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The map label for this gene is accC [H]

Identifier: 15675594

GI number: 15675594

Start: 1446711

End: 1448075

Strand: Reverse

Name: accC [H]

Synonym: SPy_1745

Alternate gene names: 15675594

Gene position: 1448075-1446711 (Counterclockwise)

Preceding gene: 15675595

Following gene: 15675593

Centisome position: 78.17

GC content: 42.34

Gene sequence:

>1365_bases
ATGTTTAAAAAAATCTTAATTGCTAATCGTGGTGAAATTGCAGTGCGTATCATTCGTGCTGCACGAGAATTAGGGATTTC
CACAGTTGCAGTTTATTCGGAAGCGGATAAGGAAGCTCTGCACACGATCTTGGCGGACGAGGCTATCTGTATTGGTCCTG
CCCGTTCCAAGGAATCCTATCTTAATATGAATTCCGTCTTGTCAGCAGCTATTGTGACAGGAGCCCAAGCGATTCACCCA
GGGTTTGGCTTTTTAAGTGAAAACTCAAAGTTTGCGACCATGTGTGAAGAGATGAATATTAAATTTATCGGTCCATCCGC
ATCGGTTATGGATAAAATGGGTGATAAAATCAATGCTCGTTCTGAAATGATTAAGGCAGGAGTGCCCGTTATTCCAGGGT
CAGATGGTGAAGTTTATAACGCTCAAGAAGCCTTAGCTATTGCCAATAAGATTGGTTATCCTGTCATGCTAAAAGCATCG
GCAGGTGGTGGAGGTAAAGGGATTCGTAAAGTGGAGACAGAAGCAGATTTGGAGGCGGCTTTCAATGCTGCCAGTCAAGA
AGCTTTGGGAGCTTTCGGAAATGGCGCCATGTATTTGGAAAAAGTAATTTATCCAGCTAGACATATTGAGGTGCAAATTT
TAGGAGACGCTTACGGTAACATCATTCACTTGGGAGAACGGGATTGCTCCTTGCAACGGAATAATCAAAAAGTCTTGGAA
GAAAGTCCATCCATTGCTATTGGCAATACCCTCAGACACGAAATGGGGCAAGCAGCGGTTAGAGCAGCTGAAGCTGTAGC
CTATGAAAATGCGGGAACCATTGAGTTTTTGTTGGACGAAGACAGCGAGAAATTCTATTTCATGGAAATGAATACCCGTA
TCCAAGTTGAGCATCCTGTCACCGAATTTGTGACAGGAGTGGATATTGTCAAAGAGCAAATCAAAATTGCAGCAGGTCAG
CCTTTGGCGATTAATCAAGAAGACATCACTATCACGGGACATGCTATTGAATGTCGTATCAATGCTGAAAATACTGCTTT
TAACTTTGCACCGAGTCCAGGAAAGATTACAGACTTGTATATGCCAAGTGGTGGTGTAGGACTACGAGTTGATTCAGCAG
TTTACAATGGCTATGCCATTCCTCCTTATTATGACAGCATGATTGCTAAAATCATCGTTCATGGAAGCAATCGATTTGAC
GCTTTGATGAAAATGCAACGTGCCTTAGTTGAATTGGAAATTGAAGGCATTATCACCAATACAGACTTCCAGCTCGATTT
GATTTCAGATAAGCGAGTGATTGCAGGAGATTATGATACCTCTTTCTTGATGGAAACGTTCCTGCCACATTACAATAAAG
ATTAG

Upstream 100 bases:

>100_bases
GAAGCCAGGGCAGAAGTTGATGGCAAGCTAGCAGCAAGTGGAACATTAACCTTTGCCTGTGGGCAATGAGAATGATTGTT
CTGCGGAGGAAGAAACCCTT

Downstream 100 bases:

>100_bases
GAGAAAATATGGCTTTATTTCGTAAAAAAGATAAATACATCCGTATTACTCCCAATAATTCCCTCAAAGGATCTGTCAGC
CATAATGTCCCAGAAGTTCC

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A 1; ACC 1 [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MFKKILIANRGEIAVRIIRAARELGISTVAVYSEADKEALHTILADEAICIGPARSKESYLNMNSVLSAAIVTGAQAIHP
GFGFLSENSKFATMCEEMNIKFIGPSASVMDKMGDKINARSEMIKAGVPVIPGSDGEVYNAQEALAIANKIGYPVMLKAS
AGGGGKGIRKVETEADLEAAFNAASQEALGAFGNGAMYLEKVIYPARHIEVQILGDAYGNIIHLGERDCSLQRNNQKVLE
ESPSIAIGNTLRHEMGQAAVRAAEAVAYENAGTIEFLLDEDSEKFYFMEMNTRIQVEHPVTEFVTGVDIVKEQIKIAAGQ
PLAINQEDITITGHAIECRINAENTAFNFAPSPGKITDLYMPSGGVGLRVDSAVYNGYAIPPYYDSMIAKIIVHGSNRFD
ALMKMQRALVELEIEGIITNTDFQLDLISDKRVIAGDYDTSFLMETFLPHYNKD

