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The map label for this gene is map [H]

Identifier: 15675287

GI number: 15675287

Start: 1119938

End: 1120798

Strand: Reverse

Name: map [H]

Synonym: SPy_1354

Alternate gene names: 15675287

Gene position: 1120798-1119938 (Counterclockwise)

Preceding gene: 15675288

Following gene: 15675286

Centisome position: 60.5

GC content: 42.04

Gene sequence:

>861_bases
ATGATAACATTAAAATCAGCCCGTGAAATAGAAGCGATGGATAGAGCAGGAGACTTCTTAGCAGGTATCCATATTGGCTT
AAGGGATATTATTAAGCCTGGTGTGGATATGTGGGAAGTGGAAGCATATGTTCGTCGCCGTTGTAAAGAAGACAACGTTC
TTCCTTTGCAAATAGGGGTTGATGGTCACATGATGGACTATCCTTATGCGACCTGTTGTGGTCTAAATGACGAAGTAGCA
CATGCCTTTCCCCGTCATTACATTCTGAAAGAAGGGGATTTGCTTAAAGTTGACATGGTACTCAGTGAGCCTTTGGATAA
ATCAATTGTTGATGTAGCAGCTTTAGATTTTGATAACGTACCTGAGATGAAGAAATGGACAGGATCTTATACCGGTGGTT
TAGCTGACTCTTGTTGGGCTTATGCTGTTGGAACACCGTCTGACGAAATAAAGCAATTAATGGATGTCACCAAAGAAGCC
ATGTACCGTGGTATTGAAAAAGCAGTAATTGGCAATCGTATTGGTGATATTGGCGCAGCTGTTCAAGAATACGCTGAAAG
CTTCGGTTATGGTGTCGTGCGTGATCTTGTTGGTCACGGTGTTGGTCCTACAATGCATGAAGAGCCAATGGTACCAAACT
ATGGAACAGCAGGTCGTGGACTTCGTCTAAAAGAAGGCATGGTCTTGACTGTTGAGCCAATGATTAATACAGGAACTTGG
GAAATTGATACCGACATCAAGACAGGTTGGGCTCATAAAACCCTAGATGGTGGTTTATCTTGCCAATACGAACACCAATT
TGTGATTACTAAAGATGGTCCCGTTATTTTAACAAGTCAAGGAGAAGAAAGAACTTACTAA

Upstream 100 bases:

>100_bases
TAGACGAAGCAGCACCATTGATATTGAAATTTTTGTGGATGATCAAGTGATTGCTAAAGCTATTATTACAACGAAAATAA
ATTAGAGGAGTAACAAAACA

Downstream 100 bases:

>100_bases
AATGGCAGAAAAAAAATGGTTTGATAAGGTACTGTCCAAGTGGCAGTATGAACCCATTCAAGTCTTTATGAGGCATTTAC
AAAGTGCAGAAATGGATTTA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MITLKSAREIEAMDRAGDFLAGIHIGLRDIIKPGVDMWEVEAYVRRRCKEDNVLPLQIGVDGHMMDYPYATCCGLNDEVA
HAFPRHYILKEGDLLKVDMVLSEPLDKSIVDVAALDFDNVPEMKKWTGSYTGGLADSCWAYAVGTPSDEIKQLMDVTKEA
MYRGIEKAVIGNRIGDIGAAVQEYAESFGYGVVRDLVGHGVGPTMHEEPMVPNYGTAGRGLRLKEGMVLTVEPMINTGTW
EIDTDIKTGWAHKTLDGGLSCQYEHQFVITKDGPVILTSQGEERTY

Sequences:

>Translated_286_residues
MITLKSAREIEAMDRAGDFLAGIHIGLRDIIKPGVDMWEVEAYVRRRCKEDNVLPLQIGVDGHMMDYPYATCCGLNDEVA
HAFPRHYILKEGDLLKVDMVLSEPLDKSIVDVAALDFDNVPEMKKWTGSYTGGLADSCWAYAVGTPSDEIKQLMDVTKEA
MYRGIEKAVIGNRIGDIGAAVQEYAESFGYGVVRDLVGHGVGPTMHEEPMVPNYGTAGRGLRLKEGMVLTVEPMINTGTW
EIDTDIKTGWAHKTLDGGLSCQYEHQFVITKDGPVILTSQGEERTY
>Mature_286_residues
MITLKSAREIEAMDRAGDFLAGIHIGLRDIIKPGVDMWEVEAYVRRRCKEDNVLPLQIGVDGHMMDYPYATCCGLNDEVA
HAFPRHYILKEGDLLKVDMVLSEPLDKSIVDVAALDFDNVPEMKKWTGSYTGGLADSCWAYAVGTPSDEIKQLMDVTKEA
MYRGIEKAVIGNRIGDIGAAVQEYAESFGYGVVRDLVGHGVGPTMHEEPMVPNYGTAGRGLRLKEGMVLTVEPMINTGTW
EIDTDIKTGWAHKTLDGGLSCQYEHQFVITKDGPVILTSQGEERTY

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=280, Percent_Identity=28.5714285714286, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI40385867, Length=282, Percent_Identity=24.113475177305, Blast_Score=92, Evalue=5e-19,
Organism=Escherichia coli, GI1786364, Length=280, Percent_Identity=32.1428571428571, Blast_Score=138, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI71996291, Length=255, Percent_Identity=27.4509803921569, Blast_Score=99, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6323273, Length=254, Percent_Identity=27.9527559055118, Blast_Score=108, Evalue=9e-25,
Organism=Drosophila melanogaster, GI21355531, Length=242, Percent_Identity=27.6859504132231, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24583427, Length=275, Percent_Identity=24.3636363636364, Blast_Score=91, Evalue=9e-19,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 31619; Mature: 31619

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITLKSAREIEAMDRAGDFLAGIHIGLRDIIKPGVDMWEVEAYVRRRCKEDNVLPLQIGV
CEECCCHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECC
DGHMMDYPYATCCGLNDEVAHAFPRHYILKEGDLLKVDMVLSEPLDKSIVDVAALDFDNV
CCCEECCCCHHHCCCCHHHHHHCCHHHEECCCCEEEEEHHHHCCCCHHHHHHHHCCCCCC
PEMKKWTGSYTGGLADSCWAYAVGTPSDEIKQLMDVTKEAMYRGIEKAVIGNRIGDIGAA
CCHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
VQEYAESFGYGVVRDLVGHGVGPTMHEEPMVPNYGTAGRGLRLKEGMVLTVEPMINTGTW
HHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEECCCCCCCE
EIDTDIKTGWAHKTLDGGLSCQYEHQFVITKDGPVILTSQGEERTY
EEECCCCCCCCCCCCCCCCEEEEECEEEEECCCCEEEECCCCCCCC
>Mature Secondary Structure
MITLKSAREIEAMDRAGDFLAGIHIGLRDIIKPGVDMWEVEAYVRRRCKEDNVLPLQIGV
CEECCCHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECC
DGHMMDYPYATCCGLNDEVAHAFPRHYILKEGDLLKVDMVLSEPLDKSIVDVAALDFDNV
CCCEECCCCHHHCCCCHHHHHHCCHHHEECCCCEEEEEHHHHCCCCHHHHHHHHCCCCCC
PEMKKWTGSYTGGLADSCWAYAVGTPSDEIKQLMDVTKEAMYRGIEKAVIGNRIGDIGAA
CCHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
VQEYAESFGYGVVRDLVGHGVGPTMHEEPMVPNYGTAGRGLRLKEGMVLTVEPMINTGTW
HHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEECCCCCCCE
EIDTDIKTGWAHKTLDGGLSCQYEHQFVITKDGPVILTSQGEERTY
EEECCCCCCCCCCCCCCCCEEEEECEEEEECCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]