Definition Streptococcus pyogenes M1 GAS chromosome, complete genome.
Accession NC_002737
Length 1,852,441

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The map label for this gene is pyrD

Identifier: 15675344

GI number: 15675344

Start: 1185686

End: 1186621

Strand: Direct

Name: pyrD

Synonym: SPy_1432

Alternate gene names: 15675344

Gene position: 1185686-1186621 (Clockwise)

Preceding gene: 15675332

Following gene: 15675346

Centisome position: 64.01

GC content: 41.45

Gene sequence:

>936_bases
ATGGTTTCTACTGCTACACAAATTGGTCATTTCTCTTTTGATAACTGTTTGATGAATGCTGCTGGTGTTTACTGCATGAC
AAAAGAAGAGCTTATGGAGGTTGAAAAGTCTCAAGCCGCTTCCTTTGTCACCAAAACAGGGACGCTTGAAGTTCGTCCAG
GTAATCCAGAACCTCGCTACGCAGATACTCGTCTTGGTTCTATCAATTCAATGGGACTCCCTAATAATGGTTTTCGCTAC
TACTTAGACTTTGTCAGTGATCTTGCCAAAACCGGGCAACATAAACCTCACTTTCTCTCCGTTGTCGGGCTATCTCCTAC
TGAAACCGAAACCATTTTAAAAGCCATCATGGCTTCAGATTATGAGGGTCTAGTGGAACTAAACCTTTCTTGCCCTAACG
TTCCAGGAAAACCACAGATTGCTTATGATTTTGAAACCACTGATCAACTTCTAGAGAACATCTTTACCTATTACACTAAA
CCTCTTGGTATCAAATTACCTCCTTATTTTGACATTGTGCATTTTGATCAAGCGGCTGCGATTTTCAATAAATACCCCCT
TTCCTTTGTTAACTGTGTCAATTCTATCGGAAATGGGCTGGTCATTAAGGATGAACAAGTCCTCATCAAGCCTAAAAATG
GCTTTGGTGGTATAGGTGGAGATTACATCAAACCTACTGCTCTAGCCAATGTCCATGCGTTTTACAAACGCTTAAAACCT
TCTATCCACATTATTGGTACAGGGGGAGTTAAAACAGGACGCGATGCCTTTGAACATATTCTTTGTGGCGCCAGCATGGT
CCAAATTGGGACAGCCCTTCATCAAGAAGGGCCAGCTATCTTTGAACGGGTCACTAAGGAACTTAAAACGATTATGGTAG
AAAAAGGCTACCAAAGCTTAGACGATTTTCGTGGGAACTTACGTTACAAAGATTAA

Upstream 100 bases:

>100_bases
TCAATAACAGTAATATATTTACATTTTTGTAAAAATAGCTTGCTATTATTCATGCCTAGTGGTAGAATAGAAAAAATTTG
TCTAAAATATGGAGGAAATA

Downstream 100 bases:

>100_bases
CCTTAATAGTCAAAAAAGCTTGGAAATGTGCACTTTGTACACTTTCCAAGCTTTTTAAAATGGGAATTTTTTTGAAGGGA
CAGCGTCACTTTCTTGGGAC

Product: dihydroorotate dehydrogenase 1A

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MVSTATQIGHFSFDNCLMNAAGVYCMTKEELMEVEKSQAASFVTKTGTLEVRPGNPEPRYADTRLGSINSMGLPNNGFRY
YLDFVSDLAKTGQHKPHFLSVVGLSPTETETILKAIMASDYEGLVELNLSCPNVPGKPQIAYDFETTDQLLENIFTYYTK
PLGIKLPPYFDIVHFDQAAAIFNKYPLSFVNCVNSIGNGLVIKDEQVLIKPKNGFGGIGGDYIKPTALANVHAFYKRLKP
SIHIIGTGGVKTGRDAFEHILCGASMVQIGTALHQEGPAIFERVTKELKTIMVEKGYQSLDDFRGNLRYKD

Sequences:

>Translated_311_residues
MVSTATQIGHFSFDNCLMNAAGVYCMTKEELMEVEKSQAASFVTKTGTLEVRPGNPEPRYADTRLGSINSMGLPNNGFRY
YLDFVSDLAKTGQHKPHFLSVVGLSPTETETILKAIMASDYEGLVELNLSCPNVPGKPQIAYDFETTDQLLENIFTYYTK
PLGIKLPPYFDIVHFDQAAAIFNKYPLSFVNCVNSIGNGLVIKDEQVLIKPKNGFGGIGGDYIKPTALANVHAFYKRLKP
SIHIIGTGGVKTGRDAFEHILCGASMVQIGTALHQEGPAIFERVTKELKTIMVEKGYQSLDDFRGNLRYKD
>Mature_311_residues
MVSTATQIGHFSFDNCLMNAAGVYCMTKEELMEVEKSQAASFVTKTGTLEVRPGNPEPRYADTRLGSINSMGLPNNGFRY
YLDFVSDLAKTGQHKPHFLSVVGLSPTETETILKAIMASDYEGLVELNLSCPNVPGKPQIAYDFETTDQLLENIFTYYTK
PLGIKLPPYFDIVHFDQAAAIFNKYPLSFVNCVNSIGNGLVIKDEQVLIKPKNGFGGIGGDYIKPTALANVHAFYKRLKP
SIHIIGTGGVKTGRDAFEHILCGASMVQIGTALHQEGPAIFERVTKELKTIMVEKGYQSLDDFRGNLRYKD

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI87082059, Length=215, Percent_Identity=26.046511627907, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322633, Length=309, Percent_Identity=58.252427184466, Blast_Score=380, Evalue=1e-106,
Organism=Drosophila melanogaster, GI281361352, Length=281, Percent_Identity=27.7580071174377, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17137316, Length=281, Percent_Identity=27.7580071174377, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_STRP1 (Q99Z28)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_269518.1
- RefSeq:   YP_282528.1
- HSSP:   P54321
- ProteinModelPortal:   Q99Z28
- SMR:   Q99Z28
- EnsemblBacteria:   EBSTRT00000001327
- EnsemblBacteria:   EBSTRT00000028287
- GeneID:   3571750
- GeneID:   901488
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_1432
- KEGG:   spz:M5005_Spy_1165
- GeneTree:   EBGT00050000027667
- HOGENOM:   HBG472415
- OMA:   KPLGVKL
- ProtClustDB:   PRK02506
- BioCyc:   SPYO160490:SPY1432-MONOMER
- BioCyc:   SPYO293653:M5005_SPY1165-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00224_B
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01037

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.3.1

Molecular weight: Translated: 34323; Mature: 34323

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 131-131

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSTATQIGHFSFDNCLMNAAGVYCMTKEELMEVEKSQAASFVTKTGTLEVRPGNPEPRY
CCCCCHHHCCCCHHHHHHHCCCEEEECHHHHHHHHHHHHHHHEEECCEEEEECCCCCCCC
ADTRLGSINSMGLPNNGFRYYLDFVSDLAKTGQHKPHFLSVVGLSPTETETILKAIMASD
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHCC
YEGLVELNLSCPNVPGKPQIAYDFETTDQLLENIFTYYTKPLGIKLPPYFDIVHFDQAAA
CCCEEEEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHH
IFNKYPLSFVNCVNSIGNGLVIKDEQVLIKPKNGFGGIGGDYIKPTALANVHAFYKRLKP
HHHHCCHHHHHHHHHHCCCEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCC
SIHIIGTGGVKTGRDAFEHILCGASMVQIGTALHQEGPAIFERVTKELKTIMVEKGYQSL
CEEEEECCCCCCHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHH
DDFRGNLRYKD
HHHCCCCCCCC
>Mature Secondary Structure
MVSTATQIGHFSFDNCLMNAAGVYCMTKEELMEVEKSQAASFVTKTGTLEVRPGNPEPRY
CCCCCHHHCCCCHHHHHHHCCCEEEECHHHHHHHHHHHHHHHEEECCEEEEECCCCCCCC
ADTRLGSINSMGLPNNGFRYYLDFVSDLAKTGQHKPHFLSVVGLSPTETETILKAIMASD
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHCC
YEGLVELNLSCPNVPGKPQIAYDFETTDQLLENIFTYYTKPLGIKLPPYFDIVHFDQAAA
CCCEEEEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHH
IFNKYPLSFVNCVNSIGNGLVIKDEQVLIKPKNGFGGIGGDYIKPTALANVHAFYKRLKP
HHHHCCHHHHHHHHHHCCCEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCC
SIHIIGTGGVKTGRDAFEHILCGASMVQIGTALHQEGPAIFERVTKELKTIMVEKGYQSL
CEEEEECCCCCCHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHH
DDFRGNLRYKD
HHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296