Sequences:

>Translated_454_residues
MFKKILIANRGEIAVRIIRAARELGISTVAVYSEADKEALHTILADEAICIGPARSKESYLNMNSVLSAAIVTGAQAIHP
GFGFLSENSKFATMCEEMNIKFIGPSASVMDKMGDKINARSEMIKAGVPVIPGSDGEVYNAQEALAIANKIGYPVMLKAS
AGGGGKGIRKVETEADLEAAFNAASQEALGAFGNGAMYLEKVIYPARHIEVQILGDAYGNIIHLGERDCSLQRNNQKVLE
ESPSIAIGNTLRHEMGQAAVRAAEAVAYENAGTIEFLLDEDSEKFYFMEMNTRIQVEHPVTEFVTGVDIVKEQIKIAAGQ
PLAINQEDITITGHAIECRINAENTAFNFAPSPGKITDLYMPSGGVGLRVDSAVYNGYAIPPYYDSMIAKIIVHGSNRFD
ALMKMQRALVELEIEGIITNTDFQLDLISDKRVIAGDYDTSFLMETFLPHYNKD
>Mature_454_residues
MFKKILIANRGEIAVRIIRAARELGISTVAVYSEADKEALHTILADEAICIGPARSKESYLNMNSVLSAAIVTGAQAIHP
GFGFLSENSKFATMCEEMNIKFIGPSASVMDKMGDKINARSEMIKAGVPVIPGSDGEVYNAQEALAIANKIGYPVMLKAS
AGGGGKGIRKVETEADLEAAFNAASQEALGAFGNGAMYLEKVIYPARHIEVQILGDAYGNIIHLGERDCSLQRNNQKVLE
ESPSIAIGNTLRHEMGQAAVRAAEAVAYENAGTIEFLLDEDSEKFYFMEMNTRIQVEHPVTEFVTGVDIVKEQIKIAAGQ
PLAINQEDITITGHAIECRINAENTAFNFAPSPGKITDLYMPSGGVGLRVDSAVYNGYAIPPYYDSMIAKIIVHGSNRFD
ALMKMQRALVELEIEGIITNTDFQLDLISDKRVIAGDYDTSFLMETFLPHYNKD

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=450, Percent_Identity=47.3333333333333, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI189095269, Length=447, Percent_Identity=48.5458612975391, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI65506442, Length=447, Percent_Identity=48.5458612975391, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI295821183, Length=447, Percent_Identity=48.5458612975391, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI106049528, Length=448, Percent_Identity=46.4285714285714, Blast_Score=404, Evalue=1e-113,
Organism=Homo sapiens, GI106049295, Length=448, Percent_Identity=46.4285714285714, Blast_Score=404, Evalue=1e-113,
Organism=Homo sapiens, GI106049292, Length=448, Percent_Identity=46.4285714285714, Blast_Score=404, Evalue=1e-113,
Organism=Homo sapiens, GI38679974, Length=509, Percent_Identity=31.8271119842829, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI38679977, Length=509, Percent_Identity=31.8271119842829, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI38679967, Length=509, Percent_Identity=31.8271119842829, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI38679971, Length=509, Percent_Identity=31.8271119842829, Blast_Score=231, Evalue=9e-61,
Organism=Homo sapiens, GI38679960, Length=509, Percent_Identity=31.8271119842829, Blast_Score=231, Evalue=9e-61,
Organism=Homo sapiens, GI134142062, Length=506, Percent_Identity=31.8181818181818, Blast_Score=228, Evalue=6e-60,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=52.9279279279279, Blast_Score=458, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI17567343, Length=447, Percent_Identity=46.7561521252796, Blast_Score=413, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI71987519, Length=442, Percent_Identity=45.4751131221719, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17562816, Length=462, Percent_Identity=44.5887445887446, Blast_Score=383, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI71997168, Length=504, Percent_Identity=32.3412698412698, Blast_Score=238, Evalue=7e-63,
Organism=Caenorhabditis elegans, GI71997163, Length=504, Percent_Identity=32.3412698412698, Blast_Score=237, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI133931226, Length=486, Percent_Identity=31.2757201646091, Blast_Score=224, Evalue=8e-59,
Organism=Saccharomyces cerevisiae, GI6319685, Length=429, Percent_Identity=45.2214452214452, Blast_Score=388, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6319695, Length=450, Percent_Identity=44.6666666666667, Blast_Score=365, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6321376, Length=450, Percent_Identity=45.5555555555556, Blast_Score=351, Evalue=2e-97,
Organism=Saccharomyces cerevisiae, GI6323863, Length=459, Percent_Identity=33.5511982570806, Blast_Score=238, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6324343, Length=485, Percent_Identity=35.0515463917526, Blast_Score=236, Evalue=5e-63,
Organism=Drosophila melanogaster, GI24651757, Length=444, Percent_Identity=47.0720720720721, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI281363050, Length=461, Percent_Identity=47.0715835140998, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652224, Length=461, Percent_Identity=47.0715835140998, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652222, Length=461, Percent_Identity=47.0715835140998, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652220, Length=461, Percent_Identity=47.0715835140998, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652218, Length=461, Percent_Identity=47.0715835140998, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652212, Length=461, Percent_Identity=47.0715835140998, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652210, Length=461, Percent_Identity=47.0715835140998, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652214, Length=461, Percent_Identity=47.0715835140998, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI19921944, Length=461, Percent_Identity=47.0715835140998, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652216, Length=461, Percent_Identity=47.0715835140998, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24651759, Length=408, Percent_Identity=45.5882352941176, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI161076407, Length=497, Percent_Identity=32.9979879275654, Blast_Score=242, Evalue=4e-64,
Organism=Drosophila melanogaster, GI24586460, Length=497, Percent_Identity=32.9979879275654, Blast_Score=242, Evalue=4e-64,
Organism=Drosophila melanogaster, GI24586458, Length=497, Percent_Identity=32.9979879275654, Blast_Score=242, Evalue=4e-64,
Organism=Drosophila melanogaster, GI161076409, Length=497, Percent_Identity=32.9979879275654, Blast_Score=242, Evalue=5e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49345; Mature: 49345

