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The map label for this gene is mutY [H]

Identifier: 15675660

GI number: 15675660

Start: 1520567

End: 1521691

Strand: Direct

Name: mutY [H]

Synonym: SPy_1833

Alternate gene names: 15675660

Gene position: 1520567-1521691 (Clockwise)

Preceding gene: 15675655

Following gene: 15675661

Centisome position: 82.08

GC content: 38.58

Gene sequence:

>1125_bases
ATGTGGGATAATGAGACAATCGCTTCTTTTCGTCGCACACTTTTAGAGTGGTATGACCAAGAAAAACGTGATCTCCCTTG
GCGAAGAACTACTAATCCATATTATATTTGGGTTTCTGAAATCATGTTGCAACAAACACAAGTTAATACGGTAATCCCTT
ATTATAAACGTTTTCTAGAGTGGTTTCCTCAAATAAAAGATTTGGCAGACGCTCCTGAAGAACAATTACTAAAGGCATGG
GAGGGACTAGGCTATTATTCTCGGGTGCGTAATATGCAAAAGGCTGCACAGCAAGTGATGGTTGATTTTGGTGGCATATT
TCCTCACACTTATGATGATATTGCTTCATTAAAAGGGATTGGTCCTTATACTGCAGGTGCTATCGCCAGCATCTCATTCA
ACTTACCAGAGCCTGCTGTTGATGGCAATGTGATGCGTGTCATGGCTCGTTTGTTTGAAGTTAATTATGATATCGGTGAC
CCTAAAAATCGTAAAATTTTTCAAGCTATTATGGAAATACTAATTGACCCTGACAGACCCGGTGATTTTAACCAGGCACT
TATGGATCTAGGTACAGACATCGAATCCGCTAAGACACCTAGGCCTGATGAAAGCCCTATTCGTTTCTTTAACGCTGCTT
ATTTGAATGGTACTTATGGTAAATACCCCATAAAAAATCCAAAGAAAAAGCCTAAACCAATGCGAATTCAGGCTTTTGTC
ATTCGTAACCAAAATGGCCAGTATCTACTGGAGAAAAATACTAAAGGGAGACTTCTAGGAGGATTTTGGTCATTTCCTAT
TATCGAAACATCACCTCTTTCTCAACAATTAGATTTATTTGATGACAATCAATCCAACCCCATAATCTGGCAAACCCAAA
ATGAAACTTTCGAAAGAGAATATCAATTAAAGCCACAATGGACTGATAATCACTTTCCAAATATTAAGCACACTTTTAGT
CACCAGAAGTGGACAATAGAACTCATAGAGGGGGTGGTCAAAGCAACAGATTTACCTAATGCTCCTCACCTAAAGTGGGT
AGCAATTGAGGACTTTTCTCTTTATCCCTTTGCAACACCACAAAAGAAAATGCTAGAGACCTACTTAAAACAGAAAAATG
CTTAA

Upstream 100 bases:

>100_bases
CCTTTTCTTTTTCGCAAATACCTAAAATCTTTTTTTACTCTTTTTAAGACTCCTGTGTTACAATAACAACATGATTGAAT
TAAAAGATTATGGTATTAAT

Downstream 100 bases:

>100_bases
TCGCAAGTGAACTATAACGGTTCACTTTTTGTTTACAATTCCTTTACGCCGCTGTAAAGTTTTTCGGTGATATTTATGGA
AATTGGTCAGCAAATTATTC

Product: putative A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MWDNETIASFRRTLLEWYDQEKRDLPWRRTTNPYYIWVSEIMLQQTQVNTVIPYYKRFLEWFPQIKDLADAPEEQLLKAW
EGLGYYSRVRNMQKAAQQVMVDFGGIFPHTYDDIASLKGIGPYTAGAIASISFNLPEPAVDGNVMRVMARLFEVNYDIGD
PKNRKIFQAIMEILIDPDRPGDFNQALMDLGTDIESAKTPRPDESPIRFFNAAYLNGTYGKYPIKNPKKKPKPMRIQAFV
IRNQNGQYLLEKNTKGRLLGGFWSFPIIETSPLSQQLDLFDDNQSNPIIWQTQNETFEREYQLKPQWTDNHFPNIKHTFS
HQKWTIELIEGVVKATDLPNAPHLKWVAIEDFSLYPFATPQKKMLETYLKQKNA

Sequences:

