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The map label for this gene is uppS

Identifier: 15675763

GI number: 15675763

Start: 1637227

End: 1637976

Strand: Reverse

Name: uppS

Synonym: SPy_1965

Alternate gene names: 15675763

Gene position: 1637976-1637227 (Counterclockwise)

Preceding gene: 15675764

Following gene: 15675762

Centisome position: 88.42

GC content: 40.8

Gene sequence:

>750_bases
ATGTTTGGATTAAAAGCGAAATCAACAAAAAAAGTTTTGGGGAGTATCCCAAAGCATATTGGAATTATCATGGATGGTAA
TGGACGTTGGGCCAAAAAAAGACTAAAACCTAGAGTGTTTGGGCATAAAGCTGGGATGGATGCTTTACAAGAAGTAACGA
TTACTGCATCTGAGTTGGGGGTTAAAGTTCTGACAGTCTATGCCTTTTCGACAGAAAACTGGTCCAGACCCCAAGATGAG
GTGTCTTTTATCATGAATTTACCAGTAACCTTCTTTGACAAATATGTGCCTGTGCTTCATGAGAACAATGTAAAGATTCA
AATGATTGGAGAGACTAGTCGTTTACCTGAAGATACCTTGGCAGCGCTAAATGCAGCCATCGACAAAACAAAACGTAATA
CGGGTTTAATTTTGAATTTTGCTCTCAATTATGGAGGACGTGCTGAGATTACCAGTGCTGTTCGCTTTATTGCTCAAGAT
GTCTTAGATGCCAAATTAAATCCAGGAGATATTACGGAGGATTTGATTGCTAATTACTTGATGACAGACCATCTGCCATA
TCTCTACCGAGACCCCGATTTGATTATTCGCACCAGTGGTGAGCTGCGTTTGAGCAATTTCTTGCCTTGGCAATCAGCTT
ACAGTGAATTTTATTTCACACCAGTCTTGTGGCCTGATTTTAAAAAGGCAGAGCTACTAAAGGCCATTGCGGATTATAAC
CGCCGCCAACGTCGTTTTGGCAAGGTCTAA

Upstream 100 bases:

>100_bases
AACATTTTGTGAAGATAAGATCTAATTGATAAAAAACAAGCCAAAAGGCGTGAAATATGATAAAATATGAGATAAGTATG
CTTATCAATAAGGAAAAAAC

Downstream 100 bases:

>100_bases
AAGGAGATAGTTATGAAAGAACGTGTTGTTTGGGGGGGAGTAGCAGTAGCTATTTTCCTACCTTTTCTCATAATAGGAAA
CCTACCATTCCAATTATTTG

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MFGLKAKSTKKVLGSIPKHIGIIMDGNGRWAKKRLKPRVFGHKAGMDALQEVTITASELGVKVLTVYAFSTENWSRPQDE
VSFIMNLPVTFFDKYVPVLHENNVKIQMIGETSRLPEDTLAALNAAIDKTKRNTGLILNFALNYGGRAEITSAVRFIAQD
VLDAKLNPGDITEDLIANYLMTDHLPYLYRDPDLIIRTSGELRLSNFLPWQSAYSEFYFTPVLWPDFKKAELLKAIADYN
RRQRRFGKV

Sequences:

>Translated_249_residues
MFGLKAKSTKKVLGSIPKHIGIIMDGNGRWAKKRLKPRVFGHKAGMDALQEVTITASELGVKVLTVYAFSTENWSRPQDE
VSFIMNLPVTFFDKYVPVLHENNVKIQMIGETSRLPEDTLAALNAAIDKTKRNTGLILNFALNYGGRAEITSAVRFIAQD
VLDAKLNPGDITEDLIANYLMTDHLPYLYRDPDLIIRTSGELRLSNFLPWQSAYSEFYFTPVLWPDFKKAELLKAIADYN
RRQRRFGKV
>Mature_249_residues
MFGLKAKSTKKVLGSIPKHIGIIMDGNGRWAKKRLKPRVFGHKAGMDALQEVTITASELGVKVLTVYAFSTENWSRPQDE
VSFIMNLPVTFFDKYVPVLHENNVKIQMIGETSRLPEDTLAALNAAIDKTKRNTGLILNFALNYGGRAEITSAVRFIAQD
VLDAKLNPGDITEDLIANYLMTDHLPYLYRDPDLIIRTSGELRLSNFLPWQSAYSEFYFTPVLWPDFKKAELLKAIADYN
RRQRRFGKV