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKILIANRGEIAVRIIRAARELGISTVAVYSEADKEALHTILADEAICIGPARSKESY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCEEEECCCCCCHHH
LNMNSVLSAAIVTGAQAIHPGFGFLSENSKFATMCEEMNIKFIGPSASVMDKMGDKINAR
CCHHHHHHHHHHHCCHHHCCCCCEECCCCHHHHHHHHCCEEEECCCHHHHHHCCCCCCHH
SEMIKAGVPVIPGSDGEVYNAQEALAIANKIGYPVMLKASAGGGGKGIRKVETEADLEAA
HHHHHCCCCCCCCCCCCEECHHHHHHHHHHCCCCEEEEECCCCCCCCCEEECCHHHHHHH
FNAASQEALGAFGNGAMYLEKVIYPARHIEVQILGDAYGNIIHLGERDCSLQRNNQKVLE
HHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEEECCCCCCEEEECCCCCCCCCCCHHHHH
ESPSIAIGNTLRHEMGQAAVRAAEAVAYENAGTIEFLLDEDSEKFYFMEMNTRIQVEHPV
CCCCEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEECCEEEEECCH
TEFVTGVDIVKEQIKIAAGQPLAINQEDITITGHAIECRINAENTAFNFAPSPGKITDLY
HHHHHHHHHHHHHHHHCCCCCEEECCCCEEEEEEEEEEEEECCCCEEEECCCCCCEEEEE
MPSGGVGLRVDSAVYNGYAIPPYYDSMIAKIIVHGSNRFDALMKMQRALVELEIEGIITN
ECCCCCCEEECCCEECCEECCCHHHHHHHHHEEECCCHHHHHHHHHHHHHEEEEEEEEEC
TDFQLDLISDKRVIAGDYDTSFLMETFLPHYNKD
CCEEEEEECCCEEEECCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MFKKILIANRGEIAVRIIRAARELGISTVAVYSEADKEALHTILADEAICIGPARSKESY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCEEEECCCCCCHHH
LNMNSVLSAAIVTGAQAIHPGFGFLSENSKFATMCEEMNIKFIGPSASVMDKMGDKINAR
CCHHHHHHHHHHHCCHHHCCCCCEECCCCHHHHHHHHCCEEEECCCHHHHHHCCCCCCHH
SEMIKAGVPVIPGSDGEVYNAQEALAIANKIGYPVMLKASAGGGGKGIRKVETEADLEAA
HHHHHCCCCCCCCCCCCEECHHHHHHHHHHCCCCEEEEECCCCCCCCCEEECCHHHHHHH
FNAASQEALGAFGNGAMYLEKVIYPARHIEVQILGDAYGNIIHLGERDCSLQRNNQKVLE
HHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEEECCCCCCEEEECCCCCCCCCCCHHHHH
ESPSIAIGNTLRHEMGQAAVRAAEAVAYENAGTIEFLLDEDSEKFYFMEMNTRIQVEHPV
CCCCEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEECCEEEEECCH
TEFVTGVDIVKEQIKIAAGQPLAINQEDITITGHAIECRINAENTAFNFAPSPGKITDLY
HHHHHHHHHHHHHHHHCCCCCEEECCCCEEEEEEEEEEEEECCCCEEEECCCCCCEEEEE
MPSGGVGLRVDSAVYNGYAIPPYYDSMIAKIIVHGSNRFDALMKMQRALVELEIEGIITN
ECCCCCCEEECCCEECCEECCCHHHHHHHHHEEECCCHHHHHHHHHHHHHEEEEEEEEEC
TDFQLDLISDKRVIAGDYDTSFLMETFLPHYNKD
CCEEEEEECCCEEEECCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7592499; 8969508; 9384377 [H]