFNQAIQLDLIKLFAFLSIIFIVALCRNVHYMIKHPASFLLSPLYGILHLFVLQPLKLYS LCTIKNTEWGTRKKVTIFK
Sequences:
>Translated_419_residues MPIFKKTLIVLSFIFLISILIYLNMYLFGTSTVGIYGVILITYLVIKLGLSFLYEPFKGKPHDYKVAAVIPSYNEDAESL LETLKSVLAQTYPLSEIYIVDDGSSNTDAIQLIEEYVNREVDICRNVIVHRSLVNKGKRHAQAWAFERSDADVFLTVDSD TYIYPNALEELLKSFNDETVYAATGHLNARNRQTNLLTRLTDIRYDNAFGVERAAQSLTGNILVCSGPLSIYRREVIIPN LERYKNQTFLGLPVSIGDDRCLTNYAIDLGRTVYQSTARCDTDVPFQLKSYLKQQNRWNKSFFKESIISVKKILSNPIVA LWTIFEVVMFMMLIVAIGNLLFNQAIQLDLIKLFAFLSIIFIVALCRNVHYMIKHPASFLLSPLYGILHLFVLQPLKLYS LCTIKNTEWGTRKKVTIFK >Mature_418_residues PIFKKTLIVLSFIFLISILIYLNMYLFGTSTVGIYGVILITYLVIKLGLSFLYEPFKGKPHDYKVAAVIPSYNEDAESLL ETLKSVLAQTYPLSEIYIVDDGSSNTDAIQLIEEYVNREVDICRNVIVHRSLVNKGKRHAQAWAFERSDADVFLTVDSDT YIYPNALEELLKSFNDETVYAATGHLNARNRQTNLLTRLTDIRYDNAFGVERAAQSLTGNILVCSGPLSIYRREVIIPNL ERYKNQTFLGLPVSIGDDRCLTNYAIDLGRTVYQSTARCDTDVPFQLKSYLKQQNRWNKSFFKESIISVKKILSNPIVAL WTIFEVVMFMMLIVAIGNLLFNQAIQLDLIKLFAFLSIIFIVALCRNVHYMIKHPASFLLSPLYGILHLFVLQPLKLYSL CTIKNTEWGTRKKVTIFK
Specific function: Glycosaminoglycan synthesis. The hyaluronic acid capsule is involved in the pathogenicity of group A Streptococci; it may be the major virulence determinant
COG id: COG1215
COG function: function code M; Glycosyltransferases, probably involved in cell wall biogenesis
Gene ontology:
Cell location: Cell membrane; Multi-pass membrane protein
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the nodC/HAS family
Homologues:
Organism=Homo sapiens, GI20302153, Length=438, Percent_Identity=27.8538812785388, Blast_Score=151, Evalue=1e-36, Organism=Homo sapiens, GI4885391, Length=434, Percent_Identity=27.8801843317972, Blast_Score=150, Evalue=2e-36, Organism=Homo sapiens, GI167466171, Length=452, Percent_Identity=27.212389380531, Blast_Score=120, Evalue=2e-27, Organism=Escherichia coli, GI1787259, Length=261, Percent_Identity=22.9885057471264, Blast_Score=65, Evalue=8e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): HASA_STRP1 (P0C0H1)
Other databases:
- EMBL: AE004092 - EMBL: CP000017 - RefSeq: NP_270107.1 - RefSeq: YP_283214.1 - ProteinModelPortal: P0C0H1 - EnsemblBacteria: EBSTRT00000000608 - EnsemblBacteria: EBSTRT00000027847 - GeneID: 3571023 - GeneID: 901875 - GenomeReviews: AE004092_GR - GenomeReviews: CP000017_GR - KEGG: spy:SPy_2200 - KEGG: spz:M5005_Spy_1851 - GeneTree: EBGT00050000026831 - HOGENOM: HBG339192 - OMA: WYHQTFL - ProtClustDB: CLSK687618 - BioCyc: SPYO160490:SPY2200-MONOMER - BioCyc: SPYO293653:M5005_SPY1851-MONOMER - GO: GO:0009405 - InterPro: IPR001173
Pfam domain/function: PF00535 Glycos_transf_2
EC number: =2.4.1.212
Molecular weight: Translated: 47887; Mature: 47755
Theoretical pI: Translated: 8.82; Mature: 8.82
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
HASH(0xe6d323c)-; HASH(0xf00cbc4)-; HASH(0xe0e92d4)-; HASH(0xefdc5d4)-; HASH(0xcf365b0)-;
Cys/Met content:
1.4 %Cys (Translated Protein) 1.4 %Met (Translated Protein) 2.9 %Cys+Met (Translated Protein) 1.4 %Cys (Mature Protein) 1.2 %Met (Mature Protein) 2.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MPIFKKTLIVLSFIFLISILIYLNMYLFGTSTVGIYGVILITYLVIKLGLSFLYEPFKGK CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC PHDYKVAAVIPSYNEDAESLLETLKSVLAQTYPLSEIYIVDDGSSNTDAIQLIEEYVNRE CCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCH VDICRNVIVHRSLVNKGKRHAQAWAFERSDADVFLTVDSDTYIYPNALEELLKSFNDETV HHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCCEECHHHHHHHHHHCCCCEE YAATGHLNARNRQTNLLTRLTDIRYDNAFGVERAAQSLTGNILVCSGPLSIYRREVIIPN EEEECCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEECCCHHHHHHHHCCCC LERYKNQTFLGLPVSIGDDRCLTNYAIDLGRTVYQSTARCDTDVPFQLKSYLKQQNRWNK HHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCH SFFKESIISVKKILSNPIVALWTIFEVVMFMMLIVAIGNLLFNQAIQLDLIKLFAFLSII HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH FIVALCRNVHYMIKHPASFLLSPLYGILHLFVLQPLKLYSLCTIKNTEWGTRKKVTIFK HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCEEEEH >Mature Secondary Structure PIFKKTLIVLSFIFLISILIYLNMYLFGTSTVGIYGVILITYLVIKLGLSFLYEPFKGK CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC PHDYKVAAVIPSYNEDAESLLETLKSVLAQTYPLSEIYIVDDGSSNTDAIQLIEEYVNRE CCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCH VDICRNVIVHRSLVNKGKRHAQAWAFERSDADVFLTVDSDTYIYPNALEELLKSFNDETV HHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCCEECHHHHHHHHHHCCCCEE YAATGHLNARNRQTNLLTRLTDIRYDNAFGVERAAQSLTGNILVCSGPLSIYRREVIIPN EEEECCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEECCCHHHHHHHHCCCC LERYKNQTFLGLPVSIGDDRCLTNYAIDLGRTVYQSTARCDTDVPFQLKSYLKQQNRWNK HHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCH SFFKESIISVKKILSNPIVALWTIFEVVMFMMLIVAIGNLLFNQAIQLDLIKLFAFLSII HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH FIVALCRNVHYMIKHPASFLLSPLYGILHLFVLQPLKLYSLCTIKNTEWGTRKKVTIFK HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCEEEEH
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 11296296