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The map label for this gene is prsA

Identifier: 15675810

GI number: 15675810

Start: 1696945

End: 1697874

Strand: Reverse

Name: prsA

Synonym: SPy_2037

Alternate gene names: 15675810

Gene position: 1697874-1696945 (Counterclockwise)

Preceding gene: 15675811

Following gene: 15675809

Centisome position: 91.66

GC content: 42.15

Gene sequence:

>930_bases
ATGAAACAAATGAATAAACTCATTACAGGAGTGGTAACGCTGGCGACAGTCGTGACCTTATCAGCTTGTCAATCATCACA
CAACAACACCAAACTCGTCTCGATGAAAGGAGACACCATCACTGTCAGTGACTTCTACAATGAGACCAAAAACACAGAAC
TCGCACAAAAAGCCATGTTAAGCTTGGTGATTAGCCGCGTTTTTGAGACACAATATGCCAACAAAGTCTCTGACAAAGAG
GTTGAAAAAGCCTATAAACAAACCGCAGACCAATACGGTACATCCTTTAAGACAGTCCTAGCACAATCAGGCTTAACGCC
AGAAACCTATAAAAAACAAATTCGCCTCACAAAATTAGTCGAATATGCCGTCAAAGAACAAGCCAAAAACGAAACCATCT
CAAAAAAAGACTACCGTCAGGCCTATGACGCTTATACCCCAACCATGACCGCAGAAATCATGCAGTTTGAAAAAGAAGAG
GATGCCAAAGCAGCGCTTGAAGCCGTCAAAGCTGAAGGGGCAGACTTTGCAGCTATTGCCAAAGAAAAAACCACTGCAGC
CGATAAAAAAACAACCTATACGTTTGACTCAGGCGAAACAACCCTACCAGCAGAAGTAGTTAGAGCTGCATCAGGCCTCA
AAGAAGGGAACAGATCAGAAATCATCACAGCGCTTGATCCAGCCACCTCAAAACGCACCTACCATATCATCAAAGTCACC
AAAAAAGCAACTAAAAAAGCAGACTGGAAAGCGTACCAAAAACGCTTGAAAGACATCATCGTGACTGGCAAATTAAAAGA
CCCTGACTTCCAAAACAAAGTCATCGCTAAAGCTCTTGATAAAGCAAATGTCAAAATCAAAGACAAAGCATTTGCCAATA
TCTTAGCCCAGTTTGCAAAACCTAACCAAAAACAACCTGCCCAAAAATAG

Upstream 100 bases:

>100_bases
CACAACGAGCAGCAACACCAAAAAGCAAGATTAAGCTACGTTTAAGACTAATGATATAAGATAACAGTAATTATTAATGA
GAAAAGAGGCTCAAAAGGAC

Downstream 100 bases:

>100_bases
AGGGTTGCCAGTTTATTTCCCTAAGGTTGCTTAAAAAGACAGCCCTAGCCATCACTCCCCTTTTCAAAACACCGATAATG
GAAACGTGTCCTATACTGAT

Product: foldase protein PrsA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MKQMNKLITGVVTLATVVTLSACQSSHNNTKLVSMKGDTITVSDFYNETKNTELAQKAMLSLVISRVFETQYANKVSDKE
VEKAYKQTADQYGTSFKTVLAQSGLTPETYKKQIRLTKLVEYAVKEQAKNETISKKDYRQAYDAYTPTMTAEIMQFEKEE
DAKAALEAVKAEGADFAAIAKEKTTAADKKTTYTFDSGETTLPAEVVRAASGLKEGNRSEIITALDPATSKRTYHIIKVT
KKATKKADWKAYQKRLKDIIVTGKLKDPDFQNKVIAKALDKANVKIKDKAFANILAQFAKPNQKQPAQK

Sequences:

