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The map label for this gene is manM [H]

Identifier: 15675588

GI number: 15675588

Start: 1440968

End: 1441777

Strand: Direct

Name: manM [H]

Synonym: SPy_1739

Alternate gene names: 15675588

Gene position: 1440968-1441777 (Clockwise)

Preceding gene: 15675587

Following gene: 15675589

Centisome position: 77.79

GC content: 45.43

Gene sequence:

>810_bases
ATGTCAGATATTTCGATTATTTCTGCAATTTTGGTCGTTATCATTGCCTTCTTCGCTGGTCTTGAAGGTATCCTCGACCA
ATTTCAAATGCACCAACCACTTGTTGCCTGTACTTTGATTGGACTTGTAACTGGACACCTTGAAGCTGGTGTCATCCTTG
GTGGTACACTTCAAATGCTTGCTCTTGGTTGGGCAAACATCGGTGCTGCCGTTGCCCCTGATGCTGCCCTTGCCTCTGTT
GCAGCTGCTATCATCATGGTCAAAAGTGGCGACTTTACTCAAAAAGGAATTACCTTTGCTTACTCAACAGCTATCCCACT
TGCTGTTGCTGGTCTTTTCCTTACAATGATCGTTCGTACTTTGTCAACTGCCCTTGTACACGCTGGTGACAAAGCTGCCG
CTGAAGGTAATTTCGCAGGTATTGAACGCTTCCACTTTATTGCCCTTCTTCTTCAAGGATTGCGTATCGCTGTCCCTGCA
GCTCTTCTTGTTGCTGTTCCTACTTCAGCCGTACAATCTGTTTTGAATGCTATGCCAAACTGGTTGAACGAAGGTATGCA
AATCGGTGGTGCGATGGTTGTTGCTGTAGGTTATGCTATGGTTATCAACATGATGGCTACTCGTGAAGTATGGCCATTCT
TCGCCCTAGGTTTTGCTCTTGCAGCTATCAGCCAATTAACCCTTATCGCTATGGGTGTTATCGGTGTAGCAATTGCCTTC
ATCTACCTTAATCTTTCTAAAAAAGGTGGTAACGGTGGTAATGCAGCAGGTTCAGCTGATCCAATCGGCGACATCTTAGA
AGACTACTAG

Upstream 100 bases:

>100_bases
AACATTAAATAAGTTTCAAACGCTATAAGGTTTTAAAACGATGACTAGCTAACTTATTAGCAAAAAGTCCTCGTTTACTA
TACTTTGAAAGGATTACAAC

Downstream 100 bases:

>100_bases
AAAGGGGTAAGAACAAATGACTGAACAAATTAAATTAACTAAATCAGACCGTCAACGTGTTTGGTGGCGTTCACAATTCT
TACAAGGTTCTTGGAACTAC

Product: PTS system mannose-specific transporter subunit IIC

Products: protein histidine; sugar phosphate

Alternate protein names: EIIC-Sor; PTS system sorbose-specific EIIC component [H]

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MSDISIISAILVVIIAFFAGLEGILDQFQMHQPLVACTLIGLVTGHLEAGVILGGTLQMLALGWANIGAAVAPDAALASV
AAAIIMVKSGDFTQKGITFAYSTAIPLAVAGLFLTMIVRTLSTALVHAGDKAAAEGNFAGIERFHFIALLLQGLRIAVPA
ALLVAVPTSAVQSVLNAMPNWLNEGMQIGGAMVVAVGYAMVINMMATREVWPFFALGFALAAISQLTLIAMGVIGVAIAF
IYLNLSKKGGNGGNAAGSADPIGDILEDY

Sequences:

>Translated_269_residues
MSDISIISAILVVIIAFFAGLEGILDQFQMHQPLVACTLIGLVTGHLEAGVILGGTLQMLALGWANIGAAVAPDAALASV
AAAIIMVKSGDFTQKGITFAYSTAIPLAVAGLFLTMIVRTLSTALVHAGDKAAAEGNFAGIERFHFIALLLQGLRIAVPA
ALLVAVPTSAVQSVLNAMPNWLNEGMQIGGAMVVAVGYAMVINMMATREVWPFFALGFALAAISQLTLIAMGVIGVAIAF
IYLNLSKKGGNGGNAAGSADPIGDILEDY
>Mature_268_residues
SDISIISAILVVIIAFFAGLEGILDQFQMHQPLVACTLIGLVTGHLEAGVILGGTLQMLALGWANIGAAVAPDAALASVA
AAIIMVKSGDFTQKGITFAYSTAIPLAVAGLFLTMIVRTLSTALVHAGDKAAAEGNFAGIERFHFIALLLQGLRIAVPAA
LLVAVPTSAVQSVLNAMPNWLNEGMQIGGAMVVAVGYAMVINMMATREVWPFFALGFALAAISQLTLIAMGVIGVAIAFI
YLNLSKKGGNGGNAAGSADPIGDILEDY

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system i

COG id: COG3715

COG function: function code G; Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-4 domain [H]

Homologues:

Organism=Escherichia coli, GI1788121, Length=263, Percent_Identity=48.6692015209125, Blast_Score=204, Evalue=5e-54,
Organism=Escherichia coli, GI1789528, Length=270, Percent_Identity=22.5925925925926, Blast_Score=86, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004700
- InterPro:   IPR018404 [H]

Pfam domain/function: PF03609 EII-Sor [H]

EC number: 2.7.1.69

Molecular weight: Translated: 27626; Mature: 27495

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS51106 PTS_EIIC_TYPE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDISIISAILVVIIAFFAGLEGILDQFQMHQPLVACTLIGLVTGHLEAGVILGGTLQML
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCEEEHHHHHHH
ALGWANIGAAVAPDAALASVAAAIIMVKSGDFTQKGITFAYSTAIPLAVAGLFLTMIVRT
HHHHHHCCCHHCCHHHHHHHHHHHHHEECCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHH
LSTALVHAGDKAAAEGNFAGIERFHFIALLLQGLRIAVPAALLVAVPTSAVQSVLNAMPN
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
WLNEGMQIGGAMVVAVGYAMVINMMATREVWPFFALGFALAAISQLTLIAMGVIGVAIAF
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYLNLSKKGGNGGNAAGSADPIGDILEDY
HHHHHHCCCCCCCCCCCCCCHHHHHHHCC
>Mature Secondary Structure 
SDISIISAILVVIIAFFAGLEGILDQFQMHQPLVACTLIGLVTGHLEAGVILGGTLQML
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCEEEHHHHHHH
ALGWANIGAAVAPDAALASVAAAIIMVKSGDFTQKGITFAYSTAIPLAVAGLFLTMIVRT
HHHHHHCCCHHCCHHHHHHHHHHHHHEECCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHH
LSTALVHAGDKAAAEGNFAGIERFHFIALLLQGLRIAVPAALLVAVPTSAVQSVLNAMPN
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
WLNEGMQIGGAMVVAVGYAMVINMMATREVWPFFALGFALAAISQLTLIAMGVIGVAIAF
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYLNLSKKGGNGGNAAGSADPIGDILEDY
HHHHHHCCCCCCCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: protein N(pi)-phosphohistidine; sugar

Specific reaction: protein N(pi)-phosphohistidine + sugar = protein histidine + sugar phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7947968 [H]