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The map label for this gene is fabH

Identifier: 15675602

GI number: 15675602

Start: 1453420

End: 1454394

Strand: Reverse

Name: fabH

Synonym: SPy_1754

Alternate gene names: 15675602

Gene position: 1454394-1453420 (Counterclockwise)

Preceding gene: 15675603

Following gene: 15675601

Centisome position: 78.51

GC content: 40.92

Gene sequence:

>975_bases
ATGATTTTTTCTAAAATCAGTCAGGTAGCCCACTATGTTCCACAGCAGTTAGTGACTAATAATGATTTAGCTAGCATAAT
GGACACTAGTCATGAGTGGATCTTTTCTCGAACAGGAATAGCAGAACGCCATATTTCTAGAGATGAAATGACTAGTGACC
TAGCTATTCAGGTTGCTGATCAGCTTTTAACTCAGTCTGGGTTAAAAGCTGATGCTATTGATTTTATTATTGTTGCAACT
ATCAGCCCTGATGCCACTATGCCATCAACAGCTGCGAAAGTTCAAGCAGCTATTGCGGCTACAAGTGCTTTTGCTTTTGA
TATGACTGCTGCTTGTAGTGGCTTTGTCTTTGCCTTGGCTATGGCAGATAAGCTTATTGCATCAGGTGCCTACCAAAACG
GAATGGTAATAGGTGCAGAGACTTTATCTAAGTTAGTAAACTGGCAGGATCGAGCGACAGCCGTTCTTTTTGGAGACGGA
GCTGGTGGCGTGCTACTGGAAGCCAGTAAAGATAAGCATGTTTTAGCGGAAACATTACACACAGATGGTGCGAGATGTCA
GAGTTTGATTTCAGGAGAAACTAGTCTTTCATCTCCTTACTCAATTGGCAAAAAAGCCATAGCGACTATTCAGATGGATG
GACGTGCCATATTTGATTTTGCGATTAGGGATGTGTCAAAAAGCATCCTCACACTAATGGCGCAATCAGATATTACAAAA
GATGACATAGACTATTGTTTATTGCATCAAGCTAATCGTCGTATACTTGATAAAATAGCACGCAAGATTGATGTTCCTCG
GGAAAAATTCCTTGAAAACATGATGCGTTATGGTAATACTAGTGCTGCTAGTATCCCAATCCTCTTGTCAGAGGCTGTTC
AAAAGGGACAGATTAGGTTAGATGGTACCCAAAAAATCTTACTTTCCGGTTTTGGTGGAGGTTTGACATGGGGAAGTCTA
ATTGTTAGAATCTAG

Upstream 100 bases:

>100_bases
TATGGTTGGACATGTCATTGCTGATATGAGTGATGAAGAGATGCAGGCATTGGTGCGTGGACTAGGGAATCTACATCAAT
TTTTGGAGGATTTGGTTTAA

Downstream 100 bases:

>100_bases
TTATTCATGTGCCTAGCACATTTATAAAAACAAATTTATATTTTTTAAGGAGAAATAAACATGGCAGTATTTGAAAAAGT
ACAAGAAATTATTGTTGAAG

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MIFSKISQVAHYVPQQLVTNNDLASIMDTSHEWIFSRTGIAERHISRDEMTSDLAIQVADQLLTQSGLKADAIDFIIVAT
ISPDATMPSTAAKVQAAIAATSAFAFDMTAACSGFVFALAMADKLIASGAYQNGMVIGAETLSKLVNWQDRATAVLFGDG
AGGVLLEASKDKHVLAETLHTDGARCQSLISGETSLSSPYSIGKKAIATIQMDGRAIFDFAIRDVSKSILTLMAQSDITK
DDIDYCLLHQANRRILDKIARKIDVPREKFLENMMRYGNTSAASIPILLSEAVQKGQIRLDGTQKILLSGFGGGLTWGSL
IVRI

Sequences:

>Translated_324_residues
MIFSKISQVAHYVPQQLVTNNDLASIMDTSHEWIFSRTGIAERHISRDEMTSDLAIQVADQLLTQSGLKADAIDFIIVAT
ISPDATMPSTAAKVQAAIAATSAFAFDMTAACSGFVFALAMADKLIASGAYQNGMVIGAETLSKLVNWQDRATAVLFGDG
AGGVLLEASKDKHVLAETLHTDGARCQSLISGETSLSSPYSIGKKAIATIQMDGRAIFDFAIRDVSKSILTLMAQSDITK
DDIDYCLLHQANRRILDKIARKIDVPREKFLENMMRYGNTSAASIPILLSEAVQKGQIRLDGTQKILLSGFGGGLTWGSL
IVRI
>Mature_324_residues
MIFSKISQVAHYVPQQLVTNNDLASIMDTSHEWIFSRTGIAERHISRDEMTSDLAIQVADQLLTQSGLKADAIDFIIVAT
ISPDATMPSTAAKVQAAIAATSAFAFDMTAACSGFVFALAMADKLIASGAYQNGMVIGAETLSKLVNWQDRATAVLFGDG
AGGVLLEASKDKHVLAETLHTDGARCQSLISGETSLSSPYSIGKKAIATIQMDGRAIFDFAIRDVSKSILTLMAQSDITK
DDIDYCLLHQANRRILDKIARKIDVPREKFLENMMRYGNTSAASIPILLSEAVQKGQIRLDGTQKILLSGFGGGLTWGSL
IVRI

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=323, Percent_Identity=35.9133126934984, Blast_Score=229, Evalue=1e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_STRP1 (Q99YD2)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_269776.1
- RefSeq:   YP_282857.1
- ProteinModelPortal:   Q99YD2
- SMR:   Q99YD2
- EnsemblBacteria:   EBSTRT00000000047
- EnsemblBacteria:   EBSTRT00000028402
- GeneID:   3571417
- GeneID:   901989
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_1754
- KEGG:   spz:M5005_Spy_1494
- GeneTree:   EBGT00050000027516
- HOGENOM:   HBG649927
- OMA:   MSPDYLT
- ProtClustDB:   PRK09352
- BioCyc:   SPYO160490:SPY1754-MONOMER
- BioCyc:   SPYO293653:M5005_SPY1494-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 34876; Mature: 34876

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: ACT_SITE 112-112 ACT_SITE 249-249 ACT_SITE 279-279

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFSKISQVAHYVPQQLVTNNDLASIMDTSHEWIFSRTGIAERHISRDEMTSDLAIQVAD
CCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHCCCHHHHHCCHHHHHHHHHHHHHH
QLLTQSGLKADAIDFIIVATISPDATMPSTAAKVQAAIAATSAFAFDMTAACSGFVFALA
HHHHHCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MADKLIASGAYQNGMVIGAETLSKLVNWQDRATAVLFGDGAGGVLLEASKDKHVLAETLH
HHHHHHHCCCCCCCEEECHHHHHHHHCCCCCCEEEEEECCCCCEEEECCCCHHHHHHHHH
TDGARCQSLISGETSLSSPYSIGKKAIATIQMDGRAIFDFAIRDVSKSILTLMAQSDITK
CCHHHHHHHHCCCCCCCCCHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCH
DDIDYCLLHQANRRILDKIARKIDVPREKFLENMMRYGNTSAASIPILLSEAVQKGQIRL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEE
DGTQKILLSGFGGGLTWGSLIVRI
CCCCEEEEECCCCCCCHHHHHEEC
>Mature Secondary Structure
MIFSKISQVAHYVPQQLVTNNDLASIMDTSHEWIFSRTGIAERHISRDEMTSDLAIQVAD
CCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHCCCHHHHHCCHHHHHHHHHHHHHH
QLLTQSGLKADAIDFIIVATISPDATMPSTAAKVQAAIAATSAFAFDMTAACSGFVFALA
HHHHHCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MADKLIASGAYQNGMVIGAETLSKLVNWQDRATAVLFGDGAGGVLLEASKDKHVLAETLH
HHHHHHHCCCCCCCEEECHHHHHHHHCCCCCCEEEEEECCCCCEEEECCCCHHHHHHHHH
TDGARCQSLISGETSLSSPYSIGKKAIATIQMDGRAIFDFAIRDVSKSILTLMAQSDITK
CCHHHHHHHHCCCCCCCCCHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCH
DDIDYCLLHQANRRILDKIARKIDVPREKFLENMMRYGNTSAASIPILLSEAVQKGQIRL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEE
DGTQKILLSGFGGGLTWGSLIVRI
CCCCEEEEECCCCCCCHHHHHEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296