>Translated_309_residues
MKQMNKLITGVVTLATVVTLSACQSSHNNTKLVSMKGDTITVSDFYNETKNTELAQKAMLSLVISRVFETQYANKVSDKE
VEKAYKQTADQYGTSFKTVLAQSGLTPETYKKQIRLTKLVEYAVKEQAKNETISKKDYRQAYDAYTPTMTAEIMQFEKEE
DAKAALEAVKAEGADFAAIAKEKTTAADKKTTYTFDSGETTLPAEVVRAASGLKEGNRSEIITALDPATSKRTYHIIKVT
KKATKKADWKAYQKRLKDIIVTGKLKDPDFQNKVIAKALDKANVKIKDKAFANILAQFAKPNQKQPAQK
>Mature_309_residues
MKQMNKLITGVVTLATVVTLSACQSSHNNTKLVSMKGDTITVSDFYNETKNTELAQKAMLSLVISRVFETQYANKVSDKE
VEKAYKQTADQYGTSFKTVLAQSGLTPETYKKQIRLTKLVEYAVKEQAKNETISKKDYRQAYDAYTPTMTAEIMQFEKEE
DAKAALEAVKAEGADFAAIAKEKTTAADKKTTYTFDSGETTLPAEVVRAASGLKEGNRSEIITALDPATSKRTYHIIKVT
KKATKKADWKAYQKRLKDIIVTGKLKDPDFQNKVIAKALDKANVKIKDKAFANILAQFAKPNQKQPAQK

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PRSA2_STRP1 (P60812)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_269984.1
- RefSeq:   YP_283095.1
- ProteinModelPortal:   P60812
- EnsemblBacteria:   EBSTRT00000000782
- EnsemblBacteria:   EBSTRT00000028779
- GeneID:   3571172
- GeneID:   901688
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_2037
- KEGG:   spz:M5005_Spy_1732
- GeneTree:   EBGT00050000028078
- HOGENOM:   HBG712792
- OMA:   FNEYKSQ
- ProtClustDB:   PRK12450
- BioCyc:   SPYO160490:SPY2037-MONOMER
- BioCyc:   SPYO293653:M5005_SPY1732-MONOMER
- HAMAP:   MF_01145
- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR008880

Pfam domain/function: PF00639 Rotamase; SSF109998 Trigger_fac_C_bac

EC number: =5.2.1.8

Molecular weight: Translated: 34350; Mature: 34350

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: PS01096 PPIC_PPIASE_1; PS50198 PPIC_PPIASE_2; PS51257 PROKAR_LIPOPROTEIN; PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQMNKLITGVVTLATVVTLSACQSSHNNTKLVSMKGDTITVSDFYNETKNTELAQKAML
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEHHHHHHCCCHHHHHHHHH
SLVISRVFETQYANKVSDKEVEKAYKQTADQYGTSFKTVLAQSGLTPETYKKQIRLTKLV
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHH
EYAVKEQAKNETISKKDYRQAYDAYTPTMTAEIMQFEKEEDAKAALEAVKAEGADFAAIA
HHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
KEKTTAADKKTTYTFDSGETTLPAEVVRAASGLKEGNRSEIITALDPATSKRTYHIIKVT
HHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCHHCEEEEECCCCCCCEEEEEEEH
KKATKKADWKAYQKRLKDIIVTGKLKDPDFQNKVIAKALDKANVKIKDKAFANILAQFAK
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHC
PNQKQPAQK
CCCCCCCCC
>Mature Secondary Structure
MKQMNKLITGVVTLATVVTLSACQSSHNNTKLVSMKGDTITVSDFYNETKNTELAQKAML
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEHHHHHHCCCHHHHHHHHH
SLVISRVFETQYANKVSDKEVEKAYKQTADQYGTSFKTVLAQSGLTPETYKKQIRLTKLV
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHH
EYAVKEQAKNETISKKDYRQAYDAYTPTMTAEIMQFEKEEDAKAALEAVKAEGADFAAIA
HHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
KEKTTAADKKTTYTFDSGETTLPAEVVRAASGLKEGNRSEIITALDPATSKRTYHIIKVT
HHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCHHCEEEEECCCCCCCEEEEEEEH
KKATKKADWKAYQKRLKDIIVTGKLKDPDFQNKVIAKALDKANVKIKDKAFANILAQFAK
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHC
PNQKQPAQK
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11296296