>Translated_374_residues
MWDNETIASFRRTLLEWYDQEKRDLPWRRTTNPYYIWVSEIMLQQTQVNTVIPYYKRFLEWFPQIKDLADAPEEQLLKAW
EGLGYYSRVRNMQKAAQQVMVDFGGIFPHTYDDIASLKGIGPYTAGAIASISFNLPEPAVDGNVMRVMARLFEVNYDIGD
PKNRKIFQAIMEILIDPDRPGDFNQALMDLGTDIESAKTPRPDESPIRFFNAAYLNGTYGKYPIKNPKKKPKPMRIQAFV
IRNQNGQYLLEKNTKGRLLGGFWSFPIIETSPLSQQLDLFDDNQSNPIIWQTQNETFEREYQLKPQWTDNHFPNIKHTFS
HQKWTIELIEGVVKATDLPNAPHLKWVAIEDFSLYPFATPQKKMLETYLKQKNA
>Mature_374_residues
MWDNETIASFRRTLLEWYDQEKRDLPWRRTTNPYYIWVSEIMLQQTQVNTVIPYYKRFLEWFPQIKDLADAPEEQLLKAW
EGLGYYSRVRNMQKAAQQVMVDFGGIFPHTYDDIASLKGIGPYTAGAIASISFNLPEPAVDGNVMRVMARLFEVNYDIGD
PKNRKIFQAIMEILIDPDRPGDFNQALMDLGTDIESAKTPRPDESPIRFFNAAYLNGTYGKYPIKNPKKKPKPMRIQAFV
IRNQNGQYLLEKNTKGRLLGGFWSFPIIETSPLSQQLDLFDDNQSNPIIWQTQNETFEREYQLKPQWTDNHFPNIKHTFS
HQKWTIELIEGVVKATDLPNAPHLKWVAIEDFSLYPFATPQKKMLETYLKQKNA

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI190358497, Length=427, Percent_Identity=33.0210772833724, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI115298648, Length=427, Percent_Identity=33.0210772833724, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI6912520, Length=427, Percent_Identity=33.0210772833724, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI115298650, Length=427, Percent_Identity=33.0210772833724, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI115298654, Length=427, Percent_Identity=33.0210772833724, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI115298652, Length=427, Percent_Identity=33.0210772833724, Blast_Score=217, Evalue=1e-56,
Organism=Escherichia coli, GI1789331, Length=260, Percent_Identity=40.7692307692308, Blast_Score=204, Evalue=8e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 43673; Mature: 43673

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWDNETIASFRRTLLEWYDQEKRDLPWRRTTNPYYIWVSEIMLQQTQVNTVIPYYKRFLE
CCCCHHHHHHHHHHHHHHCCHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHH
WFPQIKDLADAPEEQLLKAWEGLGYYSRVRNMQKAAQQVMVDFGGIFPHTYDDIASLKGI
HHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCC
GPYTAGAIASISFNLPEPAVDGNVMRVMARLFEVNYDIGDPKNRKIFQAIMEILIDPDRP
CCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCC
GDFNQALMDLGTDIESAKTPRPDESPIRFFNAAYLNGTYGKYPIKNPKKKPKPMRIQAFV
CCHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHEECCCCCCCCCCCCCCCCCCEEEEEEE
IRNQNGQYLLEKNTKGRLLGGFWSFPIIETSPLSQQLDLFDDNQSNPIIWQTQNETFERE
EECCCCCEEEECCCCCCEEECEECCCCEECCCCHHHHHCCCCCCCCCEEEECCCCCHHHH
YQLKPQWTDNHFPNIKHTFSHQKWTIELIEGVVKATDLPNAPHLKWVAIEDFSLYPFATP
EECCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEECCEECCCCCC
QKKMLETYLKQKNA
HHHHHHHHHHHCCC
>Mature Secondary Structure
MWDNETIASFRRTLLEWYDQEKRDLPWRRTTNPYYIWVSEIMLQQTQVNTVIPYYKRFLE
CCCCHHHHHHHHHHHHHHCCHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHH
WFPQIKDLADAPEEQLLKAWEGLGYYSRVRNMQKAAQQVMVDFGGIFPHTYDDIASLKGI
HHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCC
GPYTAGAIASISFNLPEPAVDGNVMRVMARLFEVNYDIGDPKNRKIFQAIMEILIDPDRP
CCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCC
GDFNQALMDLGTDIESAKTPRPDESPIRFFNAAYLNGTYGKYPIKNPKKKPKPMRIQAFV
CCHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHEECCCCCCCCCCCCCCCCCCEEEEEEE
IRNQNGQYLLEKNTKGRLLGGFWSFPIIETSPLSQQLDLFDDNQSNPIIWQTQNETFERE
EECCCCCEEEECCCCCCEEECEECCCCEECCCCHHHHHCCCCCCCCCEEEECCCCCHHHH
YQLKPQWTDNHFPNIKHTFSHQKWTIELIEGVVKATDLPNAPHLKWVAIEDFSLYPFATP
EECCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEECCEECCCCCC
QKKMLETYLKQKNA
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]