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580738, Length=230, Percent_Identity=39.5652173913043, Blast_Score=164, Evalue=5e-41,
Organism=Homo sapiens, GI45580742, Length=230, Percent_Identity=39.5652173913043, Blast_Score=164, Evalue=6e-41,
Organism=Escherichia coli, GI1786371, Length=239, Percent_Identity=44.7698744769874, Blast_Score=213, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI71993029, Length=230, Percent_Identity=36.5217391304348, Blast_Score=136, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6319474, Length=224, Percent_Identity=33.4821428571429, Blast_Score=109, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6323748, Length=224, Percent_Identity=29.9107142857143, Blast_Score=102, Evalue=4e-23,
Organism=Drosophila melanogaster, GI18857969, Length=243, Percent_Identity=37.037037037037, Blast_Score=151, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_STRP1 (Q99XY1)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_269937.1
- RefSeq:   YP_283039.1
- ProteinModelPortal:   Q99XY1
- SMR:   Q99XY1
- EnsemblBacteria:   EBSTRT00000001448
- EnsemblBacteria:   EBSTRT00000027774
- GeneID:   3571230
- GeneID:   901641
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_1965
- KEGG:   spz:M5005_Spy_1676
- GeneTree:   EBGT00050000027110
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- ProtClustDB:   PRK14830
- BioCyc:   SPYO160490:SPY1965-MONOMER
- BioCyc:   SPYO293653:M5005_SPY1676-MONOMER
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 28257; Mature: 28257

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 25-25

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGLKAKSTKKVLGSIPKHIGIIMDGNGRWAKKRLKPRVFGHKAGMDALQEVTITASELG
CCCCCCCHHHHHHHCCHHHEEEEECCCCCHHHHHCCCHHHCCHHCHHHHHHHHHHHHHCC
VKVLTVYAFSTENWSRPQDEVSFIMNLPVTFFDKYVPVLHENNVKIQMIGETSRLPEDTL
EEEEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHCCCEECCCEEEEEECCCCCCCHHHH
AALNAAIDKTKRNTGLILNFALNYGGRAEITSAVRFIAQDVLDAKLNPGDITEDLIANYL
HHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
MTDHLPYLYRDPDLIIRTSGELRLSNFLPWQSAYSEFYFTPVLWPDFKKAELLKAIADYN
HHHCCCCEEECCCEEEECCCCEEECCCCCHHHHHHHEEECCCCCCCCHHHHHHHHHHHHH
RRQRRFGKV
HHHHHHCCC
>Mature Secondary Structure
MFGLKAKSTKKVLGSIPKHIGIIMDGNGRWAKKRLKPRVFGHKAGMDALQEVTITASELG
CCCCCCCHHHHHHHCCHHHEEEEECCCCCHHHHHCCCHHHCCHHCHHHHHHHHHHHHHCC
VKVLTVYAFSTENWSRPQDEVSFIMNLPVTFFDKYVPVLHENNVKIQMIGETSRLPEDTL
EEEEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHCCCEECCCEEEEEECCCCCCCHHHH
AALNAAIDKTKRNTGLILNFALNYGGRAEITSAVRFIAQDVLDAKLNPGDITEDLIANYL
HHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
MTDHLPYLYRDPDLIIRTSGELRLSNFLPWQSAYSEFYFTPVLWPDFKKAELLKAIADYN
HHHCCCCEEECCCEEEECCCCEEECCCCCHHHHHHHEEECCCCCCCCHHHHHHHHHHHHH
RRQRRFGKV
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296