Definition Streptococcus pyogenes M1 GAS chromosome, complete genome.
Accession NC_002737
Length 1,852,441

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The map label for this gene is fabF [H]

Identifier: 15675597

GI number: 15675597

Start: 1449028

End: 1450260

Strand: Reverse

Name: fabF [H]

Synonym: SPy_1748

Alternate gene names: 15675597

Gene position: 1450260-1449028 (Counterclockwise)

Preceding gene: 15675598

Following gene: 15675596

Centisome position: 78.29

GC content: 41.93

Gene sequence:

>1233_bases
ATGACATTTAAAAGAGTAGTGGTAACAGGTTATGGTCTAACATCTCCAATCGGGCATGATCCTGAAACGTTTTGGAACAA
TCTGAAAGCTGGCCAAATTGGTATTGGTCCTATTACTAAATTTGACACGACTGATTATGCAGTCAAGAATGCTGCTGAAA
TTCAGGATTTTCCATTTGACAAATACTTTGTGAAAAAAGATTTGAACCGTTTCGATAGATATTCTCTTTATGCTCTTTAC
GCAGCGAAAGAGGCTATTAATCATGCTGATTTAAATATTGAGATGGTTGATTCCGATCGATTTGGCGTTATTGTTGCTTC
AGGTATTGGTGGAATTGCGGAGATTGAAGAGCAAGTGATTCGCTTACATGAAAAAGGGCCAAAACGTGTGAAGCCAATGA
CGTTGCCAAAAGCGCTACCAAATATGGCTGCAGGAAATGTCGCCATGTCTTTAAAAGCTCAAGGAGTATGTAAATCAATT
AATACTGCCTGCGCTTCTTCAAATGATGCGATTGGGGATGCCTTTCGTGCCATTAAATTTGGGACTCAAGATGTGATGAT
AGTTGGTGGGTCAGAGGCGGCCATAACCAAGTTTGCCATTGCTGGCTTCCAAAGTTTAACAGCTCTCTCAACAACTGAAG
ATCCAAGCAGAAGCTCTATTCCATTTGATAAAGACCGCAATGGTTTTATCATGGGAGAAGGATCAGGAATGCTTGTTTTA
GAAAGCCTAGAACATGCGCAAGAACGCGGGGCGACAATCTTAGCAGAAATTGTGGGTTATGGAAATACCTGCGATGCCTA
CCATATGACATCTCCAAATCCTGAGGGATTAGGAGCTCGTAAAGCCATCCACTTAGCCTTACAAGAAGCTGGTATTGAAG
CCAGTGCTATTAATTATGTCAATGCGCACGGAACTTCAACCCCAGCTAATGAAAAAGGAGAGAGTCAAGCAATTGTAGCC
GTTCTTGGTAAGGATGTTCCGGTGTCTTCAACAAAATCGTTTACGGGTCACCTTCTTGGAGCAGCAGGCGCTATTGAAGC
TATTGCCACTATCGAGGCTATGCGTCATAACTATGTTCCGATGACGGCTGGGACACAAGCTTTATCAGAGGATATCGAAG
CAAATGTCATCTTTGGAGAAGGAAAAGAAACAGCTATCAACTATGCCATTTCAAATACTTTTGGATTTGGTGGTCATAAT
GCTGTATTAGCTTTCAAATGTTGGGAGGAGTAG

Upstream 100 bases:

>100_bases
TTGCTCACTTAGCAAGCTTCTTGGTGGAACAAGATTATATTACGGGACAAGTTATCGCTATTGATGGCGGTATGACAATG
CAATAAGGAGACGTAGTGAA

Downstream 100 bases:

>100_bases
GTTGAATATTCAAGAAATCAAAGATTTGATGGCTCAGTTTGATACCTCAAGCCTACGTGAATTTTTATTCAAAACAAATG
AAGGTGAGCTAATCTTTAGT

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MTFKRVVVTGYGLTSPIGHDPETFWNNLKAGQIGIGPITKFDTTDYAVKNAAEIQDFPFDKYFVKKDLNRFDRYSLYALY
AAKEAINHADLNIEMVDSDRFGVIVASGIGGIAEIEEQVIRLHEKGPKRVKPMTLPKALPNMAAGNVAMSLKAQGVCKSI
NTACASSNDAIGDAFRAIKFGTQDVMIVGGSEAAITKFAIAGFQSLTALSTTEDPSRSSIPFDKDRNGFIMGEGSGMLVL
ESLEHAQERGATILAEIVGYGNTCDAYHMTSPNPEGLGARKAIHLALQEAGIEASAINYVNAHGTSTPANEKGESQAIVA
VLGKDVPVSSTKSFTGHLLGAAGAIEAIATIEAMRHNYVPMTAGTQALSEDIEANVIFGEGKETAINYAISNTFGFGGHN
AVLAFKCWEE

Sequences:

>Translated_410_residues
MTFKRVVVTGYGLTSPIGHDPETFWNNLKAGQIGIGPITKFDTTDYAVKNAAEIQDFPFDKYFVKKDLNRFDRYSLYALY
AAKEAINHADLNIEMVDSDRFGVIVASGIGGIAEIEEQVIRLHEKGPKRVKPMTLPKALPNMAAGNVAMSLKAQGVCKSI
NTACASSNDAIGDAFRAIKFGTQDVMIVGGSEAAITKFAIAGFQSLTALSTTEDPSRSSIPFDKDRNGFIMGEGSGMLVL
ESLEHAQERGATILAEIVGYGNTCDAYHMTSPNPEGLGARKAIHLALQEAGIEASAINYVNAHGTSTPANEKGESQAIVA
VLGKDVPVSSTKSFTGHLLGAAGAIEAIATIEAMRHNYVPMTAGTQALSEDIEANVIFGEGKETAINYAISNTFGFGGHN
AVLAFKCWEE
>Mature_409_residues
TFKRVVVTGYGLTSPIGHDPETFWNNLKAGQIGIGPITKFDTTDYAVKNAAEIQDFPFDKYFVKKDLNRFDRYSLYALYA
AKEAINHADLNIEMVDSDRFGVIVASGIGGIAEIEEQVIRLHEKGPKRVKPMTLPKALPNMAAGNVAMSLKAQGVCKSIN
TACASSNDAIGDAFRAIKFGTQDVMIVGGSEAAITKFAIAGFQSLTALSTTEDPSRSSIPFDKDRNGFIMGEGSGMLVLE
SLEHAQERGATILAEIVGYGNTCDAYHMTSPNPEGLGARKAIHLALQEAGIEASAINYVNAHGTSTPANEKGESQAIVAV
LGKDVPVSSTKSFTGHLLGAAGAIEAIATIEAMRHNYVPMTAGTQALSEDIEANVIFGEGKETAINYAISNTFGFGGHNA
VLAFKCWEE

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=417, Percent_Identity=36.9304556354916, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI223972627, Length=148, Percent_Identity=40.5405405405405, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI41872631, Length=419, Percent_Identity=24.582338902148, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1787337, Length=411, Percent_Identity=45.2554744525547, Blast_Score=311, Evalue=5e-86,
Organism=Escherichia coli, GI1788663, Length=413, Percent_Identity=34.8668280871671, Blast_Score=204, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI71983541, Length=408, Percent_Identity=36.7647058823529, Blast_Score=241, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI71983535, Length=259, Percent_Identity=41.3127413127413, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17550940, Length=265, Percent_Identity=30.188679245283, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI212642053, Length=363, Percent_Identity=25.068870523416, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320904, Length=443, Percent_Identity=37.9232505643341, Blast_Score=285, Evalue=9e-78,
Organism=Drosophila melanogaster, GI24644341, Length=417, Percent_Identity=39.8081534772182, Blast_Score=283, Evalue=1e-76,
Organism=Drosophila melanogaster, GI19920632, Length=364, Percent_Identity=25.5494505494505, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI221330659, Length=364, Percent_Identity=25.5494505494505, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24581345, Length=363, Percent_Identity=23.4159779614325, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43652; Mature: 43521

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00098 THIOLASE_1 ; PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFKRVVVTGYGLTSPIGHDPETFWNNLKAGQIGIGPITKFDTTDYAVKNAAEIQDFPFD
CCCEEEEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCHHHCCCCCH
KYFVKKDLNRFDRYSLYALYAAKEAINHADLNIEMVDSDRFGVIVASGIGGIAEIEEQVI
HHHHHHHHHHHHHHHEEEEEHHHHHHCCCCCEEEEECCCCCEEEEECCCCCHHHHHHHHH
RLHEKGPKRVKPMTLPKALPNMAAGNVAMSLKAQGVCKSINTACASSNDAIGDAFRAIKF
HHHHCCCCCCCCCCCHHHCCCCCCCCEEEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHC
GTQDVMIVGGSEAAITKFAIAGFQSLTALSTTEDPSRSSIPFDKDRNGFIMGEGSGMLVL
CCCEEEEECCCCHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCEEEECCCCEEEE
ESLEHAQERGATILAEIVGYGNTCDAYHMTSPNPEGLGARKAIHLALQEAGIEASAINYV
HHHHHHHHCCCEEEHHHHCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHCCCCCHHEEEE
NAHGTSTPANEKGESQAIVAVLGKDVPVSSTKSFTGHLLGAAGAIEAIATIEAMRHNYVP
ECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
MTAGTQALSEDIEANVIFGEGKETAINYAISNTFGFGGHNAVLAFKCWEE
CCCCHHHHHHCCCEEEEEECCCCEEEEEEEECCCCCCCCCEEEEEEECCC
>Mature Secondary Structure 
TFKRVVVTGYGLTSPIGHDPETFWNNLKAGQIGIGPITKFDTTDYAVKNAAEIQDFPFD
CCEEEEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCHHHCCCCCH
KYFVKKDLNRFDRYSLYALYAAKEAINHADLNIEMVDSDRFGVIVASGIGGIAEIEEQVI
HHHHHHHHHHHHHHHEEEEEHHHHHHCCCCCEEEEECCCCCEEEEECCCCCHHHHHHHHH
RLHEKGPKRVKPMTLPKALPNMAAGNVAMSLKAQGVCKSINTACASSNDAIGDAFRAIKF
HHHHCCCCCCCCCCCHHHCCCCCCCCEEEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHC
GTQDVMIVGGSEAAITKFAIAGFQSLTALSTTEDPSRSSIPFDKDRNGFIMGEGSGMLVL
CCCEEEEECCCCHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCEEEECCCCEEEE
ESLEHAQERGATILAEIVGYGNTCDAYHMTSPNPEGLGARKAIHLALQEAGIEASAINYV
HHHHHHHHCCCEEEHHHHCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHCCCCCHHEEEE
NAHGTSTPANEKGESQAIVAVLGKDVPVSSTKSFTGHLLGAAGAIEAIATIEAMRHNYVP
ECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
MTAGTQALSEDIEANVIFGEGKETAINYAISNTFGFGGHNAVLAFKCWEE
CCCCHHHHHHCCCEEEEEECCCCEEEEEEEECCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]