Definition Streptococcus pyogenes M1 GAS chromosome, complete genome.
Accession NC_002737
Length 1,852,441

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The map label for this gene is manL [H]

Identifier: 15675587

GI number: 15675587

Start: 1439887

End: 1440879

Strand: Direct

Name: manL [H]

Synonym: SPy_1738

Alternate gene names: 15675587

Gene position: 1439887-1440879 (Clockwise)

Preceding gene: 15675586

Following gene: 15675588

Centisome position: 77.73

GC content: 41.09

Gene sequence:

>993_bases
ATGGGTATCGGTATTATTATTGCCAGCCATGGTAAATTTGCTGAAGGTATTCATCAATCTGGTTCTATGATTTTTGGTGA
ACAAGAGAAAGTTCAAGTTGTTACTTTCATGCCAAACGAAGGACCAGATGATTTGTATGGACACTTCAACAATGCTATCC
AACAATTTGATGCTGATGATGAAATCCTTGTGCTAGCTGACCTTTGGAGTGGTTCTCCATTTAACCAAGCTAGTCGTGTG
GCAGGTGAAAATCCTGACCGCAAAATGGCGATCATCACTGGTCTCAACTTGCCTATGCTTATTCAAGCTTACACTGAACG
TCTTATGGATGCTGGTGCAGGTGTTGAACAAGTTGCTGCAAACATCATTAAGGAATCTAAGGACGGTATCAAAGCCCTTC
CTGAAGACCTTAACCCAGTTGAAGAAACTGCTGCAACTGAAAAAGTTGTTAACGCACTTCAAGGAGCTATTCCTGCTGGA
ACTGTCATCGGAGATGGTAAATTAAAGATCAATCTTGCTCGTGTTGACACTCGTCTTTTACACGGTCAAGTTGCAACAGC
ATGGACTCCAGCTTCTAAGGCTGACCGTATCATTGTTGCTTCTGATGAGGTTGCTCAAGATGACCTTCGCAAACAATTGA
TCAAACAGGCTGCACCTGGTGGTGTCAAAGCTAACGTTGTTCCAATTAGCAAATTGATTGAAGCTTCTAAAGATCCTCGT
TTTGGTAACACACACGCACTTATTCTTTTCCAAACCCCTCAAGATGCCCTTCGAGCGGTTGAAGGTGGTGTTGAAATCAA
CGAATTGAACGTTGGTTCAATGGCTCACTCAACTGGTAAAACAATGGTTAACAACGTTTTATCAATGGACAAAGAAGACG
TTGCTACTTTTGAAAAATTACGCGACCTAGGTGTTACATTCGACGTCCGTAAAGTTCCTAACGATTCTAAGAAAAACTTA
TTTGAGCTTATCCAAAAAACTAACATTAAATAA

Upstream 100 bases:

>100_bases
AATTTCGTTTAAGTGAAAAAGAATTGCCAAAATTTAGTTTTGGAAGGAGATTATTCTTCTTCATTTCAACGAAAAATATT
TTAAAGGAGGAAGAACAAGA

Downstream 100 bases:

>100_bases
GTTTCAAACGCTATAAGGTTTTAAAACGATGACTAGCTAACTTATTAGCAAAAAGTCCTCGTTTACTATACTTTGAAAGG
ATTACAACATGTCAGATATT

Product: mannose-specific phosphotransferase system component IIAB

Products: NA

Alternate protein names: EIIAB-Man; Mannose-specific phosphotransferase enzyme IIA component; EIII-Man; PTS system mannose-specific EIIA component; Mannose-specific phosphotransferase enzyme IIB component; PTS system mannose-specific EIIB component [H]

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MGIGIIIASHGKFAEGIHQSGSMIFGEQEKVQVVTFMPNEGPDDLYGHFNNAIQQFDADDEILVLADLWSGSPFNQASRV
AGENPDRKMAIITGLNLPMLIQAYTERLMDAGAGVEQVAANIIKESKDGIKALPEDLNPVEETAATEKVVNALQGAIPAG
TVIGDGKLKINLARVDTRLLHGQVATAWTPASKADRIIVASDEVAQDDLRKQLIKQAAPGGVKANVVPISKLIEASKDPR
FGNTHALILFQTPQDALRAVEGGVEINELNVGSMAHSTGKTMVNNVLSMDKEDVATFEKLRDLGVTFDVRKVPNDSKKNL
FELIQKTNIK

Sequences:

>Translated_330_residues
MGIGIIIASHGKFAEGIHQSGSMIFGEQEKVQVVTFMPNEGPDDLYGHFNNAIQQFDADDEILVLADLWSGSPFNQASRV
AGENPDRKMAIITGLNLPMLIQAYTERLMDAGAGVEQVAANIIKESKDGIKALPEDLNPVEETAATEKVVNALQGAIPAG
TVIGDGKLKINLARVDTRLLHGQVATAWTPASKADRIIVASDEVAQDDLRKQLIKQAAPGGVKANVVPISKLIEASKDPR
FGNTHALILFQTPQDALRAVEGGVEINELNVGSMAHSTGKTMVNNVLSMDKEDVATFEKLRDLGVTFDVRKVPNDSKKNL
FELIQKTNIK
>Mature_329_residues
GIGIIIASHGKFAEGIHQSGSMIFGEQEKVQVVTFMPNEGPDDLYGHFNNAIQQFDADDEILVLADLWSGSPFNQASRVA
GENPDRKMAIITGLNLPMLIQAYTERLMDAGAGVEQVAANIIKESKDGIKALPEDLNPVEETAATEKVVNALQGAIPAGT
VIGDGKLKINLARVDTRLLHGQVATAWTPASKADRIIVASDEVAQDDLRKQLIKQAAPGGVKANVVPISKLIEASKDPRF
GNTHALILFQTPQDALRAVEGGVEINELNVGSMAHSTGKTMVNNVLSMDKEDVATFEKLRDLGVTFDVRKVPNDSKKNLF
ELIQKTNIK

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG2893

COG function: function code G; Phosphotransferase system, mannose/fructose-specific component IIA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIB type-4 domain [H]

Homologues:

Organism=Escherichia coli, GI1788120, Length=328, Percent_Identity=39.0243902439024, Blast_Score=234, Evalue=6e-63,
Organism=Escherichia coli, GI87082217, Length=162, Percent_Identity=33.9506172839506, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789527, Length=154, Percent_Identity=31.1688311688312, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 260 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004701
- InterPro:   IPR004720 [H]

Pfam domain/function: PF03610 EIIA-man; PF03830 PTSIIB_sorb [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 35568; Mature: 35437

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS51096 PTS_EIIA_TYPE_4 ; PS51101 PTS_EIIB_TYPE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIGIIIASHGKFAEGIHQSGSMIFGEQEKVQVVTFMPNEGPDDLYGHFNNAIQQFDADD
CCEEEEEECCCCHHHHHHCCCCEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCC
EILVLADLWSGSPFNQASRVAGENPDRKMAIITGLNLPMLIQAYTERLMDAGAGVEQVAA
CEEEEEECCCCCCCCHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHH
NIIKESKDGIKALPEDLNPVEETAATEKVVNALQGAIPAGTVIGDGKLKINLARVDTRLL
HHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCEEEEEEEHHHHHHH
HGQVATAWTPASKADRIIVASDEVAQDDLRKQLIKQAAPGGVKANVVPISKLIEASKDPR
HCCHHEEECCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHCCCCCC
FGNTHALILFQTPQDALRAVEGGVEINELNVGSMAHSTGKTMVNNVLSMDKEDVATFEKL
CCCCEEEEEEECCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHH
RDLGVTFDVRKVPNDSKKNLFELIQKTNIK
HHCCCEEEEEECCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GIGIIIASHGKFAEGIHQSGSMIFGEQEKVQVVTFMPNEGPDDLYGHFNNAIQQFDADD
CEEEEEECCCCHHHHHHCCCCEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCC
EILVLADLWSGSPFNQASRVAGENPDRKMAIITGLNLPMLIQAYTERLMDAGAGVEQVAA
CEEEEEECCCCCCCCHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHH
NIIKESKDGIKALPEDLNPVEETAATEKVVNALQGAIPAGTVIGDGKLKINLARVDTRLL
HHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCEEEEEEEHHHHHHH
HGQVATAWTPASKADRIIVASDEVAQDDLRKQLIKQAAPGGVKANVVPISKLIEASKDPR
HCCHHEEECCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHCCCCCC
FGNTHALILFQTPQDALRAVEGGVEINELNVGSMAHSTGKTMVNNVLSMDKEDVATFEKL
CCCCEEEEEEECCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHH
RDLGVTFDVRKVPNDSKKNLFELIQKTNIK
HHCCCEEEEEECCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA