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The map label for this gene is murZ

Identifier: 15675291

GI number: 15675291

Start: 1123897

End: 1125156

Strand: Reverse

Name: murZ

Synonym: SPy_1358

Alternate gene names: 15675291

Gene position: 1125156-1123897 (Counterclockwise)

Preceding gene: 15675292

Following gene: 15675290

Centisome position: 60.74

GC content: 41.19

Gene sequence:

>1260_bases
ATGCGTAAAATTATTATTAATGGCGGAAAAGCCTTATCTGGAGAAGTGGCAGTTTCAGGGGCAAAAAACAGTGTTGTTGC
GCTTATTCCAGCAATCATCTTAGCCGATGATATTGTGATTCTTGATGGTGTACCTGCTATTAGTGATGTAGATAGTCTGA
TTGAAATCATGGAGCTTATGGGAGCAACAGTAAACTATCATGGTGATACTTTAGAAATTGACCCTAGAGGGGTGCAAGAC
ATCCCGATGCCTTACGGAAAGATTAATAGTCTTCGAGCTTCCTATTATTTCTACGGTAGTCTTTTAGGTCGTTTTGGACA
AGCAGTTGTTGGCTTACCTGGTGGTTGCGATTTAGGACCAAGACCAATTGACTTGCATTTGAAGGCCTTCGAGGCTATGG
GAGTTGAAGTGTCTTATGAGGGTGAAAATATGAATTTATCGACAAATGGTCAAAAAATTCATGGCGCTCATATCTATATG
GACACCGTTAGTGTCGGTGCTACAATTAATACTATGGTTGCGGCAACAAAAGCTCAAGGTAAAACGGTTATTGAAAACGC
TGCACGTGAGCCAGAGATTATTGATGTGGCTACTCTTTTGAATAACATGGGTGCGCATATTCGTGGAGCAGGTACAGATA
TTATTACGATACAAGGTGTTCAGAAATTGCATGGTACTAGACACCAAGTTATTCCTGATCGTATTGAAGCAGGGACTTAT
ATCGCTTTGGCGGCAGCTATTGGAAAAGGTGTTAAGATCACTAATGTTCTTTATGAGCATTTAGAGAGTTTCATTGCTAA
GTTAGAAGAAATGGGTGTCCGTATGACGGTAGAAGAGGATGCTATCTTTGTTGAAAAGCAAGAATCCCTCAAGGCTATTA
CAATTAAAACCTCTCCTTACCCTGGTTTTGCCACTGATTTGCAACAGCCATTAACGCCCTTGTTGTTAAAAGCAGATGGT
CGTGGAACGATTATTGACACTATATATGAAAAGCGCATTAACCATGTGCCAGAGTTGATGCGCATGGGAGCAGATATCTC
AGTTATTGGTGGTCAAATTGTTTATCAAGGGCCGTCTCGCCTGACAGGAGCTCAGGTCAAAGCCACTGATTTACGTGCCG
GAGCGGCTCTAGTGACTGCTGGTCTAATAGCTGAAGGCAAGACAGAAATTACTAATATTGAATTTATCTTACGTGGCTAT
GCTAGTATCATTGCAAAATTAACAGCACTAGGGGCAGATATTCAATTAATCGAAGACTAA

Upstream 100 bases:

>100_bases
AAAAGGGATGATTAAAAATTAAGACGTCAATAATTGTCAGGCTTCATGATTTATGATAAAATGAAAAGGTTGAATTCTAG
TATAAGAAAGTTTTGAATGT

Downstream 100 bases:

>100_bases
AGAGAAGCTAACGCTTCTCTTTTTTATATTACATGTGCTTAGGCTAATGATACTTAGGTGCATACTTTGTTGCATTTTAT
GGCTTTTTAACTGTCATAAA

Product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Products: NA

Alternate protein names: Enoylpyruvate transferase 2; UDP-N-acetylglucosamine enolpyruvyl transferase 2; EPT 2

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MRKIIINGGKALSGEVAVSGAKNSVVALIPAIILADDIVILDGVPAISDVDSLIEIMELMGATVNYHGDTLEIDPRGVQD
IPMPYGKINSLRASYYFYGSLLGRFGQAVVGLPGGCDLGPRPIDLHLKAFEAMGVEVSYEGENMNLSTNGQKIHGAHIYM
DTVSVGATINTMVAATKAQGKTVIENAAREPEIIDVATLLNNMGAHIRGAGTDIITIQGVQKLHGTRHQVIPDRIEAGTY
IALAAAIGKGVKITNVLYEHLESFIAKLEEMGVRMTVEEDAIFVEKQESLKAITIKTSPYPGFATDLQQPLTPLLLKADG
RGTIIDTIYEKRINHVPELMRMGADISVIGGQIVYQGPSRLTGAQVKATDLRAGAALVTAGLIAEGKTEITNIEFILRGY
ASIIAKLTALGADIQLIED

Sequences:

>Translated_419_residues
MRKIIINGGKALSGEVAVSGAKNSVVALIPAIILADDIVILDGVPAISDVDSLIEIMELMGATVNYHGDTLEIDPRGVQD
IPMPYGKINSLRASYYFYGSLLGRFGQAVVGLPGGCDLGPRPIDLHLKAFEAMGVEVSYEGENMNLSTNGQKIHGAHIYM
DTVSVGATINTMVAATKAQGKTVIENAAREPEIIDVATLLNNMGAHIRGAGTDIITIQGVQKLHGTRHQVIPDRIEAGTY
IALAAAIGKGVKITNVLYEHLESFIAKLEEMGVRMTVEEDAIFVEKQESLKAITIKTSPYPGFATDLQQPLTPLLLKADG
RGTIIDTIYEKRINHVPELMRMGADISVIGGQIVYQGPSRLTGAQVKATDLRAGAALVTAGLIAEGKTEITNIEFILRGY
ASIIAKLTALGADIQLIED
>Mature_419_residues
MRKIIINGGKALSGEVAVSGAKNSVVALIPAIILADDIVILDGVPAISDVDSLIEIMELMGATVNYHGDTLEIDPRGVQD
IPMPYGKINSLRASYYFYGSLLGRFGQAVVGLPGGCDLGPRPIDLHLKAFEAMGVEVSYEGENMNLSTNGQKIHGAHIYM
DTVSVGATINTMVAATKAQGKTVIENAAREPEIIDVATLLNNMGAHIRGAGTDIITIQGVQKLHGTRHQVIPDRIEAGTY
IALAAAIGKGVKITNVLYEHLESFIAKLEEMGVRMTVEEDAIFVEKQESLKAITIKTSPYPGFATDLQQPLTPLLLKADG
RGTIIDTIYEKRINHVPELMRMGADISVIGGQIVYQGPSRLTGAQVKATDLRAGAALVTAGLIAEGKTEITNIEFILRGY
ASIIAKLTALGADIQLIED

Specific function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine

COG id: COG0766

COG function: function code M; UDP-N-acetylglucosamine enolpyruvyl transferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family. MurA subfamily

Homologues:

Organism=Escherichia coli, GI1789580, Length=420, Percent_Identity=45, Blast_Score=345, Evalue=4e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURA2_STRP1 (Q99Z78)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_269465.1
- RefSeq:   YP_282470.1
- ProteinModelPortal:   Q99Z78
- SMR:   Q99Z78
- EnsemblBacteria:   EBSTRT00000001256
- EnsemblBacteria:   EBSTRT00000027368
- GeneID:   3571809
- GeneID:   901433
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_1358
- KEGG:   spz:M5005_Spy_1107
- GeneTree:   EBGT00050000028044
- HOGENOM:   HBG482701
- OMA:   IGGKVTY
- ProtClustDB:   PRK12830
- BioCyc:   SPYO160490:SPY1358-MONOMER
- BioCyc:   SPYO293653:M5005_SPY1107-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00111
- InterPro:   IPR001986
- InterPro:   IPR013792
- InterPro:   IPR005750
- Gene3D:   G3DSA:3.65.10.10
- PANTHER:   PTHR21090:SF4
- TIGRFAMs:   TIGR01072

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.7

Molecular weight: Translated: 44663; Mature: 44663

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: ACT_SITE 116-116

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKIIINGGKALSGEVAVSGAKNSVVALIPAIILADDIVILDGVPAISDVDSLIEIMELM
CCEEEEECCCEECCCEEEECCCCCHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHH
GATVNYHGDTLEIDPRGVQDIPMPYGKINSLRASYYFYGSLLGRFGQAVVGLPGGCDLGP
CCEEEECCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCC
RPIDLHLKAFEAMGVEVSYEGENMNLSTNGQKIHGAHIYMDTVSVGATINTMVAATKAQG
CCEEEEEEEEHHCCEEEEECCCCEEEECCCCEEEEEEEEEEEEECCCCHHHHEEECCCCC
KTVIENAAREPEIIDVATLLNNMGAHIRGAGTDIITIQGVQKLHGTRHQVIPDRIEAGTY
CHHHHHCCCCCCHHHHHHHHHHCCCEEECCCCEEEEECCHHHHCCCCCCCCCHHHCCCCC
IALAAAIGKGVKITNVLYEHLESFIAKLEEMGVRMTVEEDAIFVEKQESLKAITIKTSPY
EEEEHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEEECCCCEEEEEECCCC
PGFATDLQQPLTPLLLKADGRGTIIDTIYEKRINHVPELMRMGADISVIGGQIVYQGPSR
CCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCEEEECCCCC
LTGAQVKATDLRAGAALVTAGLIAEGKTEITNIEFILRGYASIIAKLTALGADIQLIED
CCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
>Mature Secondary Structure
MRKIIINGGKALSGEVAVSGAKNSVVALIPAIILADDIVILDGVPAISDVDSLIEIMELM
CCEEEEECCCEECCCEEEECCCCCHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHH
GATVNYHGDTLEIDPRGVQDIPMPYGKINSLRASYYFYGSLLGRFGQAVVGLPGGCDLGP
CCEEEECCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCC
RPIDLHLKAFEAMGVEVSYEGENMNLSTNGQKIHGAHIYMDTVSVGATINTMVAATKAQG
CCEEEEEEEEHHCCEEEEECCCCEEEECCCCEEEEEEEEEEEEECCCCHHHHEEECCCCC
KTVIENAAREPEIIDVATLLNNMGAHIRGAGTDIITIQGVQKLHGTRHQVIPDRIEAGTY
CHHHHHCCCCCCHHHHHHHHHHCCCEEECCCCEEEEECCHHHHCCCCCCCCCHHHCCCCC
IALAAAIGKGVKITNVLYEHLESFIAKLEEMGVRMTVEEDAIFVEKQESLKAITIKTSPY
EEEEHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEEECCCCEEEEEECCCC
PGFATDLQQPLTPLLLKADGRGTIIDTIYEKRINHVPELMRMGADISVIGGQIVYQGPSR
CCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCEEEECCCCC
LTGAQVKATDLRAGAALVTAGLIAEGKTEITNIEFILRGYASIIAKLTALGADIQLIED
CCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296