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The map label for this gene is aroE

Identifier: 15675472

GI number: 15675472

Start: 1302348

End: 1303226

Strand: Reverse

Name: aroE

Synonym: SPy_1584

Alternate gene names: 15675472

Gene position: 1303226-1302348 (Counterclockwise)

Preceding gene: 15675473

Following gene: 15675471

Centisome position: 70.35

GC content: 45.85

Gene sequence:

>879_bases
ATGTCAGAACGTTTATCAGGCCACACCCTGTTGGTCTCTTTGCTTGCTACCCCTATTCGTCATAGTTTGTCTCCCAAAAT
GCACAATGAAGCCTATGCTAAACTGGGGCTGGATTATGCCTACCTTGCTTTTGAAGTAGGGACAGAGCAATTAGCAGATG
CCGTGCAAGGGATTCGTGCCTTAGGAATTCGTGGCTCCAATGTGTCTATGCCAAATAAAGAAGCTATTTTACCCTTATTG
GATGACTTGTCCCCAGCTGCTGAGTTGGTCGGTGCAGTCAATACGGTTGTCAATAAGGATGGTAAAGGACATCTCGTGGG
GCATATTACAGACGGTATAGGAGCGCTCAGAGCCTTGGCTGACGAAGGAGTGTCGGTAAAGAACAAAATCATTACCCTAG
CAGGAGTTGGTGGGGCTGGGAAAGCTATCGCTGTCCAGCTCGCTTTTGACGGCGCCAAAGAGGTTCGTTTGTTTAACCGA
CAAGCTACACGTCTAAGTAGCGTTCAAAAGCTTGTGACAAAACTGAACCAGCTAACAAGGACTAAAGTAACCCTTCAAGA
CTTGGAAGATCAGACTGCCTTTAAGGAGGCCATCAGGGAATCTCATCTATTTATTGATGCTACAAGTGTAGGAATGAAGC
CTTTAGAAAATCTAAGTTTGATTACCGACCCCGAGCTCATTCGCCCAGACTTGGTGGTCTTTGACATCGTGTACAGCCCA
GCAGAAACCAAGTTACTAGCCTTTGCCCGTCAACATGGCGCCCAAAAAGTCATTAATGGGCTAGGAATGGTGCTTTATCA
AGGAGCAGAAGCTTTTAAATTAATCACTGGTCAAGACATGCCAGTTGACGCTATTAAACCTCTTTTAGGTGATGAGTAA

Upstream 100 bases:

>100_bases
GATGAATTCTGTAAAATAAGGTATAATAAAAAACAAATAGGCGTCCTTTATTACGTGAAAGGCGCCTTTACAAGGTTGAA
ATGGAAAGTGAGATTTCTAA

Downstream 100 bases:

>100_bases
CACTTTTTAAGTAAGCTTAATTATGATATATTAATAAGAGATGGAGCAGTCATCATGGGCTGCTAAAATTCTTTTTGCGA
GAGCTGTTTTTAAGAGCAAA

Product: putative shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MSERLSGHTLLVSLLATPIRHSLSPKMHNEAYAKLGLDYAYLAFEVGTEQLADAVQGIRALGIRGSNVSMPNKEAILPLL
DDLSPAAELVGAVNTVVNKDGKGHLVGHITDGIGALRALADEGVSVKNKIITLAGVGGAGKAIAVQLAFDGAKEVRLFNR
QATRLSSVQKLVTKLNQLTRTKVTLQDLEDQTAFKEAIRESHLFIDATSVGMKPLENLSLITDPELIRPDLVVFDIVYSP
AETKLLAFARQHGAQKVINGLGMVLYQGAEAFKLITGQDMPVDAIKPLLGDE

Sequences:

>Translated_292_residues
MSERLSGHTLLVSLLATPIRHSLSPKMHNEAYAKLGLDYAYLAFEVGTEQLADAVQGIRALGIRGSNVSMPNKEAILPLL
DDLSPAAELVGAVNTVVNKDGKGHLVGHITDGIGALRALADEGVSVKNKIITLAGVGGAGKAIAVQLAFDGAKEVRLFNR
QATRLSSVQKLVTKLNQLTRTKVTLQDLEDQTAFKEAIRESHLFIDATSVGMKPLENLSLITDPELIRPDLVVFDIVYSP
AETKLLAFARQHGAQKVINGLGMVLYQGAEAFKLITGQDMPVDAIKPLLGDE
>Mature_291_residues
SERLSGHTLLVSLLATPIRHSLSPKMHNEAYAKLGLDYAYLAFEVGTEQLADAVQGIRALGIRGSNVSMPNKEAILPLLD
DLSPAAELVGAVNTVVNKDGKGHLVGHITDGIGALRALADEGVSVKNKIITLAGVGGAGKAIAVQLAFDGAKEVRLFNRQ
ATRLSSVQKLVTKLNQLTRTKVTLQDLEDQTAFKEAIRESHLFIDATSVGMKPLENLSLITDPELIRPDLVVFDIVYSPA
ETKLLAFARQHGAQKVINGLGMVLYQGAEAFKLITGQDMPVDAIKPLLGDE

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1787983, Length=280, Percent_Identity=47.1428571428571, Blast_Score=265, Evalue=3e-72,
Organism=Escherichia coli, GI1789675, Length=266, Percent_Identity=29.6992481203008, Blast_Score=103, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320332, Length=285, Percent_Identity=28.7719298245614, Blast_Score=88, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_STRP1 (P63597)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_269646.1
- RefSeq:   YP_282666.1
- ProteinModelPortal:   P63597
- SMR:   P63597
- EnsemblBacteria:   EBSTRT00000001108
- EnsemblBacteria:   EBSTRT00000029143
- GeneID:   3571617
- GeneID:   901833
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_1584
- KEGG:   spz:M5005_Spy_1303
- GeneTree:   EBGT00050000027337
- HOGENOM:   HBG553408
- OMA:   SIYIDAT
- ProtClustDB:   CLSK698780
- BioCyc:   SPYO160490:SPY1584-MONOMER
- BioCyc:   SPYO293653:M5005_SPY1303-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 31277; Mature: 31145

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: ACT_SITE 73-73

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERLSGHTLLVSLLATPIRHSLSPKMHNEAYAKLGLDYAYLAFEVGTEQLADAVQGIRA
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHEEHHCHHHHHHHHHHHHH
LGIRGSNVSMPNKEAILPLLDDLSPAAELVGAVNTVVNKDGKGHLVGHITDGIGALRALA
HCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHH
DEGVSVKNKIITLAGVGGAGKAIAVQLAFDGAKEVRLFNRQATRLSSVQKLVTKLNQLTR
HCCCCCCCEEEEEEECCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TKVTLQDLEDQTAFKEAIRESHLFIDATSVGMKPLENLSLITDPELIRPDLVVFDIVYSP
HHHHHHHHHHHHHHHHHHHHCCEEEEEHHCCCCCHHCCCCCCCCHHHCCCEEEEEEEECC
AETKLLAFARQHGAQKVINGLGMVLYQGAEAFKLITGQDMPVDAIKPLLGDE
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
SERLSGHTLLVSLLATPIRHSLSPKMHNEAYAKLGLDYAYLAFEVGTEQLADAVQGIRA
CCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHEEHHCHHHHHHHHHHHHH
LGIRGSNVSMPNKEAILPLLDDLSPAAELVGAVNTVVNKDGKGHLVGHITDGIGALRALA
HCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHH
DEGVSVKNKIITLAGVGGAGKAIAVQLAFDGAKEVRLFNRQATRLSSVQKLVTKLNQLTR
HCCCCCCCEEEEEEECCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TKVTLQDLEDQTAFKEAIRESHLFIDATSVGMKPLENLSLITDPELIRPDLVVFDIVYSP
HHHHHHHHHHHHHHHHHHHHCCEEEEEHHCCCCCHHCCCCCCCCHHHCCCEEEEEEEECC
AETKLLAFARQHGAQKVINGLGMVLYQGAEAFKLITGQDMPVDAIKPLLGDE
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296